{"id":47002,"date":"2019-12-06T13:40:22","date_gmt":"2019-12-06T21:40:22","guid":{"rendered":"https:\/\/selfhacked.com\/?p=47002"},"modified":"2021-09-20T09:19:49","modified_gmt":"2021-09-20T16:19:49","slug":"sodium-bicarbonate","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/sodium-bicarbonate\/","title":{"rendered":"10 Uses of Sodium Bicarbonate (Baking Soda) + Side Effects"},"content":{"rendered":"<p>Sodium bicarbonate already aids you in your daily life, and you may not even know it. Some know it as baking soda through its popularity in oral hygiene products and baked foods. Keep reading to discover its potential health benefits and possible side effects.<\/p>\n<p><!--more--><\/p>\n<h2><span id=\"What_Is_Sodium_Bicarbonate\"><a id=\"post-47002-_qv67fz8mkp4y\"><\/a><strong>What Is Sodium Bicarbonate?<\/strong><\/span><\/h2>\n<p>Sodium bicarbonate is commonly referred to as <strong>baking soda<\/strong>, which is a popular food ingredient, medicine, and household product.<\/p>\n<p>Its neutralizing ability can <strong>relieve stomach conditions,<\/strong> such as acid indigestion and heartburn. For this purpose, sodium bicarbonate is commonly sold as an OTC antacid medicine [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25405229\">R<\/a>].<\/p>\n<p>Some <strong>kinds of toothpaste <\/strong>contain sodium bicarbonate for its ability to fight tooth decay and remove odors. Sodium bicarbonate works well with fluoride to <strong>protect teeth<\/strong>, kill bacteria, and improve overall dental health [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12017930\">R<\/a>].<\/p>\n<p>Sodium bicarbonate is also a <strong>popular ingredient for cakes and bread<\/strong>. While providing texture in foods, sodium bicarbonate can also reduce acidity, and act as a raising and leavening agent [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23604657\">R<\/a>,<a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/sodium_bicarbonate#section=Food-Additives-and-Ingredients\"> R<\/a>].<\/p>\n<p>Sodium bicarbonate also has household uses. You can use it for <strong>pest control<\/strong>, <strong>odor control<\/strong>, and even as an emergency <strong>fire extinguisher <\/strong>[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11524864\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22991095\"> R<\/a>,<a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/sodium_bicarbonate#section=Use-and-Manufacturing\"> R<\/a>].<\/p>\n<h3><span id=\"Components\"><a id=\"post-47002-_v2khc3kubhyf\"><\/a><strong>Components<\/strong><\/span><\/h3>\n<p>As the name implies, sodium bicarbonate is a <a href=\"https:\/\/selfhacked.com\/blog\/is-salt-good-or-bad-the-science-on-the-health-effects-of-salt\/\">salt<\/a> composed of <strong>sodium and bicarbonate<\/strong> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5591930\/\">R<\/a>].<\/p>\n<p>These two ions (electrically charged atoms) break apart from each other when dissolved to interact with nearby components, such as free hydrogen [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5591930\/\">R<\/a>].<\/p>\n<h3><span id=\"Mechanism_of_Action\"><a id=\"post-47002-_5z6d8hunkpm8\"><\/a><strong>Mechanism of Action<\/strong><\/span><\/h3>\n<p>Excess hydrogen increases the acidity in liquids and can cause digestive issues and, at high levels, a severe condition called acidosis. Sodium bicarbonate can remove excess hydrogen from its environment to reduce acidity. Each sodium bicarbonate molecule can bind to 3 hydrogen molecules [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5591930\/\">R<\/a>,<a href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/sodium_bicarbonate#section=Chemical-and-Physical-Properties\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3195546\/\"> R<\/a>].<\/p>\n<p>Sodium bicarbonate can also release its sodium ions, thus providing an excellent <strong>source of this electrolyte. <\/strong>Sodium is necessary to control cell volume, maintain bodily fluid acid levels, and transmit nerve impulses [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5591930\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK234935\/\">R<\/a>].<\/p>\n<h3><span id=\"Snapshot\"><a id=\"post-47002-_61v9achumf9b\"><\/a><strong>Snapshot<\/strong><\/span><\/h3>\n<h4><a id=\"post-47002-_phdwgxj0zlnx\"><\/a><strong>Proponents<\/strong><\/h4>\n<ul>\n<li>Approved for some types of metabolic acidosis<\/li>\n<li>Helps with mild acid reflux<\/li>\n<li>May improve exercise performance<\/li>\n<li>May improve oral health<\/li>\n<li>May prevent chronic kidney disease from worsening<\/li>\n<\/ul>\n<h4><a id=\"post-47002-_onbdqoipp6sn\"><\/a><strong>Skeptics<\/strong><\/h4>\n<ul>\n<li>Insufficient evidence for some benefits<\/li>\n<li>May cause some adverse effects at normal doses<\/li>\n<li>High doses or continuous administration may cause metabolic disturbances<\/li>\n<li>May interact with several drugs<\/li>\n<li>Not safe for pregnant or breastfeeding women<\/li>\n<\/ul>\n<h2><span id=\"Health_Benefits\"><a id=\"post-47002-_m68gp7onwv1d\"><\/a><strong>Health Benefits<\/strong><\/span><\/h2>\n<aside class=\"sh-partner shp-form sponsored sh-et-7388fa\">\n  <div>\n          <div class=\"partner-heading\">Get the Regimen of A Top Biohacker<\/div>\n    \n    <div class=\"partner-content\">\n      <p><span style=\"font-weight: 400\">Joe Cohen is well-known for his work as a successful entrepreneur in the health field after he overcame his many health issues using a personalized regimen. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health.\u00a0<\/span><\/p>\n    <\/div>\n\n    <div class=\"subscribe-form-container\">\n      <form method=\"POST\" action=\"\/wp-json\/wp\/v2\/posts\/47002\" class=\"sh-subscribe-form\">\n        <input type=\"email\" name=\"subscribe_form_data[email]\"\n            pattern=\"^[a-zA-Z0-9.!#$%&\u2019*+\/=?^_`{|}~-]+@[a-zA-Z0-9-]+(?:\\.[a-zA-Z0-9-]+)*$\" required\n            placeholder=\"Enter your email\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: PartnerAd Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"PartnerAd\">\n                <button type=\"submit\" class=\"btn btn-primary subscribe-submit\">Get The Regimen<\/button>\n      <\/form>\n    <\/div>\n  <\/div>\n          <style>aside.sponsored.sh-et-7388fa::before{content:\"Advertisement\"}<\/style>\n<\/aside>\n<h3><span id=\"Effective\"><a id=\"post-47002-_odx580s38mxm\"><\/a><strong>Effective<\/strong><\/span><\/h3>\n<h3><span id=\"Metabolic_Acidosis\"><a id=\"post-47002-_ltiqigw0ry7z\"><\/a><strong>Metabolic Acidosis<\/strong><\/span><\/h3>\n<p>Metabolic acidosis is a condition in which the blood becomes too acidic due to increased acid production or bicarbonate loss in the body. The main types of metabolic acidosis include [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17936961\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20308999\">R<\/a>]:<\/p>\n<ul>\n<li>Lactic acidosis: excessive production or decreased use of lactic acid<\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/ketoacidosis\/\">Ketoacidosis<\/a>: high blood levels of <a href=\"https:\/\/selfhacked.com\/blog\/ketone-bodies\/\">ketone bodies<\/a>, often due to poorly managed diabetes<\/li>\n<li>Kidney failure: since they increase blood bicarbonate and lower acid levels<\/li>\n<li>Poisoning with substances such as ethylene glycol, methanol, and salicylate<\/li>\n<li>Excessive bicarbonate loss (through diarrhea, fistula, laxative abuse)<\/li>\n<li>Excessive blood <a href=\"https:\/\/selfhacked.com\/blog\/potassium\/\">potassium<\/a> (hyperkalemia)<\/li>\n<\/ul>\n<p><strong>An injectable solution with 4.2-8.4% sodium bicarbonate is approved for people with metabolic acidosis from chronic kidney disease, hyperkalemia, or excessive bicarbonate loss<\/strong>. It also seems to help with acidosis caused by <a href=\"https:\/\/selfhacked.com\/blog\/amitriptyline-elavil\/\"><strong>amitriptyline<\/strong><\/a><strong> overdose<\/strong>. However, it is i<strong>neffective and may even worsen the condition in people with lactic acidosis or ketoacidosis<\/strong> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6538112\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8216512\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3061004\/\">R<\/a>].<\/p>\n<h3><span id=\"Possibly_Effective\"><a id=\"post-47002-_x65pa7dm1yms\"><\/a><strong>Possibly Effective<\/strong><\/span><\/h3>\n<h3><span id=\"1_Acid_Reflux\"><a id=\"post-47002-_60kbrqdy5im9\"><\/a><strong>1) Acid Reflux<\/strong><\/span><\/h3>\n<p>Acid reflux occurs when the stomach acids flow back into the esophagus and irritate its inner lining. Antacids such as sodium bicarbonate provide quick relief by neutralizing stomach acids [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6509354\/\">R<\/a>].<\/p>\n<p><strong>Sodium bicarbonate is found in many OTC remedies for acid reflux<\/strong>. For instance, Gaviscon is an antacid containing sodium bicarbonate that provides relief from acidic stomach fluids. In a clinical trial on almost 300 people with acid reflux, this antacid eliminated heartburn for 24 hours [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22361121\">R<\/a>].<\/p>\n<p><a href=\"http:\/\/selfhacked.com\/blog\/histamine\/\">Histamine<\/a> receptor blockers (such as <a href=\"https:\/\/selfhacked.com\/blog\/ranitidine\/\">ranitidine<\/a>, cimetidine, and famotidine) and proton pump inhibitors (such as <a href=\"https:\/\/selfhacked.com\/blog\/omeprazole\/\">omeprazole<\/a> and lansoprazole) are also available over the counter. <strong>Although their effects on stomach acids are slower than those of antacids, they are also stronger and longer-lasting<\/strong>. In fact, a systematic review found that sodium bicarbonate added to omeprazole wasn\u2019t more effective than omeprazole alone in managing acid reflux [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6509354\/\">R<\/a>, <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/gerd\/diagnosis-treatment\/drc-20361959\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29547594\">R<\/a>].<\/p>\n<p>More severe cases may require prescription-strength versions of these drugs, medication to tighten the esophageal muscles (e.g., <a href=\"https:\/\/selfhacked.com\/blog\/baclofen\/\">Baclofen<\/a>), and even surgical procedures such as wrapping the upper part of the stomach around the lower part of the esophagus (fundoplication) and wrapping this region with a ring of magnetic beads (Linx device) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6509354\/\">R<\/a>, <a href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/gerd\/diagnosis-treatment\/drc-20361959\">R<\/a>].<\/p>\n<p>To sum up, although sodium bicarbonate and other antacids have proven effectiveness in relieving mild acid reflux, they don\u2019t help with gastroesophageal ulcers and may be ineffective in severe cases. Discuss with your doctor if sodium bicarbonate may help in your case and never use it in place of what your doctor recommends or prescribes.<\/p>\n<h3><span id=\"2_Exercise_Performance\"><a id=\"post-47002-_rjpu421yn87d\"><\/a><strong>2) Exercise Performance<\/strong><\/span><\/h3>\n<p>When muscles do not have enough oxygen, they switch to an alternative energy production process that produces lactic acid as a byproduct. The increased blood acid levels due to the buildup of this molecule interfere with energy supply to the muscles, resulting in increased fatigue and delayed recovery [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16573355\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16573355\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1561513\">R<\/a>].<\/p>\n<p>In a trial of 9 male tennis players, those who consumed sodium bicarbonate were <strong>less fatigued<\/strong> and had lower lactic acid levels [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2978121\/\">R<\/a>].<\/p>\n<p>In another trial on 10 amateur boxers, those who consumed sodium bicarbonate supplements l<strong>anded more punches on their opponent <\/strong>[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19625976\">R<\/a>].<\/p>\n<p>In another trial on 23 people doing a judo-related exercise, sodium bicarbonate <strong>improved their performance, but increased <\/strong><a href=\"http:\/\/selfhacked.com\/blog\/the-brains-secret-backup-generator\/\"><strong>lactate<\/strong><\/a><strong> acid levels in some cases<\/strong> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17507744\">R<\/a>].<\/p>\n<p>Sodium bicarbonate <strong>improved high-intensity endurance performance<\/strong> (time to exhaustion and total work done) in 2 clinical trials on 42 cyclists. It also<strong> reduced the time to complete 2000 m<\/strong> in a trial on 20 male rowers. However, it had n<strong>o effect on power and endurance in another trial<\/strong> on 10 motocross cyclists [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4262454\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24155093\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23579002\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21465247\">R<\/a>].<\/p>\n<p>In another trial on 13 well-trained men, sodium bicarbonate i<strong>ncreased performance in a high-intensity intermittent training<\/strong> by reducing fatigue perception [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4475610\/\">R<\/a>].<\/p>\n<p>Several meta-analyses concluded that repeated intake of sodium bicarbonate may slightly improve exercise performance. However, one of them noted that the effects were lower in well-trained people [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8388767\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21923200\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31034295\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30319077\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22505127\">R<\/a>].<\/p>\n<p>Taken together, the evidence suggests that sodium bicarbonate may help improve athletic performance. You may discuss it with your doctor if it\u2019s a good idea to incorporate it into your training routine.<\/p>\n<h3><span id=\"3_Oral_Health\"><a id=\"post-47002-_qndjppc5vfg5\"><\/a><strong>3) Oral Health<\/strong><\/span><\/h3>\n<p>Cavities-causing bacteria such as <em>Streptococcus mutans <\/em>and <em>Lactobacilli <\/em>damage the enamel by releasing acids. Sodium bicarbonate oral products may help <strong>prevent cavities by neutralizing these acids<\/strong>, as seen in a clinical trial on 20 people using bicarbonate-containing chewing gum. In addition, they may have antibacterial activity. Toothpaste with sodium bicarbonate re<strong>duced the salivary counts of these bacteria<\/strong> in a clinical trial on 10 people [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30409952\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12648557\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7728829\">R<\/a>].<\/p>\n<p>In a clinical trial on 135 people with gum disease, toothpaste with 67% sodium bicarbonate was more effective at <strong>reducing bleeding and inflammation<\/strong> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27212001\">R<\/a>].<\/p>\n<p>In 8 clinical trials, oral hygiene products containing sodium bicarbonate were <strong>better at plaque removal <\/strong>during tooth brushing [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19278079\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29211950\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19278079\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22403983\">R<\/a>].<\/p>\n<p>Sodium bicarbonate also <strong>polishes and removes stains from liquids such as coffee, tea, and wine from the teeth<\/strong>. Its teeth-whitening effectiveness is not only due to its abrasiveness, since bicarbonate toothpaste removed stains better than those with more abrasive substances such as silica in 2 clinical trials on almost 200 people [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12017930\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4058574\/\"> R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10518866\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10518865\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10825858\">R<\/a>].<\/p>\n<p>Bad breath is usually caused by sulfur-producing bacteria feasting on bits of remaining food particles. Sodium bicarbonate not only helps kill these bacteria, but also <strong>eliminates foul odor<\/strong> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12017929\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11524864\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12017930\"> R<\/a>].<\/p>\n<p>All in all, the evidence suggests several benefits of oral healthcare products with sodium bicarbonate. You may discuss with your doctor if they are appropriate in your case.<\/p>\n<h3><span id=\"4_Kidney_Disease\"><a id=\"post-47002-_y3bd26ixg97o\"><\/a><strong>4) Kidney Disease<\/strong><\/span><\/h3>\n<p>In people with chronic kidney disease, the kidneys are unable to properly filter blood. Weaker kidneys cause a buildup of toxins in the blood. People with chronic kidney disease have increased blood acidity levels, which are in turn associated with increased progression of the disease [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27887750\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4341479\/\"> R<\/a>].<\/p>\n<p>In people with <strong>chronic kidney disease<\/strong>, oral supplementation with sodium bicarbonate may <strong>slow down the progression of the condition<\/strong>, as seen in 2 clinical trials on almost 200 people and a meta-analysis of 14 clinical trials [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4297707\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2736774\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31196951\">R<\/a>].<\/p>\n<p>The injection of contrast media for MRI imaging procedures is a common cause of hospital-acquired kidney injury. While s<strong>ome meta-analyses found that hydration with sodium bicarbonate was better than a regular salt solution<\/strong> to prevent this complication, others pointed out the low quality and high heterogeneity of most studies with positive results. More recently, sodium bicarbonate was found <strong>ineffective at improving the outcome in people with hospital-acquired kidney disease<\/strong> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20074886\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2693108\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2758263\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18760120\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19884624\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4368906\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26119410\">R<\/a>].<\/p>\n<p>Similarly, 4 meta-analyses found that <strong>sodium bicarbonate doesn\u2019t reduce the incidence of kidney injury from heart surgery and may even increase ICU stay<\/strong>. However, one of them found <strong>it may reduce its severity and the need for dialysis <\/strong>[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25264756\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4177432\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5289438\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25501691\">R<\/a>].<\/p>\n<p>While its role in preventing kidney damage from medical procedures is, at best, unclear, the evidence suggests that sodium bicarbonate may help slow down the progression of chronic kidney disease by reducing metabolic acidosis. You may take it for this purpose if your doctor determines it may help you. Because chronic kidney disease is a serious condition, never use sodium bicarbonate in place of what your doctor recommends or prescribes.<\/p>\n<h3><span id=\"Insufficient_Evidence\"><a id=\"post-47002-_k0sswt9eb6yd\"><\/a><strong>Insufficient Evidence<\/strong><\/span><\/h3>\n<p>The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of sodium bicarbonate for any of the below-listed uses. Remember to speak with a doctor before taking sodium bicarbonate. It should never be used as a replacement for approved medical therapies.<\/p>\n<h3><span id=\"1_Insulin_Sensitivity\"><a id=\"post-47002-_eoqee1ta691x\"><\/a><strong>1) Insulin Sensitivity<\/strong><\/span><\/h3>\n<p>In 2 studies on 18 healthy postmenopausal women and 7 people with<a href=\"https:\/\/selfhacked.com\/blog\/hyperparathyroidism\/\"> hyperparathyroidism<\/a>, sodium bicarbonate<strong> reduced <\/strong><a href=\"https:\/\/selfhacked.com\/blog\/top-tips-for-fixing-insulin-resistance\/\"><strong>insulin resistance<\/strong><\/a>, suggesting it may help prevent diabetes [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17970536\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC503056\/\">R<\/a>].<\/p>\n<p>In a clinical trial on 145 people with chronic kidney disease, the<strong> correction of their metabolic acidosis with sodium bicarbonate also increased insulin sensitivity<\/strong> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5075179\/\">R<\/a>].<\/p>\n<p>However, sodium bicarbonate<strong> did not improve insulin sensitivity or blood sugar levels<\/strong> in 2 clinical trials on almost 200 non-diabetic people [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3059747\/\">R<\/a>].<\/p>\n<p>A few clinical trials with mixed results don\u2019t allow us to draw conclusions on the effects of sodium bicarbonate on insulin sensitivity. Larger, more robust clinical trials are needed to shed some light on this subject.<\/p>\n<h3><span id=\"2_Skin_Health\"><a id=\"post-47002-_mnj89je0skrj\"><\/a><strong>2) Skin Health<\/strong><\/span><\/h3>\n<p>In a clinical trial on 96 people stung by a jellyfish (<em>Chrysaora<\/em> <em>chinensis<\/em>), topical sodium bicarbonate improved skin redness after 30 minutes [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26827260\">R<\/a>].<\/p>\n<p>Taking baths in overly acidic water can damage skin, causing a scaly appearance. For instance, public water in pools and spas is often acidic due to chlorine addition for safety purposes. Although this use is only supported by anecdotal evidence, <strong>some practitioners believe that bathing in water alkalinized with sodium bicarbonate may improve scaly skin<\/strong> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20398816\">R<\/a>].<\/p>\n<h3><span id=\"Animal_and_Cell_Research_Lack_of_Evidence\"><a id=\"post-47002-_bv2s97ca4hx2\"><\/a><strong>Animal and Cell Research (Lack of Evidence)<\/strong><\/span><\/h3>\n<p>No clinical evidence supports the use of sodium bicarbonate for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies should not be interpreted as supportive of any health benefit.<\/p>\n<h3><span id=\"Infections\"><a id=\"post-47002-_c7tcbxoqldr2\"><\/a><strong>Infections<\/strong><\/span><\/h3>\n<p>Sodium bicarbonate reduced the growth of common disease-causing fungi (such as those causing athlete\u2019s foot, candidiasis, and nail infections) in test tubes [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22991095\">R<\/a>].<\/p>\n<p><em>Streptococcus<\/em> is the bacteria commonly known to cause strep throat. Sodium bicarbonate killed <em>Streptococcus<\/em> bacteria when combined with sodium dodecyl sulfate in test tubes [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12017929\">R<\/a>].<\/p>\n<p>Note, however, that these are very preliminary results that haven\u2019t been replicated in humans and even in animals. Further research is needed to determine if sodium bicarbonate may be of any use in fighting the infections caused by these microorganisms.<\/p>\n<h3><span id=\"Cancer\"><a id=\"post-47002-_mhaam4uljhx\"><\/a><strong>Cancer<\/strong><\/span><\/h3>\n<p>Below, we will discuss some preliminary research on sodium bicarbonate\u2019s potential anticancer activity. Note, however, that many substances have anti-cancer effects in cells, including downright toxic chemicals like bleach. This doesn\u2019t mean that they have any medical value. On the contrary, most substances (natural or synthetic) fail to pass further clinical trials due to a lack of safety or efficacy. <strong>Never use sodium bicarbonate to replace proven anticancer therapies.<\/strong><\/p>\n<p>Cancer cells have an overactive metabolism that produces high amounts of acidic waste products. Many anticancer therapies have difficulty reaching tumors due to the acidic barrier. Preliminary research suggests that combining chemotherapeutic drugs with alkalinizing substances such as sodium bicarbonate may enhance their effectiveness [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21155627\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2363059\/\">R<\/a>].<\/p>\n<p>In rats and mice, oral sodium bicarbonate reduced tumor growth and spreading [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3722989\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2834485\/\">R<\/a>].<\/p>\n<h3><span id=\"Limitations_and_Caveats\"><a id=\"post-47002-_n3ayrfoi0ezb\"><\/a><strong>Limitations and Caveats<\/strong><\/span><\/h3>\n<p>Many of the studies on sodium bicarbonate infusion to prevent hospital-acquired kidney disease had small sample sizes, low quality, and mixed results. Even after several meta-analyses, the effects are unclear.<\/p>\n<p>The effects of sodium bicarbonate on insulin sensitivity have only been studied in a few, small studies with mixed results. The evidence to support the use of sodium bicarbonate in skin health comes from a single clinical trial and some anecdotal evidence. Larger, more robust clinical trials are needed to confirm these preliminary results.<\/p>\n<p>The potential role of sodium bicarbonate to fight infections and cancer has only been investigated in animals and cells, meaning there is no evidence that the results may be the same in humans.<\/p>\n<h2><span id=\"Side_Effects_Precautions\"><a id=\"post-47002-_6ik2jfccb7dx\"><\/a><strong>Side Effects &amp; Precautions<\/strong><\/span><\/h2>\n<p><em>This list does not cover all possible side effects. Contact your doctor or pharmacist if you notice any other side effects. <\/em><\/p>\n<p><em>Call your doctor for medical advice about side effects. In the US, you may report side effects to the FDA at 1-800-FDA-1088 or at <\/em><a href=\"http:\/\/www.fda.gov\/medwatch\"><em>www.fda.gov\/medwatch<\/em><\/a><em>. In Canada, you may report side effects to Health Canada at 1-866-234-2345.<\/em><\/p>\n<p>Oral sodium bicarbonate is generally safe at normal doses. In rare cases, it may cause [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3680785\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20739719\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2536538\">R<\/a>]:<\/p>\n<ul>\n<li>Digestive issues (loss of appetite, bloating, diarrhea, nausea, vomiting, stomach cramps)<\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/natural-treatment-migraines\/\">Headache<\/a><\/li>\n<li>Fatigue, nervousness, or mood changes<\/li>\n<li>Increased urge to drink or urinate<\/li>\n<li>Slow breathing<\/li>\n<li>Leg swelling<\/li>\n<\/ul>\n<p>Its rapid or prolonged intravenous administration may cause metabolic disorders such as metabolic alkalosis, high blood carbon dioxide levels (<a href=\"https:\/\/selfhacked.com\/blog\/hypercapnia\/\">hypercapnia<\/a>), low blood potassium (hypokalemia), <a href=\"https:\/\/selfhacked.com\/blog\/calcium-101\/\">calcium<\/a> (hypocalcemia), and <a href=\"https:\/\/selfhacked.com\/blog\/chloride\/\">chloride<\/a> (hypochloremia), and high blood sodium (hypernatremia) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4227445\/\">R<\/a>].<\/p>\n<p>In people with chronic kidney disease, high blood bicarbonate levels for sustained periods are associated with an increased risk of heart failure [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4579944\/\">R<\/a>].<\/p>\n<p>Sodium bicarbonate does not seem to be effective for newborns with problems related to blood acid levels and sudden loss of heart function [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18829808\">R<\/a>].<\/p>\n<p>Due to the lack of safety data, pregnant and breastfeeding women should avoid sodium bicarbonate unless their doctors think that the potential benefits outweigh the risks.<\/p>\n<p>People with a history of heart disease, kidney disease, or electrolyte imbalances should consult their doctors before taking sodium bicarbonate.<\/p>\n<h3><span id=\"Drug_Interactions\"><a id=\"post-47002-_j5dzj3k1478m\"><\/a><strong>Drug Interactions<\/strong><\/span><\/h3>\n<p><em>Supplement\/Herb\/Nutrient-drug interactions can be dangerous and, in rare cases, even life-threatening. Always consult your doctor before supplementing and let them know about all drugs and supplements you are using or considering.<\/em><\/p>\n<p>Sodium bicarbonate is known to interact with many drugs. Contact your doctor before using sodium bicarbonate if you are on prescription drugs. Some of its known interactions include:<\/p>\n<ul>\n<li>Acetazolamide (a drug that increases urine production) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/5353483\">R<\/a>]<\/li>\n<li>Aspirin [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1631808\/\">R<\/a>]<\/li>\n<li>Salicylate (an anti-inflammatory drug) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5591930\/\">R<\/a>]<\/li>\n<li>Sodium channel blockers [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5591930\/\">R<\/a>]<\/li>\n<li>Enteric-coated tablets (pills that are not digested by stomach fluid) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17227621\">R<\/a>]<\/li>\n<\/ul>\n<h2><span id=\"Supplementation\"><a id=\"post-47002-_c4zfvk5m16cm\"><\/a><strong>Supplementation<\/strong><\/span><\/h2>\n<h3><span id=\"Forms\"><a id=\"post-47002-_25g7tf7pvzsm\"><\/a><strong>Forms<\/strong><\/span><\/h3>\n<p>Sodium bicarbonate is available on the market in the forms of:<\/p>\n<ul>\n<li>Baking soda<\/li>\n<li>OTC antacid tablets, granules, powder, and liquid solutions<\/li>\n<\/ul>\n<h3><span id=\"Dosage\"><a id=\"post-47002-_tgwn8flhmo86\"><\/a><strong>Dosage<\/strong><\/span><\/h3>\n<p>The common oral dose for sodium bicarbonate used in human studies is <strong>500 mg,<\/strong> <strong>3x\/day<\/strong>. Depending on the severity of the condition, experts recommend 325-2000 mg, 1x-4x\/day. Discuss with your doctor which dose is most suitable to you based on your health status [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4522127\/\">R<\/a>].<\/p>\n<p>In people with metabolic acidosis, sodium bicarbonate is infused at doses of 50-150 mEq\/L (moderate acidosis) or 90-180 mEq\/L (severe acidosis) over 1-1.5 hours. Because infused sodium bicarbonate is only given in a clinical setting, your doctor will determine the best treatment regime.<\/p>\n<h3><span id=\"User_Experiences\"><a id=\"post-47002-_cyzze85dwz61\"><\/a><strong>User Experiences<\/strong><\/span><\/h3>\n<p><em>The opinions expressed in this section are solely those of sodium bicarbonate users, who may or may not have medical or scientific training. Their reviews do not represent the opinions of SelfHacked. SelfHacked does not endorse any specific product, service, or treatment.<\/em><\/p>\n<p><em>Do not consider user experiences as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare providers because of something you have read on SelfHacked. We understand that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.<\/em><\/p>\n<p>Most users used sodium bicarbonate for digestive issues such as heartburn and indigestion. They generally reported fast relief after 30 minutes, often followed by a painless bowel movement.<\/p>\n<p>Many users complained about the unpleasant salty taste when sodium bicarbonate is mixed with water. In a few cases, the users reported not noticing any effects.<\/p>\n<p>Some users applied sodium bicarbonate to improve skin Inflammation from insect bites and damage from sunburn. They generally reported good results in relieving the <a href=\"https:\/\/selfhacked.com\/blog\/23-ways-to-combat-pain-naturally-by-increasing-your-opioids\/\">pain<\/a>. Similarly, some people used shampoos with sodium bicarbonate to improve hair smoothness and moisture with generally good results.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sodium bicarbonate already aids you in your daily life, and you may not even know it. Some know it as baking soda through its popularity in oral hygiene products and baked foods. Keep reading to discover its potential health benefits and possible side effects.<\/p>\n","protected":false},"author":14687,"featured_media":63245,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[22,15594],"tags":[279],"yst_prominent_words":[17914,29365,29366,15017,6467,1708,29367,5500,24083,8166,8165,17554,21049,511,515,529,593,6411,29361,29362],"_links":{"self":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/47002"}],"collection":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/users\/14687"}],"replies":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/comments?post=47002"}],"version-history":[{"count":17,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/47002\/revisions"}],"predecessor-version":[{"id":114957,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/47002\/revisions\/114957"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media\/63245"}],"wp:attachment":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media?parent=47002"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/categories?post=47002"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/tags?post=47002"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/yst_prominent_words?post=47002"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}