Some users claim that you can improve your memory with Prl-8-53, the brain-boosting \u201csmart\u201d supplement. There is a lot of information across the internet that spreads the hype behind this potential nootropic drug. But is it backed by science? Read on to find out.<\/p>\n
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Prl-8-53 is a research compound that was first created in the 1970s. Its full scientific name is methyl 3-(2-(benzyl (methyl) amino) ethyl) benzoate.<\/p>\n
It is popular as a nootropic<\/a> supplement that is believed to boost cognitive function and memory.<\/p>\n Despite positive anecdotal experiences from some users, there is only one human study and one rat study on Prl-8-53, which were both were done in the 1970s. In addition, there currently is no ongoing research on this compound [R<\/a>, R<\/a>].<\/p>\n Prl-8-53\u2019s mechanisms of actions are unknown. According to some researchers, it may enhance the brain activity of acetylcholine<\/a>, a neurotransmitter that plays a role in learning and memory [R<\/a>].<\/p>\n In addition, some researchers suggest that Prl-8-53 may increase dopamine<\/a> levels, which play a role in memory, motivation<\/a>, and fatigue. It may also block serotonin<\/a> production, which plays a role in anxiety<\/a>, depression<\/a>, and insomnia [R<\/a>, R<\/a>].<\/p>\n However, the human study did not directly study these changes in neurotransmitter levels [R<\/a>].<\/p>\n Prl-8-53 has only been studied in one clinical trial that was performed in 1978, which was funded by the developer of the compound. This clinical trial was a double-blind randomized controlled study of 47 healthy adults who took a 5 mg dose of Prl-8-53 [R<\/a>].<\/p>\n According to the study, those who took Prl-8-53 were able to better recall test questions in a word recollection test than the ones who took a placebo pill. Most patients were able to better recite the correct order of words up to 4 days after listening to the words [R<\/a>].<\/p>\n Researchers also found that those who struggled in the recollection test on placebo (below 50% correct) showed significant improvement with Prl-8-53. However, average and high scoring participants didn\u2019t improve significantly [R<\/a>].<\/p>\n One rat study has also examined the effects of Prl-8-53. This study used an avoidance learning test to study Prl-8-53\u2019s memory effects. The avoidance learning test studies how well a rat can remember a response to avoid a stressful situation. The study found that rats had improved memory after Prl-8-53 supplementation [R<\/a>].<\/p>\n No other studies have looked at the effects of Prl-8-53.<\/p>\n Due to a lack of research, the safety of Prl-8-53 is unknown.<\/p>\n In the only human study of Prl-8-53 that has been conducted, a 5 mg dosage did not cause any side effects [R<\/a>].<\/p>\n However, higher Prl-8-53 doses may impair movement, according to a rat study [R<\/a>].<\/p>\n Due to a lack of research, it is unknown how Prl-8-53 may interact with other drugs. If you do take this compound, let your doctor know.<\/p>\n<\/a>Mechanism of Action<\/span><\/h3>\n
<\/a>Effects of Prl-8-53<\/span><\/h2>\n
<\/a>Insufficient Evidence For:<\/span><\/h3>\n
<\/a>Improved Memory<\/h4>\n
<\/a>Side Effects<\/span><\/h2>\n
<\/a>Drug Interactions<\/span><\/h3>\n