{"id":86582,"date":"2019-11-22T19:35:53","date_gmt":"2019-11-23T03:35:53","guid":{"rendered":"https:\/\/selfhacked.com\/?p=86582"},"modified":"2021-09-20T09:21:14","modified_gmt":"2021-09-20T16:21:14","slug":"probiotics-gut-health","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/probiotics-gut-health\/","title":{"rendered":"How Probiotics Can Benefit Gut Health"},"content":{"rendered":"<p>Probiotics may help prevent and manage a variety of gut disorders and complaints, from diarrhea to IBD to gastric ulcers. Which species have been tested, and which one could be right for you? Read on to learn more.<\/p>\n<p><!--more--><\/p>\n<h2><span id=\"Probiotics_Gut_Health\"><b>Probiotics &amp; Gut Health<\/b><\/span><\/h2>\n<p>Probiotic supplements are currently under investigation for their potential to improve a number of digestive conditions and complaints. This should come as no surprise, given the important of the gut flora to human health and well-being. As we&#8217;ve explored in other posts, the bacteria that live in our intestines have<a href=\"https:\/\/selfhacked.com\/blog\/gut-bacteria-microbiome\/\"> far-reaching consequences<\/a> for our health.<\/p>\n<p>But without going that far, without even leaving the intestines, what benefits could probiotics have? In this post, we&#8217;ll discuss the potential of good bacteria to improve digestive health, but they may not be right for everyone; remember to talk to your doctor before adding any new supplement to your regimen.<\/p>\n<h3><span id=\"Likely_Effective_For\">Likely Effective For<\/span><\/h3>\n<h3><span id=\"1_Diarrhea\"><b>1) Diarrhea<\/b><\/span><\/h3>\n<p>Use of probiotics in antibiotic-associated diarrhea decreased the risk of diarrhea by 52%, traveler\u2019s diarrhea by 8%, and acute diarrhea from various causes by 34%. Probiotics were more effective in reducing the risk of acute diarrhea in children 57% versus 26% in adults (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4748908\/\">R<\/a>).<\/p>\n<h4><b>Acute Infective Diarrhea<\/b><\/h4>\n<p><i>L. casei<\/i> reduced the incidence, duration, and severity of diarrhea in children (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3222668\/\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3858332\/\"> R<\/a>).<\/p>\n<p><i> L. paracasei<\/i> effectively <b>resolved acute diarrhea<\/b> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22324448\">R<\/a>) and ameliorated non-rotavirus-induced diarrhea in children (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15995003\">R<\/a>).<\/p>\n<p><i> L. acidophilus<\/i> reduced the duration of diarrhea in hospitalized, but not outpatient, children (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24175943\">R<\/a>), and ameliorated both rotavirus-positive diarrhea (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10630442\">R<\/a>) and rotavirus-negative diarrhea in children (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17768180\">R<\/a>).<\/p>\n<p><i> L. acidophilus<\/i> and <i>B. bifidum<\/i> shortened the duration of diarrhea in infants and children (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3026296\/\">R<\/a>).<\/p>\n<p><i> L. rhamnosus<\/i> administration was associated with significantly lower rates of and symptomatic rotavirus gastroenteritis diarrhea in hospitalized children (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21899584\">R<\/a>).<\/p>\n<p><i> L. reuteri<\/i><b> decreased the incidence of diarrhea in children <\/b>(<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15629974\">R<\/a>).<\/p>\n<p>Formula supplemented with <i>B. bifidum<\/i> and <i>S. thermophilus<\/i> reduced the incidence of acute diarrhea and rotavirus shedding in infants admitted to hospital (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7934445\">R<\/a>).<\/p>\n<p><i>B. breve <\/i>together with <i>S. thermophilus<\/i> r<b>educed the severity of acute diarrhea<\/b> and dehydration among healthy young infants (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15269618\">R<\/a>).<\/p>\n<p><i>B. animalis<\/i> spp. <i>lactis<\/i> milk formula prevents diarrhea in infants and <b>decreased diarrhea frequency and duration <\/b>(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4877827\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15076628\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25599772\"> R<\/a>).<\/p>\n<p><i>S. boulardii <\/i>significantly <b>reduced the frequency and duration of acute diarrhea<\/b> in children (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4125647\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2829915\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21997865\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18256417\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17306006\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27283364\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24958586\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21734600\"> R<\/a>). It also often <b>reduced the length of ECU and hospital stay<\/b> in acute infectious gastroenteritis in children (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25653151\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15858959\"> R<\/a>).<\/p>\n<p><i>S. boulardii <\/i>also decreased the duration and frequency of diarrhea and <b>ameliorated abdominal pain<\/b> in adults (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22476321\">R<\/a>); it shortened the length of hospital stay in patients with acute infectious diarrhea (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22335323\">R<\/a>).<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Certain probiotics\u2014especially <i>Lactobacillus, Bifidobacterium, and Saccharomyces <\/i>species\u2014reduced the duration and severity of diarrhea caused by infectious bacteria in infants, children, and adults.<\/div><\/div>\n<h4><b>Antibiotic-Associated Diarrhea<\/b><\/h4>\n<p>Treatment with <i>L. rhamnosus<\/i> reduced the risk of antibiotic-associated diarrhea (AAD) in patients treated with antibiotics from 22.4% to 12.3% (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26365389\">R<\/a>).<\/p>\n<p><i>L. casei<\/i> intake was associated with a <b>decreased risk of antibiotic-associated diarrhea<\/b> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24044687\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4229551\/\"> R<\/a>).<\/p>\n<p><i>L. helveticus<\/i> and <i>L. rhamnosus<\/i> supplementation significantly reduced the duration of antibiotic-associated diarrhea in healthy adults receiving antibiotics (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27169634\">R<\/a>).<\/p>\n<p><i>B. animalis<\/i> spp. <i>lactis<\/i> together with <i>S. thermophilus<\/i> reduced the frequency of antibiotic-associated diarrhea (AAD) in infants (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15815206\">R<\/a>).<\/p>\n<p>Concomitant administration of <i>C. butyricum<\/i> with antibiotics normalized the intestinal<a href=\"https:\/\/selfhacked.com\/blog\/how-your-gut-microbiota-can-make-you-fat-or-thin\/\"> microbiota<\/a>, prevented the decrease of Bifidobacteria, and effectively <b>prevented and improved antibiotic-associated diarrhea<\/b> in children (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12654076\">R<\/a>).<\/p>\n<p>Some studies report that <i>S. boulardii <\/i>is not effective in preventing the development of antibiotic-associated diarrhea (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22472744\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18949181\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9570649\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4785405\/\"> R<\/a>). However, many studies demonstrate that <i>S. boulardii <\/i>effectively<b> reduced the risk of antibiotic-associated diarrhea<\/b> in both children and adults (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26216624\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24311316\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15740542\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16572062\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15357564\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2494098\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7872284\"> R<\/a>).<\/p>\n<p><i>B. subtilis<\/i> significantly <b>reduced the incidence of antibiotic-associated diarrhea<\/b> and <b>prevented nausea, bloating, vomiting and abdominal pain<\/b> (<a href=\"http:\/\/jmmcr.microbiologyresearch.org\/content\/journal\/jmmcr\/10.1099\/jmmcr.0.004036\">R<\/a>).<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Probiotics have also effectively prevented or reduced diarrhea caused by antibiotics in children and adults.<\/div><\/div>\n<h4><b>Traveler\u2019s Diarrhea<\/b><\/h4>\n<p><i>S<\/i>. <i>boulardii<\/i> may <b>prevent traveler\u2019s diarrhea<\/b>, particularly in regions such as North Africa and in the Near-east (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8486328\">R<\/a>).<\/p>\n<h4><b>Chemo- and Radiotherapy-induced Diarrhea<\/b><\/h4>\n<p>Probiotics may have a beneficial effect on the prevention of chemo- and radiotherapy-induced diarrhea, where they rarely cause adverse effects (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27329608\">R<\/a>).<\/p>\n<p><i>See individual probiotic posts for more information and animal studies.<\/i><\/p>\n<aside class=\"sh-partner shp-form sponsored sh-et-7388fa\">\n  <div>\n          <div class=\"partner-heading\">8 Ways To Use Your DNA &amp; Optimize Your Health<\/div>\n    \n    <div class=\"partner-content\">\n      <p><span style=\"font-weight: 400\">What kinds of secrets could your genes hold? Read this guide and find out how you can take your health into your own hands and find the root cause of your issues through gene-based health.<\/span><\/p>\n    <\/div>\n\n    <div class=\"subscribe-form-container\">\n      <form method=\"POST\" action=\"\/wp-json\/wp\/v2\/posts\/86582\" class=\"sh-subscribe-form\">\n        <input type=\"email\" name=\"subscribe_form_data[email]\"\n            pattern=\"^[a-zA-Z0-9.!#$%&\u2019*+\/=?^_`{|}~-]+@[a-zA-Z0-9-]+(?:\\.[a-zA-Z0-9-]+)*$\" required\n            placeholder=\"Enter your email\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: PartnerAd Your DNA Your Health\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: Your DNA Your Health Guide\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"PartnerAd\">\n                <button type=\"submit\" class=\"btn btn-primary subscribe-submit\">Optimize My Health<\/button>\n      <\/form>\n    <\/div>\n  <\/div>\n          <style>aside.sponsored.sh-et-7388fa::before{content:\"Advertisement\"}<\/style>\n<\/aside>\n<h3><span id=\"2_Necrotizing_Enterocolitis\"><b>2) Necrotizing Enterocolitis<\/b><\/span><\/h3>\n<p>Necrotizing enterocolitis is an infection of the intestines of premature babies. If untreated or treated too late, it is frequently lethal [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5124124\/\">R<\/a>].<\/p>\n<p>Oral supplementation of <i>L. paracasei<\/i> <b>reduced the clinical progression of necrotizing enterocolitis in infants<\/b> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24051968\">R<\/a>).<\/p>\n<p>Prophylactic <i>L. acidophilus<\/i> and <i>B. infantis<\/i> <b>reduced the incidence and mortality of necrotizing enterocolitis<\/b> (NEC) in infants (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10575148\">R<\/a>).<\/p>\n<p><i> B. breve<\/i> was associated with decreased risk of necrotizing enterocolitis in neonates (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4783036\/\">R<\/a>).<\/p>\n<p>Oral administration of <i>B. breve<\/i> reduced the production of butyric acid in infants, which may be helpful in protecting low birth weight infants from digestive diseases such as necrotizing enterocolitis (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17255840\">R<\/a>).<\/p>\n<p>However, one study found no benefit in <i>B. breve<\/i> administration for the prevention of necrotizing enterocolitis and late-onset sepsis in very preterm infants (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26628328\">R<\/a>).<\/p>\n<p><i>B. breve<\/i> suppressed inflammation, reduces the pathology and increases survival in rats with necrotizing enterocolitis (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26420070\">R<\/a>).<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Probiotics show promise in both preventing and supporting the treatment of necrotizing enterocolitis in preterm babies.<\/div><\/div>\n<h3><span id=\"Possibly_Effective_For\">Possibly Effective For<\/span><\/h3>\n<h3><span id=\"3_Discomfort_Well-being\"><b>3) Discomfort &amp; Well-being<\/b><\/span><\/h3>\n<p>Probiotics can decrease the number of potentially pathogenic gastrointestinal microorganisms and pathogens, reduce gastrointestinal discomfort, flatulence and bloating, and improve bowel regularity (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4997396\/\">R<\/a>).<\/p>\n<p><i>B. animalis<\/i> spp. <i>lactis<\/i> <b>improved digestive comfort<\/b> and GI symptoms in healthy adults (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19236549\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3171707\/\"> R<\/a>).<\/p>\n<p>Probiotic fermented milk containing <i>B. animalis<\/i> spp. <i>lactis<\/i> by healthy women may <b>improve GI well-being<\/b> and decrease the frequency of GI symptoms (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26268077\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23480238\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19622191\"> R<\/a>).<\/p>\n<p>4 weeks\u2019 supplementation with <i>B. animalis<\/i> ssp. <i>lactis<\/i> resulted in a clinically relevant benefit on defecation frequency in healthy adults with abdominal discomfort (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4657032\/\">R<\/a>).<\/p>\n<p>Ingestion of <i>B. bifidum<\/i> significantly <b>decreased the prevalence of gastric and lower abdominal symptoms<\/b> in adults taking no medication (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25648808\">R<\/a>).<\/p>\n<p>Administration of <i>L. helveticus<\/i> to healthy human subjects resulted in a <b>significant increase in<\/b><a href=\"https:\/\/selfhacked.com\/blog\/health-benefits-butyrate-derivatives-sodium-butyrate-phenylbutyrate-trybutyrine-butyric-acid-butyrate-prodrugs-butyrate-producing-bacteria\/\"> <b>butyrate<\/b><\/a>, beneficial for gut homeostasis (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3500876\/\">R<\/a>).<\/p>\n<p>Probiotics promoted gastric mucus secretion (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906699\/\">R<\/a>) and <i>B. bifidum<\/i> alleviated acute gastric injury by enhancing the production of gastric mucin in rats (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23200466\">R<\/a>).<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Probiotic supplements have improved digestive comfort, regulated bowel movements, and decreased GI distress in human trials.<\/div><\/div>\n<h3><span id=\"4_Modifying_Gut_Microbiota\"><b>4) Modifying Gut Microbiota<\/b><\/span><\/h3>\n<p>Probiotics, in general, tend to<b> increase the levels of Lactobacilli and Bifidobacteria<\/b> in the gut, while <b>decreasing the levels of potentially pathogenic microorganisms<\/b> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25098489\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24702028\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16469146\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19029768\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24385355\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4793260\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27451450\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19847949\"> R<\/a>,<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bifidus1996\/18\/1\/18_1_27\/_pdf\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22968412\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15491374\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4507410\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20711781\"> R<\/a>).<\/p>\n<h3><span id=\"5_Drug-Induced_GI_Damage\"><b>5) Drug-Induced GI Damage<\/b><\/span><\/h3>\n<p>Probiotics maintained healthy intestinal microbiota in subjects receiving antibiotic treatment (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4997396\/\">R<\/a>).<\/p>\n<p><i>L. acidophilus<\/i> administered with amoxicillin\/clavulanate was associated with a <b>significant decrease in patient complaints of GI side effects<\/b> and yeast superinfection (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8551535\">R<\/a>).<\/p>\n<p><i>L. casei <\/i>is effective for the treatment of aspirin-associated small bowel injury in chronic low-dose aspirin users (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21556830\">R<\/a>).<\/p>\n<p>Long-term <i>L<\/i>. <i>rhamnosus<\/i> supplementation influenced the composition of the intestinal<a href=\"https:\/\/selfhacked.com\/blog\/how-your-gut-microbiota-can-make-you-fat-or-thin\/\"> microbiota<\/a> in children and <b>reduced the frequency of gastrointestinal complaints after antibiotic use<\/b>, preventing certain bacterial infections for up to 3 years after the trial (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4844131\/\">R<\/a>).<\/p>\n<p><i>L. delbrueckii<\/i> microcapsules relieved intestinal tissue damage in mice and <b>improved antibiotic-induced intestinal microbiota dysfunction<\/b> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26471401\">R<\/a>).<\/p>\n<p><i>L. paracasei<\/i> therapy prevented antibiotic induced visceral hypersensitivity and restored normal gut permeability in rats (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17634262\">R<\/a>).<\/p>\n<p><i>L. fermentum <\/i><b>normalized the composition of<\/b><a href=\"https:\/\/selfhacked.com\/blog\/how-your-gut-microbiota-can-make-you-fat-or-thin\/\"> <b>gut microbiota<\/b><\/a> and alleviated ampicillin-induced inflammation in the colon in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25869281\">R<\/a>).<\/p>\n<p><i>B. animalis<\/i> ssp. <i>lactis<\/i> <b>protected against NSAID-induced GI side effects<\/b> in rats and may prevent more serious GI mucosal damage and\/or enhance the recovery rate of the stomach mucosa (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3405648\/\">R<\/a>).<\/p>\n<p><i>S. boulardii <\/i>significantly <b>reduced the numbers of gastric ulcers<\/b> and the ulceration surface of the gastric mucosa in rats treated with ibuprofen (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20185968\">R<\/a>).<\/p>\n<p><i>S. thermophilus<\/i> <b>reduced inflammation and prevented chronic gastritis<\/b> in aspirin-treated mice (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19447974\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2848370\/\"> R<\/a>).<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Antibiotics and other drugs can damage the intestines and leave the patient vulnerable to recurrent infections. Probiotic supplements may help accelerate the recovery of the gut after treatment.<\/div><\/div>\n<h3><span id=\"6_Constipation\"><b>6) Constipation<\/b><\/span><\/h3>\n<p><i>L. paracasei<\/i> <b>relieved<\/b><a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"> <b>constipation<\/b><\/a> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22225544\">R<\/a>).<\/p>\n<p>Heat-killed <i>L. brevis <\/i><b>improved intestinal function<\/b> in women with constipation (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4034292\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24418874\"> R<\/a>).<\/p>\n<p><i>L. reuteri <\/i><b>improved<\/b><a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"> <b>constipation<\/b><\/a>, increasing the number of bowel movements in adults (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25531996\">R<\/a>) and infants (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20542295\">R<\/a>).<\/p>\n<p><i>B. breve <\/i>effectively <b>diminished abdominal pain <\/b>and increased stool frequency in children with functional constipation (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3048518\/\">R<\/a>).<\/p>\n<p><i>B. animalis<\/i> spp. <i>lactis<\/i> showed <b>beneficial effects on<\/b><a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"> <b>constipation<\/b><\/a> in human studies (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24322191\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2761588\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22284965\"> R<\/a>).<\/p>\n<p><i>B. coagulans<\/i> <b>improved<\/b><a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"> <b>constipation<\/b><\/a><b> symptoms<\/b> in children (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3724383\/\">R<\/a>) and adults (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25338680\">R<\/a>).<\/p>\n<p><i>P. freudenreichii <\/i><b>relieved<\/b><a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"> <b>constipation<\/b><\/a> in young healthy women (<a href=\"https:\/\/www.jstage.jst.go.jp\/article\/bifidus1996\/21\/2\/21_2_115\/_article\">R<\/a>).<\/p>\n<p>Some researchers believe that a synbiotic regimen of lactulose and live binary <i>B. subtilis<\/i> could be an effective and safe therapy for elderly with functional constipation (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23328284\">R<\/a>).<\/p>\n<p><i>See individual probiotic posts for more information and animal studies.<\/i><\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\"><i>Lactobacillus<\/i> and <i>Bifidobacterium<\/i> probiotics relieved constipation and reduced abdominal pain in children and adults.<\/div><\/div>\n<h3><span id=\"7_Irritable_Bowel_Syndrome\"><b>7) Irritable Bowel Syndrome<\/b><\/span><\/h3>\n<p>Irritable bowel syndrome appears to cause a reduction in intestinal <i>Lactobacilli<\/i> and <i>Bifidobacteria<\/i> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27246320\">R<\/a>). <b>Probiotics improved global<\/b><a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"> <b>IBS<\/b><\/a> symptoms and decrease IBS-associated pain (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4748908\/\">R<\/a>).<\/p>\n<p><i>L. acidophilus<\/i> <b>reduced abdominal pain and discomfort<\/b> in patients with irritable bowel syndrome (<a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\">IBS<\/a>) (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18274900\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23307089\"> R<\/a>).<\/p>\n<p><i>L. plantarum<\/i> <b>reduced gas problems and pain<\/b> in people who suffer from irritable bowel syndrome (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4594053\/\">R<\/a>).<\/p>\n<p>Probiotics containing <i>L. plantarum<\/i> and <i>B. breve<\/i> in IBS patients decreased pain by 38% in the probiotic group compared with 18% in the placebo group. After 28 days, the pain was decreased by 52% in the probiotic group compared with 11% in the placebo group (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4748908\/\">R<\/a>).<\/p>\n<p><i>L. rhamnosus<\/i> may <b>reduce pain frequency and intensity<\/b> in children (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4155824\/\">R<\/a>) and adults (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4239510\/\">R<\/a>) with IBS.<\/p>\n<p><i>L. rhamnosus<\/i> may also reduce symptoms in children with functional gastrointestinal disorders (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4239510\/\">R<\/a>).<\/p>\n<p>According to one study, <i>L. reuteri<\/i> may help produce<a href=\"https:\/\/selfhacked.com\/blog\/serotonin-happy-neurotransmitter\/\"> serotonin<\/a> and lessen susceptibility to gut problems and<a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/#7_Excess_IDO_LowTryptophan\"> <b>IBS<\/b><\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4266036\/\">R<\/a>).<\/p>\n<p><i>L. rhamnosus<\/i>, <i>L. reuteri <\/i>and VSL#3 significantly increased treatment success for functional gastrointestinal disorders (FGIDs) in children and adolescents (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27380595\">R<\/a>).<\/p>\n<p>A mixture of <i>B. infantis<\/i>, <i>B. breve<\/i>, and <i>B. longum<\/i> improve abdominal pain and the quality of life in children with irritable bowel syndrome (IBS) (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27306945\">R<\/a>).<\/p>\n<p><i>B. longum<\/i> ssp. <i>infantis<\/i> <b>reduced intestinal inflammation and improved abdominal pain\/discomfort, bloating\/distention, and bowel movement difficulty in patients with<\/b><a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"> <b>IBS<\/b><\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4997396\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19367213\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16863564\"> R<\/a>).<\/p>\n<p><i>B. bifidum<\/i> significantly <b>improved reported pain\/discomfort<\/b>,<b> distension\/bloating<\/b>,<b> urgency and digestive disorder<\/b> in patients with IBS (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21418261\">R<\/a>).<\/p>\n<p>In one study, fermented milk containing <i>B. bifidum<\/i> improved symptoms in patients with functional gastrointestinal disorders (FGID). <b>Abdominal pain<\/b>,<b> diarrhea<\/b>,<b> and constipation significantly improved<\/b>, as did acid-related dyspepsia. Psychological symptoms such as anger and hostility also improved (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4405396\/\">R<\/a>).<\/p>\n<p><i>B. animalis<\/i> had a <b>beneficial effect on discomfort<\/b>,<b> bloating and constipation<\/b> in constipation-predominant IBS patients (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17635382\">R<\/a>).<\/p>\n<p><i>B. animalis<\/i> spp. <i>lactis <\/i>significantly improved objectively measured abdominal girth and gastrointestinal transit, as well as <b>reduced symptomatology in<\/b><a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"> <b>IBS<\/b><\/a> patients (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18801055\">R<\/a>).<\/p>\n<p><i>B. coagulans<\/i> <b>decreased bloating<\/b>,<b> vomiting<\/b>,<b> diarrhea<\/b>,<b> abdominal pain<\/b>,<b> and stool frequency<\/b> and increased the quality of life in patients with diarrhea-predominant irritable bowel syndrome (IBS) (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4769834\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20140275\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19332970\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4129566\/\"> R<\/a>).<\/p>\n<p>A combination of simethicone and <i>B. coagulans<\/i> reduced bloating and discomfort in patients with IBS (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24867512\">R<\/a>).<\/p>\n<p><i>L. brevis<\/i> <b>improved the quality of life<\/b>,<b> reduced diarrhea and abdominal pain,<\/b> and increased Bifidobacteria in patients with IBS (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3489517\/\">R<\/a>).<\/p>\n<p><i>S. boulardii <\/i><b>improved the cytokine profile<\/b>,<b> histology<\/b>,<b> and the quality of life<\/b> of patients with diarrhea dominant irritable bowel syndrome (IBS-D) (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24722560\">R<\/a>) or mixed-type IBS (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21301358\">R<\/a>).<\/p>\n<p><i>S. boulardii <\/i>alone or with mesalazine <b>improved<\/b><a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"> <b>IBS<\/b><\/a><b>-D symptoms<\/b> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24474234\">R<\/a>). One study, however, found no improvement in IBS-D patients after <i>S. boulardii<\/i> treatment (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21804501\">R<\/a>).<\/p>\n<p>In one clinical trial, <i>S. cerevisiae<\/i> <b>reduced abdominal pain and discomfort<\/b> in subjects with<a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"> IBS<\/a> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25488056\">R<\/a>). In another trial, however, <i>S. cerevisiae<\/i> had no beneficial effect on IBS symptoms and wellbeing. However, it seemed to have some effect in the subgroup with constipation (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4924426\/\">R<\/a>).<\/p>\n<p>A combination product designated VSL#3, which contains large quantities of 8 bacterial species, was shown to significantly improve IBS symptoms (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4748908\/\">R<\/a>).<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Probiotic supplements improved the symptoms of both diarrhea and constipation type IBS patients in many clinical trials.<\/div><\/div>\n<h3><span id=\"8_Gut_Pain\">8) Gut Pain<\/span><\/h3>\n<p>Oral administration of <i>L. acidophilus<\/i> induced the expression of mu-opioid and<a href=\"https:\/\/selfhacked.com\/blog\/the-lectin-sensitive-gene-cannabanoid-receptor-1-genes-cnr1-rs1049353\/\"> cannabinoid<\/a> receptors in intestinal epithelial cells and <b>mediated analgesic functions<\/b> in the gut similar to the effects of morphine (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17159985\">R<\/a>).<\/p>\n<p><i>B. coagulans<\/i> + fructooligosaccharide (FOS) <b>decreased abdominal pain duration and frequency<\/b> in children with GI disorders (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4443394\/\">R<\/a>).<\/p>\n<p>A <i>B. coagulans <\/i>synbiotic improved childhood functional abdominal pain (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4285933\/\">R<\/a>).<\/p>\n<p><i>B. coagulans<\/i> significantly <b>improved abdominal pain and the quality of life<\/b> in adults with postprandial intestinal gas-related symptoms and no GI diagnoses (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2784472\/\">R<\/a>).<\/p>\n<p>In animal models of gut pain, <i>L. reuteri <\/i>has been associated with decreased activation of the nervous system and reduced pain (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23093353\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1856513\/\"> R<\/a>).<\/p>\n<p><i>L. reuteri <\/i>ingestion impacted the nerves in such a way that it may <b>slow gut motility<\/b> (improving cases of diarrhea) and <b>decrease pain perception<\/b> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19210574\">R<\/a>).<\/p>\n<p><i>L. rhamnosus<\/i> may attenuate neonatally induced chronic visceral pain; it significantly altered levels of<a href=\"https:\/\/selfhacked.com\/blog\/serotonin-happy-neurotransmitter\/\"> serotonin<\/a>,<a href=\"https:\/\/selfhacked.com\/blog\/norepinephrine-stress-hormone\/\"> noradrenaline<\/a>, and<a href=\"https:\/\/selfhacked.com\/blog\/dopamine\/\"> dopamine<\/a> in rats (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25298006\">R<\/a>).<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Probiotics reduced the perception of gut pain (both duration and frequency) in multiple human and animal trials.<\/div><\/div>\n<h3><span id=\"Insufficient_Evidence_For\">Insufficient Evidence For<\/span><\/h3>\n<p>The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of probiotics for any of the below-listed uses. Remember to speak with a doctor before taking probiotic supplements, and never use them in place of something your doctor recommends or prescribes.<\/p>\n<h3><span id=\"9_Strengthening_the_Intestinal_Barrier\">9) Strengthening the Intestinal Barrier<\/span><\/h3>\n<p>The intestinal barrier separates the contents of the gut from the rest of the body. This barrier prevents the entry of harmful substances such as foreign antigens, toxins, and microorganisms. Hyperpermeability of this barrier (\u201cleaky gut\u201d) may contribute to the pathogenesis of several gastrointestinal disorders including IBD, Celiac disease, and food allergy (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12702039\">R<\/a>).<\/p>\n<p>In humans, <i>L.<\/i> <i>rhamnosus<\/i> <b>protected against disruption of the gastric mucosal barrier<\/b> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906699\/\">R<\/a>).<\/p>\n<p>Fermented milk with <i>L. paracasei<\/i> promoted intestinal epithelial cell growth and intestinal epithelial integrity and <b>strengthened the intestinal barrier<\/b> against chemical and inflammatory stimuli-induced damage (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26147180\">R<\/a>).<\/p>\n<p><i>L. paracasei <\/i>synbiotic therapy may prevent or repair colon damage in mice with acute colitis, where this bacterium completely <b>restored epithelial barrier integrity<\/b> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25926411\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24889889\"> R<\/a>).<\/p>\n<p>In rats, <i>B. bifidum<\/i> or <i>B. animalis<\/i> protected the mucous membrane layer of the stomach (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906699\/\">R<\/a>).<\/p>\n<p><i>S. cerevisiae<\/i> strengthened epithelial barrier function (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2430332\/\">R<\/a>). Oral treatment with viable or heat-killed <i>S. cerevisiae<\/i> strain prevented bacterial translocation, <b>protects intestinal barrier integrity<\/b>, and stimulated immunity in mice with intestinal obstruction (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20437166\">R<\/a>).<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">The intestinal barrier controls which nutrients and other compounds cross from the gut into the bloodstream. In humans and animals, probiotic supplements &#8220;tightened up&#8221; this barrier and prevented harmful compounds and bacteria from crossing.<\/div><\/div>\n<h3><span id=\"10_Gastric_Ulcers\">10) Gastric Ulcers<\/span><\/h3>\n<p>According to one review, probiotics inhibited the development of acute gastric mucosal lesions and accelerated gastric ulcer healing in humans and animals (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906699\/\">R<\/a>).<\/p>\n<p><i>Lactobacilli<\/i> promoted gastric ulcer healing in rats when administered as an individual probiotic strain, such as <i>L. rhamnosus<\/i>, <i>L. gasseri<\/i>, or <i>L. acidophilus<\/i> or as a probiotic mixture (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906699\/\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906699\/\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906699\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15359087\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20834166\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906699\/\"> R<\/a>).<\/p>\n<p><i>B. breve<\/i> and <i>B. bifidum<\/i> repaired and protected the mucosa of rats against gastric ulcers and erosions (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906699\/\">R<\/a>).<\/p>\n<p>Pretreatment of mice with gastric ulcers with the probiotic <i>C. butyricum<\/i> alleviated the inflammation and gastric mucosal damage (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906699\/\">R<\/a>).<\/p>\n<p>Certain yeasts, such as <i>S. boulardii <\/i>and<i> S. cerevisiae<\/i> have also shown beneficial effects in rats with gastric ulcers (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4906699\/\">R<\/a>).<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Some probiotic supplements may help prevent development and accelerate healing of gastric ulcers, though human studies are lacking.<\/div><\/div>\n<h3><span id=\"11_Inflammatory_Bowel_Disease\">11) Inflammatory Bowel Disease<\/span><\/h3>\n<p><i>B. longum<\/i> <b>ameliorated ulcerative colitis<\/b> symptoms in Japanese patients (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26418574\">R<\/a>).<\/p>\n<p><i>S. boulardii<\/i> added to baseline therapy <b>improved intestinal permeability<\/b> in Crohn\u2019s disease (CD) patients, even though complete normalization was not achieved (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18584523\">R<\/a>). This probiotic also <b>reduced the frequency of bowel movements<\/b> in CD patients (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8465554\">R<\/a>).<\/p>\n<p><i>P. freudenreichii<\/i> was <b>effective against mild to moderate ulcerative colitis in a human pilot study<\/b> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16226014\">R<\/a>).<\/p>\n<p>In Asian studies involving patients with ulcerative colitis, the addition of a <i>B. subtilis<\/i> probiotic significantly reduced the number of days with bloody stool, led to complete remission without relapse, and significantly increased the efficacy of mesalazine or sulfasalazine therapy (<a href=\"http:\/\/www.wageningenacademic.com\/doi\/pdf\/10.3920\/BM2008.1005\">R<\/a>).<\/p>\n<p><i>L. plantarum<\/i> ameliorated ulcerative colitis in mice via both anti-inflammatory and immunomodulatory activities (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21996541\">R<\/a>) and <b>decreased the severity of intestinal inflammation<\/b> in mice with inflammatory bowel disease (IBD) (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3222668\/\">R<\/a>).<\/p>\n<p><i>B. bifidum<\/i> <b>decreased symptoms of inflammatory bowel disease<\/b> (IBD) in mice, such as thickened intestinal wall and inflammatory cell infiltration, and decreased inflammatory cytokine production (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17218154\">R<\/a>).<\/p>\n<p>Other probiotics that were effective in ameliorating colitis in animal models include <i>L. casei<\/i> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21893695\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27107798\"> R<\/a>), <i>L. paracasei<\/i> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3145352\/\">R<\/a>), <i>L. salivarius <\/i>(<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4320393\/\">R<\/a>), <i>L. delbrueckii ssp. bulgaricus<\/i> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3257032\/\">R<\/a>), <i>L. delbrueckii ssp. lactis <\/i>(<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22365194\">R<\/a>), <i>L. helveticus<\/i> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4182466\/\">R<\/a>), <i>B. longum<\/i> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19882302\">R<\/a>),<i> B. animalis<\/i> ssp. <i>lactis<\/i> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2964251\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4900019\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20310012\"> R<\/a>), <i>C. butyricum<\/i> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23768495\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11099059\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15010859\"> R<\/a>), <i>B. coagulans <\/i>(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3212889\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3484022\/\"> R<\/a>),<i> L. brevis<\/i> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21987297\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26925602\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23742179\"> R<\/a>), <i>L. fermentum<\/i> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19266568\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4100452\/\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19005763\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17150273\"> R<\/a>), <i>S. boulardii<\/i> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3508640\/\">R<\/a>), <i>L. lactis <\/i>(<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25887264\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4126083\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4965518\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19733697\"> R<\/a>), <i>S. thermophilus<\/i> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18838819\">R<\/a>),<i> P. freudenreichii<\/i> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19847949\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16314691\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1856113\/\"> R<\/a>), <i>B. subtilis<\/i> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27698758\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22297864\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22749516\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19374258\"> R<\/a>) and <i>S. cerevisiae<\/i> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26322540\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25569734\"> R<\/a>).<\/p>\n<p><i>B. longum<\/i> ssp. <i>infantis<\/i> ameliorated colitis, possibly by decreasing<a href=\"https:\/\/selfhacked.com\/blog\/supplements-people-th1-dominant\/\"> Th1<\/a> and<a href=\"https:\/\/selfhacked.com\/blog\/th17\/\"> Th17<\/a> responses (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4277968\/\">R<\/a>).<\/p>\n<p><i>S. thermophilus<\/i> also <b>repressed the<\/b><a href=\"https:\/\/selfhacked.com\/blog\/th17\/\"> <b>Th17<\/b><\/a><b> response to ameliorate intestinal lesions<\/b> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3196311\/\">R<\/a>).<\/p>\n<p><i>S. boulardii <\/i>treatment limited the infiltration of<a href=\"https:\/\/selfhacked.com\/blog\/supplements-people-th1-dominant\/\"> Th1<\/a> cells into the inflamed colon and inhibited proinflammatory cytokine production in mice with IBD (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17087945\">R<\/a>).<\/p>\n<p>Note that<i> L. crispatus<\/i> may ameliorate colitis in mice (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15681150\">R<\/a>); however, a specific strain, M206119, exacerbated intestinal inflammation (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3353368\/\">R<\/a>).<\/p>\n<p><i>Check individual probiotic posts for more information.<\/i><\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Probiotics may help manage troublesome symptoms in patients with inflammatory bowel disease (IBD). <i>B. longum <\/i>and <i>S. boulardii<\/i> produced the best results in human trials, though many strains have only been studied in animals so far.<\/div><\/div>\n<h3><span id=\"12_Diverticular_Disease\"><b>12) Diverticular Disease<\/b><\/span><\/h3>\n<p><i>L. paracasei<\/i>, in association with a high-fiber diet, effectively <b>reduced abdominal bloating and prolonged abdominal pain<\/b> in patients with symptomatic uncomplicated diverticular disease (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21372765\">R<\/a>).<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\"><\/p>\n<h3><span id=\"Takeaway\"><b>Takeaway<\/b><\/span><\/h3>\n<p>Probiotic supplements are a promising avenue for preventing and managing many intestinal conditions from diarrhea and constipation to IBD, damage from antibiotics, and even necrotizing enterocolitis. If you are suffering from persistent digestive symptoms, talk to your doctor about whether and which probiotics are right for you.<\/div><\/div>\n<h3><span id=\"Further_Reading\"><b>Further Reading<\/b><\/span><\/h3>\n<p>We\u2019ve compiled deep dives into each potential benefit of probiotics. Check them out here:<\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/a1probiotics-good-bacteria\/\">Overview<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/can-probiotic-help-with-infections\/\">Immune Function<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/probiotics-inflammation-autoimmunity\/\">Inflammation &amp; Autoimmunity<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/probiotics-cardiovascular-health\/\">Cardiovascular Health<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/probiotics-weight-blood-sugar-metabolic-health\/\">Weight &amp; Metabolic Health<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/probiotics-fertility-pregnancy\/\">Reproductive Health<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/probiotics-mood-mental-health\/\">Cognition &amp; Mental Health<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/probiotics-skin-teeth-bones\/\">Skin &amp; Bones<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/probiotics-fatigue-recovery-wound-healing\/\">Physical Stress &amp; Wound Healing<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/can-probiotics-help-with-toxins\/\">Detox<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/probiotics-healthy-aging\/\">Healthy Aging<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/probiotics-nutrient-absorption\/\">Nutrient Absorption<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/probiotics-food-allergies-sensitivities\/\">Food Sensitivities<\/a><\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/probiotics-cancer\/\">Cancer<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Probiotics may help prevent and manage a variety of gut disorders and complaints, from diarrhea to IBD to gastric ulcers. Which species have been tested, and which one could be right for you? Read on to learn more.<\/p>\n","protected":false},"author":14185,"featured_media":86732,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[22,283],"tags":[],"yst_prominent_words":[7339,5987,1636,3321,3311,3319,3324,27513,3320,3379,837,3365,20431,5986,511,515,529,593,27514,1635],"_links":{"self":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/86582"}],"collection":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/users\/14185"}],"replies":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/comments?post=86582"}],"version-history":[{"count":22,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/86582\/revisions"}],"predecessor-version":[{"id":94944,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/86582\/revisions\/94944"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media\/86732"}],"wp:attachment":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media?parent=86582"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/categories?post=86582"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/tags?post=86582"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/yst_prominent_words?post=86582"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}