Skill Level  3

Relevance:4 Technical Level:2

CFS patients typically have psych conditions both before and after developing CFS, as described on this page

Page Synopsis: I'm looking forward to using Ketamine and TCM in hopes of directly subduing my OCD. After that I hope improvements in CFS will help my mental state. I'm most excited by flare busters so that I may practice Karate, as exercise clears out my OCD.


Furthermore, there are many books and therapeutic techniques which address OCD to investigate and trial which have been on the backburner as most of my focus has been in addressing CFS both for myself and in the hopes of helping other CFS patients

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In addition to Ketamine and TCM, there are many books and potential therapies I haven't investigated. Perhaps addressing CFS will clear inflammatory and other triggers (chelation, etc) which will ameliorate OCD

Chronic anxiety affects hpa axis





Fecal Transplant



Lithium Orotate and Lithium Carbonate


                        Lithium Orotate (click to open)                                                                      click again to closeLithium Orotate
Lithium helps prevent mood swings, is anti-anxiety and antidepressant, promotes neurogenesis, protects from neurodegenerative disease, and is anti-aging Lithium is a soft, silvery-white alkali metal so reactive (it sparks when it touches water) that it’s not found in nature. Instead, it’s found in mineral compounds and in mineral water. Cosmologists believe that lithium was one of the 3 elements synthesized in the Big Bang.[i] So it’s been around for a long time.Lithium orotate as a nootropic Most of us associate lithium with treating mental illnesses like bipolar disorder and mania. Or the lithium-ion battery in our phone. Which has a tendency to blow up occasionally. Turns out that the anti-psychotic medication lithium isn’t even a drug. It’s actually a mineral. And part of the same family of minerals that include potassium and sodium. As a nootropic, micro-dosing lithium provides some amazing anti-aging benefits. Recent research shows that low-dose lithium may also help slow the progression of neurodegenerative diseases like Alzheimer’s, dementia and Parkinson’s disease. Low-dose lithium also helps neurogenesis and memory. And is a mood stabilizer. Here we’ll investigate daily or frequent use of Lithium Orotate as a nootropic, and how it benefits cognitive health. Lithium helps:     Balance mood. Lithium calms mania (extreme highs and lows) by decreasing sensitivity of the post-synaptic norepinephrine receptor.[ii] And increases uptake of norepinephrine into synaptosomes. Preventing the release of this neurotransmitter. And lithium enhances the transport of Vitamin B12 and folate into brain cells.[iii] Affecting mood and aggression.    Growth Factors. Lithium upregulates brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT3) and their receptors. And lithium stimulates the proliferation of stem cells in the brain. All boosting neurogenesis and assisting in repair from all types of brain injury.[iv]    Neuroprotection. Lithium increases brain gray matter, increases DNA replication for neurogenesis, prevents apoptosis, increases N-acetyl-aspartate (NAA), inhibits beta-amyloid secretion and protects against damage once it’s formed, chelates aluminum, and protects against glutamate toxicity. Table of Contents     Overview    How does Lithium work in the brain?    How things go bad    Lithium benefits    How does Lithium feel?    Lithium Orotate Clinical Research        Lithium Improves Memory        Lithium Increases Mood in Recovering Addicts        Lithium Orotate in the Treatment of Alcoholism    Lithium Orotate Dosage    Lithium Orotate Side Effects    Where to Buy Lithium Orotate    Nootropics Expert Recommendation Overview Lithium is an alkali mineral and one the trace elements considered essential for both animal and human reproductive health, and general health and wellness. Discovered as a chemical element in 1817, lithium’s first recorded modern medical use was in 1871 for the treatment of mania. But the use of lithium for therapeutic use goes back to ancient Greek and Roman times. People enjoyed soaking in alkali springs to help with physical and mental illness. People have been using mineral springs for therapeutic use ever since. Lithia Springs in Douglas County, Georgia was so popular that people came for miles just to drink the water.Litha Springs poster 1988 The Sweet Water hotel, a luxury 500-room resort was opened in 1887. And attracted famous authors, business people and prominent politicians who came for the spring’s health benefits. The name “Lithia” stems from water rich in lithium. Studies from around the world have shown the critical health benefits of lithium. One study using data from 27 Texas counties from 1978 – 1987 found that rates of suicide, homicide and rape were significantly higher in counties whose drinking water contained little or no lithium.[v] Another study of lithium levels in tap water in 18 municipalities in Japan showed standard mortality ratios lower in places with higher lithium levels.[vi] Yet another study conducted in Texas in 2013 confirmed the original findings in that state. Drinking water samples from 226 counties found a correlation between lithium levels and suicide rates.[vii] Researchers who conducted meta-analyses of lithium levels and public drinking water suggested “increasing lithium levels of drinking water could potentially reduce the risk of suicide, and justify administering lithium to tap water.”[viii] An article in the Lancet in 1949 by John Cade is credited for the modern medical use of lithium as an effective treatment for manic psychosis.[ix] The United States FDA approved high dose lithium carbonate and lithium citrate in 1970 for the treatment of bipolar disorder. Carbonic acid and citric acid are mineral carriers used to transport lithium throughout your body. Doctors also prescribe lithium off-label for treating migraines, seizure disorders and psychosis usually after other treatments have failed. But as we dig deeper into the most recently published research on lithium, we realize this trace element is essential for optimal health and brain function. The lithium we get from our diet prevents many neurological and psychiatric problems. Micro-dosing lithium as a nootropic with a supplement like Lithium Orotate can help make up for the what we don’t get from our food and water. Lithium is naturally available from fish, processed meat, milk, dairy products, eggs, potatoes and vegetables. Your typical dietary intake of lithium can range from 2 – 600 mcg. Amounts vary depending on where the food is grown. lithium working in the brainHow does Lithium work in the brain? Lithium helps brain health and function in several ways. But two in particular stand out.     Lithium stabilizes mood. Recent research has discovered that lithium’s mood stabilization effects may be due to its ability to boost the production of new brain cells (neurogenesis). Lithium inhibits the enzyme glycogen synthase kinase-3β (GSK-3β). This inhibition upregulates brain-derived neurotrophic factor (BDNF), and insulin-like growth factor-1 (IGF-1) which stimulates neural stem cells to produce new neurons in the hippocampus.[x] When neural stem cells produce new neurons in the hippocampus, mood and memory work as designed. But a breakdown in neurogenesis results in mood disorders. Lithium has long been known to control mania and stabilize mood in bipolar patients. But it was not generally thought of as an antidepressant. Researchers in Tel Aviv provided the first evidence that inhibiting GSK-3β exerted a rapid antidepressant effect in mice.[xi] Another team at Howard Hughes Medical Institute in Pennsylvania showed that feeding mice chow laced with low-dose lithium for 15 days produced a dose-dependent antidepressant effect.[xii] Lithium induced gene transcription in the hippocampus, amygdala and hypothalamus. All areas implicated in depression, anxiety, bipolar disorder, autism and schizophrenia.     Lithium protects your brain.  Your brain cells are at constant risk of damage from exposure to toxins you encounter every day from food, air, water and your environment. And the excitotoxins produced by ordinary brain cell metabolism. Glutamate plays a major role in the synaptic plasticity needed for learning and memory.[xiii] But over-activity of glutamate on its NMDA receptors causes neuron death and is implicated in Alzheimer’s, Huntington’s and Parkinson’s disease. Lithium inhibits this overactivity.[xiv] Lithium also increases the production of a neuroprotective protein called bcl-2.[xv] Researchers maintain that lithium is the only “medication” that has been demonstrated to significantly increase bcl-2 in several brain areas. Lithium has also recently been evaluated in preventing and treating traumatic brain injury. In a study conducted in 2014, Dr. Peter Leeds stated that lithium had “demonstrated robust beneficial effects in experimental models of Traumatic Brain Injury (TBI). These include decreases in TBI-induced brain lesion, suppression of neuroinflammation, protection against blood-brain barrier disruption, normalization of behavioral deficits, and improvement of learning and memory, among others.”[xvi] Lithium's effects on traumatic brain injuryHow things go bad In 1985, the United States EPA estimated that dietary intake of lithium from food in the USA varied from 0.6 to 3.1 mg per day.[xvii] For comparison, people who live in the Andes in Northern Argentina consume 2 to 30 mg per day, with 2 – 3 mg just from drinking water.[xviii] As your dietary sodium and caffeine increases, so does lithium excretion in urine which increases your requirement for this essential trace mineral. Your exposure to stress and toxins from things like mercury, aspartame, MSG, Bisphenol A (BPA) and other excitotoxins also raise cortisol and other stress hormones. Increasing your need for more water-soluble nutrients like B-vitamins, magnesium, zinc and lithium. Low lithium levels are associated with … ↑ Depression and anxiety increase ↓ Memory and learning ability decline ↑ Insomnia increases ↑ Sensitivity to stress and chronic pain increase ↓ Natural healing processes decline Adequate daily intake of lithium could help prevent many mental and neurological diseases due to this trace minerals effects on nervous system metabolism. And it’s anti-inflammatory and antioxidant effects. Lithium and serotoninLithium benefits The clinical research and studies on the neuroprotective benefits of lithium are so overwhelming, some scientists are beginning to ask “why isn’t everyone using lithium”? Here’s a summary of how micro-dosing lithium using Lithium Orotate can benefit your brain.     Inhibits apoptosis – lithium inhibits GSK-3 which has been linked to apoptotic cell death    NMDA-receptors – lithium reduces glutamate induced toxicity mediated by NMDA-receptors which helps in mood disorders, Alzheimer’s, and other autoimmune and inflammatory diseases    Neuroprotection – blocks the development of beta-amyloid tangles and plaque    Neurogenesis – lithium promotes the BDNF needed for synaptic plasticity in learning and memory. Lithium also boosts nerve growth factor and glial-derived neurotrophic factor affecting learning, memory, mood and overall brain health[xix]    Neuronal stem cells – lithium stimulates the stem cells needed to produce new neurons (neurogenesis)    Stabilizes mood – lithium is known for providing a calming effect in healthy people as well as those dealing with depression, bipolar disorder, and mania    Suicide prevention – adequate levels of lithium has been shown to reduce suicide risk in multiple studies worldwide    Depression – lithium helps with treatment-resistant depression. In fact, lithium has been shown to improve the effectiveness of antidepressant medications    N-acetyl aspartate (NAA) – lithium increases NAA which has been associated with higher IQ scores[xx] (i.e. lithium will make you smarter!) The benefits of supplementing with lithium go far beyond just optimizing cognitive health. Lithium also helps decrease insulin resistance, helps in treatment of alcoholism and other addictions, supports bone health, balances your circadian rhythm and more.How does Lithium feel? My personal experience with Lithium Orotate has made me a believer in micro-dosing lithium. I’m Adult ADD and deal with mood swings from time to time. If I’m going around the bend because something upset me, I take 5 mg of Lithium Orotate. Within 15 minutes my mood stabilizes and I feel normal again. Consistent use puts me in a happy does lithium work for depression Many others report you’ll feel the results taking a low dose of lithium quickly. But for some, the full effect can take anywhere from 1 to 3 weeks. Micro-dosing 5 – 10 mg of lithium daily results in consistent results within a month or two for some. I’ve experienced great results within a couple of days. So if you lash out at people in anger, and don’t fully understand why you get so angry – it could be your lithium levels are low. Many neurohackers with depression and anger issues notice results quickly. Within the first couple of days you should feel more calm, relaxed, and experience less stress. Keep in mind that lithium at any dose is not for everyone. But if you get adequate lithium from your diet and water, and still experience some of the mood swings talked about in this review, you could be dealing with other issues. You should know within a couple of hours of supplementing with low-dose lithium if this supplement is for you. For some, Lithium Orotate means feeling excited about life for the first time in a long time. Anxiety and social anxiety are no longer a problem. Life is more fun and enjoyable. Some say Lithium Orotate works better than any prescription that they’ve ever tried to treat severe depression. It provides a nice, smooth mood balance without all the toxicity associated with mega-doses of lithium carbonate. If you’re dealing with PTSD or mild insomnia, you may want to try Lithium Orotate. Focus could improve, racing thoughts diminish and motivation levels could increase. You’ll have more coping ability. lithium working in the brainLithium Orotate Clinical ResearchLithium Improves Memory A study at McMaster University in Canada set out to determine the effects on hippocampus volume in 14 bipolar patients who received lithium therapy. The researchers examined the effects of lithium on hippocampal volumes and memory performance and recall over 2 – 4 years. The patients had not received any type of medication prior to using lithium. The study found increases in hippocampus volume over time. And evidence of improvement of verbal memory performance over the 4-year measurement period. The researchers concluded that the results of the study were consistent with the literature stating the neuroprotective effects of lithium. And that long-term treatment of lithium is associated with preservation of memory and recall due to increased hippocampus size.[xxi]Lithium Increases Mood in Recovering Addicts 24 adults recovering from heroin or methamphetamine addiction participated in a study in San Diego. Group A received 400 mcg per day of lithium taken orally for 4 weeks. The placebo Group B naturally took a non-active placebo. Subjects completed a mood test questionnaire containing questions about their ability to think, work, mood and emotions. For the lithium group, mood test scores increased steadily and significantly during the 4 week period. The lithium group also reported significantly increased levels of happiness, friendliness and energy. Group B showed no improvement during the same period. The researchers concluded that low-dose lithium provided a mood-improving and stabilizing effect.[xxii]Lithium Orotate in the Treatment of Alcoholism In this study, 42 alcoholic patients were treated with Lithium Orotate during alcohol rehabilitation in a private clinical setting for six months. The data was collected from clinical practice records for the 10 years following the initial study. The patients received 150 mg of Lithium Orotate daily for six months along with calcium orotate, magnesium orotate, bromelain and essential phospholipids. Ten of the patients had no relapse from 3 – 10 years. 13 patients stayed sober from 1 – 3 years.  The remaining patients relapsed between 6 – 12 months. The researchers concluded that Lithium Orotate therapy was safe in treating addiction with minor adverse side effects.[xxiii]Lithium Orotate Dosage Lithium retains a grim and undeserved reputation. Likely because it was originally associated with serious mental illness. And like most medications, lithium can produce serious side effects if not monitored properly.Lithium Orotate Lithium carbonate or lithium chloride salts are typically prescribed for long-term control of bipolar disorder at 900 – 1200 mg per day. The major problem with such high doses of lithium are some very serious and debilitating side effects. For nootropic use, we suggest Lithium Orotate which typically contains only 5 mg of elemental lithium. Lithium Orotate is orotic acid combined with lithium. Orotic acid reportedly makes the lithium more bioavailable than lithium carbonate. The lithium is released once it crosses the blood-brain barrier. So you’ll get the benefits of lithium supplementation while avoiding the toxic side effects of high doses.[xxiv] Lithium Orotate recommended dose is 5 mg two or three times per day. See “Available Forms” for more on lithium amounts in nootropic supplements. Many neurohackers use Lithium Orotate only as needed. For example, when feeling anxious or in the middle of a mood swing. For someone with bipolar disorder or manic disorders, increasing to two 5 mg tablets up to 3-times per day may be more effective. Naturopathic doctors suggest stacking 1,000 mg of Omega-3 and 400 UI of Vitamin E (as mixed tocopherols) each day you’re using Lithium Orotate.Lithium Orotate Side Effects Do not confuse Lithium Orotate with lithium carbonate. The carbonate version of lithium is only available by prescription and comes with a host of side effects. Lithium Orotate at low doses is non-toxic and lab tests are not required to monitor your lithium levels because it does not show up in blood samples. Lithium Orotate should not be used if you are dealing with significant renal or cardiovascular disease, severe dehydration or sodium depletion, or if you’re taking diuretics or ACE inhibitors. Do not use Lithium Orotate if you are pregnant or breast-feeding. You should check with your doctor if you are on any medication before using Lithium Orotate.Where to Buy Lithium Orotate Mother Nature has already put the antipsychotic “drug” lithium in drinking water. And you get some lithium from food depending on where it’s grown. Supplemental Lithium Orotate typically comes in 120 or 130 mg capsules or tablets containing 5 mg of elemental lithium. I recommend and use Lithium Orotate by Advanced Research which was formulated by Dr. Hans Nieper.Nootropics Expert Recommendation Nootropics Expert Tested and ApprovedLithium Orotate 5 mg 2 or 3 times per day. I recommend using Lithium Orotate as a nootropic supplement if you’re feeling anxious or depressed. Or experiencing mood swings. Your body does not make lithium on its own. So you must get this essential trace mineral from your diet, or a supplement like Lithium Orotate. Lithium combined with orotic acid makes Lithium Orotate which readily crosses the blood-brain barrier, and you should feel its effects within 15 – 20 minutes of taking it. Lithium Orotate is especially effective if you’re feeling stressed, or mentally overworked. Your brain uses lithium faster and it needs to be replaced. Which you can do by using Lithium Orotate. Lithium Orotate is great if you are ADHD because lithium calms the hyperactivity in your brain. Supplementing with lithium does not change your state of consciousness. It simply helps bring you back to feeling normal and happy. I suggest trying Lithium Orotate as a nootropic supplement with your first dose at 5 mg and see how you react. If you experience no negative reaction, try another 5 mg in a few hours. Up to 3 – 5 mg doses per day. You’ll likely experience the full benefits of Lithium Orotate within a week of consistent use [i] Boesgaard A.M., Steigman G. (1985). "Big bang nucleosynthesis – Theories and observations". Annual Review of Astronomy and Astrophysics. Palo Alto, CA. 23: 319–378. (source) [ii] Swann A.C. “Norepinephrine and (Na+, K+)-ATPase: evidence for stabilization by lithium or imipramine.” Neuropharmacology. 1988 Mar;27(3):261-7. (source) [iii] Herbert V., Colman N. “Release of vitamin binding proteins from granulocytes by lithium: vitamin B12 and folate binding proteins.” Advances in Experimental Medicine and Biology. 1980;127:61-78. (source) [iv] Young W. “Review of lithium effects on brain and blood.” Cell Transplantation. 2009;18(9):951-75. (source) [v] Schrauzer G.N., Shrestha K.P. “Lithium in drinking water and the incidences of crimes, suicides, and arrests related to drug addictions.” Biological Trace Element Research. 1990 May;25(2):105-13. (source) [vi] Ohgami H., Terao T., Shiotsuki I., Ishii N., Iwata N. “Lithium levels in drinking water and risk of suicide.” British Journal of Psychiatry. 2009 May;194(5):464-5 (source) [vii] Blüml V., Regier M.D., Hlavin G., Rockett I.R., König F., Vyssoki B., Bschor T., Kapusta N.D. “Lithium in the public water supply and suicide mortality in Texas.” Journal of Psychiatric Research. 2013 Mar;47(3):407-11. (source) [viii] Terao T., Goto S., Inagaki M., Okamoto Y. “Even very low but sustained lithium intake can prevent suicide in the general population?”  Medical Hypotheses. 2009 Nov;73(5):811-2 (source) [ix] Cade J.F.J. “Lithium Salts in the Treatment of Psychotic Excitement” The Medical Journal of Australia Vol. II No. 10, September 3, 1949 (source) [x] Wada A. “Lithium and neuropsychiatric therapeutics: neuroplasticity via glycogen synthase kinase-3beta, beta-catenin, and neurotrophin cascades.” Journal of Pharmacological Sciences. 2009 May;110(1):14-28. (source) [xi] Kaidanovich-Beilin O., Milman A., Weizman A., Pick C.G., Eldar-Finkelman H. “Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.” Biological Psychiatry. 2004 Apr 15;55(8):781-4. (source) [xii] O'Brien W.T., Harper A.D., Jové F., Woodgett J.R., Maretto S., Piccolo S., Klein P.S. “Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium.” Journal of Neuroscience. 2004 Jul 28;24(30):6791-8. (source) [xiii] Collingridge G.L, Watkins J.C. “The NMDA Receptor.” New York: Oxford Univ. Press; 1994. [xiv] Chuang D., Christ L., Fujimaki K., Hashimoto R., Jeong M.R. “Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: A role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity”. FEBS Letters 2003; 538(1-3): 45-148 (source) [xv] Manji H.K, Chen G., Moore G.J. “Lithium at 50: Have the neuroprotective effects of this unique cation been overlooked?” Biological Psychiatry 1999; 46(7): 929-940 (source) [xvi] Leeds P.R., Yu F., Wang Z., Chiu C., Zhang Y., Leng Y., Linares G.R., Chuang D. “A New Avenue for Lithium: Intervention in Traumatic Brain Injury” ACS Chemical Neuroscience. 2014 Jun 18; 5(6): 422–433. (source) [xvii] Schrauzer G.N. “Lithium: occurrence, dietary intakes, nutritional essentiality.” Journal of the American College of Nutrition. 2002 Feb;21(1):14-21. (source) [xviii] Concha G., Broberg K., Grandér M., Cardozo A., Palm B., Vahter M. “High-level exposure to lithium, boron, cesium, and arsenic via drinking water in the Andes of northern Argentina.” Environmental Science and Technology. 2010 Sep 1;44(17):6875-80 (source) [xix] Angelucci F., Aloe L., Jiménez-Vasquez P., Mathé A.A. “Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression.” International Journal of Neuropsychopharmacology. 2003 Sep;6(3):225-31. (source) [xx] Aydin K., Uysal S., Yakut A., Emiroglu B., Yılmaz F. “N-acetylaspartate concentration in corpus callosum is positively correlated with intelligence in adolescents.” Neuroimage. 2012 Jan 16;59(2):1058-64 (source) [xxi] Yucel K., McKinnon M.C., Taylor V.H, Macdonald K., Alda M., Young L.T., MacQueen G.M. “Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study.” Psychopharmacology (Berlin). 2007 Dec;195(3):357-67 (source) [xxii] Schrauzer G.N., de Vroey E. “ Effects of nutritional lithium supplementation on mood. A placebo-controlled study with former drug users.” Biological Trace Element Research. 1994 Jan;40(1):89-101. (source) [xxiii] Sartori H.E. “Lithium orotate in the treatment of alcoholism and related conditions.” Alcohol. 1986 Mar-Apr;3(2):97-100. (source) [xxiv] Lakhan S., Vieira K.F. “Nutritional therapies for mental disorders” Nutrition Journal 2008; 7 
                                                                                                                         click here to closeback to top of articleAny role for Lithium reader asked me about this element today. I know that the abundance or absence of some minerals/elements have health impact. A simple introduction is here. A quick summary of interesting studies is shown below Comparative psychopharmacology of autism and psychotic-affective disorders suggests new targets for treatment [2019] ME/CFS have neurological issues often and this discusses some possible pathways.Psychotropic treatment of chronic fatigue syndrome and related disorders [1993]Lithium’s antiviral effects: a potential drug for CoViD-19 disease? [2020] ME/CFS often have virus re-activation as a contributing factor, sometimes reinforcing ME/CFS.The mood-stabilizing drug lithium eases repetitive behaviors seen in mice missing SHANK3, an autism gene, according to a new study. [2020]Emotionality is a common problem with ME/CFS. Fortunately, the people are too exhausted to become violent. But this paper raise some speculation: Is violence in part a lithium deficiency state?[2016]It is known to lower suicide rates [2020]“Trace lithium in water is negatively linked with changes in AD mortality, as well as obesity and type 2 diabetes, which are important risk factors for AD. “[2018] Translation: more lithium means less AD, obesity and diabetes.“Long-term increased lithium exposure in drinking water may be associated with a lower incidence of dementia” [2017]ProblemsLithium increases hypothyroidism [2020] [2020], unfortunately hypothyroidism is common with ME/CFS [2019]. This makes it a high risk experiment if thyroid levels are low. Zinc supplements may reduce the risk [2017] It’s known impact on the microbiome is below (and has been added to the analysis site) ” Lithium, valproate and aripiprazole administration significantly increased microbial species richness and diversity, while the other treatments were not significantly different from controls. At the genus level, several species belonging to Clostridium, Peptoclostridium, Intestinibacter and Christenellaceae were increased following treatment with lithium, valproate and aripiprazole when compared to the control group. “ Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function [2018]“Bacterial richness was increased in both treatments compared to vehicle-treated animals; moreover, at the genus level, lithium increased the relative abundance of Ruminococcaceae and decreased Bacteroides“ Psychotropics and the Microbiome: a Chamber of Secrets… [2019]Bottom LineIt appears that Lithium was tried on ME/CFS patients a few decades ago. We can infer that the results were not significant on the patient population as a whole. On the flip side, it does appear to have positive neurological impact for select conditions, with some risk. For Autism where it is known that the SHANK3 defect is present, we need a well constructed study to determine th benefits to risk factors                                                                                                                          click here to closeback to top of article                                                                                                                           click here to closeback to top of article                                                                                                                           click here to closeback to top of article





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