{"id":26353,"date":"2019-12-26T01:51:16","date_gmt":"2019-12-26T09:51:16","guid":{"rendered":"https:\/\/selfhacked.com\/?p=26353"},"modified":"2021-09-20T09:18:10","modified_gmt":"2021-09-20T16:18:10","slug":"l-crispatus","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/l-crispatus\/","title":{"rendered":"L. crispatus Potential Benefits for Urogenital Health"},"content":{"rendered":"

L. crispatus <\/em>probiotics have shown promise for the prevention of urinary and genital infections in women, but the research is still in its very early stages. What have scientists discovered? Read on to find out.<\/p>\n

<\/p>\n

What is Lactobacillus <\/em>crispatus?<\/span><\/h2>\n

Lactobacilli inhabiting the human vagina are the first line of defense in the female urogenital and reproductive tracts. Lactobacillus crispatus<\/em> is prevalent in the healthy cervicovaginal microbiota<\/a>, where it produces lactic acid<\/a>, a potent broad-spectrum bactericide, and virucide, and acts as an immunomodulatory agent (R<\/a>).<\/p>\n

Health Benefits of L. crispatus<\/em><\/span><\/h2>\n

L. crispatus<\/em> probiotic supplements have not been approved by the FDA for medical use and generally lack solid clinical research. Regulations set manufacturing standards for them but don’t guarantee that they’re safe or effective. Speak with your doctor before supplementing.<\/p>\n

Insufficient Evidence For<\/span><\/h3>\n

The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of L. crispatus<\/em> probiotics for any of the below-listed uses. Remember to speak with a doctor before taking L. crispatus, <\/em>and never use it in place of something your doctor recommends or prescribes.<\/p>\n

1) Female Urogenital Health<\/h4>\n

L. crispatus<\/em> reduced recurrent urinary tract infections in 100 premenopausal women [R<\/a>].<\/p>\n

L. crispatus<\/em> inhibited Chlamydia trachomatis<\/em>, the most common sexually transmitted bacterial pathogen, in human epithelial cells and macrophages [R<\/a>, R<\/a>].<\/p>\n

L. crispatus<\/em> promoted defense against Candida<\/em><\/a> albicans<\/em> infection in cell studies [R<\/a>, R<\/a>].<\/p>\n

L. crispatus<\/em> inhibited E. coli<\/em> activity [R<\/a>].<\/p>\n

Cervicovaginal mucus with high L. crispatus<\/em> concentrations trapped the HIV virus in a lab setting. It is unclear whether this result has any relevance to HIV infection in a clinical setting, and we recommend strongly against attempting to use L. crispatus <\/em>to prevent HIV<\/strong> [R<\/a>].<\/p>\n

Animal & Cell Research (Lacking Evidence)<\/span><\/h3>\n

No clinical evidence supports the use of L. crispatus<\/em> for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.<\/p>\n

2) Allergies<\/h4>\n

Oral ingestion of L. crispatus<\/em> alleviated allergic rhinitis in mice, possibly via the adjustment of the Th1<\/a>\/Th2<\/a> balance (R<\/a>, R<\/a>, R<\/a>).<\/p>\n

3) Gut Health<\/h4>\n

L. crispatus<\/em> ameliorated colitis<\/a> in mice (R<\/a>), however, a specific strain, M206119, exacerbated intestinal inflammation (R<\/a>).<\/p>\n