{"id":26573,"date":"2019-11-29T15:57:18","date_gmt":"2019-11-29T23:57:18","guid":{"rendered":"https:\/\/selfhacked.com\/?p=26573"},"modified":"2021-09-20T09:18:17","modified_gmt":"2021-09-20T16:18:17","slug":"b-animalis","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/b-animalis\/","title":{"rendered":"9+ Benefits of Bifidobacterium animalis (B. lactis)"},"content":{"rendered":"<p><em>B. animalis <\/em>(especially its subspecies <em>B. lactis<\/em>) is an important component of the healthy gut flora. It may promote GI well-being, especially in children, and some evidence suggests it may help the body prevent and fight off infections. What else could it do? Read on to find out.<\/p>\n<p><!--more--><\/p>\n<h2><span id=\"What_is_Bifidobacterium_animalis\"><strong>What is <em>Bifidobacterium animalis<\/em>?<\/strong><\/span><\/h2>\n<p><em>Bifidobacterium animalis<\/em> is a gram-positive rod-shaped bacterium which can be found in the gut of most mammals, including humans. It is considered to be part of the healthy, beneficial gut flora [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4908950\/\">R<\/a>].<\/p>\n<p><em>B. lactis <\/em>was previously considered to be a separate species but was shown to be a subspecies of <em>B. animalis<\/em> (hence <em>B. animalis<\/em> ssp. <em>lactis<\/em>) (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15280282\">R<\/a>), and therefore it is addressed as such in this post. Note that most of the research mentioned below were carried out with this subspecies<em>.<\/em><\/p>\n<h2><span id=\"Potential_Benefits_of_B_animalis\"><strong>Potential Benefits of <em>B. animalis<\/em><\/strong><\/span><\/h2>\n<p><em>B. animalis<\/em> probiotic supplements have not been approved by the FDA for medical use and generally lack solid clinical research. Regulations set manufacturing standards for them but don&#8217;t guarantee that they&#8217;re safe or effective. Speak with your doctor before supplementing.<\/p>\n<h3><span id=\"Possibly_Effective_For\"><strong>Possibly Effective For<\/strong><\/span><\/h3>\n<h4>1) Gut Health<\/h4>\n<h5>Diarrhea and Constipation<\/h5>\n<p><em>B. lactis<\/em> milk formula administered to 50 children with acute diarrhea <strong>decreased the frequency, duration of diarrhea<\/strong>, and hospital stay (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4877827\/\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> spp. <em>lactis<\/em> <strong>prevented acute diarrhea<\/strong> in 90 infants (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15076628\">R<\/a>).<\/p>\n<p>Treatment with <em>B. animalis<\/em> spp. <em>lactis<\/em> and inulin shortened the duration of acute diarrhea in 156 children. The benefits were most pronounced in cases of <em>Rotavirus <\/em>diarrhea (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25599772\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> spp. <em>lactis<\/em> together with <em>Streptococcus thermophilus<\/em> reduced the frequency of antibiotic-associated diarrhea (AAD) in 80 infants (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15815206\">R<\/a>).<\/p>\n<p>Ingestion of fresh cheese enriched with <em>B. animalis<\/em> spp. <em>lactis<\/em> showed <strong>beneficial effects on <\/strong><a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"><strong>constipation<\/strong><\/a> symptoms in women (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24322191\">R<\/a>).<\/p>\n<p>Fermented milk containing<em> B. animalis<\/em> spp. <em>lactis <\/em>had beneficial effects on stool frequency, defecation condition and stool consistency in 135 adult women with constipation (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2761588\/\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> increased Bifidobacteria and <strong>improved constipation<\/strong> in 17 human subjects (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22284965\">R<\/a>).<\/p>\n<h5>IBS<\/h5>\n<p><em>B. animalis<\/em> had a <strong>beneficial effect on discomfort, bloating and constipation<\/strong> in 274 constipation-predominant <a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\">IBS<\/a> patients (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17635382\">R<\/a>).<\/p>\n<p><em>B animalis<\/em> spp. <em>lactis <\/em>significantly improved objectively measured abdominal girth and gastrointestinal transit, as well as <strong>reduced symptomatology in 34 IBS<\/strong> patients (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18801055\">R<\/a>).<\/p>\n<h5>H. pylori<\/h5>\n<p><em>B. animalis<\/em> spp. <em>lactis <\/em>and inulin significantly <strong>reduced treatment side effects<\/strong> and indirectly increased eradication rates by increasing patient compliance in 47 patients with symptomatic <em>H. pylori<\/em> infection (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26448408\">R<\/a>).<\/p>\n<aside class=\"sh-partner shp-form sponsored sh-et-7388fa\">\n  <div>\n          <div class=\"partner-heading\">Get the Regimen of A Top Biohacker<\/div>\n    \n    <div class=\"partner-content\">\n      <p><span style=\"font-weight: 400\">Joe Cohen is well-known for his work as a successful entrepreneur in the health field after he overcame his many health issues using a personalized regimen. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health.\u00a0<\/span><\/p>\n    <\/div>\n\n    <div class=\"subscribe-form-container\">\n      <form method=\"POST\" action=\"\/wp-json\/wp\/v2\/posts\/26573\" class=\"sh-subscribe-form\">\n        <input type=\"email\" name=\"subscribe_form_data[email]\"\n            pattern=\"^[a-zA-Z0-9.!#$%&\u2019*+\/=?^_`{|}~-]+@[a-zA-Z0-9-]+(?:\\.[a-zA-Z0-9-]+)*$\" required\n            placeholder=\"Enter your email\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: PartnerAd Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"PartnerAd\">\n                <button type=\"submit\" class=\"btn btn-primary subscribe-submit\">Get The Regimen<\/button>\n      <\/form>\n    <\/div>\n  <\/div>\n          <style>aside.sponsored.sh-et-7388fa::before{content:\"Advertisement\"}<\/style>\n<\/aside>\n<h5>Gut Microbiota<\/h5>\n<p><em>B. animalis<\/em> spp. <em>lactis <\/em>supplementation can increase Bifidobacteria and reduce <em>Enterobacteriaceae<\/em> and <em>Clostridium<\/em> in 324 infants (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4507410\/\">R<\/a>).<\/p>\n<h5><a id=\"post-26573-_4ygokkgq31df\"><\/a>Gut Discomfort<\/h5>\n<p>4 weeks\u2019 supplementation with <em>B. animalis<\/em> ssp. <em>lactis<\/em> resulted in a clinically relevant benefit on defecation frequency in 1248 healthy adults with abdominal discomfort (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4657032\/\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> spp. <em>lactis<\/em> <strong>improved digestive comfort<\/strong> and GI symptoms in 371 healthy adults (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19236549\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3171707\/\">R<\/a>).<\/p>\n<p>Probiotic fermented milk containing <em>B. animalis<\/em> spp. <em>lactis<\/em> by healthy women may <strong>improve GI well-being<\/strong> and decrease the frequency of GI symptoms (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26268077\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23480238\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19622191\">R<\/a>).<\/p>\n<h5><a id=\"post-26573-_x6wke3to1zzs\"><\/a>Gut Benefits in Animals<\/h5>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> <strong>protected against NSAID-induced GI side effects<\/strong> in rats and may prevent more serious GI mucosal damage and\/or enhance the recovery rate of the stomach mucosa (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3405648\/\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> <strong>improved colitis<\/strong> in mice (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2964251\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4900019\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20310012\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> spp. <em>lactis<\/em> exhibited anti-inflammatory effects and reduces the incidence of diarrhea in rats with colitis (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17897185\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> protected barrier functions by restoring intestinal permeability, colonic goblet cell populations, and cytokine levels. It also restores the Th1\/Th2 ratio by increasing the Th2 response in mice with chronic low-grade intestinal inflammation (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4858658\/\">R<\/a>).<\/p>\n<h4>2) Infections<\/h4>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> <strong>reduced days with cold\/flu<\/strong> in 30 young healthy adults (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26821116\">R<\/a>).<\/p>\n<p>109 infants and children receiving <em>B. animalis<\/em> ssp. <em>lactis<\/em> experienced <strong>fewer respiratory tract infections<\/strong> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26372517\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20863419\">R<\/a>).<\/p>\n<p>This probiotic did not, however, have an effect on the prevention of gastrointestinal and respiratory tract infections in daycare centers (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26031908\">R<\/a>) and hospitalized children (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25733653\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> protected mice and rats from <em>Toxoplasma gondii<\/em> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4826079\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20409588\">R<\/a>) and nematode parasite infections (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4085849\/\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> protected mice against <em>Salmonella<\/em> infection and reduced infection severity (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10832963\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24902954\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> reduced the severity of infection due to <em>E. coli<\/em> in mice (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11388612\">R<\/a>).<\/p>\n<h4>3) Infant Growth<\/h4>\n<p><em>B. animalis<\/em> spp. <em>lactis <\/em>s&#8217;upplementation had <strong>a positive effect on growth<\/strong> in 594 vulnerable infants, such as infants born to mothers with HIV (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19844090\">R<\/a>), and preterm infants (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18552710\">R<\/a>).<\/p>\n<h3><span id=\"Insufficient_Evidence_For\">Insufficient Evidence For<\/span><\/h3>\n<p>The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of <em>B. animalis<\/em> for any of the below listed uses. Remember to speak with a doctor before taking <em>B. animalis<\/em> supplements and should never be used as a replacement for approved medical therapies.<\/p>\n<h4>4) Obesity<\/h4>\n<p>Daily ingestion of milk containing <em>B. animalis<\/em> ssp. <em>lactis<\/em> significantly <strong>reduced the BMI, total cholesterol, low-density lipoprotein, and inflammatory markers<\/strong> in a study of 51 human patients with metabolic syndrome (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27126957\">R<\/a>).<\/p>\n<p>In the same study, <em>B. animalis<\/em> ssp. <em>lactis<\/em> significantly reduced BMI, total cholesterol, low-density lipoprotein and inflammatory cytokines (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27126957\">R<\/a>).<\/p>\n<p>The presence of <em>B. animalis<\/em> was also found to be <strong>negatively associated with BMI<\/strong> in two studies of a total of 378 human volunteers (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3826031\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3374072\/\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> reduced <a href=\"https:\/\/selfhacked.com\/blog\/a-comprehensive-list-of-effective-ways-to-lose-weight\/\">weight<\/a> gain, fat mass and improved glucose tolerance in obese mice (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25062610\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> <strong>improved glycemia<\/strong> and <strong>reduced <\/strong><a href=\"https:\/\/selfhacked.com\/blog\/insulin-101\/\"><strong>insulin<\/strong><\/a><strong> levels<\/strong> in obese rats (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24124012\">R<\/a>).<\/p>\n<h4>5) Anemia in Children<\/h4>\n<p>Milk with <em>B. animalis<\/em> ssp. <em>lactis<\/em> and prebiotic oligosaccharides <strong>reduced the risk of being anemic and iron deficient<\/strong> by 45% and increased weight gain by 0.13 kg\/year in 624 children from 1-4 years of age (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20601905\">R<\/a>).<\/p>\n<h4>6) Immunity<\/h4>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> <strong>augmented immunity<\/strong> in 26 healthy young women (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3265429\/\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> spp. <em>lactis <\/em>supplementation in pregnancy influenced fetal immune parameters as well as immunomodulatory factors in breast milk in 71 women (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18631345\">R<\/a>).<\/p>\n<p>In a study of 172 otherwise healthy infants, <em>B. animalis<\/em> ssp. <em>lactis<\/em> mitigated the negative immune-related effects of not breastfeeding and cesarean delivery, possibly by augmenting the immune response, evidenced by increased anti-rotavirus- and anti-poliovirus-specific IgA (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22237870\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> stimulated the immune response to vaccination in 211 healthy adults (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21899798\">R<\/a>).<\/p>\n<h4>7) Allergy<\/h4>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> significantly <strong>improved eczema<\/strong> symptoms in 27 infants (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11069570\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis <\/em>improved immune parameters, decreased <a href=\"https:\/\/selfhacked.com\/blog\/supplements-people-th2-dominant\/\">Th2<\/a> cytokines, and <strong>improved nasal symptoms in adult subjects suffering from seasonal allergic rhinitis<\/strong> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23299716\">R<\/a>).<\/p>\n<p><em>B animalis<\/em> skewed the <a href=\"https:\/\/selfhacked.com\/blog\/supplements-people-th1-dominant\/\">Th1<\/a>\/<a href=\"https:\/\/selfhacked.com\/blog\/supplements-people-th2-dominant\/\">Th2<\/a> balance towards <a href=\"https:\/\/selfhacked.com\/blog\/supplements-people-th1-dominant\/\">Th1<\/a> in mice with allergies (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2633237\/\">R<\/a>).<\/p>\n<h4>8) Inflammation<\/h4>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> added to yogurt post-fermentation had <strong>anti-inflammatory properties<\/strong> in 30 healthy adults (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26621631\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> inhibited inflammation in elderly volunteers (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16794305\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> reduced inflammatory and T cells mediators, promoted <a href=\"https:\/\/selfhacked.com\/blog\/treg\/\">regulatory T cells<\/a> specific markers, reduced weight loss, and attenuated epithelial damage in mice with colitis (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3027012\/\">R<\/a>).<\/p>\n<h4>9) Aging<\/h4>\n<p><em>B. animalis<\/em> spp. <em>lactis <\/em><strong>beneficially modified <\/strong><a href=\"https:\/\/selfhacked.com\/blog\/how-your-gut-microbiota-can-make-you-fat-or-thin\/\"><strong>gut microbiota<\/strong><\/a> in 20 elderly volunteers, by increasing Bifidobacteria, Lactobacilli, and Enterococci and reducing Enterobacteria (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17315077\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> spp. <em>lactis<\/em> <strong>enhanced natural immunity<\/strong> in 25 healthy elderly subjects (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10713750\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> spp. <em>lactis<\/em> increased leukocyte phagocytic and NK cell tumor-cell-killing activity in the elderly. Increases in the proportions of total, helper (CD4(+)), and activated (CD25(+)) T lymphocytes and <a href=\"https:\/\/selfhacked.com\/blog\/intro-natural-killer-cells-increase-decrease\/\">natural killer cells<\/a> were also observed (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11722966\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11114680\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4153077\/\">R<\/a>).<\/p>\n<h3><span id=\"Animal_Research_Lacking_Evidence\">Animal Research (Lacking Evidence)<\/span><\/h3>\n<p>No clinical evidence supports the use of <em>B. animalis<\/em> for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.<\/p>\n<h4>10) Diabetes<\/h4>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> reduced weight gain and fat mass and <strong>improves glucose tolerance<\/strong> in diabetic mice (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25062610\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> <strong>decreased fasting insulin and blood glucose<\/strong> and significantly improved insulin tolerance in mice with noninsulin-dependent diabetes mellitus. This probiotic also improved diabetes-induced total cholesterol and triglyceride (TG) levels and increased the muscle glycogen content (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24925305\">R<\/a>).<\/p>\n<h4>11) Antioxidant Activity<\/h4>\n<p><em>B. animalis<\/em> culture supernatant, intact cells, and intracellular cell-free extracts all <strong>effectively scavenged free radicals<\/strong> and significantly <strong>enhanced the activities of antioxidative enzymes<\/strong> in mice (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21132298\">R<\/a>).<\/p>\n<h4>12) Celiac Disease<\/h4>\n<p>Live <em>B. animalis<\/em> ssp. <em>lactis<\/em> bacteria directly counteracted the harmful effects exerted by celiac-toxic gluten (or, rather, a component of gluten called gliadin) on human intestinal cells (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2453197\/\">R<\/a>).<\/p>\n<h4>13) Autoimmune Disease<\/h4>\n<p>In rats with experimental autoimmune encephalomyelitis, <em>B. animalis<\/em> significantly reduced the duration of clinical symptoms (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2633237\/\">R<\/a>).<\/p>\n<h4>14) Oxalate<\/h4>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> possesses the <em>OXC <\/em>gene, encoding oxalyl-coenzyme A (CoA) decarboxylase, a key enzyme in oxalate degradation (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2918965\/\">R<\/a>).<\/p>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> significantly decreased urinary oxalate excretion in mice with hyperoxaluria by <strong>degrading dietary oxalate<\/strong> thus limiting its absorption across the intestine (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4629830\/\">R<\/a>).<\/p>\n<h3><span id=\"Cancer_Research\"><strong>Cancer Research<\/strong><\/span><\/h3>\n<p><em>B. animalis<\/em> ssp. <em>lactis<\/em> decreased the mean number and size of tumors in mice with colitis-associated cancer (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20310012\">R<\/a>).<\/p>\n<p>The synbiotic combination of carbohydrate \u2018resistant starch\u2018 and <em>B. animalis<\/em> ssp. <em>lactis<\/em> protected against the development of colorectal cancer (CRC) in rats (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19696163\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15867271\">R<\/a>).<\/p>\n<p>These effects have not been observed in humans, and the degree to which gut flora or probiotics can affect the development of cancer in humans is unknown. Furthermore, people who are currently undergoing cancer treatment are often immunosuppressed, making them potentially vulnerable to adverse effects from probiotics.<\/p>\n<p><strong>Always talk to your doctor before starting a new probiotic, especially if you are being treated for cancer.<\/strong><\/p>\n<h2><span id=\"Mechanism_of_Effect\"><strong>Mechanism of Effect<\/strong><\/span><\/h2>\n<p>Researchers have been investigating the mechanisms by which <em>B. animalis<\/em> exerts its effects in animals and cells. In their findings, this probiotic has:<\/p>\n<ul>\n<li>Increased IgA (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24902954\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18631345\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22237870\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11388612\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3265429\/\">R<\/a>), IgG, IgG1, and IgG3 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21899798\">R<\/a>).<\/li>\n<li>Elevated NK-cell cytotoxicity (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26821116\">R<\/a>).<\/li>\n<li>Decreased <a href=\"https:\/\/selfhacked.com\/blog\/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6\/\">TNF<\/a>-\u03b1 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27126957\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17897185\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16794305\">R<\/a>).<\/li>\n<li>Increased <a href=\"https:\/\/selfhacked.com\/blog\/tgf\/\">TGF<\/a>-\u03b21 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18631345\">R<\/a>).<\/li>\n<li>Increased IFN-\u03b1 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10713750\">R<\/a>) and IFN-\u03b3 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20409588\">R<\/a>).<\/li>\n<li>Increased <a href=\"http:\/\/selfdecode.com\/gene\/il2\/\">IL-2<\/a> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26821116\">R<\/a>) and <a href=\"https:\/\/selfhacked.com\/blog\/il-10\/\">IL-10<\/a> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24902954\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4858658\/\">R<\/a>).<\/li>\n<li>Increased <a href=\"https:\/\/selfdecode.com\/gene\/il4\/\">IL-4<\/a> and <a href=\"http:\/\/selfdecode.com\/gene\/il5\/\">IL-5<\/a> in low-grade inflammation (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4858658\/\">R<\/a>).<\/li>\n<li>Decreased <a href=\"http:\/\/selfdecode.com\/gene\/il5\/\">IL-5<\/a> and <a href=\"http:\/\/selfdecode.com\/gene\/IL13\/\">IL-13<\/a> in allergy (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23299716\">R<\/a>).<\/li>\n<li>Both decreased (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27126957\">R<\/a>) and increased (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1782184\/\">R<\/a>) <a href=\"https:\/\/selfhacked.com\/blog\/interleukin-6\/\">IL-6<\/a>.<\/li>\n<li>Decreased <a href=\"https:\/\/selfdecode.com\/gene\/nos2\/\">iNOS<\/a>, <a href=\"https:\/\/selfdecode.com\/gene\/cox2\/?utm_source=seo&amp;utm_medium=selfhacked&amp;utm_campaign=id00002\">COX-2<\/a> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17897185\">R<\/a>), PCK1 and G6PC (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24925305\">R<\/a>).<\/li>\n<li>Increased PP-1, <a href=\"https:\/\/selfdecode.com\/gene\/SLC2A4\/\">GLUT4<\/a> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24925305\">R<\/a>) and FOXP3 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3027012\/\">R<\/a>).<\/li>\n<li>Induced CD19 lymphocyte proliferation in parasite infection (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4826079\/\">R<\/a>).<\/li>\n<li>Mostly decreased <a href=\"https:\/\/selfhacked.com\/blog\/nuclear-factor-kappa-beta\/\">NF-\u03baB<\/a> (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3016395\/\">R<\/a>, <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20310012\">R<\/a>) (a study where it was increased:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1782184\/\"> R<\/a>).<\/li>\n<\/ul>\n<h2><span id=\"Safety\"><strong>Safety<\/strong><\/span><\/h2>\n<p><em>B. animalis<\/em> is safe and well tolerated in infants, adults and elderly. Probiotics are generally considered safe but should be avoided in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms. <strong>To avoid adverse effects and unexpected interactions, talk to your doctor before starting any new probiotics.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p><em>B. animalis <\/em>(especially its subspecies <em>B. lactis<\/em>) is an important component of the healthy gut flora. It may promote GI well-being, especially in children, and some evidence suggests it may help the body prevent and fight off infections. What else could it do? Read on to find out.<\/p>\n","protected":false},"author":14185,"featured_media":64583,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[22,283],"tags":[279,280],"yst_prominent_words":[7274,7268,3321,1629,19013,19004,28531,28530,28528,28532,28527,3487,7275,28529,19012,19011,511,515,529,6832],"_links":{"self":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/26573"}],"collection":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/users\/14185"}],"replies":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/comments?post=26573"}],"version-history":[{"count":11,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/26573\/revisions"}],"predecessor-version":[{"id":111229,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/26573\/revisions\/111229"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media\/64583"}],"wp:attachment":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media?parent=26573"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/categories?post=26573"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/tags?post=26573"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/yst_prominent_words?post=26573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}