{"id":44399,"date":"2019-11-12T18:10:40","date_gmt":"2019-11-13T02:10:40","guid":{"rendered":"https:\/\/selfhacked.com\/?p=44399"},"modified":"2021-09-20T09:19:25","modified_gmt":"2021-09-20T16:19:25","slug":"health-benefits-phosphatidylcholine","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/health-benefits-phosphatidylcholine\/","title":{"rendered":"7 Phosphatidylcholine Benefits + Dosage &#038; Side Effects"},"content":{"rendered":"<p>Phosphatidylcholine is a key component of our cells. Increased intake may improve mental, liver, and gut health, but the available clinical evidence is weak. Phosphatidylcholine injections are used for reducing fat deposits. Read more about its benefits, dosage, and side effects.<\/p>\n<p><!--more--><\/p>\n<h2><span id=\"What_Is_Phosphatidylcholine\"><b>What Is Phosphatidylcholine?<\/b><\/span><\/h2>\n<p>Phosphatidylcholine (PC) is a molecule that contains two fatty acids attached to a glycerol backbone with a phosphate group and <a href=\"http:\/\/selfhacked.com\/blog\/top-18-scientific-health-benefits-choline-cdp-choline-alpha-gpc\/\">choline<\/a>.<\/p>\n<p>It is found in every single cell of your body as a key component of the cell membrane [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3316137\/\">R<\/a>].<\/p>\n<p>Apart from its role in maintaining cell structure, <a href=\"https:\/\/selfhacked.com\/blog\/health-benefits-phosphatidylcholine\/\">phosphatidylcholine <\/a>[<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3565322\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3316137\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3562414\/\"> R,<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7782901\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23295697\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22134222\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10690951\"> R<\/a>]:<\/p>\n<ul>\n<li>builds a mixture of fats and proteins lining our lungs and enabling us to breathe.<\/li>\n<li>is one of the main components of mucus that lines and protects our gut.<\/li>\n<li>shields the nerves by increasing<a href=\"https:\/\/selfhacked.com\/blog\/top-18-scientific-health-benefits-choline-cdp-choline-alpha-gpc\/\"> choline<\/a> and<a href=\"https:\/\/selfhacked.com\/blog\/acetylcholine\/\"> acetylcholine<\/a> levels in the brain<\/li>\n<li>protects the liver<\/li>\n<li>helps breaks down fats<\/li>\n<\/ul>\n<p>Phosphatidylcholine levels may decrease as we age. For example, in the brain, there is a 10% reduction between age 40 and age 100, according to some researchers [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3565322\/\">R<\/a>].<\/p>\n<p>Because choline is needed to make phosphatidylcholine, low choline levels can limit its production. Choline deficiency can decrease phosphatidylcholine levels in the liver, leading to liver damage [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16144842\">R<\/a>].<\/p>\n<p>Phosphatidylcholine is also responsible for the production of very<a href=\"https:\/\/selfhacked.com\/blog\/ldl-cholesterol\/\"> low-density lipoprotein<\/a> (VLDL) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21979151\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3343237\"> R<\/a>].<\/p>\n<h3><span id=\"Why_Are_Low_PC_Levels_Bad\"><b>Why Are Low PC Levels Bad?<\/b><\/span><\/h3>\n<ul>\n<li>Low levels of phosphatidylcholine in the brain may be associated with Alzheimer&#8217;s disease [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12898349\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10411344\/\"> R<\/a>]. On the other hand, high levels of docosahexaenoic acid (the fatty acid which is attached to phosphatidylcholine in the brain) were associated with a decreased risk of dementia in some studies [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17101822\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4925799\/\"> R<\/a>].<\/li>\n<li>Low phosphatidylcholine levels in certain brain areas may be associated with schizophrenia [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18778095\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28152600\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15219471\"> R<\/a>].<\/li>\n<li>Low levels of phosphatidylcholine in the liver are associated with fatty liver (NAFLD) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22095799\">R<\/a>].<\/li>\n<\/ul>\n<h3><span id=\"Food_Sources\">Food Sources<\/span><\/h3>\n<p>Food sources of phosphatidylcholine include [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12730414\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3257636\/\"> R<\/a>]:<\/p>\n<ul>\n<li>Egg yolks (6,771 mg\/100g)<\/li>\n<li>Pig liver (1,668 mg\/100g)<\/li>\n<li>Chicken liver (1,120 mg\/100g)<\/li>\n<li>Soybeans (917 mg\/100g)<\/li>\n<li>Squid (777 mg\/100g)<\/li>\n<li>Chicken breast (391 mg\/100g)<\/li>\n<li>Beef (408 mg\/100g)<\/li>\n<li>Peanuts (270 mg\/100g)<\/li>\n<li>Cod (331 mg\/100g)<\/li>\n<li>Spinach (37 mg\/100g)<\/li>\n<li>Potato (38 mg\/100g)<\/li>\n<li>Carrot (23 mg\/100g)<\/li>\n<li>Apple (21 mg\/100g)<\/li>\n<li>Cow\u2019s milk (12 mg\/100g)<\/li>\n<\/ul>\n<h2><span id=\"Health_Benefits_of_Phosphatidylcholine\"><b>Health Benefits of Phosphatidylcholine<\/b><\/span><\/h2>\n<h3><span id=\"Possibly_Effective\">Possibly Effective:<\/span><\/h3>\n<h3><span id=\"1_Ulcerative_Colitis_IBD\"><b>1) Ulcerative Colitis (IBD)<\/b><\/span><\/h3>\n<p>In four studies of 316 patients with<a href=\"https:\/\/selfhacked.com\/blog\/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections\/\"> ulcerative colitis<\/a>, phosphatidylcholine (PC) supplementation reduced disease severity, improved quality of life, and induced remissions. It also decreased dependence on corticosteroids and resulted in complete therapy withdrawal in some patients [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1774598\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24796768\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20048683\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17975182\"> R<\/a>].<\/p>\n<p>Modified-release PC (3.2 grams daily for 12 weeks) even improved the symptoms of drug-resistant ulcerative colitis. However, this trial was funded by the supplement manufacturer, which indicates a potential conflict of interest [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24796768\">R<\/a>].<\/p>\n<h3><span id=\"2_Infant_Brain_Development\"><b>2) Infant Brain Development<\/b><\/span><\/h3>\n<p>Multiple reviews of human and animal trials have proclaimed choline a vital nutrient for fetal brain development. Optimal choline intake during pregnancy [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2438605\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2430654\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29451849\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16504295\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4466850\/\"> R<\/a>]:<\/p>\n<ul>\n<li>Ensures proper brain structure and functioning<\/li>\n<li>May enhance memory and cognition<\/li>\n<li>Prevents birth defects and mental illnesses<\/li>\n<\/ul>\n<p>According to one clinical review, prenatal phosphatidylcholine (PC) supplementation as a dietary source of choline may promote brain development in the fetus and offer protection against mental illnesses [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4466850\/\">R<\/a>].<\/p>\n<p>In a study of 49 mothers, those who received prenatal PC supplements reported \u201cfewer attention problems and less social withdrawal\u201d in their 40-month old children [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5892450\/\">R<\/a>].<\/p>\n<p>In 100 pregnant women, phosphatidylcholine supplementation prevented the delay in certain areas of brain development in fetuses that were genetically susceptible to schizophrenia [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3640283\/\">R<\/a>].<\/p>\n<p>However, prenatal PC (750 mg) didn\u2019t enhance infants\u2019 cognition in 140 women who consumed enough choline [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3497930\/\">R<\/a>].<\/p>\n<p>It may be that PC supplementation is beneficial only in cases of inadequate choline intake, <b>but more research is needed to evaluate its effectiveness.<\/b><\/p>\n<aside class=\"sh-partner shp-form sponsored sh-et-7388fa\">\n  <div>\n          <div class=\"partner-heading\">8 Ways To Use Your DNA &amp; Optimize Your Health<\/div>\n    \n    <div class=\"partner-content\">\n      <p><span style=\"font-weight: 400\">What kinds of secrets could your genes hold? Read this guide and find out how you can take your health into your own hands and find the root cause of your issues through gene-based health.<\/span><\/p>\n    <\/div>\n\n    <div class=\"subscribe-form-container\">\n      <form method=\"POST\" action=\"\/wp-json\/wp\/v2\/posts\/44399\" class=\"sh-subscribe-form\">\n        <input type=\"email\" name=\"subscribe_form_data[email]\"\n            pattern=\"^[a-zA-Z0-9.!#$%&\u2019*+\/=?^_`{|}~-]+@[a-zA-Z0-9-]+(?:\\.[a-zA-Z0-9-]+)*$\" required\n            placeholder=\"Enter your email\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: PartnerAd Your DNA Your Health\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: Your DNA Your Health Guide\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"PartnerAd\">\n                <button type=\"submit\" class=\"btn btn-primary subscribe-submit\">Optimize My Health<\/button>\n      <\/form>\n    <\/div>\n  <\/div>\n          <style>aside.sponsored.sh-et-7388fa::before{content:\"Advertisement\"}<\/style>\n<\/aside>\n<h3><span id=\"3_NSAID-Induced_Stomach_Ulcers\"><b>3) NSAID-Induced Stomach Ulcers<\/b><\/span><\/h3>\n<p>In three studies of 345 participants, phosphatidylcholine protected the stomach from injuries caused by nonsteroidal anti-inflammatory drugs (NSAIDs). <b>It\u2019s important to note that the researchers chemically connected PC and tested drugs; taking them separately may not give the same results<\/b> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10406241\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21081908\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3353548\/\"> R<\/a>].<\/p>\n<p>Studies on rats also showed the potential of phosphatidylcholine to reduce the toxicity of NSAIDs and increase their therapeutic properties [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22100851\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9558035\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11408553\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19366347\"> R<\/a>].<\/p>\n<h3><span id=\"Insufficient_Evidence\">Insufficient Evidence:<\/span><\/h3>\n<p><i>No valid clinical evidence supports the use of phosphatidylcholine for any of the conditions in this section. Below is a summary of up-to-date animal studies, cell-based research, or low-quality clinical trials which should spark further investigation. However, you shouldn\u2019t interpret them as supportive of any health benefit.<\/i><\/p>\n<h3><span id=\"4_Liver_Health\"><b>4) Liver Health<\/b><\/span><\/h3>\n<p>Low levels of choline and phosphatidylcholine (PC) can contribute to non-alcoholic fatty liver disease (NAFLD) in humans [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23703836\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26773011\"> R<\/a>].<\/p>\n<p>A study using a combination of <a href=\"http:\/\/selfhacked.com\/blog\/milk-thistle\/\">milk thistle<\/a> (silybin),<a href=\"https:\/\/selfhacked.com\/blog\/milk-thistle\/\"> phosphatidylcholine<\/a>, and vitamin E showed a significant improvement in liver enzymes,<a href=\"https:\/\/selfhacked.com\/blog\/insulin-101\/\"> insulin<\/a><a href=\"https:\/\/selfhacked.com\/blog\/top-tips-for-fixing-insulin-resistance\/\"> resistance<\/a>, and liver structure in 179 patients with NAFLD [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22343419\">R<\/a>].<\/p>\n<p>Very low levels of phosphatidylcholine can cause liver damage and even death in mice. An animal study showed that phosphatidylcholine can promote<a href=\"https:\/\/selfhacked.com\/blog\/regenerate-liver-naturally-6-step-program\/\"> liver regeneration<\/a> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1497696\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16144842\">R<\/a>].<\/p>\n<p>In other animal studies, scientists observed the potential of choline and PC to prevent the progression of non-alcoholic fatty liver disease and increase the chance of survival after liver surgery [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22095799\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1497696\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15975496\"> R<\/a>].<\/p>\n<h3><span id=\"5_Memory\"><b>5) Memory<\/b><\/span><\/h3>\n<p>Low levels of phosphatidylcholine are associated with memory loss and<a href=\"https:\/\/selfhacked.com\/blog\/alzheimer\/\"> Alzheimer&#8217;s<\/a> disease in some patients [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26402628\">R<\/a>].<\/p>\n<p>In a study of 80 healthy young adults, phosphatidylcholine supplementation improved memory [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9377589\">R<\/a>].<\/p>\n<p>Phosphatidylcholine increased the levels of choline and acetylcholine in the brain, improved memory, and protected the brain in mice with dementia [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26268328\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7782901\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8569416\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4997672\/\"> R<\/a>].<\/p>\n<h3><span id=\"6_Hepatitis_B_and_C\"><b>6) Hepatitis B and C<\/b><\/span><\/h3>\n<p>In a trial of 176 patients. phosphatidylcholine helped treat chronic hepatitis C but not hepatitis B [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9684137\">R<\/a>].<\/p>\n<p>It did help treat chronic hepatitis B in a smaller trial of 15 patients [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6757621\">R<\/a>].<\/p>\n<p><b>Further research is needed to evaluate the effectiveness of phosphatidylcholine for hepatitis B and C.<\/b><\/p>\n<h3><span id=\"7_Fat_Breakdown_Lipolysis\"><b>7) Fat Breakdown (Lipolysis)<\/b><\/span><\/h3>\n<p>Fat breakdown involves the breakdown of triglyceride into glycerol and free fatty acids. Phosphatidylcholine (PC) increases the production of <a href=\"http:\/\/selfhacked.com\/blog\/ppargamma-role-weight-gain-inflammation-natural-activators\/\">PPAR-gamma<\/a> receptor, responsible for the breakdown of fats [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26331321\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23911798\">R<\/a>].<\/p>\n<p>Judging by the clinical experience of some doctors, PC injections directly into the fat deposits can cause fat breakdown and may be used as an alternative to surgery. <b>In the lack of controlled trials, we can\u2019t tell if this treatment is safe and effective<\/b> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14558399\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23621400\"> R<\/a>].<\/p>\n<p>PC injections reduced fat in the eyelids of 30 patients, acting as an alternative to eyelid surgery [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11298713\">R<\/a>].<\/p>\n<p>According to limited preliminary evidence, they may also help with lipomas, benign tumors caused by fat buildup. However, <b>the researchers emphasized the need for further well-designed studies<\/b> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/m\/pubmed\/25013540\/\">R<\/a>].<\/p>\n<h3><span id=\"Animal_and_Cellular_Research_Lacking_Evidence\">Animal and Cellular Research (Lacking Evidence)<\/span><\/h3>\n<p><i>No clinical evidence supports the use of phosphatidylcholine for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research. They should guide further investigational efforts but should not be interpreted as supportive of any health benefit.<\/i><\/p>\n<h4>8) Inflammation<\/h4>\n<p>Treatment with phosphatidylcholine decreased inflammation and<a href=\"https:\/\/selfhacked.com\/blog\/how-to-increase-and-decrease-white-blood-cells\/\"> white blood cell<\/a> reaction related to arthritis in one study rats [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19766625\/\">R<\/a>].<\/p>\n<p>Dietary phosphatidylcholine improved rheumatoid arthritis symptoms in mice by reducing inflammation. In another study on mice, it decreased inflammatory white blood cell levels and inflammation [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19296835\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18987473\/\">R<\/a>].<\/p>\n<p>In a cell study, scientists observed the ability of phosphatidylcholine to prevent the inflammation caused by TNF-alpha [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19594939\/\">R<\/a>].<\/p>\n<h4>9) Nerve Protection<\/h4>\n<p>Inflammation can decrease the production of new neurons in the hippocampus, a brain region important for learning and memory. Phosphatidylcholine prevented this decrease in mice by suppressing <a href=\"http:\/\/selfhacked.com\/blog\/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6\/\">TNF-alpha<\/a> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21937953\">R<\/a>].<\/p>\n<p>Lecithin, a mixture of fats including phosphatidylcholine, increased antioxidant enzymes (MDA, <a href=\"https:\/\/selfdecode.com\/gene\/CAT\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">CAT<\/a>) in rat brains damaged by the lack of blood flow and oxygen [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15549708\">R<\/a>].<\/p>\n<h4>10) Gallstones<\/h4>\n<p>In one study on mice, researchers observed the ability of dietary phosphatidylcholine to prevent the formation of gallbladder stones [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12837851\">R<\/a>].<\/p>\n<h3><span id=\"Possibly_Ineffective\">Possibly Ineffective:<\/span><\/h3>\n<p>According to preliminary clinical research, phosphatidylcholine supplementation may not help with:<\/p>\n<ul>\n<li>Acute viral hepatitis (hepatitis A) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8824659\">R<\/a>]<\/li>\n<li>Tardive dyskinesia (a movement disorder) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2864962\">R<\/a>]<\/li>\n<\/ul>\n<h2><span id=\"Phosphatidylcholine_Side_Effects_Precautions\"><b>Phosphatidylcholine Side Effects &amp; Precautions<\/b><\/span><\/h2>\n<p><i>This list does not cover all possible side effects. Contact your doctor or pharmacist if you notice any other side effects. In the US, you may report side effects to the FDA at 1-800-FDA-1088 or at <\/i><a href=\"http:\/\/www.fda.gov\/medwatch\"><i>www.fda.gov\/medwatch<\/i><\/a><i>. In Canada, you may report side effects to Health Canada at 1-866-234-2345.<\/i><\/p>\n<p>Phosphatidylcholine was safe and well-tolerated in most clinical trials. In a smaller number of patients, it caused side effects such as [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4466850\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24796768\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20048683\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17975182\"> R<\/a>]:<\/p>\n<ul>\n<li>sweating<\/li>\n<li>stomach upset<\/li>\n<li>diarrhea<\/li>\n<li>nausea<\/li>\n<li>vomiting<\/li>\n<\/ul>\n<p>Unlike most supplements, PC appears to be safe for pregnant women, <b>but they should consult a doctor before supplementing<\/b>.<\/p>\n<p>PC injections are possibly safe when used in recommended intervals and doses. Possible side effects include [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17177743\">R<\/a>] :<\/p>\n<ul>\n<li>irritation<\/li>\n<li>swelling<\/li>\n<li>redness<\/li>\n<li>itching<\/li>\n<li>burning<\/li>\n<li>bruising<\/li>\n<li><a href=\"https:\/\/selfhacked.com\/blog\/23-ways-to-combat-pain-naturally-by-increasing-your-opioids\/\">pain<\/a><\/li>\n<li>dizziness<\/li>\n<\/ul>\n<p>Phosphatidylcholine injections directly in fat deposits may cause inflammation or tissue death (necrosis). The safety of long-term use is uncertain [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18370980\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22418769\"> R<\/a>].<\/p>\n<p>Phosphatidylcholine injections directly in fat deposits should be avoided by pregnant women and people with heart disease, kidney disease, uncontrolled diabetes or<a href=\"https:\/\/selfhacked.com\/blog\/low-thyroid-hormones-low-t3-syndrome\/\"> hypothyroidism<\/a>, infections, active or previous autoimmune disease, or active skin disorders [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3486781\/\">R<\/a>].<\/p>\n<h3><span id=\"The_Risk_of_Heart_Disease\"><b>The Risk of Heart Disease<\/b><\/span><\/h3>\n<p>Byproducts of dietary phosphatidylcholine include <a href=\"https:\/\/selfhacked.com\/blog\/tmao\/\">trimethylamine N-oxide<\/a> (<a href=\"https:\/\/selfhacked.com\/blog\/tmao\/\">TMAO<\/a>), which may increase the risk of atherosclerosis and heart disease in excessive amounts [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3086762\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4526767\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23614584\"> R<\/a>].<\/p>\n<p>However, the link between TMAO and heart disease is controversial and still debated in the scientific literature.<\/p>\n<p>PC supplementation increased blood triglyceride levels in a study of 26 participants. However, in that same study, PC decreased<a href=\"https:\/\/selfhacked.com\/blog\/optimal-homocysteine-levels-increase-decrease\/\"> homocysteine<\/a>, which is a potential risk factor for heart disease [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15916468\">R<\/a>].<\/p>\n<p><b>Further studies should cast more light on the conflicting effects of phosphatidylcholine supplementation on heart health.<\/b><\/p>\n<h2><span id=\"Phosphatidylcholine_Supplements_and_Dosage\"><b>Phosphatidylcholine Supplements and Dosage<\/b><\/span><\/h2>\n<p><i>PC supplements have not been approved by the FDA for medical use. In general, regulatory bodies aren\u2019t assuring the quality, safety, and efficacy of supplements. Speak with your doctor before supplementing.<\/i><\/p>\n<p><i>The below doses may not apply to you personally. If your doctor suggests using PC, work with them to find the optimal dosage according to your health condition and other factors.<\/i><\/p>\n<p>Phosphatidylcholine can be administered in capsules, tablets, and injections.<\/p>\n<p>Clinical studies have used various oral phosphatidylcholine doses, ranging from <b>0.5-4 g per day<\/b> for up to 12 weeks [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15951544\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17975182\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20048683\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24796768\"> R<\/a>].<\/p>\n<p>Phosphatidylcholine injections for fat reduction contain between 40 cc and 60 cc [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3486781\/\">R<\/a>].<\/p>\n<h3><span id=\"User_Experiences\"><b>User Experiences<\/b><\/span><\/h3>\n<p><i>The opinions expressed in this section are solely from the users who may or may not have a medical background. SelfDecode does not endorse any specific product, service, or treatment. Do not consider user experiences as medical advice. Never delay or disregard seeking professional medical advice because of something you have read on SelfDecode.<\/i><\/p>\n<p>One user reported that using phosphatidylcholine for a few years reversed his fatty liver and returned his high liver enzymes back to normal.<\/p>\n<p>Another user reported that over a period of nearly two months their belly fat \u201cdecreased tremendously.\u201d<\/p>\n<p>One user who took phosphatidylcholine for three years had outstanding results. They said that the difference for memory boost and overall health.<\/p>\n<p>A user who received phosphatidylcholine injections said they were rushed to the ER twice due to low blood pressure after the therapy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Phosphatidylcholine is a key component of our cells. Increased intake may improve mental, liver, and gut health, but the available clinical evidence is weak. Phosphatidylcholine injections are used for reducing fat deposits. Read more about its benefits, dosage, and side effects.<\/p>\n","protected":false},"author":15399,"featured_media":69542,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[22],"tags":[279],"yst_prominent_words":[26728,1354,1037,26724,26723,13247,1744,13246,1737,26726,26721,13250,26722,26725,26727,511,515,529,593,598],"_links":{"self":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/44399"}],"collection":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/users\/15399"}],"replies":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/comments?post=44399"}],"version-history":[{"count":25,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/44399\/revisions"}],"predecessor-version":[{"id":112985,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/44399\/revisions\/112985"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media\/69542"}],"wp:attachment":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media?parent=44399"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/categories?post=44399"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/tags?post=44399"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/yst_prominent_words?post=44399"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}