Many drugs and viruses can damage mitochondria. Herpesviruses, for example, cause mitochondrial fragmentation, and many infections lead to peroxynitrite production which damage mitochondrial membranes and impair mito complex 'Mitochondrial changes associated with viral infectious' https://onlinelibrary.wiley.com/doi/full/10.1002/rmv.2232
Find CDR which turned off with epigenetics, reverse manually