{"id":42742,"date":"2019-11-26T13:25:01","date_gmt":"2019-11-26T21:25:01","guid":{"rendered":"https:\/\/selfhacked.com\/?p=42742"},"modified":"2021-09-20T09:19:08","modified_gmt":"2021-09-20T16:19:08","slug":"substance-p-roles","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/substance-p-roles\/","title":{"rendered":"7 Proven Roles of Substance P & Its Associated Diseases"},"content":{"rendered":"

Substance P is a neuropeptide (neurotransmitter) most known for its role in pain<\/a> perception. It also has a wide range of effects in nausea, stress<\/a> responses, emotional behavior, learning, and memory.<\/p>\n

However, although substance P is important for survival, excess levels are harmful and can lead to a variety of diseases. Read more to learn about what conditions are associated with high and low levels of substance P and how to increase and decrease it.<\/p>\n

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What is Substance P?<\/span><\/h2>\n

Substance P was first isolated from horse brain and gut extracts in the 1930s as a mystery substance with strong blood pressure-lowering and smooth muscle contractile properties [R<\/a>].<\/p>\n

Because it was in powdered form, it was named substance P (\u201cP\u201d for powder) [R<\/a>].<\/p>\n

Today, it is fully recognized as a neurotransmitter that is widely dispersed throughout the body, with high levels in the brain, gut, and spinal cord [R<\/a>, R<\/a>].<\/p>\n

Function<\/span><\/h3>\n

Because of its broad distribution in the body, substance P influences a diverse range of functions. It also amplifies or excites most cellular processes [R<\/a>].<\/p>\n

Substance P is involved in:<\/p>\n