{"id":42428,"date":"2019-11-26T10:00:22","date_gmt":"2019-11-26T18:00:22","guid":{"rendered":"https:\/\/selfhacked.com\/?p=42428"},"modified":"2021-09-20T09:19:07","modified_gmt":"2021-09-20T16:19:07","slug":"hordenine-benefits","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/hordenine-benefits\/","title":{"rendered":"Health Benefits of Hordenine + Side Effects &#038; Dosage"},"content":{"rendered":"<p>Hordenine is mainly found in barley and bitter orange. For this reason, drinking beer may raise blood hordenine levels. Very limited research in animals and cells suggests it may help increase energy and focus or whiten the skin. However, taking too much hordenine may cause false positives in drug tests and produce a variety of negative side effects. Read below to learn more about this barley compound.<!--more--><\/p>\n<h2><span id=\"What_Is_Hordenine\"><a id=\"post-42428-_8vj5kb4w3j89\"><\/a><strong>What Is Hordenine?<\/strong><\/span><\/h2>\n<p>Hordenine, otherwise known as N, N-dimethyltyramine, is an alkaloid mainly found in plants used as feed for animals, such as barley. Indeed, its name comes from the Latin name for barley (<em>hordeum<\/em>) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8582256\">R<\/a>].<\/p>\n<p>It is <em>adrenergic<\/em>, meaning <strong>it causes brain cells to release the neurotransmitters<\/strong> <strong>epinephrine (adrenaline) and<\/strong><a href=\"https:\/\/selfhacked.com\/blog\/norepinephrine-stress-hormone\/\"><strong> norepinephrine<\/strong><\/a><strong> (noradrenaline)<\/strong>. These neurotransmitters increase energy and focus and are part of the \u201cfight-or-flight\u201d response [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8582256\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3056281\/\"> R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1959222\/\"> R<\/a>].<\/p>\n<p>Several scandals involving racing horses given food containing hordenine to improve their performance have come to light. However, the slight increase in performance caused by hordenine is deemed insufficient to be considered cheating in most countries [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8582256\">R<\/a>].<\/p>\n<p>This is mainly because hordenine\u2019s effects are short-lived and a very high concentration of hordenine is needed to bring about any noticeable effects [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8582256\">R<\/a>].<\/p>\n<p>In Canada, however, it is considered illegal and horses are not allowed to eat hordenine-rich diets [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2269269\">R<\/a>].<\/p>\n<p><strong>Hordenine can be used to measure beer consumption<\/strong>, as hordenine levels in the blood increase significantly following consumption. For instance, a study suggested its use in forensic toxicology [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26869341\">R<\/a>].<\/p>\n<h3><span id=\"Food_Sources_of_Hordenine\"><a id=\"post-42428-_vlhj69tj9xl0\"><\/a><strong>Food Sources of Hordenine<\/strong><\/span><\/h3>\n<p>The main sources are:<\/p>\n<ul>\n<li>Bitter orange [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18425642\">R<\/a>]<\/li>\n<li>Barley (more commonly beer brewed from this cereal) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6533024\">R<\/a>]<\/li>\n<\/ul>\n<h3><span id=\"Snapshot\"><a id=\"post-42428-_t8cgdixv3t2q\"><\/a><strong>Snapshot<\/strong><\/span><\/h3>\n<h4><a id=\"post-42428-_i2lsfhrwjez\"><\/a><strong>Proponents<\/strong><\/h4>\n<ul>\n<li>Potential use to enhance alertness, energy, and focus<\/li>\n<li>Potential use to help with diabetes<\/li>\n<li>Potential use in skincare products<\/li>\n<li>Potential use as antimicrobial<\/li>\n<\/ul>\n<h4><a id=\"post-42428-_d5wbmv2jz6yh\"><\/a><strong>Skeptics<\/strong><\/h4>\n<ul>\n<li>Lack of clinical trials<\/li>\n<li>Unknown safety profile<\/li>\n<li>May cause the buildup of other neurotransmitters<\/li>\n<li>May cause blood pressure fluctuations<\/li>\n<li>May cause seizures<\/li>\n<li>May reduce UV protection<\/li>\n<li>May damage the kidneys<\/li>\n<li>May test positive for opioids<\/li>\n<\/ul>\n<h2><span id=\"Health_Benefits_of_Hordenine\"><a id=\"post-42428-_xu0a7k7s0r8x\"><\/a><strong>Health Benefits of Hordenine<\/strong><\/span><\/h2>\n<h3><span id=\"Animal_and_Cell_Research_Lack_of_Evidence\"><a id=\"post-42428-_v3xeiu4eopns\"><\/a><strong>Animal and Cell Research Lack of Evidence<\/strong><\/span><\/h3>\n<p>No clinical evidence supports the use of hordenine for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies should not be interpreted as supportive of any health benefit.<\/p>\n<aside class=\"sh-partner shp-form sponsored sh-et-7388fa\">\n  <div>\n          <div class=\"partner-heading\">Get the Regimen of A Top Biohacker<\/div>\n    \n    <div class=\"partner-content\">\n      <p><span style=\"font-weight: 400\">Joe Cohen is well-known for his work as a successful entrepreneur in the health field after he overcame his many health issues using a personalized regimen. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health.\u00a0<\/span><\/p>\n    <\/div>\n\n    <div class=\"subscribe-form-container\">\n      <form method=\"POST\" action=\"\/wp-json\/wp\/v2\/posts\/42428\" class=\"sh-subscribe-form\">\n        <input type=\"email\" name=\"subscribe_form_data[email]\"\n            pattern=\"^[a-zA-Z0-9.!#$%&\u2019*+\/=?^_`{|}~-]+@[a-zA-Z0-9-]+(?:\\.[a-zA-Z0-9-]+)*$\" required\n            placeholder=\"Enter your email\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: PartnerAd Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"PartnerAd\">\n                <button type=\"submit\" class=\"btn btn-primary subscribe-submit\">Get The Regimen<\/button>\n      <\/form>\n    <\/div>\n  <\/div>\n          <style>aside.sponsored.sh-et-7388fa::before{content:\"Advertisement\"}<\/style>\n<\/aside>\n<h3><span id=\"1_Increasing_Alertness_Energy_and_Focus\"><a id=\"post-42428-_d8rpdme4tcnk\"><\/a><strong>1) Increasing Alertness, Energy, and Focus<\/strong><\/span><\/h3>\n<p><strong>Horses injected with hordenine (intravenously) showed increased alertness within two minutes<\/strong>. A 100% increase in heart and breathing rate accompanied this increased alertness. However, the effect only lasted 20 minutes and wasn\u2019t observed when hordenine was given by mouth [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2269269\">R<\/a>].<\/p>\n<p><strong>Hordenine increased response to noradrenaline in rats by 65%<\/strong>. A similar effect was also seen in guinea pigs. Indeed, hordenine didn\u2019t increase alertness by itself, but by preventing noradrenaline removal [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2570842\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/4302376\"> R<\/a>].<\/p>\n<p>Because hordenine increases response to noradrenaline, some effects of this neurotransmitter, such as<strong> increased energy and focus,<\/strong> are possible after hordenine consumption. However, no clinical trials have been conducted [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3548657\/\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2621122\/\"> R<\/a>].<\/p>\n<h3><span id=\"2_Diabetes\"><a id=\"post-42428-_ybzij7sdoz75\"><\/a><strong>2) Diabetes<\/strong><\/span><\/h3>\n<p>In diabetic mice, hordenine <strong>enhanced the effectiveness of insulin at reducing blood sugar levels<\/strong> before and after a meal. Additionally, it <strong>prevented kidney damage<\/strong> by reducing tissue scar, inflammation, and oxidative damage [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29775900\">R<\/a>].<\/p>\n<h3><span id=\"3_Skin_Appearance\"><a id=\"post-42428-_lb6gdxarc52k\"><\/a><strong>3) Skin Appearance<\/strong><\/span><\/h3>\n<p>When melanin, a skin pigment, is overproduced, it can cause several skin disorders such as freckles, age spots, and melasma (brown patches on the face) [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23768344\">R<\/a>].<\/p>\n<p><strong>Hordenine decreased melanin production in human cells by 30%<\/strong>. It achieved this by inhibiting cAMP production, which is responsible for expressing proteins needed to create melanin [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23768344\">R<\/a>].<\/p>\n<h3><span id=\"4_Antibacterial\"><a id=\"post-42428-_5hc2b85t2c0d\"><\/a><strong>4) Antibacterial<\/strong><\/span><\/h3>\n<p>In test tubes, hordenine <strong>prevented the following bacteria that often cause hospital-acquired infections from forming biofilms<\/strong>:<\/p>\n<ul>\n<li>Pseudomonas aeruginosa [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29155399\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29353476\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30128579\">R<\/a>]<\/li>\n<li>Serratia marcescens [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/30609368\">R<\/a>]<\/li>\n<\/ul>\n<p>Note, however, that these are very preliminary results that haven\u2019t been replicated in humans and even in animals. Further research is needed to determine if hordenine may be of any use in preventing and treating infections caused by these microorganisms.<\/p>\n<h2><span id=\"Hordenine_Side_Effects_Limitations_Dosage\"><a id=\"post-42428-_6veq17t8mx0c\"><\/a><strong>Hordenine Side Effects, Limitations &amp; Dosage<\/strong><\/span><\/h2>\n<p>Keep in mind that the safety profile of hordenine is unknown, given the lack of clinical studies. The list of side effects below is not a definite one and you should consult your doctor about other potential side effects based on your health condition and possible drug or supplement interactions<em>.<\/em><\/p>\n<h3><span id=\"1_May_Reduce_the_Breakdown_of_Other_Neurotransmitters\"><a id=\"post-42428-_ptot13ehcrp2\"><\/a><strong>1) May Reduce the Breakdown of Other Neurotransmitters<\/strong><\/span><\/h3>\n<p>Monoamine oxidase-B (<a href=\"https:\/\/selfdecode.com\/gene\/maob\/?utm_source=seo&amp;utm_medium=selfhacked&amp;utm_campaign=id00002\">MAO-B<\/a>) inactivates hordenine. MAO-B is responsible for inactivating other neurotransmitters such as<a href=\"https:\/\/selfhacked.com\/blog\/dopamine\/\"> dopamine<\/a> and phenylethylamine. When MAO-B is busy breaking down hordenine, it may cause other neurotransmitters to build up [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2570842\">R<\/a>,<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10389141\"> R<\/a>].<\/p>\n<p>Dopamine buildup can cause increased reactivity to<a href=\"https:\/\/selfhacked.com\/blog\/63-factors-raising-stress-cortisol-level-backed-science\/\"> stress<\/a> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10389141\">R<\/a>].<\/p>\n<h3><span id=\"2_May_Cause_Fluctuations_In_Blood_Pressure\"><a id=\"post-42428-_m23rhftne6fn\"><\/a><strong>2) May Cause Fluctuations In Blood Pressure<\/strong><\/span><\/h3>\n<p>In cats, hordenine initially decreased blood pressure, but this was followed by a large spike. Afterward, blood pressure fluctuated from lower to higher values [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1395273\/\">R<\/a>].<\/p>\n<p><strong>People sensitive to blood pressure changes should probably avoid hordenine<\/strong>.<\/p>\n<h3><span id=\"3_May_Cause_Seizures\"><a id=\"post-42428-_r9li5c2aqyi5\"><\/a><strong>3) May Cause Seizures<\/strong><\/span><\/h3>\n<p><strong>Hordenine increased seizures <\/strong>(measured by knee jerks) in cats [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1395273\/\">R<\/a>].<\/p>\n<p>It is a cholinesterase inhibitor, meaning it keeps the enzyme cholinesterase from breaking down<a href=\"https:\/\/selfhacked.com\/blog\/acetylcholine\/\"> acetylcholine<\/a>. Acetylcholine carries the signals from nerve cells, which for instance allows movement. By preventing cholinesterase from breaking down acetylcholine, the body cannot naturally stop moving and may keep convulsing [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1395273\/\">R<\/a>].<\/p>\n<h3><span id=\"4_May_Decrease_Protection_from_UV_Radiation\"><a id=\"post-42428-_kmcr1qmm1xcg\"><\/a><strong>4) May Decrease Protection from UV Radiation<\/strong><\/span><\/h3>\n<p>Melanin protects human skin by absorbing free radicals and preventing<a href=\"https:\/\/selfhacked.com\/blog\/avoiding-sun-will-kill-14-proven-science-based-health-benefits-sun\/\"> UV<\/a> damage.<strong> Because hordenine may decrease melanin production, it can increase UV damage<\/strong>. In people without melanin overproduction (hyperpigmentation), hordenine may do more harm than good [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23768344\">R<\/a>].<\/p>\n<h3><span id=\"5_May_Damage_the_Kidneys\"><a id=\"post-42428-_90zxeh9dbix4\"><\/a><strong>5) May Damage the Kidneys<\/strong><\/span><\/h3>\n<p><strong>Voles fed high doses of hordenine-containing foods developed damage in a region of the kidneys <\/strong>(the proximal tubules). Glycosuria, a disease in which <a href=\"https:\/\/selfhacked.com\/blog\/glucose\/\">glucose<\/a> is released from the kidneys into the urine, occurred in 62% of the voles [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7020159\">R<\/a>].<\/p>\n<p><strong>People with kidney issues may want to avoid hordenine.<\/strong><\/p>\n<h3><span id=\"6_May_Cause_False_Positives_in_Drug_Testing\"><a id=\"post-42428-_7vsqk0o463o8\"><\/a><strong>6) May Cause False Positives in Drug Testing<\/strong><\/span><\/h3>\n<p><strong>Hordenine can cause false positives in the following drug tests for<\/strong> opioids [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1618458\">R<\/a>]:<\/p>\n<ul>\n<li>Morphine<\/li>\n<li>Oxymorphone<\/li>\n<li>Hydromorphone<\/li>\n<li>Apomorphine<\/li>\n<\/ul>\n<p>The main cause of high blood hordenine levels in humans is beer consumption. <strong>People who need to take opioid drug tests on a regular basis should avoid hordenine supplements and cut down on their beer consumption<\/strong> [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/1618458\">R<\/a>].<\/p>\n<h3><span id=\"Dosage\"><a id=\"post-42428-_tr5wfufyovr7\"><\/a><strong>Dosage<\/strong><\/span><\/h3>\n<p>Because hordenine is not approved by the FDA for any condition, <strong>there is no official dose<\/strong>. Additionally, the lack of clinical trials means there is no <em>proven <\/em>dose either. Users and supplement manufacturers have established unofficial doses based on trial and error. Discuss with your doctor if hordenine may be useful as a complementary approach in your case and which dose you should take.<\/p>\n<p>A hordenine capsule supplement recommends taking one capsule of hordenine (50 mg) with each meal [<a href=\"https:\/\/www.bodybuilding.com\/store\/live\/hordenine.html?skuId=LIVE007&amp;PLASKU=LIVE007&amp;mcid=CG_PLA_US_GS_livelong_nutrition&amp;bbdevice=c&amp;bbtargetid=120147270000105021&amp;catargetid=120147270000105021&amp;cadevice=c&amp;gclid=CjwKCAjwjJjOBRBVEiwAfvnvBLOVM_uPRRN4uITQghUl97u6xM4a2KQlAFbeIi8U2OL43pqNE8WDmBoCbuwQAvD_BwE\">R<\/a>].<\/p>\n<p>One study gave cats 5 mg\/kg of hordenine without noticing any health effects and considered 10-30 mg\/kg as \u2018high\u2019 doses [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1395273\/\">R<\/a>].<\/p>\n<h3><span id=\"Limitations_and_Caveats\"><a id=\"post-42428-_9jc3tbmjweye\"><\/a><strong>Limitations and Caveats<\/strong><\/span><\/h3>\n<p>Because there are no clinical tests on hordenine yet, there is no data on its potential health benefits and adverse effects in humans. More extensive testing is needed to confirm its preliminary results in animals.<\/p>\n<h2><span id=\"User_Reviews\"><a id=\"post-42428-_aylvpsaxc3i3\"><\/a><strong>User Reviews<\/strong><\/span><\/h2>\n<p><em>The opinions expressed in this section are solely those of hordeine users, who may or may not have medical or scientific training. Their reviews do not represent the opinions of SelfHacked. SelfHacked does not endorse any specific product, service, or treatment.<\/em><\/p>\n<p><em>Do not consider user experiences as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare providers because of something you have read on SelfHacked. We understand that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.<\/em><\/p>\n<p>There are not many reviews out for hordenine, as its usage as a supplement is limited. One satisfied user claimed that hordenine provided them with energy throughout the day and gave.<\/p>\n<p>Another user noted that it provided \u201cserious stimulation\u201d and increased well-being and pleasure without being addictive. He strongly recommended the supplement.<\/p>\n<p>One reviewer recommended taking the supplement along with other pre-workout supplements.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hordenine is mainly found in barley and bitter orange. For this reason, drinking beer may raise blood hordenine levels. Very limited research in animals and cells suggests it may help increase energy and focus or whiten the skin. However, taking too much hordenine may cause false positives in drug tests and produce a variety of negative side effects. Read below to learn more about this barley compound.<\/p>\n","protected":false},"author":14687,"featured_media":42759,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[20303,15594],"tags":[279],"yst_prominent_words":[28180,28186,28182,501,809,28184,28167,28165,5132,15462,15459,28185,28179,28183,28178,26597,28181,511,515,598],"_links":{"self":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/42428"}],"collection":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/users\/14687"}],"replies":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/comments?post=42428"}],"version-history":[{"count":17,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/42428\/revisions"}],"predecessor-version":[{"id":112038,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/42428\/revisions\/112038"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media\/42759"}],"wp:attachment":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media?parent=42428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/categories?post=42428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/tags?post=42428"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/yst_prominent_words?post=42428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}