{"id":26470,"date":"2019-12-12T11:42:08","date_gmt":"2019-12-12T19:42:08","guid":{"rendered":"https:\/\/selfhacked.com\/?p=26470"},"modified":"2021-09-20T09:18:12","modified_gmt":"2021-09-20T16:18:12","slug":"b-bifidum","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/b-bifidum\/","title":{"rendered":"Top 11 Health Benefits of B. bifidum Probiotic + Safety"},"content":{"rendered":"

B. bifidum<\/em> is a probiotic typically used to ameliorate digestive issues. B. bifidum <\/em>may also ameliorate improve blood sugar control, reduce stress, and help combat infections when combined with a healthy diet. Read on to learn more about B<\/em>. bifidum <\/em>and its potential health benefits.<\/p>\n

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<\/a>What Is Bifidobacterium bifidum<\/em>?<\/strong><\/span><\/h2>\n

Bifidobacteria account for more than 80% of microorganisms within the intestine, being Bifidobacterium bifidum<\/em> the second most prominent species found in breast-fed infants. During adulthood, the levels of Bifidobacteria decrease considerably but remain relatively stable (2-14%) until they start decreasing again in old age [R<\/a>, R<\/a>].<\/p>\n

Various diseases such as obesity<\/a>, diabetes, and allergies have been associated with lower numbers of Bifidobacteria at various stages of life [R<\/a>].<\/p>\n

\"bifidobacteria-levels\"<\/p>\n

Source: [R<\/a>]<\/p>\n

B. bifidum<\/em> is an important bacterium that inhibits other microbes of the human gut microbiota<\/a>. This probiotic has potential health benefits, such as reducing irritable bowel syndrome, diarrhea, and pathogen infections [R<\/a>].<\/p>\n

<\/a>How Does It Work?<\/strong><\/span><\/h2>\n

By increasing IgA, IgM<\/a>, and IgG while decreasing IgE, B<\/em>. bifidum <\/em>may help both boost the immune system and reduce allergies [R<\/a>, R<\/a>].<\/p>\n

B. bifidum <\/em>may also help with allergies by lowering the production of the pro-inflammatory cytokines IL-4<\/a> and IL-5<\/a> , balancing the levels of IFN-\u03b3<\/a>, and increasing the production of the anti-inflammatory cytokine IL-10<\/a> and specific immune cell types (CD25 and Foxp3) [R<\/a>, R<\/a>].<\/p>\n

In aging mice, B. bifidum<\/em> stimulated the immune system by significantly increasing cytokines IL-2<\/a> and IFN-\u03b3<\/a> while decreasing IL-6<\/a> and TNF-\u03b1<\/a> levels [R<\/a>].<\/p>\n

In mice with IBD<\/a>, B<\/em>. bifidum <\/em>reduced inflammation by inhibiting the Th1<\/a> response and reducing pro-inflammatory cytokines (IL-1\u03b2<\/a>, IL-6<\/a>, and keratinocyte-derived chemokine), chemokines (MCP-1<\/a>) and enzymes (COX-2<\/a>, MPO<\/a>). It can also reduce cell death by increasing the production of TLR-2 and PGE2<\/sub><\/a> [R<\/a>, R<\/a>, R<\/a>].<\/p>\n

In mice with H. pylori<\/em><\/a> infection, B<\/em>. bifidum <\/em>suppressed the pro-inflammatory IL-8<\/a> and NF-\u03baB<\/a> signaling pathways in [R<\/a>].<\/p>\n

B. bifidum also increased the cytotoxic activity of peripheral CD8+ cells<\/a> without reducing lymphocyte<\/a> survival. Some strains may stimulate Th17<\/a> generation [R<\/a>, R<\/a>].<\/p>\n

<\/a>Snapshot<\/strong><\/span><\/h3>\n

<\/a>Proponents<\/strong><\/h4>\n