{"id":87250,"date":"2019-10-26T13:02:23","date_gmt":"2019-10-26T20:02:23","guid":{"rendered":"https:\/\/selfhacked.com\/?p=87250"},"modified":"2020-02-06T21:03:06","modified_gmt":"2020-02-07T05:03:06","slug":"genes-that-control-uric-acid-levels","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/genes-that-control-uric-acid-levels\/","title":{"rendered":"Genes that Control Uric Acid Levels"},"content":{"rendered":"

<\/p>\n

SLC2A9 Gene – The Absorptive Urate Transporter:<\/span><\/h3>\n

The SLC2A9<\/a> gene encodes the glucose transporter 9 protein (GLUT4). It transports fructose and aids in the reabsorption of filtered urate by proximal tubules in the kidney. Loss-of-function mutations in this gene can cause hereditary hypouricemia due to reduced urate absorption (R<\/a>).<\/p>\n

    \n
  1. RS10017674<\/a><\/li>\n
  2. RS10018204<\/a><\/li>\n
  3. RS1014290<\/a> – The “G” allele is associated with a lower age at onset of Parkinson’s disease (R<\/a>). Individuals with the TT genotype had higher blood uric acid levels after increasing their consumption of soft drinks (R<\/a>). The GG genotype is associated with significantly higher serum uric acid levels when compared with the TT\/TG genotypes (R<\/a>).<\/li>\n
  4. RS1079128<\/a><\/li>\n
  5. RS10805346<\/a><\/li>\n
  6. RS11722228<\/a> – The “T” allele is linked to higher blood uric acid levels in females compared to males (R<\/a>).<\/li>\n
  7. RS12498150<\/a><\/li>\n
  8. RS12498742<\/a> – Each copy of the minor “G” allele reduces the risk of gout (R<\/a>).<\/li>\n
  9. RS12498956<\/a><\/li>\n
  10. RS13103879<\/a><\/li>\n
  11. RS13129697<\/a> – The “C” allele is linked to lower blood urate levels in the Croatian population (R<\/a>).<\/li>\n
  12. RS13131257<\/a> – The “T” allele is associated with lower blood uric acid levels in Mexican Americans (R<\/a>).<\/li>\n
  13. RS13328050<\/a><\/li>\n
  14. RS16868246<\/a><\/li>\n
  15. RS16890979<\/a><\/li>\n
  16. RS17185835<\/a><\/li>\n
  17. RS17185870<\/a><\/li>\n
  18. RS1850744<\/a><\/li>\n
  19. RS2018643<\/a><\/li>\n
  20. RS3733585<\/a> – The “G” allele is associated with cleft palate (R<\/a>).<\/li>\n
  21. RS3733591<\/a> – The “C” allele increases the risk of severe gout for some populations (R<\/a>).<\/li>\n
  22. RS3775948<\/a> – The “G” allele is associated with an increased risk of gout (R<\/a>).<\/li>\n
  23. RS4311316<\/a><\/li>\n
  24. RS4312757<\/a><\/li>\n
  25. RS4314284<\/a><\/li>\n
  26. RS4339211<\/a><\/li>\n
  27. RS4455410<\/a><\/li>\n
  28. RS4473653<\/a><\/li>\n
  29. RS4475146<\/a> – The “A” allele is associated with gout (R<\/a>).<\/li>\n
  30. RS4481233<\/a><\/li>\n
  31. RS4519796<\/a><\/li>\n
  32. RS4580649<\/a><\/li>\n
  33. RS4621431<\/a><\/li>\n
  34. RS6449157<\/a><\/li>\n
  35. RS6449159<\/a><\/li>\n
  36. RS6449171<\/a><\/li>\n
  37. RS6449172<\/a><\/li>\n
  38. RS6449174<\/a><\/li>\n
  39. RS6449176<\/a><\/li>\n
  40. RS6449178<\/a><\/li>\n
  41. RS6449201<\/a><\/li>\n
  42. RS6449213<\/a> – This variant is associated with higher blood urate levels (R<\/a>).<\/li>\n
  43. RS6814664<\/a><\/li>\n
  44. RS6815001<\/a><\/li>\n
  45. RS6823361<\/a><\/li>\n
  46. RS6832439<\/a> – The “A” allele is associated with decreasing blood uric acid levels (R<\/a>).<\/li>\n
  47. RS6834893<\/a><\/li>\n
  48. RS6836706<\/a><\/li>\n
  49. RS6838021<\/a><\/li>\n
  50. RS6839490<\/a><\/li>\n
  51. RS6843873<\/a><\/li>\n
  52. RS6844316<\/a><\/li>\n
  53. RS6849729<\/a><\/li>\n
  54. RS6852441<\/a><\/li>\n
  55. RS6855911<\/a> – The “G” allele is associated with less uric acid (R<\/a>).<\/li>\n
  56. RS733175<\/a><\/li>\n
  57. RS734553<\/a> – The “T” allele is associated with gout (R<\/a>).<\/li>\n
  58. RS737267<\/a> – The GG genotype is associated with 1.25 times higher risk of gout (R<\/a>).<\/li>\n
  59. RS7376948<\/a><\/li>\n
  60. RS7378305<\/a><\/li>\n
  61. RS7378340<\/a><\/li>\n
  62. RS7435196<\/a><\/li>\n
  63. RS7442295<\/a> – The more common “A” allele is associated with higher blood urate levels and hyperuricemia (R<\/a>).<\/li>\n
  64. RS7658170<\/a><\/li>\n
  65. RS7671266<\/a><\/li>\n
  66. RS7672947<\/a><\/li>\n
  67. RS7676733<\/a><\/li>\n
  68. RS7677710<\/a><\/li>\n
  69. RS7680126<\/a><\/li>\n
  70. RS7686538<\/a><\/li>\n
  71. RS938554<\/a><\/li>\n
  72. RS9993410<\/a><\/li>\n
  73. RS9994266<\/a><\/li>\n<\/ol>\n

    ABCG2 Gene – The Multi-functional Transporter That Exports Urate:<\/span><\/h3>\n

    The ABCG2<\/a> gene encodes a multifunctional transporter that belongs to the ATP-binding cassette family and controls the export of various compounds including urate using ATP (R<\/a>).<\/p>\n

      \n
    1. RS13120400<\/a><\/li>\n
    2. RS1481012<\/a> – The “A” allele is associated with an increased risk of gout (R<\/a>). Heterozygous carriers of the minor allele “G” have a lower risk of colorectal cancer (R<\/a>).<\/li>\n
    3. RS17731538<\/a><\/li>\n
    4. RS2199936<\/a> – The “A” allele is associated with incident gout (R<\/a>).<\/li>\n
    5. RS2231137<\/a> – The T” (minor) allele is associated with:\n