{"id":26262,"date":"2019-12-09T12:20:24","date_gmt":"2019-12-09T20:20:24","guid":{"rendered":"https:\/\/selfhacked.com\/?p=26262"},"modified":"2021-09-20T09:18:09","modified_gmt":"2021-09-20T16:18:09","slug":"l-fermentum","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/l-fermentum\/","title":{"rendered":"10 Benefits of Lactobacillus fermentum (L. fermentum)"},"content":{"rendered":"<p><em>L. fermentum <\/em>is one of the less studied probiotic strains that has shown promise in early clinical studies on cholesterol and immunity. Learn more here.<\/p>\n<p><!--more--><\/p>\n<h2><span id=\"What_is_Lactobacillus_fermentum\"><a id=\"post-26262-_uqf6gsvmpric\"><\/a><strong>What is <em>Lactobacillus fermentum<\/em>?<\/strong><\/span><\/h2>\n<p><em>Lactobacillus fermentum <\/em>is a Gram-positive <a href=\"http:\/\/selfhacked.com\/blog\/the-brains-secret-backup-generator\/\">lactic acid<\/a> bacterium, commonly found in fermenting animal and plant material. It is also commonly found as a component of the human <a href=\"http:\/\/selfhacked.com\/blog\/how-your-gut-microbiota-can-make-you-fat-or-thin\/\">microbiota<\/a>.<\/p>\n<p><em>L. fermentum <\/em>exhibits significant <strong>antioxidant properties<\/strong> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24985014\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2670518\/\"> R<\/a>).<\/p>\n<h2><span id=\"Health_Benefits_of_L_fermentum\"><a id=\"post-26262-_io2cgjf7jvxd\"><\/a><strong>Health Benefits of <em>L. fermentum<\/em><\/strong><\/span><\/h2>\n<p><em>L. fermentum <\/em>probiotic supplements have not been approved by the FDA for medical use and generally lack solid clinical research. Regulations set manufacturing standards for them but don&#8217;t guarantee that they&#8217;re safe or effective. Speak with your doctor before supplementing.<\/p>\n<h3><span id=\"Insufficient_Evidence_For\"><a id=\"post-26262-_tr5qcu3313r5\"><\/a>Insufficient Evidence For<\/span><\/h3>\n<p>The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of <em>L. fermentum<\/em> for any of the below-listed uses. Remember to speak with a doctor before taking probiotic supplements and never use them to replace something your doctor recommends or prescribes.<\/p>\n<h4><a id=\"post-26262-_ixb18ew4t59p\"><\/a>1) Cholesterol<\/h4>\n<p><em>L. fermentum <\/em>modestly improved cholesterol in a clinical study of 46 people (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17126768\">R<\/a>).<\/p>\n<p><em>L. fermentum<\/em> reduced total blood cholesterol, total triglyceride levels and low-density lipoprotein (<a href=\"https:\/\/selfhacked.com\/blog\/ldl-cholesterol\/\">LDL<\/a>) cholesterol in mice. It also decreased body<a href=\"https:\/\/selfhacked.com\/blog\/a-comprehensive-list-of-effective-ways-to-lose-weight\/\"> weight<\/a> and liver weight\/body weight ratio (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21218486\">R<\/a>).<\/p>\n<h4><a id=\"post-26262-_2jhojvg3z3i\"><\/a>2) Immunity<\/h4>\n<p><em>L. fermentum<\/em> reduced the duration and severity of respiratory illness in highly trained distance runners (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18272539\">R<\/a>).<\/p>\n<p><em>L. fermentum<\/em> reduced the severity of gastrointestinal and respiratory illness symptoms in male but not female cyclists (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3083335\/\">R<\/a>).<\/p>\n<p><em>L. fermentum<\/em> reduced gastrointestinal and upper respiratory tract infections in infants (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21873895\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22155106\"> R<\/a>).<\/p>\n<p><em>L. fermentum<\/em> also alleviated <a href=\"https:\/\/selfhacked.com\/blog\/23-ways-to-combat-pain-naturally-by-increasing-your-opioids\/\">pain<\/a> and reduces the load of <em>Staphylococcus<\/em> in the breastmilk of women suffering from painful breastfeeding (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26352805\">R<\/a>).<\/p>\n<h3><span id=\"Animal_Cell_Research_Lacking_Evidence\"><a id=\"post-26262-_st3r3rgma2j1\"><\/a>Animal &amp; Cell Research (Lacking Evidence)<\/span><\/h3>\n<p>No clinical evidence supports the use of <em>L. fermentum <\/em>for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.<\/p>\n<h4><a id=\"post-26262-_oyf9ozwf73mi\"><\/a>3) Nutrient Bioavailability<\/h4>\n<p><em>L. fermentum<\/em> was shown to <strong>increase the bioavailability of<\/strong><a href=\"https:\/\/selfhacked.com\/blog\/calcium-101\/\"><strong> calcium<\/strong><\/a>,<a href=\"https:\/\/selfhacked.com\/blog\/phosphorus\/\"><strong> phosphorus<\/strong><\/a>,<strong> and<\/strong><a href=\"https:\/\/selfhacked.com\/blog\/literally-everything-wanted-know-zinc-backed-science\/\"><strong> zinc<\/strong><\/a> in fermented goat milk (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23179347\">R<\/a>).<\/p>\n<aside class=\"sh-partner shp-form sponsored sh-et-7388fa\">\n  <div>\n          <div class=\"partner-heading\">Get the Regimen of A Top Biohacker<\/div>\n    \n    <div class=\"partner-content\">\n      <p><span style=\"font-weight: 400\">Joe Cohen is well-known for his work as a successful entrepreneur in the health field after he overcame his many health issues using a personalized regimen. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health.\u00a0<\/span><\/p>\n    <\/div>\n\n    <div class=\"subscribe-form-container\">\n      <form method=\"POST\" action=\"\/wp-json\/wp\/v2\/posts\/26262\" class=\"sh-subscribe-form\">\n        <input type=\"email\" name=\"subscribe_form_data[email]\"\n            pattern=\"^[a-zA-Z0-9.!#$%&\u2019*+\/=?^_`{|}~-]+@[a-zA-Z0-9-]+(?:\\.[a-zA-Z0-9-]+)*$\" required\n            placeholder=\"Enter your email\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: PartnerAd Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"PartnerAd\">\n                <button type=\"submit\" class=\"btn btn-primary subscribe-submit\">Get The Regimen<\/button>\n      <\/form>\n    <\/div>\n  <\/div>\n          <style>aside.sponsored.sh-et-7388fa::before{content:\"Advertisement\"}<\/style>\n<\/aside>\n<h4><a id=\"post-26262-_lmbritoaocbq\"><\/a>4) Inflammation<\/h4>\n<p>Both live and dead <em>L. fermentum <\/em>have been demonstrated to <strong>attenuate the inflammatory process<\/strong> and diminish inflammatory mediators in laboratory experiments (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25700085\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17206643\"> R<\/a>).<\/p>\n<p><em>L. fermentum <\/em>can reduce inflammation of the upper small intestine in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19005975\">R<\/a>).<\/p>\n<p><em>L. fermentum<\/em> ameliorates the inflammatory response in <a href=\"https:\/\/selfhacked.com\/blog\/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections\/\">colitis<\/a> rats (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16052308\">R<\/a>).<\/p>\n<h4><a id=\"post-26262-_4pbrz6uu7wva\"><\/a>5) Lactose Intolerance<\/h4>\n<p><em>L. fermentum <\/em><strong>degrades \u03b1S1-casein<\/strong> and lowers the recognition and the binding of this casein to IgE from the blood of patients with cow\u2019s milk allergy (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21385515\">R<\/a>).<\/p>\n<h4><a id=\"post-26262-_l5828b3siqkw\"><\/a>6) Gut Health<\/h4>\n<p><em>L. fermentum <\/em>increases <em>Lactobacillus<\/em>, <em>Bifidobacterium<\/em> and <em>Eubacterium<\/em> levels in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19719673\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4963891\/\"> R<\/a>).<\/p>\n<p><em>L. fermentum<\/em> <strong>normalizes the composition of<\/strong><a href=\"https:\/\/selfhacked.com\/blog\/how-your-gut-microbiota-can-make-you-fat-or-thin\/\"><strong> gut microbiota<\/strong><\/a> and alleviates ampicillin-induced inflammation in the colon in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25869281\">R<\/a>).<\/p>\n<p><em>L. fermentum<\/em> alleviates<a href=\"https:\/\/selfhacked.com\/blog\/causes-ibs-general-gut-dysfunction\/\"> constipation<\/a> in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26052143\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4284683\/\"> R<\/a>).<\/p>\n<p><em>L. fermentum<\/em> <strong>ameliorates <\/strong>ethanol-induced<strong> gastric injury<\/strong> in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4808883\/\">R<\/a>).<\/p>\n<p><em>L. fermentum<\/em> <strong>attenuates colitis <\/strong>and accelerates colitis recovery in mice and rats (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19266568\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4100452\/\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19005763\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17150273\"> R<\/a>).<\/p>\n<h4><a id=\"post-26262-_52lrijhgejgv\"><\/a>7) Mood and Cognitive Function<\/h4>\n<p><em>L. fermentum <\/em><strong>reduces <\/strong><a href=\"https:\/\/selfhacked.com\/blog\/natural-treatments-anxiety\/\"><strong>anxiety<\/strong><\/a>-like behavior and alleviates the ampicillin-induced impairment in memory retention in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25869281\">R<\/a>).<\/p>\n<h4><a id=\"post-26262-_4xpvfarrpgwu\"><\/a>8) Liver Damage<\/h4>\n<p><em>L. fermentum<\/em> significantly <strong>alleviates liver damage<\/strong> in alcoholic liver disease mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4433256\/\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4737872\/\"> R<\/a>).<\/p>\n<p><a href=\"http:\/\/selfhacked.com\/blog\/green-tea\/\">Green tea<\/a> extract and <em>L. fermentum <\/em>protect liver cells against ethanol exposure (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23221715\">R<\/a>).<\/p>\n<p><em>L. fermentum<\/em> enhances the protective effect of Ssanghwa-tang (SHT), a traditional herbal medicine formula, on rat liver (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3252232\/\">R<\/a>).<\/p>\n<h4><a id=\"post-26262-_jyxtzb9li5fa\"><\/a>9) Infections<\/h4>\n<h5><a id=\"post-26262-_xfjpz2p0hbr6\"><\/a>Viruses<\/h5>\n<p><em>L. fermentum<\/em> improves resistance against lethal influenza infection in both mice and chicken, by activating the <a href=\"http:\/\/selfhacked.com\/blog\/supplements-people-th1-dominant\/\">Th1<\/a> response and augmenting IgA production (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24201084\">R<\/a>).<\/p>\n<p>Oral administration of <em>L. fermentum<\/em> potentates the immunologic response of an anti-influenza vaccine and may provide enhanced systemic protection by <strong>increasing the<\/strong><a href=\"https:\/\/selfhacked.com\/blog\/supplements-people-th1-dominant\/\"><strong> Th1<\/strong><\/a><strong> response<\/strong> and virus-neutralizing antibodies. The incidence of an influenza-like illness 5 months after vaccination was decreased in the group that consumed this probiotic (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17352961\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27447674\"> R<\/a>).<\/p>\n<h5><a id=\"post-26262-_htqu3sohmhgh\"><\/a>Bacteria &amp; Fungi<\/h5>\n<p><em>L. fermentum<\/em> suppresses the growth of staphylococci, enterotoxigenic enterobacteria and <a href=\"http:\/\/selfhacked.com\/blog\/treat-cure-candida\/\"><em>Candida<\/em><\/a><em> albicans<\/em> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26267163\">R<\/a>). It was shown to combat <em>S. aureus<\/em> and <em>P. aeruginosa<\/em>, common pathogens in hospital-acquired infections (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21701187\">R<\/a>).<\/p>\n<p><em>L. fermentum <\/em>combats <em>Streptococcus pneumoniae<\/em> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11720814\">R<\/a>), <em>Pseudomonas aeruginosa<\/em> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3934337\">R<\/a>), <em>S. typhimurium<\/em> infection in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2518159\/\">R<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20955459\">R<\/a>) and <em>Salmonella<\/em> infection in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18077037\">R<\/a>).<\/p>\n<p><em>L. fermentum <\/em><strong>inhibits both <em>C. albicans<\/em> and <em>C. glabrata<\/em><\/strong>, the two most common pathogenic yeasts of humans, in the laboratory (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17965352\">R<\/a>).<\/p>\n<h5><a id=\"post-26262-_iybnu86xlck3\"><\/a>Aging &amp; Immunity<\/h5>\n<p><em>L. fermentum<\/em> <strong>alleviates immunosenescence<\/strong> by enhancing antioxidant enzyme activities and was shown to reduce <em>E. coli<\/em> infection in aging mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25311611\">R<\/a>).<\/p>\n<h3><span id=\"Mechanism_of_Effect\"><a id=\"post-26262-_dqewzahzb61f\"><\/a>Mechanism of Effect<\/span><\/h3>\n<p>Researchers have investigated the potential mechanisms of <em>L. fermentum<\/em>\u2019s benefits in cell and animal studies. They have found that this probiotic:<\/p>\n<ul>\n<li>Increased the activity of antioxidant enzymes<a href=\"https:\/\/selfhacked.com\/blog\/the-brain-fog-gene-rs4880-or-sod2\/\"> superoxide dismutase<\/a>,<a href=\"https:\/\/selfhacked.com\/blog\/catalase-benefits\/\"> catalase<\/a>, and <a href=\"http:\/\/selfhacked.com\/blog\/30-scientifically-proven-health-benefits-glutathione\/\">glutathione<\/a><a href=\"https:\/\/selfdecode.com\/gene\/gpx1\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\"> peroxidase<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25311611\">R<\/a>).<\/li>\n<li>Increased the IgG2a response over IgG1, indicating a Th1-biased humoral response (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27447674\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25311611\"> R<\/a>).<\/li>\n<li>Increased IgA (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24201084\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17352961\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15771184\"> R<\/a>), and decreases IgE (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25311611\">R<\/a>).<\/li>\n<li>Increased the proportion of natural killer (NK) cells (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17352961\">R<\/a>).<\/li>\n<li>Increased <a href=\"https:\/\/selfhacked.com\/blog\/interferon-gamma-how-to-increase-decrease-high-low-levels\/\">IFN-\u03b3<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27447674\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25311611\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24201084\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18272539\"> R<\/a>) (a study where it was decreased: (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20955459\">R<\/a>)).<\/li>\n<li>Increased <a href=\"http:\/\/selfdecode.com\/gene\/il2\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">IL-2<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24201084\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19266568\"> R<\/a>) and decreased <a href=\"http:\/\/selfhacked.com\/blog\/interleukin-6\/\">IL-6<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19266568\">R<\/a>) and <a href=\"http:\/\/selfhacked.com\/blog\/il-8\/\">IL-8<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17206643\">R<\/a>).<\/li>\n<li>Both increased (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19266568\">R<\/a>) and decreased <a href=\"https:\/\/selfdecode.com\/gene\/il4\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">IL-4<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25311611\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24201084\"> R<\/a>).<\/li>\n<li>Both increased (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20955459\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18077037\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4433256\/\"> R<\/a>) and decreased <a href=\"http:\/\/selfhacked.com\/blog\/il-10\/\">IL-10<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25311611\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24201084\"> R<\/a>).<\/li>\n<li>Decreased <a href=\"http:\/\/selfhacked.com\/blog\/interleukin-1\/\">IL-1\u03b2<\/a>, <a href=\"http:\/\/selfhacked.com\/blog\/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6\/\">TNF-\u03b1<\/a>, and <a href=\"https:\/\/selfdecode.com\/gene\/nos2\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">iNOS<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25700085\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16052308\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4433256\/\"> R<\/a> ).<\/li>\n<li>Decreased Rac, <a href=\"http:\/\/selfdecode.com\/gene\/map3k3\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">p38<\/a>, and <a href=\"https:\/\/selfhacked.com\/blog\/nuclear-factor-kappa-b\/\">NF-kappaB<\/a> activation (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17206643\">R<\/a>).<\/li>\n<li>Increased occludin, <a href=\"https:\/\/selfdecode.com\/gene\/egf\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">EGF<\/a>,<a href=\"https:\/\/selfhacked.com\/blog\/egfr\/\"> EGFR<\/a>, <a href=\"http:\/\/selfhacked.com\/blog\/need-know-vegf-good-bad\/\">VEGF<\/a>, Fit-1, I\u03baB-\u03b1, nNOS, eNOS, Mn-<a href=\"http:\/\/selfhacked.com\/blog\/the-brain-fog-gene-rs4880-or-sod2\/\">SOD<\/a>, Cu\/Zn-SOD, <a href=\"https:\/\/selfdecode.com\/gene\/CAT\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">CAT<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4808883\/\">R<\/a>).<\/li>\n<li>Increased <a href=\"http:\/\/selfdecode.com\/gene\/ptges2\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">PGE2<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19266568\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4433256\/\"> R<\/a>).<\/li>\n<li>Stimulated mucosal immunity, possibly by stimulating tracheal <a href=\"https:\/\/selfhacked.com\/blog\/lymphocytes\/\">lymphocyte<\/a> proliferation and increasing lung macrophage population (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10963306\">R<\/a>).<\/li>\n<li>Elevated mineralocorticoid and N-methyl-D-aspartate receptors in the hippocampus after ampicillin treatment (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25869281\">R<\/a>).<\/li>\n<\/ul>\n<h2><span id=\"Safety\"><a id=\"post-26262-_9omnu1it8h9p\"><\/a><strong>Safety<\/strong><\/span><\/h2>\n<p><em>L. fermentum <\/em>is commonly found in fermented food products and is considered a \u201cgenerally recognized as safe\u201d (GRAS) organism by the US FDA (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3828418\/#pone.0078774\">R<\/a>). It was found to be safe in infants and children (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25697549\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25519525\"> R<\/a>).<\/p>\n<p>However, in immunocompromised individuals, it can lead to bacteremia (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3710909\/\">R<\/a>). The use of <a href=\"https:\/\/selfhacked.com\/blog\/probiotics-good-bacteria\/\">probiotics<\/a> in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms should be avoided.<\/p>\n<p>A strain of <em>L. fermentum<\/em> AGR1487 causes a pro-inflammatory response in the host and should be avoided (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4740858\/\">R<\/a>).<\/p>\n<p>In order to avoid adverse effects or unexpected interactions, talk to your doctor before using <em>L. fermentum<\/em> probiotics.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><em>L. fermentum <\/em>is one of the less studied probiotic strains that has shown promise in early clinical studies on cholesterol and immunity. Learn more here.<\/p>\n","protected":false},"author":14185,"featured_media":21524,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[22,283],"tags":[279,280],"yst_prominent_words":[5841,6955,29750,29746,710,6957,6953,25809,14902,1352,554,592,27904,25991,511,28208,515,529,548,14901],"_links":{"self":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/26262"}],"collection":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/users\/14185"}],"replies":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/comments?post=26262"}],"version-history":[{"count":7,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/26262\/revisions"}],"predecessor-version":[{"id":112309,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/26262\/revisions\/112309"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media\/21524"}],"wp:attachment":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media?parent=26262"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/categories?post=26262"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/tags?post=26262"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/yst_prominent_words?post=26262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}