Page Synopsis: At this point, with the exception of physical rehabilitation, all therapies are alternative therapies


"Lithium calms mania and mood swings by decreasing the sensitivity of norepinephrine receptors. It upregulates brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT3) and their receptors.


And lithium stimulates the proliferation of stem cells in the brain. All boosting neurogenesis and assisting in repair from all types of brain injury.


Lithium also increases brain gray matter, increases DNA replication for neurogenesis, prevents apoptosis, increases N-acetyl-aspartate (NAA), inhibits beta-amyloid secretion and protects against damage once it’s formed, chelates aluminum, and protects against glutamate toxicity"


Skill Level  5

Relevance:5 Technical Level:3

Somewhat uncharted territory, therefore please leave comments of your experience below


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From: Reviving the Broken Marionette: Treatments for CFS/ME and Fibromyalgia

Phenytoin is believed to act by modulating glutamatergic transmission. It has been in clinical use as an anticonvulsant for over 50 years, but it is also an antiarrhythmic similar to lidocaine and mexiletine. It has analgesic, anxiolytic and mood stabilizing properties. Jay Goldstein has used it to treat CFS/ME and fibromyalgia in a low dose of 100 mg a day.62 He reports synergistic effects from combining it with gabapentin.


Phenytoin may also help tinnitus.63


Phenytoin is generally thought to have adverse effects on cognition, but this may only apply to the large doses used to treat epilepsy. Smaller doses have even been shown to positively influence cognition.64 In one study phenytoin was found to cause a significant increase in right brain volume in patients with PTSD.65


The most common side effects include tiredness, nausea, ataxia (impaired coordination), nystagmus, dizziness and tremor. Phenytoin may reduce the blood levels of folic acid, biotin, calcium, vitamins B1 and B12, vitamin D, vitamin K and carnitine, but folate also decreases blood levels of the drug. Phenytoin can also interact with a number of different medications, including many antibiotics, anticoagulants, azoles, opiates, benzodiazepines, other anticonvulsants and oral contraceptives.


Phenytoin is available virtually everywhere and it is very inexpensive. It can be used topically as an analgesic, but this form is not commercially available and must be compounded

What is meldonium and why was it banned


Meldonium is used to treat ischaemia: A lack of blood flow to parts of the body, particularly in cases of angina, chronic heart failure, cardiomyopathy and other cardiovascular disorders.The drug also helps to adjust the body's use of energy and can boost stamina and endurance. It increases blood flow, which improves exercise capacity in athletes and increased blood flow means more oxygen to muscle tissue

Lithium side effects can include fatigue. In some patients it has shown to combat fatigue. There are two types of medicinal Lithium Lithium is prescription and Lithium is otc. It may help CFS (page 3), TBIcf alttherapy (59) and OCD (68), supplements (8

Psilopcybin and neuroplasticity is a topic I will review and update the site with

Note: Site update will include off label use of Phenytoin and "New Drug Could Help Stop Depression, Anxiety, Brain Injury, and Cognitive Disorders" (a kinase Cdk5 inhibitor)


For even more medicines and potential therapeutiucs, please review 'Lithium Orotate for anxiety & depression' page 68 and visit links page

Note: there is too much info to place on this site, link goes to full report. Click for list of site topics

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