{"id":97815,"date":"2020-03-09T22:41:51","date_gmt":"2020-03-10T05:41:51","guid":{"rendered":"https:\/\/selfhacked.com\/?p=97815"},"modified":"2021-11-03T02:07:12","modified_gmt":"2021-11-03T09:07:12","slug":"coronavirus-genetic-link","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/coronavirus-genetic-link\/","title":{"rendered":"Coronavirus: A Potential Genetic Link"},"content":{"rendered":"

This article is for informational purposes only. The current coronavirus outbreak is an ongoing event and certain details may change as new information comes to light.<\/i><\/p>\n

None of the information here should be taken as medical advice. If you suspect you may have any kind of infection, seek medical help immediately.<\/i><\/p>\n

This article will focus on genetic factors that may affect the body\u2019s response to COVID-19. For more information on the disease, including symptoms and prevention, <\/i>check out these resources from the Centers for Disease Control and Prevention<\/i><\/a>.<\/i><\/p>\n

<\/p>\n

Coronavirus Disease (COVID-19)<\/span><\/h2>\n

The current outbreak of coronavirus disease, better known as COVID-19<\/b>, is a disease caused by an infection of a virus called SARS-CoV-2<\/b> (formerly known as 2019-nCoV) [R<\/a>].<\/p>\n

Generally speaking, the large majority of COVID-19 cases are mild and involve cold-like symptoms [R<\/a>].<\/p>\n

However, about 14% of cases are considered severe and 5% of cases result in critical illness, according to preliminary data from Chinese centers [R<\/a>].<\/p>\n

The World Health Organization estimates that about 3.4% of COVID-19 cases have resulted in death globally [R<\/a>].<\/p>\n

While these numbers will likely change as we learn more about the disease, it appears that COVID-19 may affect certain groups of people differently.<\/p>\n

Initial research suggests that age, gender, geographic location, and underlying health conditions may all influence the severity and susceptibility to COVID-19 [R<\/a>, R<\/a>].<\/p>\n

Interestingly enough, there is some evidence that genetics may also play a role in disease severity. More specifically, the ACE2<\/i> gene may have important interactions with the coronavirus [R<\/a>, R<\/a>].<\/p>\n

Coronavirus and ACE2<\/span><\/h2>\n

Coronavirus actually refers to a group of viruses, including SARS, MERS, and SARS-CoV-2<\/b> (the virus that is responsible for the current outbreak of COVID-19) [R<\/a>].<\/p>\n

Viruses, in general, work by invading the body\u2019s own cells and using the components inside to help replicate and spread.<\/p>\n

The SARS-CoV-2 virus, in particular, appears to enter human cells by attaching to the ACE2 receptor<\/b>, which serves as an entry point for the virus [R<\/a>].<\/p>\n

Normally, the ACE2 receptor plays an important role in regulating the body\u2019s blood pressure and fluid balance [R<\/a>].<\/p>\n

ACE2 receptors can be found in the body\u2019s airways, making them a target for several types of viruses [R<\/a>].<\/p>\n

How Do Genetics Affect Coronavirus?<\/span><\/h2>\n

One recent study suggests there may be a connection between genetics and the body\u2019s response or susceptibility to SARS-CoV-2 [R<\/a>].<\/p>\n

Researchers from this study identified a number of ACE2<\/i> variants that are significantly more common in East Asian populations compared to other groups.<\/p>\n

Some of these variants (also known as SNPs) include rs4646127, rs2158082, rs5936011, rs6629110, rs4830983, and rs5936029 [R<\/a>].<\/p>\n

In all these variants, the major allele (more common variant) is present in over 95% of people from East Asian populations [R<\/a>].<\/p>\n

In contrast, less than 65% of European populations carry this major allele [R<\/a>].<\/p>\n

The major allele in all these variants is associated with greater expression of ACE2, which researchers theorize may increase susceptibility or severity of COVID-19 because this genetic variant potentially provides more entry points for the virus [R<\/a>].<\/p>\n

However, further research is required to confirm a link between the ACE2<\/i> gene and COVID-19.<\/p>\n

Researchers from this study also tried to identify any ACE2<\/i> gene variants that may prevent the virus from attaching to the body\u2019s cells, but no evidence was found [R<\/a>].<\/p>\n

Treatment of COVID-19<\/span><\/h2>\n

CDC Guidelines<\/span><\/h3>\n

When to Seek Medical Advice<\/h4>\n

If you are experiencing symptoms of COVID-19, seek medical advice at once. If your city, state, or country has communicated a protocol to follow to get tested, follow those instructions carefully. If not, call your doctor to determine next steps.<\/b><\/p>\n

The CDC has advised that most cases of COVID-19 should be treated at home, seeking a doctor\u2019s advice by phone only. The reason for this advice is that COVID-19 is highly contagious, and even physically entering a doctor\u2019s office could spread the virus to at-risk patients. However, even if you have a mild case, your local health department will want to know whether you have COVID-19. Therefore, people with symptoms of respiratory coronavirus infection should call their doctors regardless of the severity of those symptoms<\/b> [R<\/a>].<\/p>\n

Home Care<\/h4>\n

Unfortunately, there are currently no vaccines, drugs, or investigational products<\/b> approved by the FDA to treat COVID-19. If you are sick or caring for someone at home, the CDC recommends having your healthcare provider\u2019s phone number on hand and carefully monitoring symptoms in case they get worse. Emergency warning signs include difficulty breathing, persistent pain or pressure in the chest, confusion, or a bluish tint in the lips or face [R<\/a>, R<\/a>].<\/p>\n

As part of any regimen for preventing infection and recovering from illness, it is extremely important to focus on hygiene and rest.<\/p>\n

Click here for the CDC\u2019s complete guide to caring for someone with COVID-19 at home<\/a>.<\/p>\n