{"id":86587,"date":"2019-11-22T19:54:23","date_gmt":"2019-11-23T03:54:23","guid":{"rendered":"https:\/\/selfhacked.com\/?p=86587"},"modified":"2021-09-20T09:21:18","modified_gmt":"2021-09-20T16:21:18","slug":"probiotics-food-allergies-sensitivities","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/probiotics-food-allergies-sensitivities\/","title":{"rendered":"Can Probiotics Help Food Allergies & Sensitivities?"},"content":{"rendered":"

Certain probiotics may help the human body distinguish between safe and dangerous compounds and avoid allergic reactions to otherwise harmless foods. Read on to see the results of many promising clinical studies.<\/p>\n

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Probiotics & Food Tolerance<\/b><\/span><\/h2>\n

Allergic reactions result when the immune system overreacts to an otherwise harmless food or compound like milk, eggs, or peanuts. In many promising clinical trials, certain probiotic supplements reduced sensitization, prevented reactions, and even promoted tolerance of these allergens, especially in children.<\/p>\n

In this post, we’ll discuss the most promising avenues of research into probiotics and allergies. Remember that probiotics may not be right for everyone; talk to your doctor before starting a new probiotic supplement.<\/p>\n

Insufficient Evidence For<\/span><\/h3>\n

The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of probiotics for any of the below-listed uses. Remember to speak with a doctor before taking probiotic supplements, and never use it in place of something your doctor recommends or prescribes.<\/p>\n

1) Food Allergies<\/b><\/span><\/h3>\n

L. rhamnosus<\/i> accelerated oral tolerance acquisition in cow\u2019s milk allergic infants (R<\/a>, R<\/a>).<\/p>\n

L. rhamnosus<\/i> decreased the allergic response to peanuts in children (R<\/a>).<\/p>\n

In one study of milk-hypersensitive adults, L. rhamnosus<\/i> reduced the immunoinflammatory response (R<\/a>).<\/p>\n

L. plantarum<\/i> reduced the allergenicity of soy flour (R<\/a>).<\/p>\n

S. salivarius<\/i>, L. paracasei<\/i>, B. animalis <\/i>and B. bifidum <\/i>prevented atopic sensitization to common food allergens. The authors of this study believe that this probiotic blend could thereby reduce the incidence of atopic eczema in early childhood (R<\/a>).<\/p>\n

L. delbrueckii ssp. bulgaricus<\/i> degraded the allergenic whey protein \u03b2-lactoglobulin and inhibited IgE binding in allergic patients (R<\/a>).<\/p>\n

L. helveticus<\/i> alone or in combination with S. thermophiles<\/i> effectively reduced the antigenicity<\/b> of \u03b1-lactalbumin and \u03b2-lactoglobulin, the major allergens in cow\u2019s milk<\/b> (R<\/a>).<\/p>\n

L. helveticus<\/i> can significantly degrade the major allergens<\/b> in propolis<\/a>, including esters of caffeic acid (R<\/a>).<\/p>\n

L. fermentum <\/i>degraded \u03b1S1-casein<\/b> and lowered the recognition and the binding of this casein to IgE from the blood of patients with cow\u2019s milk allergy (R<\/a>).<\/p>\n

B. breve<\/i> improved symptoms of allergic hypersensitivity to cow\u2019s milk<\/b> in infants (R<\/a>).<\/p>\n

Lactobacillus <\/i>probiotics appear to promote oral tolerance to allergenic foods in humans. Some species may also degrade common allergens.<\/div><\/div>\n

2) Lactose Intolerance<\/b><\/span><\/h3>\n

L. delbrueckii ssp. bulgaricus and S. thermophilus <\/i>improved lactose digestion<\/b> in the gastrointestinal tract and reduced symptoms of lactose intolerance<\/b> (R<\/a>).<\/p>\n

L. acidophilus<\/i> may improve lactose digestion and tolerance<\/b> (R<\/a>, R<\/a>).<\/p>\n

3) Oxalate<\/b><\/span><\/h3>\n

L. gasseri<\/i> degraded oxalate in laboratory experiments; according to some researchers, it may therefore be beneficial in managing oxalate kidney stone disease (R<\/a>).<\/p>\n

A mixture of L. casei<\/i> and B. breve<\/i> lowered urinary oxalate excretion through a mechanism that may be dependent on dietary oxalate intake (R<\/a>).<\/p>\n

B. animalis<\/i> ssp. lactis<\/i> possesses the oxc<\/i> gene, encoding oxalyl-coenzyme A (CoA) decarboxylase, a key enzyme in oxalate degradation (R<\/a>). B. animalis<\/i> ssp. lactis<\/i> significantly decreased urinary oxalate excretion in mice with hyperoxaluria, possibly by degrading dietary oxalate and thus limiting its absorption across the intestine (R<\/a>).<\/p>\n

4) MSG<\/b><\/span><\/h3>\n

Capsules containing L. brevis<\/i> reduced monosodium glutamate <\/b>(MSG<\/b>) levels<\/b> and MSG symptom complex<\/b> in humans (R<\/a>).<\/p>\n

L. brevis<\/i> inhibited the absorption of MSG from the intestine into the blood in mice (R<\/a>).<\/p>\n

Animal & Cell Research (Lacking Evidence)<\/span><\/h3>\n

No clinical evidence supports the use of probiotics for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.<\/p>\n

5) Histamine Intolerance<\/h4>\n

L. plantarum<\/i> is able to degrade biogenic amines<\/a> [R<\/a>]; thus, some researchers believe it could help with histamine intolerance.<\/p>\n

L. casei <\/i>degrades biogenic amines (BAs) and reduces histamine<\/a> and tyramine accumulation in cheese (R<\/a>).<\/p>\n

Note that some probiotics may produce or increase biogenic amines (see Safety section).<\/p>\n

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Takeaway<\/span><\/h3>\n

When patients were given probiotics in multiple clinical trials (most commonly Lactobacillus<\/em>), they were more likely to develop oral tolerance to allergens; that is, they were less likely to have allergic reactions. Certain probiotic bacteria may also degrade the allergenic compounds in common foods.<\/p>\n

Among the common allergens and intolerance triggers tested against probiotics are histamine, oxalates, lactose, and MSG. Not everyone will respond to probiotics in the same way; talk to your doctor before starting a new probiotic.<\/div><\/div>\n

Further Reading<\/b><\/span><\/h3>\n

We\u2019ve compiled deep dives into each potential benefit of probiotics. Check them out here:<\/p>\n