{"id":64937,"date":"2019-11-07T17:53:55","date_gmt":"2019-11-08T01:53:55","guid":{"rendered":"https:\/\/selfhacked.com\/?p=64937"},"modified":"2021-09-20T09:20:36","modified_gmt":"2021-09-20T16:20:36","slug":"chanca-piedra","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/chanca-piedra\/","title":{"rendered":"6 Chanca Piedra Benefits + Dosage &#038; Side Effects"},"content":{"rendered":"<p>Chanca piedra long remained a well-kept secret, though it was widely used in both Amazonian and Ayurvedic medicine. While its name translates to &#8220;stone breaker&#8221;, this herb may also protect the liver, lower inflammation, help with diabetes, and combat infections. Find out if it can really clear your kidney stones, and learn more about its benefits and possible side effects.<\/p>\n<p><!--more--><\/p>\n<h2><span id=\"What_Is_Chanca_Piedra\"><b>What Is Chanca Piedra?<\/b><\/span><\/h2>\n<p>Chanca piedra is part of a big plant genus known as <i>Phyllanthus. <\/i>These plants grow in tropical regions all over the world &#8211; from China to India to the vast and largely unexplored rainforests of the Amazon. &#8220;Phyllanthus&#8221; simply means &#8220;leaf and flower,&#8221; because the flowers (and fruits) of these plants are joined together with the leaves [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21982793\">R<\/a>].<\/p>\n<p>The myriad of chanca piedra\u2019s folk uses reflect this plant\u2019s incredible geographical and herbal diversity.<\/p>\n<p>In India, <i>Phyllanthus <\/i>plants were traditionally used for liver and kidney diseases. In the rest of Asia, they are considered a remedy for digestive disorders, while in South America folks use them for urinary tract infections. In Africa, on the other hand, they\u2019re deemed useful for malaria and wound healing [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4854999\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3296349\/\">R<\/a>].<\/p>\n<p>And if you think these uses sound too wide-ranging for just one plant species, you\u2019re right. In reality, two different species &#8211; <b><i>Phyllanthus niruri<\/i><\/b> and <b><i>Phyllanthus amarus <\/i><\/b>&#8211; are both referred to as chanca piedra or &#8220;stone breaker&#8221; [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4854999\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3296349\/\">R<\/a>].<\/p>\n<p>The first thrives in humid, warm places and likes a bit of shade. Its exact origin is a mystery, but it flourishes in the Amazonian rainforest, India, China, the Philippines, and even the Bahamas. The second also grows in the Amazon, but it originates from Asia and South Africa [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21982793\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20185303\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28848436\">R<\/a>].<\/p>\n<h3><span id=\"The_Stone_Breaker\"><b>The &#8220;Stone Breaker&#8221;<\/b><\/span><\/h3>\n<p>Chanca piedra is well-known for its use to <b>dissolve kidney stones<\/b>. Research suggests it may also protect the liver, fight infections, and lower <a href=\"https:\/\/selfhacked.com\/blog\/oxidative-stress-101\/\">oxidative stress<\/a> and inflammation. Plus, it contains some potential cancer-fighting compounds that have yet to be further explored [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27283048\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21982793\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4854999\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3932249\/\">R<\/a>].<\/p>\n<p>Recently, Brazilian teams set out to conduct medically-oriented research about chanca piedra for the first time. They wanted to understand the traditional use of this plant by indigenous people. But despite their efforts, few records of its folk use in the Amazonian region exist [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5554347\/\">R<\/a>].<\/p>\n<p>In Brazil, people call it &#8220;Quebra Pedra,&#8221; which means &#8220;stone breaker&#8221; in Portuguese. Some consider it an excellent remedy for a range of kidney disorders [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5554347\/\">R<\/a>].<\/p>\n<p>Its use in Ayurvedic traditional medicine is well-documented. In Ayurveda, chanca piedra has been used for [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21982793\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28848436\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9664291\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24672382\">R<\/a>]:<\/p>\n<ul>\n<li>Jaundice and fever<\/li>\n<li>Malaria<\/li>\n<li>Diabetes<\/li>\n<li>Skin diseases<\/li>\n<li>Digestive complaints (such as <a href=\"http:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\">constipation<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/23-ways-to-combat-pain-naturally-by-increasing-your-opioids\/\">pain<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections\/\">IBD<\/a>, and indigestion)<\/li>\n<li>Sexually transmitted diseases (syphilis, gonorrhea)<\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/bladder-infection\/\">Urinary tract infections<\/a><\/li>\n<li>Menstrual problems<\/li>\n<\/ul>\n<p>Chanca piedra is also used in cosmetic, dental, and skincare products, including hair dye, face creams, and toothpaste [<a href=\"https:\/\/www.researchgate.net\/publication\/259758390_Phyllanthus_niruri_A_Review_on_its_Ethno_Botanical_Phytochemical_and_Pharmacological_Profile\">R<\/a>].<\/p>\n<h3><span id=\"Bioactive_Components\"><b>Bioactive Components<\/b><\/span><\/h3>\n<p>All chanca piedra species are abundant in bioactive components, which carry their purported health benefits. The most important ones are [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21982793\">R<\/a>, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0040402001825941\">R<\/a>, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/003194229290071W\">R<\/a>, <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/pca.2800040507\">R<\/a>, <a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/10412905.2009.9700201\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21698198\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1417694\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15982679\">R<\/a>]:<\/p>\n<ul>\n<li>Tannins (geraniin, corilagin), which can <b>fight viruses<\/b>,<b> bacteria<\/b>,<b> and free radicals<\/b>; they also help prevent cancer<\/li>\n<li>Lignans (phyllanthin, hypophyllanthin), which have <b>anticancer<\/b> properties.<\/li>\n<li>Flavonoids (gallocatechin, <a href=\"https:\/\/selfhacked.com\/blog\/rutin\/\">rutin<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/quercetin-22-scientifically-proven-benefits-quercetin\/\">quercetin<\/a>, kaempferol) which have <b>anti-inflammatory<\/b> and antioxidant properties.<\/li>\n<\/ul>\n<h3><span id=\"Snapshot\"><b>Snapshot<\/b><\/span><\/h3>\n<p>Here\u2019s an overview of the health benefits and risks of chanca piedra [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21982793\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27283048\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28512988\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28848436\"> R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30297661\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9664291\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24672382\">R<\/a>]:<\/p>\n<h4><b>Proponents<\/b><\/h4>\n<ul>\n<li>May dissolve kidney stones<\/li>\n<li>May protect the liver, digestive system, and heart<\/li>\n<li>May help with diabetes<\/li>\n<li>May lower inflammation, pain, and oxidative stress<\/li>\n<\/ul>\n<h4><b>Skeptics<\/b><\/h4>\n<ul>\n<li>Insufficient research for most benefits<\/li>\n<li>Lack of research for many traditional uses<\/li>\n<li>May cause infertility<\/li>\n<li>Possible drug interactions<\/li>\n<li>Likely unsafe for pregnant women<\/li>\n<\/ul>\n<h2><span id=\"Chanca_Piedra_Health_Benefits\"><b>Chanca Piedra Health Benefits<\/b><\/span><\/h2>\n<aside class=\"sh-partner shp-form sponsored sh-et-7388fa\">\n  <div>\n          <div class=\"partner-heading\">Get the Regimen of A Top Biohacker<\/div>\n    \n    <div class=\"partner-content\">\n      <p><span style=\"font-weight: 400\">Joe Cohen is well-known for his work as a successful entrepreneur in the health field after he overcame his many health issues using a personalized regimen. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health.\u00a0<\/span><\/p>\n    <\/div>\n\n    <div class=\"subscribe-form-container\">\n      <form method=\"POST\" action=\"\/wp-json\/wp\/v2\/posts\/64937\" class=\"sh-subscribe-form\">\n        <input type=\"email\" name=\"subscribe_form_data[email]\"\n            pattern=\"^[a-zA-Z0-9.!#$%&\u2019*+\/=?^_`{|}~-]+@[a-zA-Z0-9-]+(?:\\.[a-zA-Z0-9-]+)*$\" required\n            placeholder=\"Enter your email\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: PartnerAd Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"PartnerAd\">\n                <button type=\"submit\" class=\"btn btn-primary subscribe-submit\">Get The Regimen<\/button>\n      <\/form>\n    <\/div>\n  <\/div>\n          <style>aside.sponsored.sh-et-7388fa::before{content:\"Advertisement\"}<\/style>\n<\/aside>\n<h3><span id=\"Possibly_Effective_for\"><b>Possibly Effective for:<\/b><\/span><\/h3>\n<h3><span id=\"1_Dissolving_Kidney_Stones\"><b>1) Dissolving Kidney Stones<\/b><\/span><\/h3>\n<p><b>Kidney stones<\/b> are deposits of minerals and salts that build up in the kidneys or urinary tract. In clinical studies with over 200 people with kidney stones, chanca piedra (<i>Phyllanthus niruri<\/i>) <b>reduced their kidney stones<\/b>, helping to clear the<b> minerals and <\/b><a href=\"https:\/\/selfhacked.com\/blog\/is-salt-good-or-bad-the-science-on-the-health-effects-of-salt\/\"><b>salt<\/b><\/a><b> deposits<\/b> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5817324\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22150656\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29617079\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16890682\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15221244\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21176271\">R<\/a>].<\/p>\n<p>Chanca piedra may truly act as a &#8220;stone crusher.&#8221; According to rat and cell-based studies, it might<b> dissolve kidney stones<\/b> by [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19397979\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12599017\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29617079\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15221244\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29544490\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21176271\">R<\/a>]:<\/p>\n<ul>\n<li>Blocking the growth and the clustering of salts that form kidney stones<\/li>\n<li>Dissolving already-formed kidney stones<\/li>\n<li>Clearing this dissolved mixture of salts and minerals from kidney stones (uric acid, oxalate, <a href=\"https:\/\/selfhacked.com\/blog\/potassium\/\">potassium<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/calcium-101\/\">calcium<\/a>, and <a href=\"http:\/\/selfhacked.com\/blog\/21-proven-science-based-reasons-magnesium-amazing-including-drawbacks\/\">magnesium<\/a>) and helping eliminate them by promoting urination<\/li>\n<\/ul>\n<p>Overall, the available evidence is limited but suggests it works. <b>More clinical studies are desperately needed<\/b>,<b> but chanca piedra appears to be a promising herbal remedy for clearing kidney stones naturally<\/b>.<\/p>\n<h3><span id=\"2_Protecting_the_Liver\"><b>2) Protecting the Liver<\/b><\/span><\/h3>\n<p>In clinical studies with over 3.5k people, chanca piedra blocked the growth and division of the <b>hepatitis B virus<\/b>, reduced virus levels in the blood (HBsAg), and <b>recovered<\/b> liver function [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11485076\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2901611\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21455448\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10921385\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11555193\">R<\/a>].<\/p>\n<p>However, in several studies with over 1K people with hepatitis B, antiviral drugs worked better than chanca piedra [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1791391\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21491412\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23633363\">R<\/a>].<\/p>\n<p>In a clinical study on 100 people with <b>hepatitis C<\/b>, chanca piedra increased multiple important antioxidant compounds (<a href=\"http:\/\/selfhacked.com\/blog\/the-brain-fog-gene-rs4880-or-sod2\/\">superoxide dismutase<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/catalase-benefits\/\">catalase<\/a>, <a href=\"http:\/\/selfhacked.com\/blog\/30-scientifically-proven-health-benefits-glutathione\/\">glutathione<\/a>, <a href=\"http:\/\/selfhacked.com\/blog\/need-know-vitamin-c-32-science-based-health-benefits\/\">vitamin C<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/vitamin-e-can-help-fertility-pregnancy\/\">vitamin E<\/a>). It also decreased <a href=\"https:\/\/selfhacked.com\/blog\/oxidative-stress-101\/\">oxidative stress<\/a> and <b>prevented<\/b> liver damage [<a href=\"https:\/\/www.researchgate.net\/publication\/266419380_Role_of_Phyllanthus_amarus_treatment_in_Hepatitis-C\">R<\/a>].<\/p>\n<p>In animal and cellular studies, <b>chanca piedra prevented liver injury caused by toxins, drugs, or alcohol and protected liver function <\/b>by lowering <a href=\"https:\/\/selfhacked.com\/blog\/oxidative-stress-101\/\">oxidative stress<\/a> and blocking harmful compounds [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28718838\">R<\/a>, <a href=\"https:\/\/www.ajol.info\/index.php\/ajb\/article\/view\/56893\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17720339\">R<\/a>, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2222180814604163\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19702178\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20064596\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21047178\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17870264\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18524448\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21844996\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22649471\">R<\/a>].<\/p>\n<p>Traditionally, chanca piedra has been used for reducing jaundice, a yellowing of the skin related to liver problems [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28848436\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27200104\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22408311\">R<\/a>].<\/p>\n<p>What does chanca piedra do to enhance liver function and reduce damage?<\/p>\n<p>Overall, it may protect the liver by [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11485076\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2901611\">R<\/a>, <a href=\"https:\/\/www.researchgate.net\/publication\/228660173_Gastroprotective_and_antioxidant_activities_of_Phyllanthus_amarus_extracts_on_absolute_ethanol-induced_ulcer_in_albino_rats\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28718838\">R<\/a>, <a href=\"https:\/\/www.ajol.info\/index.php\/ajb\/article\/view\/56893\">R<\/a>, <a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/13880200701214706\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25755316\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21440018\">R<\/a>, <a href=\"https:\/\/www.ajol.info\/index.php\/tjpr\/article\/view\/160736\">R<\/a>]:<\/p>\n<ul>\n<li>Decreasing enzymes linked to liver damage (<a href=\"https:\/\/selfhacked.com\/blog\/alanine-aminotransferase\/\">ALT<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/aspartate-aminotransferase-ast\/\">AST<\/a>)<\/li>\n<li>Reducing <a href=\"https:\/\/selfhacked.com\/blog\/bilirubin-benefit-how-to-optimize\/\">bilirubin<\/a> levels, high levels of which indicate liver disease<\/li>\n<li>\u201cDe-blocking\u201d liver detox pathways; it blocks an enzyme that reverses the detoxifying process of <a href=\"https:\/\/selfhacked.com\/blog\/glucuronidation-detox-estrogen-hormone-balance-prevent-cancer-red-meat\/\">glucuronidation<\/a> (beta-glucuronidase)<\/li>\n<li>Increasing antioxidant enzymes (<a href=\"https:\/\/selfhacked.com\/blog\/the-brain-fog-gene-rs4880-or-sod2\/\">superoxide dismutase<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/catalase-benefits\/\">catalase<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/glutathione-30-scientifically-proven-health-benefits-glutathione\/\">glutathione<\/a>)<\/li>\n<li>Lowering <a href=\"https:\/\/selfhacked.com\/blog\/oxidative-stress-101\/\">oxidative stress<\/a> and inflammation<\/li>\n<\/ul>\n<p>To sum it up, <b>chanca piedra may help combat viral hepatitis<\/b>,<b> but it\u2019s probably not superior to conventional antivirals<\/b>. It may also help clear toxins and support healthy liver function.<\/p>\n<p><b>You may try chanca piedra as a supportive measure if your doctor thinks it may help in your case, but never use it in place of what your doctor recommends or prescribes.<\/b><\/p>\n<h3><span id=\"3_Protecting_the_Heart\"><b>3) Protecting the Heart<\/b><\/span><\/h3>\n<p>Chanca piedra<b> lowered high blood pressure <\/b>in clinical studies with over 1K people [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8786163\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26550547\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29057143\">R<\/a>].<\/p>\n<p>This benefit was explored in detail in animal studies. In rats and mice, chanca piedra had powerful lipid-balancing effects; it reduced total <a href=\"https:\/\/selfhacked.com\/blog\/cholesterol\/\">cholesterol<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/triglycerides\/\">triglycerides<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/ldl-cholesterol\/\">LDL cholesterol<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/vldl-cholesterol-levels\/\">VLDL cholesterol<\/a> and increased <a href=\"https:\/\/selfhacked.com\/blog\/hdl-cholesterol\/\">HDL<\/a><a href=\"https:\/\/selfhacked.com\/blog\/hdl-cholesterol\/\"> cholesterol<\/a>. Balanced blood lipid levels are key to preventing heart disease [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28718838\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12169400\">R<\/a>, <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2016\/ra\/c6ra10774e#!divAbstract\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27318080\">R<\/a>, <a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/13880200701499034\">R<\/a>, <a href=\"https:\/\/www.ajol.info\/index.php\/ajb\/article\/view\/57772\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20843268\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23085308\">R<\/a>].<\/p>\n<p>In other studies on rabbits, rats, and cells, chanca piedra reduced blood pressure, prevented excessive <a href=\"https:\/\/selfhacked.com\/blog\/platelets\/\">platelet<\/a> clumping, relaxed blood vessels, and improved heart function [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18323250\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17268086\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16394535\">R<\/a>, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006295217303982\">R<\/a>, <a href=\"https:\/\/www.researchgate.net\/publication\/295073643_Evaluation_of_In_vivo_Efficacy_of_Aqueous_Leaf_Extract_of_Phyllanthus_Niruri_in_Diabetic_Hypertensive_Rats\">R<\/a>].<\/p>\n<p>It might also keep the heart healthy by decreasing enzymes that signal oxidative stress, heart or tissue damage (such as dehydrogenase, <a href=\"http:\/\/selfhacked.com\/blog\/creatine\/\">creatine<\/a> phosphokinase, and <a href=\"https:\/\/selfhacked.com\/blog\/alkaline-phosphatase\/\">alkaline phosphatase<\/a>) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8786163\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28718838\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12169400\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21455418\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17268086\">R<\/a>].<\/p>\n<p><b>All in all<\/b>,<b> chanca piedra seems to be good for the heart<\/b>. It may lower blood pressure, cholesterol, and heart damage while relaxing and protecting your blood vessels. Clinical studies are still limited, though.<\/p>\n<h3><span id=\"Insufficient_Evidence_for\"><b>Insufficient Evidence for:<\/b><\/span><\/h3>\n<h3><span id=\"1_Diabetes\"><b>1) Diabetes<\/b><\/span><\/h3>\n<p>In small clinical studies with 30 people,chanca piedra (the <i>Phyllanthus amarus<\/i> species)<b> lowered their blood sugar<\/b> levels. The same was confirmed in numerous studies with diabetic rats [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8786163\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11746836\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21323477\">R<\/a>, <a href=\"https:\/\/www.researchgate.net\/publication\/236621364_Evaluation_of_the_hypoglycemic_effect_of_aqueous_extract_of_Phyllanthus_amarus_in_alloxan-induced_diabetic_albino_rats\">R<\/a>, <a href=\"https:\/\/scialert.net\/abstract\/?doi=jas.2011.2968.2973\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21844996\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12597020\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27318080\">R<\/a>, <a href=\"https:\/\/www.researchgate.net\/publication\/286499752_Antidiabetic_and_antioxidant_potential_of_Phyllanthus_fraternus_in_alloxan_induced_diabetic_animals\">R<\/a>, <a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/13880200701499034\">R<\/a>, <a href=\"https:\/\/www.ajol.info\/index.php\/ajb\/article\/view\/77801\/68223\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23085308\">R<\/a>, <a href=\"https:\/\/www.researchgate.net\/publication\/295073643_Evaluation_of_In_vivo_Efficacy_of_Aqueous_Leaf_Extract_of_Phyllanthus_Niruri_in_Diabetic_Hypertensive_Rats\">R<\/a>].<\/p>\n<p>For one, it may act by blocking enzymes that digest complex carbs, such as alpha-<a href=\"https:\/\/selfhacked.com\/blog\/amylase\/\">amylase<\/a>. Subsequently, it delays sugar absorption and may prevent spikes in sugar levels after a meal. Secondly, it may increase sugar storage in the liver, which reduces blood sugar levels [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20185303\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3210010\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21323477\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28928090\">R<\/a>].<\/p>\n<p>Note that a small clinical trial and a few animal studies cannot be considered sufficient evidence that chanca piedra helps with diabetes. Larger, more robust clinical trials are needed.<\/p>\n<h3><span id=\"2_Protecting_the_Gut_and_Stomach\"><b>2) Protecting the Gut and Stomach<\/b><\/span><\/h3>\n<p>In a clinical study of 30 children with viral diarrhea, chanca piedra (<i>Phyllanthus niruri<\/i>) <b>improved symptoms<\/b> such as stool consistency, fever, vomiting, stomach pain, loss of appetite, and dehydration. Overall, it worked better than the placebo [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4147545\/\">R<\/a>].<\/p>\n<p>Plus, the other chanca piedra species (<i>Phyllanthus amarus<\/i>) delayed diarrhea onset in mice; in mice with diarrhea, it normalized bowel movements [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11379441\">R<\/a>].<\/p>\n<p>In rats and mice, chanca piedra prevented stomach damage and ulcers caused by various harmful substances; it also decreased stomach inflammation [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28511679\">R<\/a>, <a href=\"https:\/\/www.researchgate.net\/publication\/228660173_Gastroprotective_and_antioxidant_activities_of_Phyllanthus_amarus_extracts_on_absolute_ethanol-induced_ulcer_in_albino_rats\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12860307\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27220075\">R<\/a>, <a href=\"https:\/\/www.semanticscholar.org\/paper\/Gastroprotective-potentials-of-aqueous-leaf-of-on-Uwakwe-Monago-Ighorodje\/507eb809c7ae6ae3f892f5c8f7d9122813022f71\">R<\/a>, <a href=\"https:\/\/www.researchgate.net\/publication\/266479920_Gastroprotective_effect_of_Phyllanthus_niruri_leaf_extract_against_ethanol-induced_gastric_mucosal_injury_in_rats\">R<\/a>].<\/p>\n<p>Chanca piedra contains powerful antioxidants: <b>rutin<\/b> and <b>quercitrin <\/b>(<b>a cousin of the better-known<\/b> <a href=\"https:\/\/selfhacked.com\/blog\/quercetin-22-scientifically-proven-benefits-quercetin\/\"><b>quercetin<\/b><\/a>). These active compounds helped with <a href=\"https:\/\/selfhacked.com\/blog\/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections\/\">inflammatory bowel disease<\/a> and diarrhea in rats [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9472728\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12008093\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7480174\">R<\/a>].<\/p>\n<p>To sum up, the existing studies suggest that chanca piedra may help with several digestive issues, but the evidence is insufficient. More clinical trials on larger populations are needed to confirm these preliminary findings.<\/p>\n<h3><span id=\"3_Reducing_Pain_and_Swelling\"><b>3) Reducing Pain and Swelling<\/b><\/span><\/h3>\n<p>In a clinical study of 33 people with nerve damage caused by diabetes (also known as diabetic neuropathy), chanca piedra decreased pain and the sensation of numbness, tingling, and in the legs [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22529650\">R<\/a>].<\/p>\n<p>According to studies in mice and rats, it blocks pain signals and swelling indirectly: by lowering inflammatory compounds that build up around nerves [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21834261\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7837046\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14575799\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16925995\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12860307\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28511679\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10967476\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8690236\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23333746\">R<\/a>].<\/p>\n<p>Again, only one clinical trial and a few animal studies have investigated the potential benefits of chanca piedra in pain and swelling. Further clinical research is required.<\/p>\n<h3><span id=\"Animal_and_Cell_Research_Lack_of_Evidence\"><b>Animal and Cell Research (Lack of Evidence)<\/b><\/span><\/h3>\n<p>No evidence supports the use of chanca piedra for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.<\/p>\n<h3><span id=\"Infections\"><b>Infections<\/b><\/span><\/h3>\n<p>In mice and cells, chanca piedra <b>inhibited the growth<\/b> of various bacteria, fungi, and parasites, including those that cause <b>malaria<\/b>,<b> snail fever<\/b>, and infections of the urinary tract, bowel, stomach, blood and skin (<i>Plasmodium species, Escherichia coli, Staphylococcus, Enterobacter, Bacillus, Salmonella, Streptococcus, <\/i><a href=\"https:\/\/selfhacked.com\/blog\/h-pylori-part-1\/\"><i>Helicobacter pylori<\/i><\/a> , <a href=\"http:\/\/selfhacked.com\/blog\/treat-cure-candida\/\"><i>Candida<\/i><\/a>) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21771471\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23375028\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11235553\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17882995\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15507366\">R<\/a>, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2314853516301986\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29074138\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25346933\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24049481\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22034238\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16644526\">R<\/a>, <a href=\"https:\/\/www.ajol.info\/index.php\/ajbr\/article\/view\/50712\">R<\/a>].<\/p>\n<p>Furthermore, in cells, it <b>blocked the replication <\/b>of hepatitis C and hepatitis B, HIV-1, herpes virus (HSV-1) and dengue virus [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21440018\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1283310\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15498604\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22619617\">R<\/a>, <a href=\"https:\/\/link.springer.com\/article\/10.1079\/IVP2004560\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12748977\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1283310\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14515028\/\">R<\/a>, <a href=\"https:\/\/www.ajol.info\/index.php\/tjpr\/article\/view\/160736\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22131154\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25260580\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14515028\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8991954\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25669140\">R<\/a>].<\/p>\n<p>To sum it up, chanca piedra may fight incredibly diverse types of infections. However, its efficacy in humans is unknown as the available data are limited to animal and cell-based studies.<\/p>\n<h3><span id=\"Cancer\"><b>Cancer<\/b><\/span><\/h3>\n<p>Below, we will discuss some preliminary research on chanca piedra\u2019s potential anticancer compounds. It\u2019s still in the animal and cell stage and further clinical studies have yet to determine if these compounds are useful in cancer therapies.<\/p>\n<p><b>Do not under any circumstances attempt to replace conventional cancer therapies with chanca piedra or any other supplements.<\/b> If you want to use it as a supportive measure, talk to your doctor to avoid any unexpected interactions.<\/p>\n<p>In mice and rats, chanca piedra blocked cancer growth, reduced tumors and increased survival rates [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21609315\">R<\/a>, <a href=\"https:\/\/www.researchgate.net\/publication\/279903322_Antitumour_effect_of_Phyllanthin_and_Hypophyllanthin_from_Phyllanthus_amarus_against_Ehrlich_Ascites_Carcinoma_in_mice\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19815595\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20192590\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12111712\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11025159\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10211933\">R<\/a>, <a href=\"https:\/\/www.researchgate.net\/publication\/275863777_Inhibition_by_Phyllanthus_amarus_of_Hepatocarcinogenesis_Induced_by_N-Nitrosodiethylamine\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12020923\">R<\/a>].<\/p>\n<p>In test tubes, it prevented the growth and spread of different cancer cells (lung, breast, colorectal, liver, ovarian, skin, pancreas, brain), triggering their death [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21698198\">R<\/a>, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1466856410000354\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22919249\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15158999\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23410205\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16819159\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12111712\">R<\/a>, <a href=\"https:\/\/thescipub.com\/abstract\/10.3844\/ajptsp.2006.65.71\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17054045\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28930257\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27777954\">R<\/a>].<\/p>\n<h3><span id=\"Inflammation_and_Oxidative_Stress\"><b>Inflammation and Oxidative Stress<\/b><\/span><\/h3>\n<p>Chanca piedra reduced <a href=\"https:\/\/selfhacked.com\/blog\/oxidative-stress-101\/\">oxidative stress<\/a> and lowered inflammation in rats, mice, and cell-based studies [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22231455\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21609315\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20336219\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24991228\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28930257\">R<\/a>, <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2314853516301986\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28511679\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22432563\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20380522\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28391709\">R<\/a>].<\/p>\n<p>This herb may act by [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22231455\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23458355\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21609315\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20336219\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12860307\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28511679\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22432563\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20380522\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28391709\">R<\/a>]:<\/p>\n<ul>\n<li>Increasing important antioxidant, detoxifying compounds (<a href=\"https:\/\/selfhacked.com\/blog\/the-brain-fog-gene-rs4880-or-sod2\/\">superoxide dismutase<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/catalase-benefits\/\">catalase<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/glutathione-30-scientifically-proven-health-benefits-glutathione\/\">glutathione<\/a>)<\/li>\n<li>Lowering key inflammatory cytokines, enzymes, and messengers (<a href=\"http:\/\/selfhacked.com\/blog\/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6\/\">TNF-a<\/a>,<a href=\"http:\/\/selfhacked.com\/blog\/interleukin-1\/\"> IL-1<\/a><a href=\"https:\/\/selfhacked.com\/blog\/interleukin-1\/\"> beta<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/bradykinin\/\">bradykinin<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/prostaglandins\/\">prostaglandin<\/a>, <a href=\"http:\/\/selfhacked.com\/blog\/cox2-natural-cox2-inhibitors\/\">Cox-2<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/nuclear-factor-kappa-b\/\">NF-\u03baB<\/a>)<\/li>\n<li>Increasing <a href=\"https:\/\/selfdecode.com\/gene\/il4\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">IL-4<\/a>, which can act as an anti-inflammatory cytokine<\/li>\n<li>Activating immune cells (<a href=\"https:\/\/selfhacked.com\/blog\/lymphocytes\/\">lymphocytes<\/a> and other <a href=\"https:\/\/selfhacked.com\/blog\/how-to-increase-and-decrease-white-blood-cells\/\">white blood cells<\/a>)<\/li>\n<\/ul>\n<h3><span id=\"Brain_Protection\"><b>Brain Protection<\/b><\/span><\/h3>\n<p>In mice, chanca piedra <b>improved memory<\/b> and <b>reversed amnesia<\/b> [<a href=\"https:\/\/www.ajol.info\/index.php\/ajbr\/article\/view\/50622\">R<\/a>].<\/p>\n<p>To understand how it might act, we\u2019re going to dive into neuroscience a bit, so bear with us.<\/p>\n<p><a href=\"https:\/\/selfhacked.com\/blog\/acetylcholine\/\">Acetylcholine<\/a> is a neurotransmitter mainly used by the rest-and-digest nervous system. It supports <a href=\"https:\/\/selfhacked.com\/blog\/cholinergic-activity-natural-boosters\/\">cholinergic activity<\/a> in the body that counters your fight-or-flight response. Acetylcholine is extremely important for memory, focus, and good cognitive function [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2659740\/\">R<\/a>].<\/p>\n<p>Chanca piedra may work by blocking the enzymes that break down acetylcholine (<a href=\"https:\/\/selfdecode.com\/gene\/ache\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">acetylcholinesterase<\/a> and butyrylcholinesterase). In turn, it might boost acetylcholine levels in the brain, which would be useful to people with <a href=\"https:\/\/selfhacked.com\/blog\/alzheimer\/\">Alzheimer&#8217;s<\/a> disease [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24868872\">R<\/a>, <a href=\"https:\/\/www.researchgate.net\/publication\/284572629_Evaluation_of_antiamnesic_potentials_of_6-gingerol_and_phyllanthin_in_mice\">R<\/a>].<\/p>\n<p>And while this is promising, remember that the research is still preliminary. We have yet to see clinical studies of chanca piedra in people with <a href=\"http:\/\/selfhacked.com\/blog\/the-cause-of-brain-fog\/\">cognitive dysfunction<\/a>.<\/p>\n<h3><span id=\"Protection_from_Radiation\"><b>Protection from Radiation<\/b><\/span><\/h3>\n<p>In mice and cells, chanca piedra (<i>Phyllanthus amarus) <\/i><b>prevented radiation damage<\/b> by lowering oxidative stress and increasing antioxidants compounds in blood and liver [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17917369\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19461166\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15133301\">R<\/a>].<\/p>\n<p>With more clinical research, it might be used to reduce the side effects of radiation therapy in cancer patients.<\/p>\n<h3><span id=\"Hair_Growth_Promotion\"><b>Hair Growth Promotion<\/b><\/span><\/h3>\n<p>In one study, researchers gave <a href=\"https:\/\/selfhacked.com\/blog\/testosterone-will-add\/\">testosterone<\/a> to mice to induce baldness. Chanca piedra (<i>Phyllanthus niruri<\/i>) blocked an enzyme (5\u03b1-reductase) involved in baldness and <b>increased the animals<\/b>\u2019<b> hair growth<\/b>. Since overactivity of this enzyme is thought to underlie baldness in men, chanca piedra might turn out to be a targeted remedy for hair re-growth [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26693408\">R<\/a>].<\/p>\n<p>This may sound like great news to many, but we still don\u2019t know if it can enhance hair growth in humans.<\/p>\n<h3><span id=\"Other_Traditional_Uses\"><b>Other Traditional Uses<\/b><\/span><\/h3>\n<p>The uses below have been brought up in literature and are common in folk medicine, but there are no scientific studies about them [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21982793\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28848436\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9664291\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24672382\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28512988\">R<\/a>, <a href=\"https:\/\/www.thieme-connect.com\/products\/ejournals\/abstract\/10.1055\/s-0029-1234757\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27200104\">R<\/a>]:<\/p>\n<ul>\n<li>Jaundice<\/li>\n<li>Fever<\/li>\n<li>Skin diseases (scabies, rash)<\/li>\n<li>Cough<\/li>\n<li>Asthma and lung inflammation (bronchitis)<\/li>\n<li>Ringworm<\/li>\n<li>Eye and mouth inflammation<\/li>\n<li>Constipation and low stomach acid<\/li>\n<li>Sexually transmitted diseases (syphilis, gonorrhea)<\/li>\n<li>Urinary tract infections<\/li>\n<li>Menstrual problems<\/li>\n<li>Anemia<\/li>\n<li>Leprosy<\/li>\n<li>Anorexia<\/li>\n<\/ul>\n<h3><span id=\"Limitations_and_Caveats\"><b>Limitations and Caveats<\/b><\/span><\/h3>\n<p>Studies about the benefits of chanca piedra are limited; many are reviews and historical documents rather than clinical trials.<\/p>\n<p>Furthermore, the few clinical trials that were carried out had a small number of participants and some of their findings are debatable.<\/p>\n<p>Additional research on the benefits and side effects of chanca piedra should be encouraged.<\/p>\n<h2><span id=\"Chanca_Piedra_Dosage_Supplementation\"><b>Chanca Piedra Dosage &amp; Supplementation<\/b><\/span><\/h2>\n<p>Chanca piedra is available in various forms, including liquid drops, capsules, tablets, tea, and powder [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21982793\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27283048\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29617079\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16890682\">R<\/a>].<\/p>\n<p>However, the preparation of these products varies from brand to brand. Some products may not be standardized. Regulations set manufacturing standards for them but don&#8217;t guarantee that they&#8217;re safe or effective. Consult your doctor before supplementing with chanca piedra.<\/p>\n<h3><span id=\"Dosage\"><b>Dosage<\/b><\/span><\/h3>\n<p>Because chanca piedra is not approved by the FDA for any conditions, there is no official dose. Users and supplement manufacturers have established unofficial doses and guidelines based on trial and error.<\/p>\n<h4><b>For Kidney Stones and Liver Support<\/b><\/h4>\n<p>The dosage varied in studies and depends on the form of supplementation and the product.<\/p>\n<p><b>For kidney stones and supporting liver function<\/b>, the recommended dosage is [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29617079\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16890682\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28512988\">R<\/a>]:<\/p>\n<ul>\n<li>1 &#8211; 2 capsules (400 &#8211; 500 mg chanca piedra extract per capsule) daily between meals <b>or<\/b><\/li>\n<li>30 &#8211; 60 drops (chanca piedra extract), 3 times a day, 30 minutes before meals or 2 hours after meals<\/li>\n<\/ul>\n<h4><b>For Other Health Benefits<\/b><\/h4>\n<p><b>For lowering blood pressure<\/b>, 100 g of chanca piedra powder should be diluted in 2 L of water. It\u2019s recommended to drink <b>500 mL<\/b> of the mixture daily, for one to 10 weeks [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29057143\">R<\/a>].<\/p>\n<p><b>For lowering blood sugar<\/b>, you can dilute 12.5 g of chanca piedra powder in 100 ml of water; according to the clinical studies, you should drink this mix two times a day, for one to 10 weeks [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11746836\">R<\/a>].<\/p>\n<h3><span id=\"Chanca_Piedra_Side_Effects_Precautions\"><b>Chanca Piedra Side Effects &amp; Precautions<\/b><\/span><\/h3>\n<p>One species of chanca piedra &#8211; <i>Phyllanthus niruri &#8211; <\/i>is safe and non-toxic. Common side effects are mild and include [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21455448\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15221244\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29617079\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22319255\">R<\/a>]:<\/p>\n<ul>\n<li>Stomach pain<\/li>\n<li>Diarrhea<\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/natural-treatment-migraines\/\">Headache<\/a> or dizziness<\/li>\n<\/ul>\n<p>However, the other species &#8211; <i>Phyllanthus amarus &#8211; <\/i><b>could be toxic<\/b> in high doses. It enlarged blood vessels and caused kidney damage in rats and mice [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22624139\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16220579\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22468010\">R<\/a>].<\/p>\n<p><b>Pregnant women and women taking fertility-enhancing drugs should avoid taking chanca piedra<\/b>. Traditionally, this plant was used for abortions and may cause abnormalities with the fetus. It should also <b>not be taken while breastfeeding or by children<\/b> due to the lack of safety data in these two populations. Although there is no clinical evidence, chanca piedra lowered both male and female fertility in mice [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21982793\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11351367\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14610373\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18807755\"> R<\/a>].<\/p>\n<h3><span id=\"Drug_Interactions\"><b>Drug Interactions<\/b><\/span><\/h3>\n<p><b>Consult your doctor before supplementing with chanca piedra if you are on medication<\/b>. Chanca piedra (<i>Phyllanthus amarus<\/i>) inhibits the activity of the <a href=\"https:\/\/selfhacked.com\/blog\/cyp-enzymes-interact-supplements-related-genes\/\"><b>CYP540<\/b><\/a> family of liver enzymes that break down (or activate) drugs (<a href=\"https:\/\/selfhacked.com\/blog\/cyp1a1\/\">CYP1A1<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/cyp1a2\/\">CYP1A2<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/cyp2d6\/\">CYP2D6<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/cyp2e1-enzyme-alcohol-paracetamol-and-cancer-riskyp2e1\/\">CYP2E1<\/a>, CYP2<a href=\"https:\/\/selfhacked.com\/blog\/thiamine\/\">B1<\/a>\/2, and <a href=\"https:\/\/selfhacked.com\/blog\/cyp3a4\/\">CYP3A4<\/a>). <b>Inhibition of these enzymes may cause unpredictable drug interactions<\/b> (e.g. with midazolam, some antidepressants, beta-blockers, statins, warfarin, and anti-seizure drugs) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21178301\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16819159\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22339466\"> R<\/a>].<\/p>\n<p>Additionally, chanca piedra may reduce blood sugar levels. Its combination with anti-diabetes therapies (e.g. glimepiride, <a href=\"https:\/\/selfhacked.com\/blog\/insulin-101\/\">insulin<\/a>, rosiglitazone, tolbutamide) might cause excessive drops in blood sugar levels [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8786163\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11746836\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21323477\">R<\/a>].<\/p>\n<p>Since chanca piedra may reduce blood pressure, it may also increase the effects of blood pressure-lowering drugs [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8786163\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26550547\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29057143\">R<\/a>].<\/p>\n<p>Chanca piedra (<i>Phyllanthus amarus<\/i>) can increase urination and interfere with the effects of water pills (diuretics); this can result in additional fluid loss [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8786163\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29544490\">R<\/a>].<\/p>\n<p>This herb may also counter the effects of <a href=\"https:\/\/selfhacked.com\/blog\/norepinephrine-stress-hormone\/\">norepinephrine<\/a>. Norepinephrine constricts blood vessels, while chanca piedra (<i>Phyllanthus niruri<\/i>) contains a compound that can relax them [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16394535\">R<\/a>].<\/p>\n<h3><span id=\"User_Experiences\"><b>User Experiences<\/b><\/span><\/h3>\n<p><em>The opinions expressed in this section are solely those of chanca piedra users, who may or may not have medical or scientific training. Their reviews do not represent the opinions of SelfHacked. SelfHacked does not endorse any specific product, service, or treatment.<\/em><\/p>\n<p><em>Do not consider user experiences as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare providers because of something you have read on SelfHacked. We understand that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.<\/em><\/p>\n<p>Most users were impressed with chanca piedra, as they reported it dissolved their kidney stones or gallstones and relieved them from pain and discomfort. A few users reported slight diarrhea or dizziness after taking the supplement.<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\"><\/p>\n<h3><span id=\"Takeaway\">Takeaway:<\/span><\/h3>\n<p>Chanca piedra is a medicinal herb used for over 2,000 years for a variety of diseases, including jaundice, kidney stones, gut disorders, and malaria. It is used by folk healers in the Amazon and Ayurvedic practitioners alike.<\/p>\n<p>Clinical studies seem to confirm its \u201cstone-breaking\u201d ability and also support its use for liver detox, viral hepatitis, diabetes, and infections. For kidney stones, chanca piedra is best taken as an extract at a dosage of 400-1000 mg\/day.<\/p>\n<p>Animal and cell-based studies reveal chanca piedra contains powerful antioxidant, anti-inflammatory, anti-cancer, and antibacterial compounds. However, few clinical studies have been carried out. Based on the available evidence, this herb cannot be confidently recommended for most conditions.<\/p>\n<p>Furthermore, chanca piedra is not safe for pregnant women and can interact with various drugs. Consult a healthcare professional before you use chanca piedra if you are taking medication.<\/p>\n<\/div><\/div>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chanca piedra long remained a well-kept secret, though it was widely used in both Amazonian and Ayurvedic medicine. While its name translates to &#8220;stone breaker&#8221;, this herb may also protect the liver, lower inflammation, help with diabetes, and combat infections. Find out if it can really clear your kidney stones, and learn more about its benefits and possible side effects.<\/p>\n","protected":false},"author":14687,"featured_media":64940,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[347,22],"tags":[279],"yst_prominent_words":[505,19317,19310,19308,19311,19314,19312,19315,5841,19316,13997,19321,816,19322,19309,19319,19313,593,19320,19318],"_links":{"self":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/64937"}],"collection":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/users\/14687"}],"replies":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/comments?post=64937"}],"version-history":[{"count":24,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/64937\/revisions"}],"predecessor-version":[{"id":114070,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/64937\/revisions\/114070"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media\/64940"}],"wp:attachment":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media?parent=64937"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/categories?post=64937"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/tags?post=64937"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/yst_prominent_words?post=64937"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}