{"id":26618,"date":"2019-12-09T05:15:31","date_gmt":"2019-12-09T13:15:31","guid":{"rendered":"https:\/\/selfhacked.com\/?p=26618"},"modified":"2021-09-20T09:18:18","modified_gmt":"2021-09-20T16:18:18","slug":"c-butyricum","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/c-butyricum\/","title":{"rendered":"Top 3+ Health Benefits of Clostridium butyricum Probiotics"},"content":{"rendered":"

Clostridium butyricum<\/em> is a potentially beneficial gut bacterium that may promote gut health and suppress H. pylori<\/em>, but there may be some safety concerns. Learn more here.<\/p>\n

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<\/a>What is Clostridium butyricum<\/em>?<\/strong><\/span><\/h2>\n

Clostridium butyricum<\/em> is a butyric acid-producing, Gram-positive bacteria found in soil and the intestines of healthy animals and humans (R<\/a>).<\/p>\n

Butyrate<\/a> (butyric acid) is a short-chain fatty acid (SCFA) that serves as energy for colonic epithelial cells, plays a key role in maintaining gut immunological homeostasis, and exerts anti-inflammatory effect (R<\/a>).<\/p>\n

Furthermore, butyrate is not restricted to the intestinal tract but can be disseminated systemically and is detected in the brain. Butyrate in the brain can exert neuroprotective effects on neurodegenerative disorders and improve behavioral deficits via the inhibition of histone deacetylases (HDACs) (R<\/a>).<\/p>\n

Clinical research about C. butyricum<\/em> is still pretty limited, but you can check out the benefits of butyrate here<\/a>.<\/p>\n

C. butyricum<\/em> has been used as a probiotic<\/a> for non-antimicrobial induced diarrhea, antimicrobial-associated diarrhea, constipation, and irritable bowel syndrome (R<\/a>).<\/p>\n

Tablets containing C. butyricum<\/em> were approved from the Japanese Ministry of Health and Welfare for human clinical use since 1970 (R<\/a>) and are widely used in Asia.<\/p>\n

<\/a>Health Benefits of C. butyricum<\/em><\/strong><\/span><\/h2>\n

C. butyricum<\/em> probiotic supplements have not been approved by the FDA for medical use. Supplements generally lack solid clinical research. Regulations set manufacturing standards for them but don’t guarantee that they’re safe or effective. Speak with your doctor before supplementing.<\/p>\n

<\/a>Possibly Effective For<\/span><\/h3>\n

<\/a>1) Gut Health<\/h4>\n
<\/a>Diarrhea<\/h5>\n

Concomitant administration of C. butyricum<\/em> with antibiotics normalizes the intestinal microbiota, prevents the decrease of Bifidobacteria, effectively prevented antibiotic-associated diarrhea in 110 children (R<\/a>).<\/p>\n

<\/a>IBD<\/h5>\n

In 80 ulcerative colitis<\/a> (UC<\/a>) patients with food allergy, specific immunotherapy (SIT) and C. butyricum<\/em> significantly improved UC clinical symptoms, reduced the use of UC-control medicines, and suppressed the Th2<\/a> response (R<\/a>).<\/p>\n

Probiotic therapy with C. butyricum<\/em> achieved favorable results with minimal side effects in 17 pouchitis in patients with UC who had undergone ileal pouch-anal anastomosis (IPAA) (R<\/a>).<\/p>\n

<\/a>Mouse Studies<\/h5>\n

C. butyricum<\/em> prevents acute colitis<\/strong> in mice through induction of IL-10<\/a>, an anti-inflammatory cytokine (R<\/a>).<\/p>\n

C. butyricum<\/em> effectively prevents bloody diarrhea and mucosal damage<\/strong> in rats with IBD, with or without prebiotics (R<\/a>, R<\/a>).<\/p>\n

C. butyricum<\/em> increases Lactobacilli and Eubacterium<\/em>, increases n-butyrate, propionate, and acetate concentrations, and alleviates colitis in rats (R<\/a>).<\/p>\n

Treatment with C. butyricum<\/em> is at least as efficient as treatment with mesalamine in rats with colitis (R<\/a>).<\/p>\n

C. butyricum<\/em> beneficially modifies the intestinal microbiota<\/a> in mice by increasing Bifidobacteria <\/em>and Lactobacilli <\/em>and reducing the populations of unwanted bacteria (R<\/a>).<\/p>\n

C. butyricum<\/em> increased survival in E. coli<\/em> infected mice (R<\/a>).<\/p>\n