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Page Synopsis: Be careful what medicines you take


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                     Fluoride, Fluoridosis and CFS click here                                                          click again to close Exposure to fluoridated water and attention deficit hyperactivity disorder prevalence among children and adolescents in the United States: an ecological association,environmental%20risk%20factor%20for%20ADHD Increasing fluoride levels in drinking water by just 1% can cause 131,000 ADHD cases, study shows Fluoride
 Did you know that fluoride was used in the past to treat hyperthyroidism and that it was frequently used at levels below the current "optimal" intake of 1mg per day. Did you know that fluoride is able to mimic the action of TSH? Researcher Andreas Schuld has found that excess fluoride correlates with other thyroid-related issues such as iodine deficiency. When there is excess of fluoride in the body it can interfere with the function of the thyroid gland. For more information about fluoride, see the National Pure Water Association's  or Fluoride Fatigue. Fluoride poisoning: is fluoride in your drinking water, and from other sources, making you sick individuals who are sensitive to fluoride may experience a wide variety of symptoms: chronic fatigue, not relieved by extra sleep or rest; headaches; nausea; visual disturbances; dryness of the throat and excessive water consumption; gastrointestinal disturbances; spasms, aches and stiffness in the muscles; arthritis-like pains; skin rash or itching; and others. ... Citing case reports, including double-blind tests, from the research of Drs George Waldbott, AK Susheela, Harvey T Petraborg, Hans Moolenburgh, GW Grimbergen WHAT TO DO WHEN YOU GET FLOXED Toxicity Symptoms from a Functional Medicine Perspective You’re either here because you have been floxed, have a friend or family member who has been floxed and/or maybe, you’re researching the topic for school. As one of the first practitioners to treat floxies (aka those who have symptoms of cipro toxicity) in the NY area, I’ve seen it all – regardless of where you fall in your search – you’re in the right place. Fluoroquinolone Toxicity is something not a lot of doctors are familiar with. I became of it a year after graduating & entering into Osteopathic medicine – and worked at a family practice. We had a girl come in who was experiencing blurry vision, cognitive impairment & depression. Her mom commented that the girl before us was a shell of her normally cheerful, athletic, studious and  smart as a whip daughter from last week. We put our heads together, looked at her newly run labs & comprehensive history to finally pinpoint the problem: she had been prescribed and taken Levofloxacin weeks before for a bacterial infection. Cross correlating that her symptoms showed up shortly after she finished the bottle and several lab markers (that we’ll address below) we decided to explore if Levofloxacin played a role in the girl we had before us days prior. The symptoms of fluoroquinolone toxicity she was experiencing sent my co-workers and I down a rabbit hole of of emergent thinking. What if antibiotics may not just harm our microbiome, but they severely damage human cells? – Dr. PaulvinNow onto the research + support as adverse reactions to fluoroquinolones have received considerable attention over the years. Out of every 10,000 prescriptions given, an average of 9.2 are reported to result in emergency room visits. The most widely-used fluoroquinolones being: Ciprofloxacin, Levofloxacin, and Moxifloxacin. What is fluoroquinolone toxicity syndrome?Signs + SymptomsFluoroquinolone drugs have been linked to some potentially serious, long-term, and permanently disabling side effects, including toxicity to the central nervous system, cardiovascular system, and musculoskeletal system. Other Cipro toxicity symptoms include: Mitochondrial dysfunction and DNA damageBrain FogPeripheral NeuropathyBlurry VisionDNA DamageAnxiety/Depression due to the effect and Gaba and Gut DamageTendonitisMuscle AtrophyIncreased reflexesEarly signs of Cipro toxicity include low back pain, tendonitis, tendon rupture, arthralgia, pain in extremities, gait disturbance, neuropathies associated with paraesthesia, depression, fatigue, memory impairment, sleep disorders, and impaired hearing, vision, taste, and smell. Long term, fluoroquinolones may increase the risk of peripheral neuropathy by 47%. Ciprofloxacin is shown to inhibit normal maintenance and transcription of mitochondrial DNA by changing mtDNA topology. Mitochondrial damage to tenocytes during fluoroquinolone treatment may be involved in tendinitis and tendon rupture. It can also lead to fatigue, and inflammation, Warning: If you have been exposed to quinolones, it is advisable to not use Ibuprofen, Steroids, or Fluorinated compounds that include PPI’s. Asthma inhalers and some SSRI’s fall into this camp. How to treat Cipro toxicityMany people want to know if (and how) they can detox from Cipro, Levaquin, Avelox, and other fluoroquinolone drug reactions. The reaction can be treated if diagnosed early. Functional medicine may be a viable fluoroquinolone toxicity solution. Functional medicine seeks to identify and address the root cause of disease, rather than treating the symptoms. Comprehensive health treatments are used to support the patient’s overall health and longevity. There is hope! Your symptoms can be managed if we focus on healing across the mind & body. Reducing the Toxicity of FluoroquinoloneDetox Detox DetoxImmediate ingestion of antacids or magnesium supplements (in appropriate amounts) can prevent some of the quinolones from entering the bloodstream. Quinolone absorption is markedly reduced with antacids containing aluminium, magnesium and/or calcium. Other metallic ion-containing drugs such as sucralfate, iron salts, and zinc salts, can also reduce absorption. However, this may also result in therapeutic failure. Treatment with NAC has been shown to reduce intracellular reactive oxygen species (ROS) and the SOS response caused by ciprofloxacin without affecting its antibacterial potential. Recovery from Fluoroquinolone ToxicityAlthough not comprehensive, here are a few treatments that may be beneficial. Please schedule an appointment with Dr. Paulvin for a bio-individual & comprehensive treatment plan. Mitochondrial support & healing modalities & treatments.Oxidative stress can be reduced by increasing levels of endogenous and exogenous antioxidants and by stabilising mitochondrial energy production with α-lipoic acid and ubiquinone (coenzyme Q10).Cells treated with mitoquinol mesylate showed less oxidative stress and maintained more mitochondrial membrane potential.Cipro Neuropathy TreatmentNeuropathy can be treated with medications, technology and supplements.  medications used to treat and manage associated neuropathy include gabapentin, lidocaine, imipramine, carbamazepine, and nutritional support.   Supplements such as carnosine and alpha lipoic acid plus red light therapy and hyperbaric can help. Peptide TherapyAlternatives to fluoroquinolones are now being sought. Antimicrobial peptides are rapidly gaining attention for their clinical potential as an alternative to antibiotics. Chemical modifications to the peptide backbone can be used to improve biological activity and stability and reduce toxicity. Zinc carnosine has been shown to improve the eradication of Helicobacter pylori. Gut Health RestorationRestoring the gut microbiome and intestinal lining after antibiotics is crucial. You should work directly with your practitioner to understand which strains of probiotic therapies would best for your individuality – but a few things that I have seen work include Colostrum, IonBiome and/or BPC 157 tablets. Cipro Toxicity Testing & Treatment in NYCHave you already had your labs done, suspect you may have Cipro Toxicity & don’t know what to look for? Cipro, Levaquin & Avelox Side Effects have been the focus of increasing scrutiny for their potential to cause rare, but serious, life-altering side effects. Authorities warn that doctors should curtail prescribing these very popular antibiotics to avoid so-called “collateral damage.” In addition to causing common reactions such as abdominal pain and diarrhea, the drugs can lead to mental health problems and permanent damage to tendons and nerves. Fluoroquinolones make up the third most commonly prescribed class of antibiotics for outpatients, according to the Centers for Disease Control and Prevention. These drugs — in use for more than 30 years — include the most popular, Cipro (ciprofloxacin), as well as Avelox (moxifloxacin) and the discontinued Levaquin (levofloxacin). Because this class of antibiotics brings the potential for major side effects, the FDA urges doctors not to over-use them. In fact, the agency has restricted the recommended uses for these drugs and has required several updates to the drugs’ labels to warn of life-altering risks. Researchers have taken to use the phrase “collateral damage” in describing the serious side effects these drugs can cause. In particular, this term often refers to the potential for the development of antibiotic-resistant bacteria, a serious public health issue which researchers say is increasing with fluoroquinolone use. Other rare, serious side effects associated with these drugs include tendon problems, heart issues and mental health conditions. According to the National Center for Health Research, drug companies often fight efforts by the FDA to require strong warnings about dangerous side effects because these warnings often reduce the number of prescriptions. In 2012, Johnson & Johnson settled more than 800 lawsuits over its failure to provide sufficient warning — before the FDA required the company do so — about the risk of tendon ruptures linked to LevaquinCommon Side Effects, Allergic Reaction and C. diff InfectionCommon side effects of fluoroquinolones include nausea, diarrhea, vomiting, abdominal pain or discomfort, and trouble sleeping. Some patients also develop sensitivity to sunlight and ultraviolet light, such as the lights used in tanning salons. The package insert for Cipro says there have been rare reports of patients developing allergic reactions to this class of drugs, even after a single dose. Patients who develop hives, trouble breathing or other signs of a serious allergic reaction should seek emergency treatment immediately. Researchers say the fluoroquinolones are responsible for more than 20,000 emergency room visits each year. According to CDC researchers, the drugs are associated with a high risk for later development of Clostridium difficile infection, a potentially life threatening, antibiotic-resistant condition that causes watery diarrhea. FDA Warns of Increased Risk of Aortic Ruptures or TearsIn December 2018, the FDA warned about an increased risk of aortic ruptures or tears with fluoroquinolones and said it was requiring manufactures to add a new warning about this risk to the prescribing information and patient Medication Guide for all drugs in the class. The agency reached its decision after it had searched the FDA Adverse Event Reporting System (FAERS) database and reviewed four epidemiological studies published between 2015 and 2018. An aortic aneurysm is a bulge in the aorta, which is the artery responsible for carrying blood from the heart through the chest and torso. The lining of the aorta is made up of collagen. Scientists suspect that fluoroquinolones break down collagen in the body. Two 2015 studies published in the medical journals JAMA and BMJ revealed a connection between the antibiotics and collagen damage that may lead to aortic aneurysmsAortic aneurysms can act in two ways:Tears can form in the aorta, allowing blood to leak in between the layers of tissue in the vessel wall, separating them. This is called aortic dissection.The aneurysm can also rupture, which is when it bursts completely, causing bleeding inside the body.According to the JAMA study, fluoroquinolones were associated with a two-fold increase in risk of dissection and aneurysm within 60 days of using the drug. “Clinicians should continue to be vigilant for the appearance of aortic aneurysm and dissection in high-risk patients treated with fluoroquinolones,” the authors wrote. The BMJ study found nearly a three-fold increase in the risk of aneurysm. Authors of this study followed about 1.7 million patients and found one third of them received a prescription for a fluoroquinolone. More than 1 percent of the patients experienced aortic aneurysms. “Reducing unnecessary fluoroquinolone treatments or prolonged treatment courses might have possibly prevented more than 200 aortic aneurysms in this population,” the authors wrote. More recently, a study published in BMJ in January 2018 found an increased risk of aortic aneurysm or dissection with fluoroquinolones compared to amoxicillin. Researchers used nationwide data from Swedish registries from July 2006 to December 2013 to look at the rate of aortic aneurysm or dissection within 60 days from start of treatment. They concluded that there was a 66 percent increased rate among patients who took fluoroquinolones compared to those who received amoxicillinFDA Updates Mental Health and Low Blood Sugar WarningsIn July 2018, the U.S. Food and Drug Administration required safety labeling changes for fluoroquinolones to strengthen the warnings about mental health side effects and serious blood sugar problems. The agency said the changes were required following a comprehensive review of its adverse event reports as well as case reports in medical literature. All fluoroquinolone labels must list the following mental health side effects:Disturbances in attentionDisorientationAgitationNervousnessMemory impairmentDeliriumThese are in addition to the central nervous system side effects already linked to the drugs, including anxiety, depression, hallucinations, suicidal thoughts and confusion. “The new class-wide labeling changes will require that the mental health side effects be listed separately from other central nervous system side effects and be consistent across the labeling of the fluoroquinolone class,” the FDA saidThe agency’s review also found instances of patients who went into hypoglycemic coma where users of the drugs experienced hypoglycemia. Consequently, the antibiotics must carry an explicit warning about the potential risk of coma with hypoglycemia. The July 2018 safety announcement advised patients to tell their doctors if they take a diabetes medicine when the health care professional is considering an antibiotic. These patients may be asked to check their blood sugar more frequently when taking one of these drugs. The FDA said patients using these drugs should keep an eye out for early signs of low blood sugar such as confusion, dizziness, feeling shaky and headaches. Other symptoms include unusual hunger, irritability, pounding heart or very fast pulse, pale skin, sweating, trembling, weakness and unusual anxiety. These symptoms can get worse and become life-threatening. The FDA advises patients experiencing serious symptoms, including confusion, seizures or loss of consciousness, to seek help immediately by calling 911 or going to an emergency room. ‘Disabling and Potentially Irreversible Adverse Reactions’The European Medicines Agency held a hearing about side effects of the drugs in the summer of 2018. According to its summary of the hearing, patients who appeared “described life-changing symptoms following treatment … including pain and disability lasting several years, with some patients only experiencing limited improvement over time.” “Furthermore, some patients can no longer work or engage in exercise and active pursuits or even carry out daily tasks such as tying a shoe lace or buttoning a shirt,” the summary said. “Some are in constant pain, with symptoms affecting a wide range of muscles and tendons.” LIFE-CHANGING SYMPTOMSSome patients experienced pain and disability for years, unable to work, exercise or even dress themselves.Source: European Medicines AgencyThe agency said it heard repeatedly that doctors lacked knowledge of the possible side effects and that patients were not informed of the risks. In 2016, the FDA announced that a review found 178 patients over an 18-year period who reported developing “disabling and potentially irreversible adverse reactions that appeared as a constellation of symptoms.” The FDA said 97 percent of the affected patients reported pain associated with musculoskeletal adverse reactions. “The ongoing neuropsychiatric adverse reactions were reported to be distressing, affecting employment and quality of life,” the agency saidThe review considered only patients who reported adverse reactions lasting longer than a month and involving two or more body systems. The majority of the complications affected primarily the musculoskeletal system, peripheral nervous system and central nervous system. “Many patients described how seriously the disability impacted their lives, including job loss and the resulting lack of health insurance, large medical bills, financial problems and family tension or dissolution,” according to the FDA. The reactions lasted an average of 14 months, with the longest duration being 9 years. It’s possible, the FDA said, that some of these reactions may be permanent. Patients were advised to contact their health care professional immediately if they developed any serious side effects while taking these drugs. The FDA said some signs and symptoms include:Tendon, joint and muscle painA “pins and needles” tingling or pricking sensationConfusionHallucinationsTendon ProblemsFluoroquinolones are associated with an increased risk of tendinitis and tendon rupture. The first published report of a tendon injury associated with the use of the drugs was published in New Zealand in 1983, according to a 2010 article by Dr. Grace Kim in The Journal of Clinical and Aesthetic Dermatology. Many anecdotal case reports and case-controlled studies reporting similar findings came out after the 1983 publication, mostly from researchers in France. A 2003 World Health Organization (WHO) survey in Australia found that ciprofloxacin was the cause of 90 percent of fluoroquinolone-induced tendon injuries, Kim said. But other reports have also indicated norfloxacin, pefloxacin, ofloxacin and levofloxacin in such injuries. “Pain, swelling, inflammation, and tears of tendons including the Achilles, shoulder, hand, or other tendons can happen in patients taking fluoroquinolone antibiotics.”Source: U.S. Food and Drug Administrationand tendon rupture. The consumer group even went as far as suing the FDA to compel the agency to act on the petition. In 2008, the FDA issued a decision on the petition, requiring manufacturers to add a boxed warning to their drugs’ labels about the increased risk of developing tendinitis and tendon rupture. The agency and the consumer group reached an agreement to dismiss the lawsuit. “Pain, swelling, inflammation, and tears of tendons including the Achilles, shoulder, hand, or other tendons can happen in patients taking fluoroquinolone antibiotics,” the agency said in a 2008 FDA alert. The agency added that the risk of tendinitis and tendon rupture is increased for people older than 60, patients taking corticosteroid drugs, and recipients of kidney, heart and lung transplantsPeripheral NeuropathyIn 2013, the FDA announced it was strengthening warnings in the labels for fluoroquinolones to better describe the disabling side effect of peripheral neuropathy. Previous warnings about this serious nerve damage were not strong enough or clear enough, the FDA said. Specifically, the federal agency said older labels failed to explain fully that neuropathy damage can happen immediately after taking the drugs and can be permanent. The FDA told doctors and consumers to discontinue the medication immediately if symptoms of nerve damage surfaceFDA data shows a continued association between the drugs and the crippling nerve disorder, which occurs in the arms and legs. In fact, the onset of peripheral neuropathy after starting the antibiotics was rapid, often within a few days. In some patients, the symptoms had lasted for more than a year, even after users had stopped taking the drugs. Several patients were continued on the antibiotics despite their showing signs of the disorder. The FDA ultimately concluded peripheral neuropathy can occur at any time during treatment with fluoroquinolones and can last for months to years after the drug is stopped or can be permanent. A study published in 2014 by the peer-reviewed journal Neurology further supported the FDA’s findings. The study showed long-time users of the antibiotics had twice the risk of developing peripheral neuropathy, while new users had a slightly greater risk than those not taking the drugs. “Clinicians should weigh the benefits against the risk of adverse events when prescribing these drugs to their patients,” the authors wrote. Researchers studied more than 30,000 men in the U.S. from 2001 to 2011  Counter argumentDo all SSRI contain fluoride?'norad'I read that most SSRI contain fluoride. I'm not really keen on getting extra fluoride. I read that fluoride affects the will of a person and makes them less critical and easier to control, which doesn't really sound good to me. I don't want to turn into a zombie.Do you know if there are also SSRI or SNRI which don't contain fluoride? I'm already thinking about what options I have if citalopram shouldn't work and in this case I'd like a med which doesn't have fluoridescarpiaThat's not true about fluoride. Millions of people get fluoride in food and water. It is a natural mineral that is in many wells. None actually have fluoride - they have covalently bonded fluorines in their structure.Several also have cyano groups, but it doesn't mean they have the same effect as hydrogen cyanide. An early SSRI - zimeldine doesn't have any fluorine. It has bromineFluoride is not an element. It is the anion - a reduced form -of the element fluorine. They are very different. Covalenty bonded florine to carbon is very stable and that makes it difficult for your body to convert it into fluorideDuke of PrunesIt's also worth noting the obvious that a compound doesn't necessarily inherit the properties of it's constituents unless the structure is such that those constituents are separated by some metabolic process. In the case of fluoxetine at least, it's pretty obvious that the fluoride isn't going anywhere, eliminating any chance of fluorine release and related toxicity. That's not to say that the presence of fluoride in an otherwise harmless compound couldn't render it toxic, but the toxicity would be caused by the compound as a whole and wouldn't be in any way related to that of fluorine. Fluorine poisoning is possible with things like sodium fluoride, but the amount found in tap water is trivial, and if you're stupid enough to swallow ten tubes of toothpaste despite the big warning on the back that says 'CONTAINS SODIUM FLUORIDE - DO NOT SWALLOW', you've only yourself to blame if something bad happensScarpiaNo SSRI contains fluoride. Many have fluorine atoms that are inert because they are strongly bonded to carbon. Your body will not convert the fluorine to fluoride. I don't know a better way to answer your question Fluoride Containing Medications has been written on the affect that fluoride has on thyroid metabolism, but not much has been said about medications that have an adverse affect on thyroid function; directly. This information came from the Fluoride Toxicity Research Collaborative.  I am only going to list what I consider to be the most common medications used, but for a full list see the FTRC website at PrevacidCiproLevaquinProzacPaxilLuvoxCelexaLexaproDiflucanLipitorVytorinCelebrexAdvairAvodartThe medications in bold are more pertinent to our discussion here as what they are prescribed for what can be directly related to insufficient thyroid function.  Anxiety and depression are two very common symptoms related to thyroid disease.  Pathognomonic (meaning a particular sign whose presence means that a particular disease is present beyond any doubt) of hypothyroidism is an elevated cholesterol.  So, the medication used to lower blood cholesterol levels can actually cause thyroid disease directly, not just indirectly. All this on top of the aspect of these medications inhibit the body’s ability to convert thyroid hormone. The very medications used to alleviate symptoms actually worsen the cause Prescription Drugs That Contain Fluoride (Search 325+ Drugs) Fluoride and Bromide containing medications that contain either fluoride or bromide or both.  Avoid these medications in general, but especially if you have conditions that are worsened by further exposure, such as low thyroid or fluoroquinolone toxicity. Advair (fluticasone) Alphagen (brimonidine) bromide Atrovent (Ipratropium) bromide Avelox (moxifloxacin) Adovart (dulasteride) Celebrex (celecoxib) Celexa (citalopram) both fluoride and bromide Cipro (ciprofloxacin) Clinoril (sulindac) Combivent (from the ipratropium)bromide Crestor (rosuvastatin) Diflucan (fluconazole) DuoNeb (nebulized Combivent) Enablex (darifenacin) bromide Flonase (fluticasone) Flovent (fluticasone) Guaifenex DM (dextromethorphan) bromide Lescol (fluvastatin) Levaquin (levofloxacin) Lexapro (escitalopram) Lipitor (atorvastatin) Lotrisone topical cream Paxil (paroxetine) Prevacid (lansoprazole) Protonix (pantoprazole) Prozac (fluoxetine) Pulmicort (budesonide) Razadyne (galantamine) bromide Risperdal (risperidone) Spiriva (tiotropium) bromide Tobra Dex (from dexamethasone) Travatan (travoprost) Triamcinolone Vigamox (moxifloxacin) Vytorin (from eztimibe) Zetia (eztimibe) If fluoride is in your medicine, it could be making you sick Pharmacist: You said that some drugs are related to fluoride and may cause hypothyroidism or other diseases of the reproductive system. Which medications and why? — D.L., Ft. Lauderdale, Fla. Answer: Shocking, I know! Some of the most popular medications in the world are “fluorinated,” meaning they were created using a backbone of fluoride. It’s the same fluoride used in toothpaste, insecticides and some supplements. The situation with fluoride is that it competes with iodine in your body. It tricks the cell into thinking it is iodine because it looks similar. Once enough fluorine atoms hook onto your cell, you become iodine deficient. advertisementThat could make you thyroid deficient because your thyroid gland cannot produce any thyroid hormone without iodine. Iodine protects your male and female reproductive organs, like your breasts, uterus, ovaries, prostate, testicles and all your private parts. When you take a fluorine-containing drug, I worry that you will become deficient in other minerals, especially iodine. You may become fluoride toxic. I’m not saying drugs cause illness in your private parts (though they could), but really, it’s the drug mugging effect of fluoride-based medications that could raise risk for iodine deficiency. Chronic fluoride ingestion could cause side effects, which unfortunately won’t get spotted as side effects. Instead, they will be diagnosed as some new disease that you don’t authentically have. Many practitioners and patients have no idea their medication contains so much fluoride-related compounds. I’m a pro at the drug nutrient depletion effect (what I call “drug mugging”), so I am happy to empower you with this information. You can ask your doctor if you need to continue your medication or if you can switch drugs to something in the same therapeutic category that is not fluorinated. Never suddenly stop taking a medication, because some cause dangerous withdrawal reactions, particularly antidepressants. If you have to take your medication, then you can evaluate your iodine status with a 24-hour urine analysis. If it’s low, you may want to supplement. Now, here are some popular fluorinated drugs: Some statin cholesterol drugs such as atorvastatin (Lipitor), fluvastatin (Lescol) Fluoroquinolone antibiotics such as ciprofloxacin (Cipro) and levofloxacin (Levaquin) implicated with dangerous “floxing.” The antidepressants fluoxetine (Prozac), paroxetine (Paxil), citalopram (Celexa) and escitalopram (Lexapro). The popular antifungal fluconazole (Diflucan) The medication used for major depression and obsessive compulsive disorder called fluvoxamine (Luvox) The infamous drug midazolam (Versed) which was implicated in the death of pop superstar Michael Jackson. It’s commonly used to relieve anxiety and induce drowsiness before surgery. The symptoms of fluoride overload are too numerous to mention here. They include problems with hormones, thyroid, sexual organs, the heart, nervous system and GI tract. Do you think you have fluorine overload or iodine deficiency? It’s a possibility if you take a fluorinated drug Thyroid damage caused by fluoride in the water's your thyroid -- the "master gland" in charge of energy, metabolism and your overall wellbeing. And right now, it's coming under constant attack from a toxic metal in your own home. Most American communities deliberately pollute their water with fluoride, and you don't have to be a card-carrying conspiracy theorist to believe it's wrecking your body from the inside.New research proves beyond doubt that the levels flowing from your kitchen sink are enough to cause serious and even debilitating thyroid damage. And if you live in an area with fluoridated water yourself, you're facing double the risk of hypothyroidism, according to the study in the Journal of Epidemiology & Community Health. The study finds that the risk kicks in at levels of 0.3 milligrams per liter -- which is miniscule compared to the 0.7 milligrams per liter that most communities start at. Many contain double those levels or more. The damage doesn't kick in overnight or even over a few years. It can take decades -- and by the time your own thyroid is reeling from this constantthere are easy ways to restore your thyroid function so it can get back to work again and you can lose that spare tire, regain your energy and lift your mood. I recommend supplementing with the minerals zinc, copper and selenium for starters. Fluoride And Your Thyroid FLUORIDE AS A NEUROTOXIN: HOW IT HARMS YOUR BRAIN AS A NEUROTOXIN: HOW IT HARMS YOUR BRAIN➤ Content➤ ProductsLast updated September 23, 2021.Edited and medically reviewed by Patrick Alban, DC. Written by Deane Alban.Fluoride is a trace mineral that, in sufficient quantity, is harmful to mental health. Consider these reasons to avoid fluoridated water and toothpaste.Fluoride is a trace mineral that naturally occurs in the earth’s crust and in water.About 6% of the world’s population, including about 75% of the US, receive artificially fluoridated water.Fluoride added to water and toothpaste is a public health measure thought to prevent dental decay and build healthy teeth.But artificially adding fluoride to drinking water is a controversial practice.The US Centers for Disease Control call the fluoridation of water “one of 10 great public health achievements of the 20th century.”On the other hand, PubChem, a National Institutes of Health’s chemistry database, considers fluoride toxic and lists numerous acute health affects.There’s reason to doubt that fluoridated water prevents tooth decay since people in pro-fluoride countries don’t have healthier teeth than the rest of the world.Many countries have actually experienced a substantial decline in cavities without the use of fluoride.But there’s little debate about what fluoride, a known neurotoxin, does to your brain.Here are some of the best reasons to consider avoiding added fluoride for the sake of the health and function of your brain.1. FLUORIDE IS A DEVELOPMENTAL NEUROTOXINA neurotoxin is a substance that’s poisonous or destructive to the tissues in the brain, spinal cord, and nervous system.A developmental neurotoxin is one that affects the brain during the most susceptible stages of life — before birth and during early childhood.A systematic review of studies published in The Lancet, one of the most prestigious and highly regarded medical journals, recommended that fluoride be classified as a developmental neurotoxin which would put it in the same category as lead, mercury, arsenic, PCBs, and toluene." Fluoridated water leaches lead and greatly increases the amount in potable water, by up to 9-fold.Study authors believe that there is a “pandemic of developmental neurotoxicity” and fluoride is a contributor.Developmental neurotoxins are linked to increases in attention deficit hyperactivity disorder (ADHD), dyslexia, loss of IQ points, disruptive behavior, and other cognitive impairments.There’s also a link between increases in autism and chronic fluoride exposure. 2. THE INGESTION OF FLUORIDE LOWERS IQ IN CHILDRENHarvard School of Public Health and China Medical University in Shenyang, China performed a joint analysis of 27 studies on the effects of fluoride.Researchers found a strong correlation between fluoride and adverse effects on brain development.Children in high-fluoride areas had significantly lower IQ scores than those living in low-fluoride areas.Related —5 Neurotoxins Found in Popular FoodsThis is not the only study that supports these findings.To date, more than 70 human studies have linked fluoride to reduced IQ in both children and adults. You can find a list of these studies on the Fluoride Action Network, a registered non-profit organization.3. FLUORIDE FACILITATES THE ENTRY OF ALUMINUM INTO THE BRAINIn the 1970s, autopsies revealed that Alzheimer’s patients had higher than normal concentrations of neurotoxic aluminum in their brains.It’s now understood that fluoride may play a role in the aluminum-Alzheimer’s connection.The blood-brain barrier is a semipermeable membrane designed to keep foreign substances — like fluoride and aluminum — out of the brain.[Over 1,000 natural and man-made chemicals are known neurotoxins. Discover how to safeguard your brain against them.]When aluminum comes into contact with fluoride, it hitches a ride into the brain as aluminum fluoride, bypassing the blood-brain barrier.The presence of aluminum fluoride in the brain has been linked to Alzheimer’s.4. FLUORIDATED DRINKING WATER INCREASES RISK OF HYPOTHYROIDISMFluoride, especially when added to drinking water, nearly doubles the risk of developing hypothyroidism (underactive thyroid). Fluoride binds with iodine receptors in the thyroid, displacing iodine.And when there isn’t adequate iodine available, the thyroid can’t synthesize thyroid hormones.That is bad news for your brain.Brain fog, memory loss, lack of focus, depression, anxiety, and other cognitive and mental health issues are some of the most problematic side effects of thyroid disorders.5. FLUORIDE CAUSES NERVOUS SYSTEM DEGENERATIONOnce fluoride crosses the blood-brain barrier, it causes degeneration in certain parts of the brain, specifically the hippocampus, neocortex, and cerebellum.The hippocampus is considered the seat of memory and is critical for learning, emotional regulation, and shutting off the stress response.The neocortex is considered the most evolved area of the brain; it’s where the brain processes sensory perception, conscious thought, and language skills.The cerebellum is responsible for coordination and balance.The damage from fluoride doesn’t stop at your brain; it continues on to the spinal cord and sciatic nerve.6. FLUORIDE IMPAIRS PINEAL GLAND FUNCTIONThe pineal gland is a pea-sized structure in the brain where melatonin is produced.Melatonin is known mainly as a sleep hormone, but it’s much more than that.Melatonin is a potent antioxidant that is especially protective of the brain.It can offset the damage of serious brain disorders, including dementia and Alzheimer’s.It may even help you live longer.Melatonin has been shown to work at least as well as antidepressant medications and is particularly useful for a certain kind of depression known as seasonal affective disorder (SAD). The pineal gland is susceptible to accumulating calcium deposits in a process known as calcification.Pineal gland calcification has been linked to mild cognitive impairment, dementia, and Alzheimer’s.Similarly, the pineal gland is also prone to accumulating fluoride, where it is found in strikingly high concentrations.This affects melatonin production, contributing to insomnia, depression, and accelerated brain aging.7. FLUORIDATED WATER LEACHES LEAD FROM PIPES AND FAUCETSIf you are of a certain age, you may remember when paint, gasoline, and water pipes regularly contained lead.Lead is another neurotoxin that posed a serious health threat, leading to a series of bans in the US.Lead has been banned from paint since 1978, phased out of gasoline in the 1990s, and outlawed in the manufacture of water pipes since 1986.But if you live in a house built after 1986, you might still consume lead from your tap water since brass or chrome-plated faucets can contain some lead.And, depending on where you live, the main water lines to your home may be much older.Some US cities still use water mains installed before the Civil War!Fluoridated water coming through lead pipes and chrome faucets, creates the “perfect neurotoxin storm” since fluoridated water leaches lead and greatly increases the amount in your water, by up to 9-fold.Young brains are most at risk, but brains of all ages can suffer from lead exposure manifesting as memory loss, mood disorders, lower IQ, and learning disabilities.8. ATTENTION DISORDERS ARE LINKED TO FLUORIDERates of attention disorders skyrocketed about the same time that fluoridation of water supplies was on the rise in the United States. This may not be a coincidence since researchers have found a correlation between water fluoridation and ADHD.States with the largest number of ADHD cases also have the greatest proportion of people drinking fluoridated water.Natural Remedies for ADHD (evidence-based guide)According to the Centers for Disease Control, 73% of the US population receives fluoridated water, but the numbers vary greatly by state.If you live in Washington, DC, the chances of fluoridated water coming out of your tap are 100%.States with the lowest rates of fluoridation are Hawaii at 11% and New Jersey at 15%.9. FLUORIDE IS FOUND IN ANTIDEPRESSANTSIf you are one of the millions of people taking Prozac, you may have noticed that the generic name for Prozac is fluoxetine.  It’s not a coincidence that the name sounds a lot like fluoride.Some of the most commonly prescribed drugs contain significant amounts of fluoride, including antidepressants and anti-anxiety drugs.This is disturbing since there’s evidence that fluoride can cause depression and anxiety.Besides Prozac, other antidepressants that contain fluoride include Paxil, Celexa, and Lexapro.If you currently take one of these medications, you may want to discuss switching to a fluoride-free antidepressant or try some natural ways to relieve depression instead.But do not stop taking any medication before talking to your health care professional.HOW TO AVOID ADDED FLUORIDEFor most of us, the main sources of fluoride are toothpaste and drinking water.It’s easy to find fluoride-free toothpaste.Many “natural” personal care companies that carry fluoride-free toothpaste.But even better is to switch to a toothpaste that contains nano-hydroxyapatite, which studies show remineralizes teeth better than flouride.But avoiding fluoride in your drinking water is a bit more complicated.The first question to answer is …DOES YOUR DRINKING WATER CONTAIN FLUORIDE?Some countries, including the US, Canada, Australia, Ireland, and Brazil, add fluoride to much of their public water supply.If you live in one of these countries, you may be surprised to learn that most of the world does not fluoridate its water.It’s estimated that less than 6% of the world’s population drinks artificially fluoridated water.On the other hand, many parts of the world have groundwater with naturally high fluoride concentrations that can reach dangerous levels.These areas are known as “fluoride belts” and include parts of Africa, China, India, and the Middle East.People who live in these areas are at risk for dental fluorosis, which stains and pits teeth, and skeletal fluorosis, a crippling bone disease. If you live in the US, you can easily determine if your water is fluoridated at the Centers for Disease Control’s interactive webpage My Water’s Fluoride.Or you can contact your local water department directly, since this information is required by law to be available to the public.If you have a well, you can download the government report Quality of Water from Domestic Wells to check whether fluoride levels are high in your area.GET A FLUORIDE-REDUCING WATER FILTERWhether your water is fluoridated or naturally high in fluorides, it’s possible to filter fluoride from your water.But be aware that very few water filters reliably remove fluoride.Some claim “fluoride reduction” as a feature but, in fact, remove negligible amounts.If a filter does not specifically state that it removes fluoride, assume it doesn’t.FLUORIDE AS A NEUROTOXIN: TAKE THE NEXT STEPFluoride is a toxic substance often added to toothpaste and water supplies with the intent of building healthy teeth.However, fluoride is not necessary for healthy teeth and most countries do not add fluoride to their water supplies.In fact, fluoride is a known neurotoxin that directly, and indirectly, affects the health and function of your brain.Fortunately, it’s not all that difficult to avoid.Use fluoride-free toothpaste and get a filter that removes fluoride from your drinking water. The Effects Of Chronic Fluoride On The Body Chronic Fluoride Can Damage Mitochondria And The Gut BiomeThe Effects Of Chronic Fluoride On The Body Fluoride is a trace element, but it is found in our daily exposure more than a "trace". RIn small amounts, it appears to be okay. RThe problems with fluoride appear to be in chronic use of it over long periods of time and/or being exposed to a high dose of it in a single instance. RApart from the effects on skeletal tissue and teeth, fluoride can cause changes in the kidneys, liver, thyroid, pituitary gland, testis, muscle tissues, stomach, brain, neurons, and immune system. RI have mild dental fluorosis, probably from drinking too much fluoridated water, using fluoridated toothpaste, along with taking fluoride at the dentist to protect my enamel, so I will cover a little bit of fluorosis as well.In this post I will be discussing how fluoride works on the body and what you can do to protect yourself.Contents:BasicsHow Fluoride Affects The Whole BodyHow To Prevent Toxicity And TestingMechanism Of ActionGeneticsMore ResearchBasicsFluoride is an element that is toxic to the body. R R R RChronic exposure to fluoride seems to be bad, whereas acute exposure once in a while probably isn't that bad, and may have some benefits (not recommended). RIt has been added to our water to strengthen our bones and act as a microbial.It has also been added to toothpaste to strengthen our teeth and protect against tooth decay. R RSome believe it calcifies your "third eye" as you may see calcification of the pineal gland with age in x-rays (partially true).The US Department of Health and Human Services's National Toxicology Program addresses that fluoride under the World Health Organization's (WHO) set levels may cause neurological problems, depression, anxiety and other functional problems. RBillions of people are exposed to fluoride daily. R R R RHow Fluoride Affects The Whole Body1. Affects The Brain and Central Nervous System Fluorine is toxic to the central nervous system (CNS), in both human developmental stages and adulthood (more on development below). R R RFluoride causes neuroinflammation (inflammation in the brain). R R R RFor example, fluoride creates oxidative stress and shrinkage of the brain, especially the cerebellum and hippocampus. R R ROne way it does this is by fluoride's ability to crosses the blood brain barrier, accumulate in neurons, and create higher amounts of advanced glycation end products (AGEs), which cause free radicals in the brain. RFluoride changes the metabolism of neurotransmitters (mainly glutamate neurotransmission). RFor example, fluoride at normal drinking water levels causes changes in the secretion of serotonin, dopamine, norepinephrine, acetylcholine and epinephrine. R RFluoride may affect cognition as well.For example, higher fluoride intake is associated with lower IQ. R R RIn animal models, fluoride exposure decreases spacial memory and learning capacity. R R RFluoride also causes improper glucose utilization in the brain. RHigh fluoride intake is associated with demylination and smaller dendritic size of neurons. R RFluoride also changes the pH of brain cells and causes DNA damage to brain cells. R RFluoride may also cause paralysis. R2. Affects Mitochondria And InflammationFluoride causes mitochondria to produce less energy. RFor example, fluoride decreases the ability for cells to utilize glucose effectively. RIt also decreases ATP production in immune cells and blood cells. R RFluoride also increases free radicals in cells, such as reactive oxygen species (ROS), while decreasing cell's abilities to clean it up (aka oxidative stress and inflammation). RThis degrades mitochondrial DNA and causes apoptosis (cell death). RThis ROS may be beneficial, as in an adaptive response (called Hormesis), fluoride may upregulate some beneficial genes such as SIRT1 (good for longevity), Klotho (good for intelligence) and UCPs (good for making brown fat). R RFluoride also causes stress in the endoplasmic reticulum (ER). R R R3. Affects Circadian RhythmsFluoride may affect circadian rhythms.For example, fluoride decreases a protein called Rab-10, which interacts with melatonin receptors. R RAlso, fluoride interacts with another protein called CK1ε, which is a regulator of the central clock in the suprachiasmatic nucleus. R R4. Alters The Gut Microbiome And Is An Antimicrobial Fluoride may make alcohol more damaging to the gut. RIt also has an effect on gut bacteria.For example, fluoride can inhibit biofilms of certain bacteria. R R RIt may also alter the gut microbiome by increasing Escherichia coli and Enterococcus spp while decreasing Lactobacillus spp. and Bifidobacterium spp. RFluoride can also fight some pathogens (bacteria and fungi): R⦁ Candida albicans ⦁ R⦁ Pseudomonas aeruginosa ⦁ R⦁ Staphylococcus aureus ⦁ R⦁ Streptococcus mutans ⦁ R ⦁ R5. Alters DevelopmentExposure to fluoride in the womb changes the brain and metabolism, causing problems with memory and learning later on in life. R R R R RAfter birth, fluoride can be transferred from the mother to the child via breast milk. RMothers who chronically consume fluoride may have children with lower abilities to produce antioxidants. RIn geographical areas where the amounts of fluoride are higher, children are correlated to having significantly lower intelligence (may be influenced by COMT, see below). R R R RThere is also a higher prevalence of attention deficit disorder in children exposed to higher levels of fluoride in their drinking water. R6. Affects The Immune SystemIn animal studies, fluoride causes toxic effects to the development of the spleen. RIn humans, fluoride causes immune cells to self destruct. RFluoride also causes a decreased function of the immune system in:⦁ Spleen ⦁ R ⦁ R⦁ Thymus ⦁ R ⦁ RHaving dental fluorosis my increase levels of sIgA and sIgG. RBy causing cell death, fluoride may have a protective effect against cancer. R7. Affects Hormone StatusChronic use of fluoride may decrease leptin levels. R RIt may also decrease estrogen levels and gonadotropin-releasing hormone (GNRH). RVitamin D may prevent fluorosis. R8. Affects The Sex Organs Fluoride may damage sex organs and reproduction.For example, female rats exposed to chronic fluoride had less children. RIn multiple studies with male rats, fluoride consumption could damage the testicles. R R R RFluoride may also decrease sperm count. R RVitamin E and calcium may protect the testicles from fluoride damage. R9. Affects The ThyroidFluoride prevalence in water may predict hypothyroidism. RExcess fluoride can cause damage to the thyroid. RFor example, fluoride can increase parathyroid hormone (PTH), but reduce total T3 (TT3), total T4 (TT4) free T3 (FT3), and free T4 (FT4). R R RTaurine may stabilize some of these hormonal changes to the thyroid. R10. Affects Fat Cells and PancreasFluoride can cause insulin levels to rise without the presence of sugar. RFluoride may also cause decreased insulin sensitivity. R R R11. Affects The LungsChronic exposure to fluoride may build up in the lungs and cause lung damage. R R12. Affects The HeartFluoride may increase blood pressure. RFluoride can also increase lactate in the heart. RFluoride intake may also increase triglyceride levels and increase the risk for atherosclerosis. R RFluoride may also inhibit the formation of blood clots. R13. Affects The LiverExcessive and chronic fluoride intake may reduce antioxidants in the liver of adults and children. R R RIn animal models, consuming fluoride during pregnancy reduces antioxidants in the offsprings liver. RAlso in animal models, chronic fluoride consumption causes DNA damage to liver cells and for those cells to die. R R R RSome of the toxic effects to the liver can be mitigated by calcium, Vitamin E, Vitamin C, and resveratrol. R RFluoride may also reduce phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) levels in the liver. R14. Affects The Kidneys Fluoride consumption may cause damage to the kidneys. RFluoride's synergistic effect with heavy metals may make kidney damage worse. RVitamin C, curcumin, and taurine may protect the kidneys from fluoride exposure. R R15. Affects Our Bones And TeethFluoride stores itself in bones and in teeth. R RChronic use of fluoride may cause bone cells to die, while small amounts may cause them to grow. R R RFor example, dental fluorosis happens when there is too much stress on bone cells. R R R ROne way it does this is by fluoride's ability to damage enamel cells. R R RAnother way by fluoride's ability to demineralize teeth. R RFor example, fluoride changes calcium homeostasis in bones. R R R RIt can also disturb the collagen levels in bone. R RFluoride can also cause skeletal fluorosis by disrupting proper bone turnover. R RFluoride has also been implicated to cause spinal canal stenosis (narrowing of the spinal canal). RIt also may inhibit bone growth and development by decreasing IGF1 expression. R RFluoride in water, toothpaste, and mouthwash may help against tooth decay since it's small amounts. R ROne way it does this is by decreasing the loss of dentin. R R16. Alters Hair GrowthBy increasing oxidative stress in hair follicles, fluoride may cause slow hair growth and hair loss. RFor example, mice exposed to chronic fluoride had alopecia and less fur. R17. May Cause DeathHigh levels of fluoride is deadly. RFluoride may cause a potassium imbalance in the heart and cause death. RAlso in animal studies, mice exposed to chronic fluoride died faster than control groups. RHow To Prevent Toxicity And Testing buy on amazonSupplements and ActionsLifestyle:Acupuncture ⦁ RCold Thermogenesis + Exercise ⦁ RProtective Supplements:Apple Cider Vinegar ⦁ RBacopa Monneri ⦁ RBanaba ⦁ RCalcium ⦁ R ⦁ RCharcoal ⦁ RCistanche ⦁ RChitosan ⦁ RCholine ⦁ RCurcumin (strong) ⦁ R ⦁ RGinkgo Biloba (and ⦁ EGb-761) ⦁ R ⦁ R⦁ Gulingtongbi Wan ⦁ RLycopene ⦁ R ⦁ RMagnesium ⦁ RMelatonin ⦁ RMethionine (combined with ⦁ Vitamin E) ⦁ RMilk Thistle ⦁ RNAC ⦁ R ⦁ RPanax Ginseng ⦁ RPomegranate ⦁ RResveratrol (strong) ⦁ RSelenium (strong) ⦁ R ⦁ R ⦁ R ⦁ R ⦁ RTamarind ⦁ RTaurine (strong) ⦁ RtBHQ ⦁ RVitamin C ⦁ R ⦁ RVitamin E ⦁ R ⦁ RZinc ⦁ RFluoride Causes These Deficiencies:Calcium ⦁ R ⦁ RGlutathione ⦁ RPhosphatidylcholine ⦁ RPhosphatidylethanolamine ⦁ RPhosphatidylserine ⦁ RVitamin A ⦁ RVitamin D ⦁ RVitamin E ⦁ RDrugs:⦁ 4-phenylbutyrate (4PBA) ⦁ R⦁ Teriperatide ⦁ RPathways:⦁ Activating AQP5 ⦁ R⦁ Activate FOXO1 ⦁ R⦁ Activate ⦁ NRF2 ⦁ R⦁ Activate SIRT1 ⦁ RFoods/Liquids To Watch Out ForAlthough naturally occurring, fluoride can be found in various foods, teas, and supplements indirectly. RHere are a few examples:⦁ Beer ⦁ R ⦁ R⦁ Coffee ⦁ R⦁ Krill Oil ⦁ R⦁ Infant Formula ⦁ R⦁ Prepackaged Foods (if made using fluorinated water) ⦁ R⦁ Rice ⦁ R⦁ Table Salt⦁ Tea (although the polyphenols in tea may protect against fluoride's effect on bones) ⦁ R ⦁ R ⦁ R ⦁ R⦁ Wine ⦁ RWater Alternatives buy on amazonFirst of all, stay away from unfiltered tap water. R R R RI use glass spring water and will also use a berkey filter.Toothpaste Alternatives buy on amazonThe benefits to teeth do not outweigh the negatives of our body so it's probably best to stay away from conventional toothpastes and mouthwashes. R RFor example (if you couldn't already feel this when using mouthwash yourself), fluoride causes oxidative stress on salivary glands. RAlternative mouthwashes:Aloe Vera ⦁ RCoconut Oil ⦁ RPerioBriteXylitol ⦁ RRecommended toothpastes (also watch out for brands with sodium lauryl sulfate): RMeswak ⦁ RPerioBrite ToothpasteWhitening ToothpasteTestingYou can test your water with this water test.Here are other possible biomarkers:⦁ Calcification of the pineal gland (other contributing factors to this) ⦁ R ⦁ R⦁ Fluoride in blood or urine ⦁ R⦁ γH2AX ⦁ R⦁ p-ATM ⦁ R8-oxoguanine ⦁ RWhat Makes Fluoride Exposure Worse?⦁ Aging ⦁ RAlcohol ⦁ R⦁ Aluminum ⦁ R ⦁ RArsenic ⦁ RCadmium ⦁ R⦁ Coal burning - fluorine in coal can be easily released into the atmosphere by burning and can then be taken in by breathing ⦁ R⦁ Lead ⦁ RMechanism Of ActionSimple:⦁ Decreases ⦁ Acetylcholine ⦁ R⦁ Decreases α3 nAChR ⦁ R⦁ Decreases α4 nAChR ⦁ R⦁ Decreases α7 nAChR ⦁ R⦁ Decreases CK1ε ⦁ R⦁ Decreases CORO1A ⦁ R⦁ Decreases DA ⦁ R ⦁ R ⦁ R⦁ Decreases FEZ1 ⦁ R⦁ Decreases Glutamate (when chornically exposed, will increase glutamate when ingested acutely) ⦁ R ⦁ R ⦁ R⦁ Decreases Glutathione ⦁ R⦁ Decreases GLUT1 ⦁ R⦁ Decreases GPD1⦁ R⦁ Decreases GPx ⦁ R⦁ Decreases GSTP1 ⦁ R⦁ Decreases IGF1 ⦁ R⦁ Decreases IL-2 ⦁ R⦁ Decreases IL-10 (increased in spleen) ⦁ R ⦁ R⦁ Decreases MAPK ⦁ R⦁ Decreases Mfn1 ⦁ R⦁ Decreases mGluR5 ⦁ R⦁ Decreases MMP2 ⦁ R⦁ Decreases MMP9 ⦁ R ⦁ R⦁ Decreases MMP-20 ⦁ R⦁ Decreases M1 mAChR ⦁ R⦁ Decreases M3 mAChR ⦁ R⦁ Decreases NE ⦁ R⦁ Decreases PDI ⦁ R⦁ Decreases PEBP1 ⦁ R⦁ Decreases Pleiotrophin ⦁ R⦁ Decreases RACK1 ⦁ R⦁ Decreases Rab-1A, Rab-1B, Rab-3A, Rab5b, Rab5c, Rab-8B, Rab-10, Rab-14, and Rab-26 ⦁ R⦁ Decreases SOD ⦁ R⦁ Decreases TGFB-1 ⦁ R ⦁ R ⦁ R⦁ Increases ⦁ α-Klotho ⦁ R⦁ Increases Casr ⦁ R⦁ Increases AGEs ⦁ R⦁ Increases ⦁ BDNF ⦁ R⦁ Increases CAT ⦁ R⦁ Increases Cbfa1 ⦁ R⦁ Increases CGRP (with high exposure it decreases) ⦁ R⦁ Increases CK-MB ⦁ R⦁ Increases Drp1 ⦁ R⦁ Increases Epinephrine ⦁ R⦁ Increases Fgf1rc ⦁ R⦁ Increases Fis1 ⦁ R⦁ Increases GFAP ⦁ R⦁ Increases Histamine ⦁ R⦁ Increases ICAM1 ⦁ R⦁ Increases IL-1b ⦁ R⦁ Increases IL-6 ⦁ R⦁ Increases ⦁ IL-8 ⦁ R⦁ Increases LDH ⦁ R⦁ Increases MCP1 ⦁ R⦁ Increases MDA ⦁ R⦁ Increases ⦁ NRF2 ⦁ R⦁ Increases ⦁ NO ⦁ R⦁ Increases NOX2 ⦁ R⦁ Increases OCN ⦁ R⦁ Increases P-sel ⦁ R⦁ Increases PTH ⦁ R⦁ Increases RAGE ⦁ R⦁ Increases ROS ⦁ R⦁ Increases Serotonin ⦁ R⦁ Increases SIRT1 ⦁ R⦁ Increases SP ⦁ R⦁ Increases TIPM1 ⦁ R⦁ Increases TNF-alpha (decreased in the spleen) ⦁ R ⦁ R⦁ Increases UCP1 ⦁ R⦁ Increases UCP2 ⦁ R⦁ Increases VCAM1 ⦁ R⦁ Increases VDR ⦁ R⦁ Increases VIP ⦁ RAdvanced:⦁ Fluoride is the ionic form of fluorine, a halogen with the most electronegative elements on the periodic table. ⦁ R⦁ When combined with hydrogen, it forms the acid hydrogen fluoride, which is easily absorbed into tissue in the body. ⦁ R⦁ For example, in the gut, 50% of ingested fluoride is absorbed within 30 minutes and 80% is absorbed if there are no cations or calcium being digested. ⦁ R⦁ 99% of the body's fluoride is found in calcified tissues, which it is strongly bound, but not irreversibly.⦁ Fluoride is excreted through the kidneys, which takes about 30-40min per ml, and 75mintues per ml when filtereing serum fluoride. ⦁ R⦁ In bacteria, fluoride inhibits bacteria's ability to uptake glucose, thus helping protect against bacterial growth in the mouth and plaque fluid, although this same action is damaging to the gut microbiome as well. ⦁ R⦁ In the hippocampus, fluoride can decrease in the expression of tubulins forming the heterodimers (Tuba1 and TubB2a). ⦁ R⦁ Also in the hippocampus, fluorine causes a increase in the outflow of cholride ions from the cells by changing the activity of mitogen-activated protein kinases (MAPK), which is necessary for volume and activity of neurons. ⦁ R⦁ Fluoride also causes lowers amounts of neural cell adhesion molecules (NCAM), glial fibrillary acidic protein (GFAP), and increased ⦁ brain-derived neurotrophic factor (BDNF). ⦁ R⦁ Fluorine, via Ras, can change the activity of ERK-JNK and p58, leading to less growth and differentiation of cells, as well as problems with apoptosis and gene expression. ⦁ R⦁ In grey matter, fluorine decreases the content of Nissl bodies (which makes brain matter gray), which are concentrations of ribosomes and RNA in neurons. ⦁ R⦁ In the cell, fluorine changes the flow of ions and water from the cytoplasm to the extracellular space. ⦁ R⦁ Fluorine decreases the ability for mitochondria to use glucose properly, decreasing the expression of GLUT1. ⦁ R⦁ Fluroine also increases the activity of ATP5h (creating a disbalance between ATP and ADP), as well as decreasing NADH-ubichinon oxidorecductase, and a decrease in the activity of complexes I, II, III, and IV. ⦁ R⦁ Thus fluorine creates more ROS in the mitochondria and degrades mitocnohdrial DNA, leading to cell death. ⦁ R⦁ Apart from more ROS, there is more malondialdehyde (MDA), catalyase (CAT), hydroxide (OH), and ⦁ nitric oxide (NO), as well as decreased superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), and glutathione. ⦁ R⦁ This change in antioxidants causes a shorter lifespan of cells, growth problems, and cell death. ⦁ R⦁ Fluorine increases the activity of AGE receptors (RAGE) and NADPH oxidase 2 (NOX2), initiating NF-kB and causing increased ROS and demyelination of dendrites and degeneration of neurons. ⦁ R ⦁ R⦁ Prolonged exposure to fluorine decreases the concentration of glutatmate in the brain (serum, hippocampus, and cerebral cortex), which is a downregulation mechanism to protect the brain as bergmann gilal cells (BGC) die. ⦁ R⦁ This lowers aspartate transaminase (AST) and alanine aminotransferase (ALT) and decreased plasticity and "spacial learning" in the brain from decreased ability of mGluR1 and mGluR5. ⦁ R⦁ Fluorine also changes the secretion of serotonin, dopamine, histamine, norepinephrine, ⦁ acetylcholine, and epinephrine, at normal concentrations in drinking water, for example drinking water at 100mg/L caused increase in hippocampla, striatal and cerebral cortex noradrenalin and serotonin. ⦁ R ⦁ R⦁ Fluorine influences the activity of complexes of the respiratory chain and of enzymes of the citric acid cycle as seen with a decrease in the activity of complexes I, II, III and IV; isocitrate dehydrogenase and succinate dehydrogenase was observed in the cerebral cortex, cerebellum and hippocampus of mice exposed to high concentrations of fluorine. ⦁ R⦁ Fluoride may decrease learning by decreasing α3, α4, and α7 nicotinic acetylcholine receptors (nAChRs) as well as M1 and M3 muscarinic acetylcholine receptors (mAChRs). ⦁ R ⦁ R ⦁ R⦁ In duodenum, fluoride exposure increases wall thickness as well as vasoactive intestinal polypeptide (VIP), calcitonin gene related peptide (CGRP) and substance P (SP). ⦁ R⦁ Fluoride also downregulates Pleiotrophin and its respected proteins, protein disulfide-isomerase (PDI), guanine nucleotide-binding protein subunit beta-2-like 1 (RACK1), glycerol-3-phosphate dehydrogenase [NAD(+)]-cytoplasmic (GPD1), and Glutathione S-transferase P (GSTP1). ⦁ R⦁ Fluoride decreases Ras-related protein Rab-1A, Rab-1B, Rab-3A, Rab5b, Rab5c, Rab-8B, Rab-10, Rab-14, and Rab-26. ⦁ R⦁ Rab-10 interacts with Melatonin receptor type 1A, which mediates circadian actions of melatonin. ⦁ R⦁ Fluoride also interacts with Casein kinase 1 epsilon (CK1ε), a Ser-Thr protein kinase that acts as a key regulator of the central clock in the suprachiasmatic nucleus and that is also involved in circadian regulation of gene expression. ⦁ R ⦁ R ⦁ R⦁ Fluoride also downregulates Phosphatidylethanolamine-binding protein 1 (PEBP1, a synaptic signaling protein which helps neuronal survival), Fasciculation and elongation protein zeta-1 (FEZ-1, affects mitochondrial motility and neuronal morphology), and Coronin-1A (CORO1A, involved in cytoskeleton organization and rearrangement in neuronal cells). ⦁ R ⦁ R ⦁ R ⦁ R⦁ In the heart and kidneys, fluoride can increase myeloperoxidase, xanthine oxidase, blood urea nitrogen, creatinine, Lactate dehydrogenase (LDH), Creatinine kinase myocardial band (CK-MB), P-selectin (P-sel), vascular cell adhesion molecule-1(VCAM-1), and IL-8. ⦁ R ⦁ R⦁ In the kidneys fluoride causes a significant increase in the levels of thiobarbituric acid reactive substances and reduced the GSH concentration and the activities of SOD and catalase. ⦁ R⦁ Fluoride also increases the levels of urea, uric acid, blood urea nitrogen, creatinine, and phosphate and decreasing the levels of calcium. ⦁ R⦁ In the spleen, fluoride causes an increase in Interleukin 10 (IL-10), with a decrease in TNF-a, interleukin 2 (IL-2), transforming growth factor beta (TGF-beta), interferon gamma (IFN-gamma) and cyclin (E/D and CDK2/4). ⦁ R⦁ Fluoride causes ameloblasts (enamel tooth cells) to decrease ameloblastin and to go into apoptosis. ⦁ R⦁ Fluoride activates the Rho/ROCK pathway in ameloblasts, inducing endoplasmic reticulum (ER) stress, leading to protein misfolding. ⦁ R ⦁ RGeneticsAQP5⦁ rs923911 (CA or CG) + rs1996315 (CA or CG) has have a protective effect against caries ⦁ RCOL1A2⦁ PvuII - PP (carrying two dominant) alleles had a significantly increased risk of dental fluorosis compared withthose bearing 2 copies of the p (minor) allele ⦁ RCOMT⦁ rs4680 - Val/Val homozygote showed lower IQ scores in children than those with Met/Met homozygote or Met/Val heterozygote ⦁ RCTR⦁ C1377T - CC had higher prevalence of fluorosis followed by TT ⦁ R⦁ Unknown SNP - TC & TT alleles had higher prevalence of F bone injury risk than the CC genotype ⦁ RDLX1PMID: 28131910DLX2PMID: 28131910DSPP⦁ rs2615487 - CC allele protective effect against carries ⦁ RER-alpha⦁ rs3798577 - CG heterozygote had lower GNRH than women were carrying C/C, C/T or T/T ⦁ RFSHR⦁ rs1394205 - AA allele had lower serum E2 level in those chronically exposed to fluoride ⦁ RKLK4⦁ rs2235091 - GC allele have protective effect against carries vs risk haplotype GG ⦁ R⦁ rs198969 - GC allele have protective effect against carries vs risk haplotype GG ⦁ RGSTP1⦁ rs1695 - GG allele had a significantly decreased risk of skeletal fluorosis vs AA ⦁ RMMP2⦁ rs2287074 - AA alleles had about 80 percent lower probability of developing skeletal fluorosis than GG genotype in Tibetans ⦁ RMPO⦁ rs2333227 - AA allele might increase the risk of fluorosis ⦁ R⦁ rs61007103 -TT allele might increase the risk of fluorosis ⦁ R⦁ rs12601419 - AA allele might increase the risk of fluorosis ⦁ R⦁ rs34721594 - TT allele might increase the risk of fluorosis ⦁ RPRL⦁ rs1341239 - T allele decreases the risk of brick tea SF ⦁ RTIMP1PMID: 28131910VDR⦁ rs2228570 - CT/TT allele had a significantly decreased risk of skeletal fluorosis compared to CC ⦁ R- CC allele has higher risk of male factor infertility ⦁ RMore Research⦁ Fluoride is toxic to worms. ⦁ R⦁ In zebrafish, fluoride activates ⦁ NRF2. ⦁ R⦁ 50 Reasons To Oppose Fluoridation ⦁ R   Fluoride Alert modern pharmaceuticals (e.g. Prozac, Paxil) contain “organofluorines.” An organofluorine is a chemical compound that contains both carbon and fluorine. The fact, however, that a pharmaceutical is made with an organofluorine does not mean that it will increase your exposure to fluoride. This is because the fluorine in the drug forms a very strong bond with the carbon and this bond resists metabolizing into fluoride ion. It is generally believed, therefore, that most organofluorine drugs do not contribute to daily fluoride exposure. There are some organofluorine drugs, however, that do metabolize into fluoride. This is evident by studies finding elevated levels of fluoride showing up in the urine or blood following use of the drug. Because organofluorine drugs contain high quantities of fluorine, any drug that metabolizes into fluoride will likely be a very large source of daily exposure. Drugs that are known to break down into fluoride ion include: fluorinated anesthetics, Cipro, Niflumic acid, Flecainide, and Voriconazole.  It is possible, and indeed likely, that other drugs do so as well, but have not yet been discovered. The following are a list of studies documenting inorganic fluoride exposure from the use of organofluorine drugs: ANESTHETICS (CLICK FOR MORE STUDIES: ISOFLURANE, SEVOFLURANE) Blanco et al, (1995). Comparison of maintenance and recovery characteristics of sevoflurane-nitrous oxide and enflurane-nitrous oxide anaesthesia. European Journal of Anaesthesiology 12(5):517-23. Cabibel et al. (2018). Complete Nephrogenic Diabetes Insipidus After Prolonged Sevoflurane Sedation: A Case Report About 3 Cases. A&A Practice. Funk et al. (1996). Sevoflurane or halothane in inhalational anesthesia induction in childhood. Anesthesia quality and fluoride level. Der Anaesthesist 45(1):22-30. Hoggard et al. (2019). Gaseous Anesthetics. StatPearls [Internet]. April 6. Hoemberg M, et al. (2012). Plasma fluoride concentrations during prolonged administration of isoflurane to a pediatric patient requiring renal replacement therapy. Paediatric Anaesthia 22(4):412-3. Lermon et al. (1994). The pharmacology of sevoflurane in infants and children. Anesthesiology 80(4):814-24. Natsume et al. (1990). Teratogenicity caused by halothane, enflurane, and sevoflurane, and changes depending on O2 concentration. Teratology 42(6):30A. Nishiyama et al. (1996). Inorganic fluoride kinetics and renal tubular function after sevoflurane anesthesia in chronic renal failure patients receiving hemodialysis. Anesthesia and Analgesia 83(3):574-7. Oc B, et al. (2012). The effects of sevoflurane anesthesia and cardiopulmonary bypass on renal function in cyanotic and acyanotic children undergoing cardiac surgery. Renal Failure 34(2):135-41. Rohm et al. (2009). Renal integrity in sevoflurane sedation in the intensive care unit with the anesthetic-conserving device: a comparison with intravenous propofol sedation. Anesthesia and Analgesia108(6):1848-54. Steffey(2005) et al. Effects of sevoflurane dose and mode of ventilation on cardiopulmonary function and blood biochemical variables in horses. American Journal of Veterinary Research 66(4):606-14. Wang, et al. (2013). Neonatal sevoflurane anesthesia induces long-term memory impairment and decreases hippocampal PSD-95 expression without neuronal loss. European Review for Medical and Pharmacological Sciences 17(7):941-50. Waugh DT. (2019). Cancer and Other Outcomes After Surgery With Fluoridated Anesthesia. JAMA Network Open. June 26. Wiesner et al. (1996). Serum fluoride concentrations and exocrine kidney function with sevoflurane and enflurane. An open, randomized, comparative phase III study of patients with healthy kidneys. Anaesthesist 45(1):31-6. ENFLURANE AND HALOTHANE Mazze et al. (1977). Inorganic fluoride nephrotoxicity: prolonged enflurane and halothane anesthesia in volunteers. Anesthesiology 46(4):265-71. CIPRO: Pradhan KM, et al. (1995). Safety of ciprofloxacin therapy in children: magnetic resonance images, body fluid levels of fluoride and linear growth. Acta Paediatrica 84(5):555-60. FLECAINIDE: Rimoli CN, et al. (1991). Relationship between serum concentrations of flecainide and fluoride in humans. Boll. Chim. Farmaceutico 130(7):279-82. NIFLUMIC ACID: Gras-Champel V, et al. (2003). [Chronic fluorine intoxication during prolonged treatment with niflumic acid]. [Article in French] Presse Med. 2003 Jun 7;32(20):933. Welsch M, et al. (1990). [Iatrogenic fluorosis. 2 cases]. [Article in French] Therapie. 45(5):419-22. Meunier PJ, et al. (1980). Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis? Clin Orthop Relat Res. 148:304-9. Prost A, et al. (1978). [Fluorine osteosis caused by a very long-term niflumic acid treatment in 2 cases of rheumatoid arthritis]. [Article in French] Rev Rhum Mal Osteoartic. 45(12):707-16. VORICONAZOLE – SEE MORE STUDIES HERE Chen L, Milligan ME. (2011). Medication-induced periostitis in lung transplant patients: periostitis deformans revisited. Skeletal Radiology 40:143-48. Moon et al. (2014). Plasma fluoride level as a predictor of voriconazole induced periostitis in patients with skeletal pain. Clinical Infectious Diseases 59(9):1237-45. Rad et al. (2015). Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment. Annals of Clinical Biochemistry 52(Pt 5):611-4. Wermers (2011). Fluoride excess and periostitis in transplant patients receiving long-term voriconazole therapy. Clinical Infectious Diseases 52(5):604-11. HOSPITAL PERSONNEL Cakmak et al. (2018). Genetic damage of operating and recovery room personnel occupationally exposed to waste anaesthetic gases. Human & Experimental Toxicology Fluoride serotonin re-uptake inhibitor (SSRI) drugs incorporate fluorine in their chemical structureBrand Name Generic NameCelexa ‣ citalopramLexapro ‣ escitalopram oxalateLuvox ‣ fluvoxamine maleatePaxil ‣ paroxetineProzac ‣ fluoxetineZoloft ‣ sertraline (chlorine instead of fluorine)  Selenium increases expression of HSP70 and antioxidant enzymes to lessen oxidative Fincoal type fluorosis has only been reported from China, but its pathogenesis is unclear. Many people believe that fluorosis is associated with oxidative stress. Oxidative stress can be reduced at higher selenium (Se) level. Heat shock protein (HSP70) is the most conserved and induced against different stressors. The aim of this study is to detect the expression of HSP70 in fluorosis patients and explore the role of Se in fluorosis protection. The subjects were divided into four groups: "High Se + F group" (n = 50), "High F group" (n = 50), "High Se group" (n = 20) and "Control group" (n = 46). Expression of HSP70 was evaluated by Western blotting and real-time PCR techniques. The concentration of fluoride, content of Se in hair, activity of antioxidant enzymes (GSH-Px, SOD, CAT) and content of malondialdehyde (MDA) were determined. The relative amount of HSP70 gene transcription was significantly higher in "High Se + F group" than the other groups. The same results were found for expression of HSP70 protein to beta-actin ratio. There was a significant difference between "High Se + F group" and "High F group" regarding MDA content and glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activity. These results suggest that oxidative stress plays an important role in the pathogenesis of the Fincoal type fluorosis and it can be reduced at higher Se leveldamage in Fincoal-type fluorosis Fluoride in Tea.In his paper, "Fluoride—What's Wrong With This Picture?" Andreas Schuld tells us about fluoride in tea.  Here is an abstract of his article: "In their drive to fluoridate the public water supplies, dental health officials continue to pretend that no other sources of fluoride exist other than drinking water. This notion becomes absurd when one looks at the fluoride content in tea. Tea is very high in fluoride because tea leaves accumulate more fluoride (from pollution of soil and air) than any other edible plant (49,50,51). It is well established that fluoride in tea gets absorbed by the body in a manner similar to the fluoride in drinking water (49,52).teaFluoride content in tea has risen dramatically over the last 20 years due to industry contamination. Recent analyses have revealed a fluoride content of 22.2 mg per teabag or cup in Chinese green tea, and 17.25 mg of soluble fluoride ions per teabag or cup in black tea. Aluminum content was also high—over 8 mg. Normal steeping time was five minutes. The longer a tea bag steeped, the more fluoride and aluminum were released. After ten minutes, the measurable amounts of fluoride and aluminum almost doubled (53). A website by a pro-fluoridation infant medical group states that a cup of black tea contains 7.8 mgs of fluoride (54) which is the equivalent amount of fluoride from 7.8 litres of water in an area fluoridated at  the "optimal" concentraion of  1ppm.  Some British and African studies from the 1990s showed a daily fluoride intake of between 5.8 mgs and 9 mgs a day from tea alone (55, 56, 57). Tea has been found to be a primary cause of dental fluorosis in many international studies (58-70). In Britain, over three-quarters of the population over the age of ten years consumes three cups of tea per day (71), thereby ingesting far more than the "optimal" dose. Next to water, tea is the most widely consumed beverage in the world. Tea can be found in almost 80 percent of all US households and on any given day, nearly 127 million people—half of all Americans—drinktea (71). The high content of both aluminum and fluoride in tea is cause for great concern as aluminum greatly potentiates fluoride's effects on G protein activation (72), the On/Off switches involved in cell communication and of absolute necessity in thyroid hormone function and regulation." For the full article go to There has been research on this topic - Fung KF, Zhang ZQ, Wong JWC, Wong MH. Fluoride contents in tea and soil from tea plantations and the release of fluoride into tea liquor during infusion. Environmental Pollution. 1999;104(2):197-205 The Linus Pauling Institute has a lot of information on fluoride and tea.He uses a table to show the fluoride content of tea - "The fluoride contents of 17 brands of green, oolong, and black teas is presented in the table below. These values do not include the fluoride content of the water used to make the tea. For more information, see the separate article on Fluoride." - You can see that the more tea you drink, the more fluoride you are ingesting and if you live in a fluoridated area, you are ingesting much more




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