{"id":45318,"date":"2019-10-18T15:21:41","date_gmt":"2019-10-18T22:21:41","guid":{"rendered":"https:\/\/selfhacked.com\/?p=45318"},"modified":"2021-09-20T09:19:35","modified_gmt":"2021-09-20T16:19:35","slug":"stinging-nettle","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/stinging-nettle\/","title":{"rendered":"5+ Stinging Nettle Benefits + Side Effects"},"content":{"rendered":"<p>While stinging nettle may sound like a dangerous plant, it can be prepared into a supplement with potential benefits against inflammation, allergies, and arthritis. Although it is considered safe, stinging nettles has its risks and side effects as well.<!--more--><\/p>\n<h2><span id=\"What_is_Stinging_Nettle\"><b>What is Stinging Nettle?<\/b><\/span><\/h2>\n<p>Stinging nettle (<i>Urtica dioica<\/i>) is an herb native to parts of Europe, Africa, Asia, and North America. Civilizations as old as Ancient Greece used this plant for its medicinal properties, though our modern names for it come from the Anglo-Saxon \u201cnoedl\u201d (needle) and the Latin \u201curtica\u201d (to burn) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17509841\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6100552\/\"> R<\/a>].<\/p>\n<p>Stinging nettle has been used as a food, fabric, medicine, and cosmetics for thousands of years. Its wide array of uses includes everything from enhancing male health to easing nasal congestion [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3349212\/\">R<\/a>,<a href=\"http:\/\/iopscience.iop.org\/article\/10.1088\/1757-899X\/201\/1\/012001\"> R<\/a>].<\/p>\n<p>Touching the leaves of a wild stinging nettle can cause skin irritation. However, when processed for consumption, the nettle\u2019s stinging hairs are crushed, cooked, or boiled in a way that eliminates their stinging abilities and makes them safe for consumption [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2322858\/\">R<\/a>].<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Stinging nettle is a spiny, irritating herb that has been used for food, fabric, medicine, and cosmetics for thousands of years. It must be processed, with the spines removed, to be safe for consumption.<\/div><\/div>\n<h3><span id=\"Snapshot_of_Stinging_Nettle\">Snapshot of Stinging Nettle<\/span><\/h3>\n<h4><b>Proponents:<\/b><\/h4>\n<ul>\n<li><span>Reduces arthritis pain<\/span><\/li>\n<li><span>May relieve benign prostatic hyperplasia<\/span><\/li>\n<li><span>May decrease blood pressure and blood sugar<\/span><\/li>\n<li><span>Reduces inflammation<\/span><\/li>\n<li><span>Other possible benefits for testosterone, water retention, and healing<\/span><\/li>\n<\/ul>\n<h4><b>Skeptics:<\/b><\/h4>\n<ul>\n<li><span>Stinging spines may cause a rash<\/span><\/li>\n<li><span>Rare allergic reactions to raw juice or pur\u00e9e<\/span><\/li>\n<li><span>May have dangerous drug interactions<\/span><\/li>\n<li><span>May worsen conditions with too much testosterone<\/span><\/li>\n<\/ul>\n<h3><span id=\"Components\">Components<\/span><\/h3>\n<h4>Bioactive Compounds of Leaves<\/h4>\n<p>Stinging nettle contains multiple bioactive compounds responsible for its health and antioxidant effects. These include [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3349212\/\">R<\/a>]:<\/p>\n<ul>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/22-scientifically-proven-benefits-quercetin\/\">Quercetin<\/a>, an antioxidant and anti-diabetic compound [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26393898\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27633685\"> R<\/a>]<\/li>\n<li>Rutin, closely related to quercetin [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28117024\">R<\/a>]<\/li>\n<li>Kaempferol, a potent anti-inflammatory compound [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25982933\">R<\/a>]<\/li>\n<li>Quinic acid, an antioxidant and anti-inflammatory compound [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29032340\">R<\/a>]<\/li>\n<li>Caffeic acid, another strong antioxidant [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28911606\">R<\/a>]<\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/top-18-scientific-health-benefits-choline-cdp-choline-alpha-gpc\/\">Choline<\/a>, a vital nutrient with anti-inflammatory properties [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2782876\/\">R<\/a>]<\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/lecithin\/\">Lecithin<\/a>, a healthy fat that may help reduce cholesterol [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21490917\">R<\/a>]<\/li>\n<\/ul>\n<h4>Bioactive Compounds of Root<\/h4>\n<p><b>Stinging nettle root has a significantly different chemical profile than the leaves<\/b>, with about half the quinic acid and almost no caffeic acid by comparison. However, the roots also contain some compounds not found in the leaves, such as fatty acids, plant sterols, secoisolariciresinol, vanillin, and scopoletin [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6100552\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9270373\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25992248\/\"> R<\/a>].<\/p>\n<p>The compounds in nettle root may protect against heart disease, affect the brain, and reduce cholesterol. <b>The root is also particularly effective against benign prostatic hyperplasia<\/b> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6100552\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9270373\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25992248\/\"> R<\/a>].<\/p>\n<aside class=\"sh-partner shp-form sponsored sh-et-7388fa\">\n  <div>\n          <div class=\"partner-heading\">Get the Regimen of A Top Biohacker<\/div>\n    \n    <div class=\"partner-content\">\n      <p><span style=\"font-weight: 400\">Joe Cohen is well-known for his work as a successful entrepreneur in the health field after he overcame his many health issues using a personalized regimen. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health.\u00a0<\/span><\/p>\n    <\/div>\n\n    <div class=\"subscribe-form-container\">\n      <form method=\"POST\" action=\"\/wp-json\/wp\/v2\/posts\/45318\" class=\"sh-subscribe-form\">\n        <input type=\"email\" name=\"subscribe_form_data[email]\"\n            pattern=\"^[a-zA-Z0-9.!#$%&\u2019*+\/=?^_`{|}~-]+@[a-zA-Z0-9-]+(?:\\.[a-zA-Z0-9-]+)*$\" required\n            placeholder=\"Enter your email\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: PartnerAd Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"PartnerAd\">\n                <button type=\"submit\" class=\"btn btn-primary subscribe-submit\">Get The Regimen<\/button>\n      <\/form>\n    <\/div>\n  <\/div>\n          <style>aside.sponsored.sh-et-7388fa::before{content:\"Advertisement\"}<\/style>\n<\/aside>\n<h4>Nutritional Value<\/h4>\n<p>Fresh stinging nettle plants contains many valuable vitamins and nutrients, including<a href=\"https:\/\/selfhacked.com\/blog\/importance-real-vitamin-retinol\/\"> provitamin A<\/a>,<a href=\"https:\/\/selfhacked.com\/blog\/thiamine\/\"> vitamin B1<\/a>, vitamin K,<a href=\"https:\/\/selfhacked.com\/blog\/potassium\/\"> potassium<\/a>,<a href=\"https:\/\/selfhacked.com\/blog\/calcium-101\/\"> calcium<\/a>, and<a href=\"https:\/\/selfhacked.com\/blog\/iron-balance-blood-test-iron-deficiency-anemia-overload\/\"> iron<\/a>. It also contains<a href=\"https:\/\/selfhacked.com\/blog\/15-inflammatory-substances-naturally-found-plant-based-foods\/#7_Oxalates\"> oxalates<\/a>, which will bind to these minerals and reduce their absorption [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3349212\/\">R<\/a>].<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Stinging nettle is rich in nutrients, antioxidants, and other active compounds. Its roots and leaves have significantly different chemical profiles from one another.<\/div><\/div>\n<h3><span id=\"Mechanism_of_Action\">Mechanism of Action<\/span><\/h3>\n<p>Stinging nettle is an antioxidant: it blocks the oxidation of fats, linoleic acid, deoxyribose, and muscle proteins, thereby protecting many tissues from oxidative stress [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6100552\/\">R<\/a>].<\/p>\n<p>Stinging nettle reduces inflammatory cytokine release and reduces inflammatory biomarkers like<a href=\"https:\/\/selfhacked.com\/blog\/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6\/\"> TNF-a<\/a>,<a href=\"https:\/\/selfhacked.com\/blog\/interleukin-1\/\"> IL-1<\/a>,<a href=\"https:\/\/selfhacked.com\/blog\/interleukin-6\/\"> IL-6<\/a>, and hs-<a href=\"https:\/\/selfhacked.com\/blog\/c-reactive-protein\/\">CRP<\/a>. It also interferes with the way the body sends<a href=\"https:\/\/selfhacked.com\/blog\/23-ways-to-combat-pain-naturally-by-increasing-your-opioids\/\"> pain<\/a> signals and decreases the sensation of pain [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8967906\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22303583\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29157001\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15013182\"> R<\/a>].<\/p>\n<p>These anti-inflammatory effects appear to also help allergies, reduce nasal congestion, help with arthritis, and more [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6100552\/\">R<\/a>].<\/p>\n<h3><span id=\"Why_Touching_a_Wild_Nettle_Hurts\">Why Touching a Wild Nettle Hurts<\/span><\/h3>\n<p><b>If you see a stinging nettle plant growing wild<\/b>,<b> don\u2019t touch it without gloves<\/b>! Nettle leaves and stems are covered with tiny, stinging hairs called trichomes, which will pierce your skin and inject an irritating fluid containing formic acid, histamine, acetylcholine, and serotonin. Histamine is an inflammatory compound that will make your skin red and irritated, and <b>formic acid is the chemical that causes pain from ant and bee stings<\/b> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6100552\/\">R<\/a>].<\/p>\n<p><b>Proper preparation of stinging nettle leaves deactivates the formic acid<\/b>. A high-quality stinging nettle leaf product will not contain anywhere near enough formic acid to cause concern [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6100552\/\">R<\/a>].<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">The spines of stinging nettle contain formic acid, histamine, acetylcholine, and serotonin, which together cause pain and inflammation on contact with skin.<\/div><\/div>\n<h2><span id=\"Health_Benefits_of_Stinging_Nettle\"><b>Health Benefits of Stinging Nettle<\/b><\/span><\/h2>\n<p><span>Stinging nettle supplements have not been approved by the FDA for medical use and generally lack solid clinical research. Regulations set manufacturing standards for them but don&#8217;t guarantee that they&#8217;re safe or effective. Speak with your doctor before supplementing. <\/span><\/p>\n<h3><span id=\"Possibly_Effective_For\"><span>Possibly Effective For<\/span><\/span><\/h3>\n<h4><span>1) Arthritis and Pain<\/span><\/h4>\n<p><span>Stinging nettle\u2019s anti-inflammatory properties could potentially help relieve arthritis symptoms. A combination of stinging nettle leaf extract and devil&#8217;s claw significantly reduced symptoms of arthritis compared to a placebo in a 12-week study of 92 arthritis patients [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28614869\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>These arthritis-relieving properties may be due to nettle\u2019s ability to inhibit the activation of a protein called NF-\u03baB, which would otherwise increase the production of inflammatory compounds. NF-\u03baB is often overactive in people with arthritis [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9923611\/\"><span>R<\/span><\/a><span>,<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4308835\/\"> <span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>Stinging nettle is often used by traditional practitioners. Urtication, also known as \u2018flogging with nettles,\u2019 is a technique where users apply raw, unprocessed stinging nettle leaves or stems to the body to generate inflammation. This has been used since Ancient Roman times for relieving chronic rheumatism, but researchers have only just begun to investigate its effectiveness [<\/span><a href=\"http:\/\/www.bmj.com\/rapid-response\/2011\/10\/27\/alternative-treatment-joint-pains-stinging-nettle\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>There is also evidence that using stinging nettle leaves topically can help relieve<\/span><a href=\"https:\/\/selfhacked.com\/blog\/pain\/\"><span> pain<\/span><\/a><span> in those with:<\/span><\/p>\n<ul>\n<li><span>Lower back pain [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18950450\/\"><span>R<\/span><\/a><span>]<\/span><\/li>\n<li><span>Thumb pain [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2322858\/\"><span>R<\/span><\/a><span>]<\/span><\/li>\n<li><span>Knee pain [<\/span><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0965229907000349\"><span>R<\/span><\/a><span>]<\/span><\/li>\n<\/ul>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">A traditional practice called urtication, by which people rub raw stinging nettle leaves onto their skin to relieve rheumatic pain. Clinical studies have found evidence that this process could work.<\/div><\/div>\n<h3><span id=\"Insufficient_Evidence_For\"><span>Insufficient Evidence For<\/span><\/span><\/h3>\n<p><span>The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of stinging nettle for any of the below-listed uses. Remember to speak with a doctor before using stinging nettle, and never use it in place of something your doctor recommends or prescribes.<\/span><\/p>\n<h4><span>2) Allergies (Hay Fever)<\/span><\/h4>\n<p><b>Taking stinging nettle leaf extracts help decrease<\/b><a href=\"https:\/\/selfhacked.com\/blog\/oral-tolerance\/\"> <b>allergies<\/b><\/a><span>. Scientists believe this may be due to the plant\u2019s ability to reduce<\/span><a href=\"https:\/\/selfhacked.com\/blog\/histamine\/\"><span> histamine<\/span><\/a><span> production and inflammatory markers.<\/span><\/p>\n<p><span>Both freeze-dried nettle leaves and nettle tea may also help with nasal allergies and allergic reactions [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19140159\/\"><span>R<\/span><\/a><span>,<\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2210803312000978\"><span> R<\/span><\/a><span>].<\/span><\/p>\n<p><span>In one study, 57% of patients were said to have rated nettle as \u2018effective\u2019 in helping allergies, with 48% even saying nettle was more effective than allergy medications they had used previously [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2192379\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>However, <\/span><b>stinging nettle also contains histamine<\/b><span> &#8211; especially the leaves and hairs. <\/span><b>More research is required to fully understand how this plant can reduce mast cell activation despite containing histamine<\/b><span>. Many of its other bioactive compounds likely act together to achieve an altogether allergy-relieving effect [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19140159\/\"><span>R<\/span><\/a><span>,<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6100552\/\"> <span>R<\/span><\/a><span>].<\/span><\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Stinging nettle leaf extract and tea have been found to reduce allergic reactions.<\/div><\/div>\n<h4><span>3) Benign Prostatic Hyperplasia (BPH)<\/span><\/h4>\n<p><span>Benign prostatic hyperplasia (BPH) is a condition wherein the prostate gland becomes enlarged, usually due to age. This can cause difficulty urinating and various other symptoms, including sexual dysfunction [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3989825\/\"><span>R<\/span><\/a><span>,<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1477638\/\"><span> R<\/span><\/a><span>].<\/span><\/p>\n<p><span>Stinging nettle root extracts are among the most popular herbal remedies used to ease the symptoms of enlarged prostates, though the evidence is still considered insufficient for medical use [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22512478\/\"><span>R<\/span><\/a><span>,<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmedhealth\/PMH0072387\/\"><span> R<\/span><\/a><span>].<\/span><\/p>\n<p><span>A review of several studies showed that stinging nettle root extract effectively improves the symptoms of an enlarged prostate, with a low risk of negative effects or toxicity [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17509841\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>In a study of 246 BPH patients, a special extract of stinging nettle safely and effectively reduced the adverse effects of prostate enlargement when compared to placebo [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15045190\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>In another 6-month study of 558 people, stinging nettle roots significantly improved multiple measures of prostate health, including [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16635963\/\"><span>R<\/span><\/a><span>]:<\/span><\/p>\n<ul>\n<li><span>Relief of lower urinary tract<\/span><\/li>\n<li><span>Maximum urinary flow rate<\/span><\/li>\n<li><span>Residual urine volume<\/span><\/li>\n<li><span>Prostate size<\/span><\/li>\n<li><span>International Prostate Symptom Score<\/span><\/li>\n<\/ul>\n<p><span>Another study combined stinging nettle and saw palmetto extract. It was as effective as and better tolerated than the prescription drug finasteride, which is used to treat enlarged prostates [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/m\/pubmed\/10971268\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>The inhibiting effects of stinging nettle root extracts were also demonstrated in rats and mice with induced large prostates [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/m\/pubmed\/9270373\/\"><span>R<\/span><\/a><span>,<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/m\/pubmed\/25992248\/\"><span> R<\/span><\/a><span>].<\/span><\/p>\n<p><span>Note that stinging nettle root has been significantly more effective than leaf or stem in studies of people with BPH. This may be due to high lignan content, which the leaves don\u2019t contain.<\/span><\/p>\n<p><span>Larger and more robust studies with standardized extracts and preparations will be required to determine the role of stinging nettle in BPH.<\/span><\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Stinging nettle root extracts have emerged as a promising remedy for benign prostatic hyperplasia, though additional research is required before it can be broadly recommended.<\/div><\/div>\n<h4><span>4) Blood Sugar<\/span><\/h4>\n<p><span>Stinging nettle leaves and stems<\/span> <span>&#8211; but not roots &#8211; may help decrease blood sugar. Chemicals in nettle leaves appear to trigger the release of insulin and other compounds that reduce blood sugar [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24273930\/\"><span>R<\/span><\/a><span>, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14630172\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>In a study of 92 subjects, stinging nettle extract decreased fasting blood sugar levels and other blood sugar levels when compared with the placebo [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/m\/pubmed\/24273930\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>Stinging nettle also decreased blood sugar and increased insulin in rat studies [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14522431\/\"><span>R<\/span><\/a><span>, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14630172\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>A leaf extract of stinging nettle improved blood sugar balance in mice and helped with<\/span><a href=\"https:\/\/selfhacked.com\/2013\/11\/07\/top-tips-for-fixing-insulin-resistance\"><span> insulin resistance<\/span><\/a><span>, which delayed the onset of type 2 diabetes [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4768183\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\">Stinging nettle leaf and stem extracts have decreased blood sugar in small human studies.<\/div><\/div>\n<h4><span>5) Inflammation<\/span><\/h4>\n<p><span>Stinging nettle leaf extracts may block inflammatory markers (TNF-a, IL-1, IL-6,<\/span><a href=\"https:\/\/selfhacked.com\/blog\/nuclear-factor-kappa-b\/\"><span> NF-kB<\/span><\/a><span>, etc.) and reduce inflammation in the body<\/span> <span>[<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8967906\"><span>R<\/span><\/a><span>, <\/span><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22303583\"><span>R<\/span><\/a><span>, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9923611\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>In a study of 37 arthritis patients, combining stinging nettle tea with diclofenac (a non-steroidal anti-inflammatory drug or NSAID) enhanced the drug\u2019s anti-inflammatory effects [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23195396\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>In mouse immune cells (macrophages), stinging nettle extract was as effective at reducing<\/span><a href=\"https:\/\/selfhacked.com\/blog\/podcast-interview-lectin-avoidance-diet-autoimmunity-inflammation-weight-gain-part-2-dr-steven-gundry\/\"><span> inflammation<\/span><\/a><span> as celastrol from<\/span><a href=\"https:\/\/selfhacked.com\/blog\/15-promising-thunder-god-vine-benefits\/\"> <span>thunder god vine<\/span><\/a><span>. Both were powerful antioxidants and anti-inflammatories [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3529973\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>Nettle also inhibited human leukocyte elastase, which is known to increase inflammation [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17509841\/\"><span>R<\/span><\/a><span>, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7952645\"><span>R<\/span><\/a><span>,<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18568075\/\"><span> R<\/span><\/a><span>].<\/span><\/p>\n<p><span><div class=\"sh-summary\"><div class=\"sh-summary-content\">Stinging nettle leaf extracts contain active compounds that block inflammatory markers. In one human study, stinging nettle and an NSAID reduced inflammation more than the NSAID alone.<\/div><\/div><\/span><\/p>\n<h3><span id=\"Animal_Cell_Research_Lacking_Evidence\"><span>Animal &amp; Cell Research (Lacking Evidence)<\/span><\/span><\/h3>\n<p><span>No clinical evidence supports the use of stinging nettle for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.<\/span><\/p>\n<h4><span>6) Free Testosterone<\/span><\/h4>\n<p><span>Free<\/span><a href=\"https:\/\/selfhacked.com\/blog\/testosterone-will-add\/\"> <span>testosterone<\/span><\/a><span> is the available blood testosterone, not bound to<\/span><a href=\"https:\/\/selfhacked.com\/blog\/sex-hormone-binding-globulin-shbg\/\"> <span>sex hormone binding globulin<\/span><\/a><span>, or<\/span><a href=\"https:\/\/selfhacked.com\/blog\/sex-hormone-binding-globulin-shbg\/\"> <span>SHBG<\/span><\/a><span>. The less testosterone that\u2019s bound to SHBG, the more free testosterone is available for the body to use. Testosterone bound to SHBG is unusable to the body [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2890370\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>Stinging nettle roots contain substances called ligans, which bind to SHBG. This reduces the amount of SHBG that can bind testosterone; hence, while nettle does not increase total testosterone in the blood, it may increase <\/span><i><span>available<\/span><\/i><span> testosterone. Bodybuilders have traditionally used similar plant substances to increase free testosterone [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9434605\"><span>R<\/span><\/a><span>,<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16635963\/\"> <span>R<\/span><\/a><span>,<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7700987\"><span> R<\/span><\/a><span>].<\/span><\/p>\n<p><span>Multiple cell studies have shown that lignans from stinging nettle roots reduced SHBG binding to testosterone [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9434605\/\"><span>R<\/span><\/a><span>,<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7702715\/\"> <span>R<\/span><\/a><span>,<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7700987\"><span> R<\/span><\/a><span>].<\/span><\/p>\n<p><span>There is also evidence that stinging nettle blocks the conversion of testosterone into<\/span><a href=\"https:\/\/selfhacked.com\/blog\/estradiol\/\"><span> estrogen<\/span><\/a><span>, an effect that may be increased with the addition of<\/span><a href=\"https:\/\/selfhacked.com\/blog\/benefits-saw-palmetto\/\"> <span>saw palmetto<\/span><\/a><span>. This combination appears to act on an enzyme called aromatase, which converts testosterone to estrogen, but does not affect testosterone receptors [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17509841\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span><div class=\"sh-summary\"><div class=\"sh-summary-content\">While stinging nettle is a popular supplement for boosting testosterone, there is currently nowhere near enough research to confirm this benefit. Future human studies will tell us more.<\/div><\/div><\/span><\/p>\n<h4><span>7) Blood Pressure<\/span><\/h4>\n<p><span>Stinging nettle stems and leaves may reduce blood pressure, but they could also increase the risk of blood pressure dropping too low. In rats, stinging nettle lowered blood pressure by increasing the amount of salt that the kidneys filtered out of the blood [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11025144\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>Stinging nettle can also lower blood pressure by triggering the release of nitric oxide, which causes blood vessels to widen [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12020933\/\"><span>R<\/span><\/a><span>, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5009491\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span><div class=\"sh-summary\"><div class=\"sh-summary-content\">In animals, stinging nettle has reduced blood pressure by multiple mechanisms.<\/div><\/div><\/span><\/p>\n<h4><span>8) Water Retention<\/span><\/h4>\n<p><span>Diuretics, sometimes called water pills, are medications that increase urine production. They can help remove excess sodium and water from the body. In animal studies, stinging nettle increased urine flow and acted as a diuretic [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11025144\/\"><span>R<\/span><\/a><span>, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12522584\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>Proper use of diuretics can help with various health complications by [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6385697\/\"><span>R<\/span><\/a><span>, <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11025144\"><span>R<\/span><\/a><span>]:<\/span><\/p>\n<ul>\n<li><span>Decreasing blood pressure<\/span><\/li>\n<li><span>Compensating for poor kidney function<\/span><\/li>\n<li><span>Reducing bloating<\/span><\/li>\n<\/ul>\n<h4><span>9) Wound Healing<\/span><\/h4>\n<p><span>In rats, stinging nettle leaf extracts improved the quality of healing of second-degree burns in rats when applied to their skin. It accelerated healing and reduced scarring more effectively than conventional methods (vaseline and silver sulfadiazine) [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4298861\/\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<p><span>A very limited human study of eight experimental burns using a gel with stinging nettle leaf extracts with <\/span><a href=\"https:\/\/selfhacked.com\/blog\/arnica\/\"><span>arnica extracts<\/span><\/a><span> seems to support this benefit [<\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21944657\"><span>R<\/span><\/a><span>].<\/span><\/p>\n<h3><span id=\"Limitations_and_Caveats\"><b>Limitations and Caveats<\/b><\/span><\/h3>\n<p>Although there is a large body of promising research, caution should always be used when extrapolated the results of animal studies to humans. Also, as with any supplement, care should be used in taking it.<\/p>\n<p>A few studies have demonstrated that different parts of the stinging nettle plant contain different chemical compounds and may have completely different effects. Some research that claims that nettle extracts either do or do not have certain benefits may not have investigated each part of the plant, each extract, or even the ideal extract for the job.<\/p>\n<h2><span id=\"Side_Effects_Safety\"><b>Side Effects &amp; Safety<\/b><\/span><\/h2>\n<p>Although certain applications require the leaves to be applied directly to the skin, we do not recommend touching a wild stinging nettle with your bare hands. The formic acid and histamine in the sharp \u201chairs\u201d on the nettle\u2019s surface will likely cause a red, lumpy rash. In addition, <b>some people may experience an allergic reaction to raw pur\u00e9ed nettle or nettle juice<\/b> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6100552\/\">R<\/a>].<\/p>\n<p>Stinging nettle may increase free testosterone and may, therefore, worsen any health conditions characterized by too much testosterone, such as polycystic ovarian syndrome (PCOS) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28531286\">R<\/a>].<\/p>\n<p>Due to possible contractions of the uterus, <b>stinging nettle may be unsafe to take during pregnancy<\/b>. Contractions of the uterus can cause a miscarriage or cause women to go into early labor. There are no available studies about the effects of stinging nettle on nursing infants, so it is recommended to <b>consult your doctor if you are considering taking it while breastfeeding<\/b> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2322858\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK501777\/\"> R<\/a>].<\/p>\n<p>Stinging nettle is sometimes used to increase milk production in nursing mothers, but no safety data exists; we therefore caution against using stinging nettle while breastfeeding [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2322858\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK501777\/\"> R<\/a>].<\/p>\n<h3><span id=\"Drug_Interactions\"><b>Drug Interactions<\/b><\/span><\/h3>\n<p>Combining stinging nettle with hypertension and diabetes drugs may cause your blood pressure and blood sugar to become too low [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5009491\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14522431\/\"> R<\/a>].<\/p>\n<p>The active compounds in stinging nettle may block metabolic enzymes in the CYP1A family, thereby increasing the effects of any drugs broken down by these enzymes. In rats, this effect has been demonstrated with <b>melatonin<\/b>; other drugs that may be affected include <b>caffeine, warfarin, and many others<\/b> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28070878\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5599467\/\"> R<\/a>].<\/p>\n<p>By the same token, stinging nettle can increase the beneficial effects of <b>non-steroidal anti-inflammatory drugs (NSAIDs)<\/b> like ibuprofen (Advil) and naproxen (Aleve) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4877453\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23195396\/\"> R<\/a>].<\/p>\n<p><b>Talk to your doctor before supplementing with stinging nettle to prevent adverse events or unexpected interactions<\/b>.<\/p>\n<h2><span id=\"Supplementation_Dosage\"><b>Supplementation &amp; Dosage<\/b><\/span><\/h2>\n<h3><span id=\"Forms_of_Stinging_Nettle\"><b>Forms of Stinging Nettle<\/b><\/span><\/h3>\n<p>Stinging nettle is usually available in the following forms:<\/p>\n<ul>\n<li>Tea<\/li>\n<li>Capsules (leaf or root extract)<\/li>\n<li>Tinctures (extract dissolved in alcohol)<\/li>\n<li>Loose leaves<\/li>\n<li>Dried roots<\/li>\n<li>Cream or gel (for arthritis and pain)<\/li>\n<\/ul>\n<p>If collected and processed carefully, wild stinging nettle can also be gathered and cooked into many recipes. <b>Look for instructions from experts before attempting to harvest nettle yourself<\/b>.<\/p>\n<p>Always check the label to make sure which part of the plant was used to make a given product.<\/p>\n<h3><span id=\"Dosage\"><b>Dosage<\/b><\/span><\/h3>\n<p>There is no safe and effective dose of stinging nettle for any medical purpose because no sufficiently powerful study has been conducted to find one. That being said, many studies have found an association between certain doses of nettle and beneficial effects.<\/p>\n<p>A dosage of<b> 450 mg of dry stinging nettle root extract <\/b>per day is associated with beneficial effects for benign prostatic hyperplasia. Many commercial root supplements come in 250 mg or 500 mg capsules [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15045190\/\">R<\/a>].<\/p>\n<p>Increasing free testosterone is dose-dependent. A root tincture with a concentration of 0.6 mg\/ml significantly blocked testosterone binding to SHBG; at a concentration of 10 mg\/ml, binding was inhibited completely [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7700987\/\">R<\/a>].<\/p>\n<p><b>Commercial leaf extracts sometimes come with recommendations of between 275 mg and 2 g<\/b> of their product per day; note that the quality and content of these extracts is likely variable. Raw stinging nettle leaf, cut from the live plant, significantly reduces pain when applied to directly to an arthritic joint for thirty seconds, once per day [<a href=\"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/014107680009300607\">R<\/a>].<\/p>\n<div class=\"sh-summary\"><div class=\"sh-summary-content\"><\/p>\n<h3><span id=\"Takeaway\">Takeaway<\/span><\/h3>\n<p>Stinging nettle is a common plant that grows all over the world. People have used it to treat rheumatism and pain for thousands of years, and more recent research shows that it may reduce inflammation, relieve allergies, increase free testosterone, reduce blood sugar and pressure, act as a diuretic, and improve wound healing.<\/p>\n<p>It is generally considered safe, though the fresh leaves and stem of the plant can cause a nasty, stinging rash when touched. True allergy to stinging nettle is rare, but possible. This supplement may increase the effect of NSAIDs and other drugs; caution is advised when combining stinging nettle with medication.<\/p>\n<p>Stinging nettle is available in many forms, including loose leaf, capsules, tincture, root, tea, cream, or live (often wild) plant. Researchers do not agree on an effective dosage for all people, conditions, or parts of the plant.<\/p>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>While stinging nettle may sound like a dangerous plant, it can be prepared into a supplement with potential benefits against inflammation, allergies, and arthritis. Although it is considered safe, stinging nettles has its risks and side effects as well.<\/p>\n","protected":false},"author":26632,"featured_media":45321,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[347,22],"tags":[279],"yst_prominent_words":[12351,12354,501,18804,635,13476,25833,18801,18803,18802,511,515,14724,18798,32756,18799,18800,18797,25835,25834],"_links":{"self":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/45318"}],"collection":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/users\/26632"}],"replies":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/comments?post=45318"}],"version-history":[{"count":25,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/45318\/revisions"}],"predecessor-version":[{"id":111606,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/45318\/revisions\/111606"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media\/45321"}],"wp:attachment":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media?parent=45318"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/categories?post=45318"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/tags?post=45318"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/yst_prominent_words?post=45318"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}