{"id":26180,"date":"2019-12-12T14:48:41","date_gmt":"2019-12-12T22:48:41","guid":{"rendered":"https:\/\/selfhacked.com\/?p=26180"},"modified":"2021-09-20T09:18:08","modified_gmt":"2021-09-20T16:18:08","slug":"l-helveticus","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/l-helveticus\/","title":{"rendered":"6+ Scientific Health Benefits of Lactobacillus helveticus"},"content":{"rendered":"<p><em>L. helveticus<\/em> makes cheese taste great. It also confers a multitude of health benefits. The most promising results have come from studies on blood pressure, while other clinical trials have observed benefits to mental health, sleep, immunity, and more.<\/p>\n<p><!--more--><\/p>\n<h2><span id=\"What_is_Lactobacillus_helveticus\"><a id=\"post-26180-_pjii7p94qq4k\"><\/a><strong>What is <em>Lactobacillus helveticus<\/em>?<\/strong><\/span><\/h2>\n<p><em>Lactobacillus helveticus<\/em> is a <a href=\"http:\/\/selfhacked.com\/blog\/the-brains-secret-backup-generator\/\">lactic acid<\/a> bacterium, traditionally used in the manufacture of Swiss-type cheeses and long-ripened Italian cheeses such as Emmental, Gruyere, Grana Padano and Parmigiano Reggiano (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4081610\/\">R<\/a>).<\/p>\n<p>More recently, <em>L. helveticus<\/em> has become increasingly recognized as an important health-promoting probiotic (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4081610\/\">R<\/a>).<\/p>\n<h2><span id=\"Health_Benefits_of_L_helveticus\"><a id=\"post-26180-_uzyfy1p55ap1\"><\/a><strong>Health Benefits of <em>L. helveticus<\/em><\/strong><\/span><\/h2>\n<p><em>L. helveticus<\/em> probiotic supplements have not been approved by the FDA for medical use and generally lack solid clinical research. Regulations set manufacturing standards for them but don&#8217;t guarantee that they&#8217;re safe or effective. Speak with your doctor before supplementing.<\/p>\n<h3><span id=\"Possibly_Effective_For\"><a id=\"post-26180-_dywy5bcucp1i\"><\/a>Possibly Effective For<\/span><\/h3>\n<h4><a id=\"post-26180-_238ditbbuzcb\"><\/a>1) Blood Pressure<\/h4>\n<p><em>L. helveticus<\/em> fermented milk lowered blood pressure in 154 hypertensive subjects (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16364832\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15175633\"> R<\/a>).<\/p>\n<p>In 40 subjects with high-normal blood pressure or mild hypertension, daily ingestion of tablets containing powdered fermented milk with <em>L. helveticus<\/em> reduced blood pressure without any adverse effects (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16093403\">R<\/a>).<\/p>\n<p>Long-term treatment with <em>L. helveticus<\/em>-fermented milk reduced arterial stiffness in 89 hypertensive subjects (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2857163\/\">R<\/a>).<\/p>\n<p><em>L. helveticus<\/em> produces angiotensin-converting enzyme (ACE)-inhibitory peptides that may prevent or control high blood pressure (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26004829\">R<\/a>).<\/p>\n<h3><span id=\"Insufficient_Evidence_For\"><a id=\"post-26180-_i6q2bblzfrgm\"><\/a>Insufficient Evidence For<\/span><\/h3>\n<p>The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of <em>L. helveticus<\/em> for any of the below-listed uses. Remember to speak with a doctor before taking <em>L. helveticus <\/em>probiotics, and never use them in place of something your doctor recommends or prescribes.<\/p>\n<h4><a id=\"post-26180-_snee90q7ikpi\"><\/a>2) Depression<\/h4>\n<p>In a study of 55 volunteers, <em>L. helveticus <\/em>and <em>Bifidobacterium longum<\/em> reduced psychological <a href=\"https:\/\/selfhacked.com\/blog\/63-factors-raising-stress-cortisol-level-backed-science\/\">stress<\/a> levels and markers of depression in subjects who took the <a href=\"https:\/\/selfhacked.com\/blog\/probiotics-good-bacteria\/\">probiotics<\/a> regularly (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4997396\/\">R<\/a>).<\/p>\n<p><em>L. helveticus<\/em> also improved depression in rats (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26408987\">R<\/a>).<\/p>\n<h4><a id=\"post-26180-_jgj3mtwervw4\"><\/a>3) Sleep<\/h4>\n<p><em>L. helveticus-<\/em>fermented milk significantly improved<a href=\"https:\/\/selfhacked.com\/blog\/health-benefits-sleep\/\"> sleep<\/a> efficiency in 29 healthy elderly people (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17851460\">R<\/a>).<\/p>\n<aside class=\"sh-partner shp-form sponsored sh-et-7388fa\">\n  <div>\n          <div class=\"partner-heading\">Get the Regimen of A Top Biohacker<\/div>\n    \n    <div class=\"partner-content\">\n      <p><span style=\"font-weight: 400\">Joe Cohen is well-known for his work as a successful entrepreneur in the health field after he overcame his many health issues using a personalized regimen. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health.\u00a0<\/span><\/p>\n    <\/div>\n\n    <div class=\"subscribe-form-container\">\n      <form method=\"POST\" action=\"\/wp-json\/wp\/v2\/posts\/26180\" class=\"sh-subscribe-form\">\n        <input type=\"email\" name=\"subscribe_form_data[email]\"\n            pattern=\"^[a-zA-Z0-9.!#$%&\u2019*+\/=?^_`{|}~-]+@[a-zA-Z0-9-]+(?:\\.[a-zA-Z0-9-]+)*$\" required\n            placeholder=\"Enter your email\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: PartnerAd Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"PartnerAd\">\n                <button type=\"submit\" class=\"btn btn-primary subscribe-submit\">Get The Regimen<\/button>\n      <\/form>\n    <\/div>\n  <\/div>\n          <style>aside.sponsored.sh-et-7388fa::before{content:\"Advertisement\"}<\/style>\n<\/aside>\n<h4><a id=\"post-26180-_52t2059acjo8\"><\/a>4) Immunity<\/h4>\n<p>In a study of 39 athletes, <em>L. helveticus<\/em> supplementation significantly shortened the duration and decreased the number of symptoms of upper respiratory tract illness and increased their sense of vigor (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27363733\">R<\/a>).<\/p>\n<p><em>L. helveticus<\/em> containing cheese exhibits immunoregulatory actions, including an increase in regulatory T cell population and a reduction in proinflammatory cytokines in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24881786\">R<\/a>).<\/p>\n<p><em>L. helveticus<\/em> has the ability to inhibit different pathogenic microorganisms and has beneficial effects on the intestine, vaginal mucosa, and pharyngeal epithelium (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3500876\/\">R<\/a>).<\/p>\n<p>Milk fermented by <em>L. helveticus<\/em> protects against <em>Salmonella<\/em> infection in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17336831\">R<\/a>).<\/p>\n<p>Milk fermented with <em>L. helveticus<\/em> may enhance specific and nonspecific immunity (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3587842\/\">R<\/a>).<\/p>\n<h4><a id=\"post-26180-_l0ll3si6fvit\"><\/a>5) GI Tract<\/h4>\n<p><em>L. helveticus<\/em> may positively affect the host<a href=\"https:\/\/selfhacked.com\/blog\/how-your-gut-microbiota-can-make-you-fat-or-thin\/\"> microbiota<\/a> composition. Administration of <em>L. helveticus<\/em> to 3 healthy human subjects resulted in a significant increase in <a href=\"http:\/\/selfhacked.com\/blog\/health-benefits-butyrate-derivatives-sodium-butyrate-phenylbutyrate-trybutyrine-butyric-acid-butyrate-prodrugs-butyrate-producing-bacteria\/\">butyrate<\/a>, beneficial for gut homeostasis (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22579985\/\">R<\/a>, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3500876\/\">R<\/a>).<\/p>\n<p>In mice, the administration of <em>L. helveticus<\/em> increased the levels of total Lactobacilli and decreased total enterobacteria and sulfur-reducing clostridia (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19121230\">R<\/a>).<\/p>\n<h4><a id=\"post-26180-_bzbxxygdtgvf\"><\/a>6) Calcium Absorption<\/h4>\n<p><em>L. helveticus<\/em> increased blood<a href=\"https:\/\/selfhacked.com\/blog\/calcium-101\/\"> calcium<\/a> levels in 59 elderly volunteers (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4866133\/\">R<\/a>), and 20 postmenopausal women (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15083312\">R<\/a>).<\/p>\n<h3><span id=\"Animal_Cell_Research_Lacking_Evidence\"><a id=\"post-26180-_q9wbfwgew7vf\"><\/a>Animal &amp; Cell Research (Lacking Evidence)<\/span><\/h3>\n<p>No clinical evidence supports the use of <em>L. helveticus <\/em>for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.<\/p>\n<h4><a id=\"post-26180-_ei1wyl40vkwe\"><\/a>7) Anxiety<\/h4>\n<p><em>L. helveticus<\/em> <strong>improves anxiety-like behavior<\/strong> in rats with <a href=\"https:\/\/selfhacked.com\/blog\/dr-jared-younger-cutting-edge-research-on-cfs-neuroinflammation-pain-and-fatigue\/\">neuroinflammation<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24554471\">R<\/a>).<\/p>\n<p><em>L. helveticus<\/em> prevents the negative effect of a Western-style diet on anxiety-like behavior and memory in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23566632\">R<\/a>).<\/p>\n<p><em>L. helveticus<\/em> combined with <em>Bifidobacterium longum<\/em> <strong>decreases anxiety-like behavior<\/strong> in rats and humans (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4934620\/\">R<\/a>).<\/p>\n<h4><a id=\"post-26180-_xu98669ojinc\"><\/a>8) Cognitive Function<\/h4>\n<p><em>L. helveticus<\/em> restores cognitive function in rats with neuroinflammation (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24554471\">R<\/a>).<\/p>\n<p><em>L. helveticus<\/em> <strong>improves stress-induced <\/strong><a href=\"http:\/\/selfhacked.com\/blog\/the-cause-of-brain-fog\/\"><strong>cognitive dysfunction<\/strong><\/a> in rats (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26408987\">R<\/a>).<\/p>\n<p>An <em>L. helveticus<\/em>-fermented milk product significantly improves scopolamine-induced cognitive impairments, and object recognition memory in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24694020\">R<\/a>).<\/p>\n<h4><a id=\"post-26180-_exu7j68rt4wg\"><\/a>9) Inflammation<\/h4>\n<p><em>L. helveticus<\/em> is protective against <a href=\"https:\/\/selfhacked.com\/blog\/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections\/\">colitis<\/a> in mice and increases anti-inflammatory cytokine <a href=\"http:\/\/selfhacked.com\/blog\/il-10\/\"><strong>IL-10<\/strong><\/a> in human peripheral blood mononuclear cells (PBMCs) (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4591576\/\">R<\/a>).<\/p>\n<p><em>L. helveticus<\/em> alleviates colitis in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4182466\/\">R<\/a>).<\/p>\n<h4><a id=\"post-26180-_omercq4myw96\"><\/a>10) Arthritis<\/h4>\n<p><em>L. helveticus<\/em> strongly alleviated symptoms of arthritis in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4182466\/\">R<\/a>).<\/p>\n<h4><a id=\"post-26180-_e8iictpozz8c\"><\/a>11) Allergies<\/h4>\n<p><em>L. helveticus<\/em> alone or in combination with <em>S. thermophiles<\/em> reduced the antigenicity of \u03b1-lactalbumin and \u03b2-lactoglobulin, the major allergens in cow\u2019s milk (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20583192\">R<\/a>).<\/p>\n<p><em>L. helveticus<\/em> significantly degraded the major allergens in <a href=\"https:\/\/selfhacked.com\/blog\/bee-propolis\/\">propolis<\/a>, including esters of caffeic acid (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3370499\/\">R<\/a>).<\/p>\n<h4><a id=\"post-26180-_ge1ruxomsyoq\"><\/a>12) Bone Loss<\/h4>\n<p><em>L. helveticus<\/em> fermented milk whey contains bioactive components that may promote bone formation (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15268972\">R<\/a>).<\/p>\n<p><em>L. helveticus-<\/em>fermented milk prevented bone loss by decreasing bone turnover and increasing bone mineral density in rats (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17356257\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15334032\"> R<\/a>).<\/p>\n<h4><a id=\"post-26180-_gy66zfta57a\"><\/a>13) Dermatitis<\/h4>\n<p>Oral intake of <em>L. helveticus<\/em>-fermented milk whey lowered water loss, reduced dermatitis area size, and ameliorated the moisture content in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20057148\">R<\/a>).<\/p>\n<h4><a id=\"post-26180-_dtxgcuxauk16\"><\/a>14) Candida<\/h4>\n<p><em>L. helveticus<\/em> shifts vaginal microflora and inhibits vulvovaginal candidiasis in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22735758\">R<\/a>).<\/p>\n<h4><a id=\"post-26180-_5wyheu2kbhe4\"><\/a>15) HACs<\/h4>\n<p><em>L. helveticus<\/em> has a high ability to inactivate heterocyclic aromatic amines (HACs), the most abundant mutagens in charred red meat (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3500876\/\">R<\/a>).<\/p>\n<h3><span id=\"Cancer_Research\"><a id=\"post-26180-_d3yl4pb03m9f\"><\/a><strong>Cancer Research<\/strong><\/span><\/h3>\n<p><em>L. helveticus<\/em> inhibited the proliferation of human gastric cancer cells (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24708988\">R<\/a>), human colon cancer cells (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26601580\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25942063\"> R<\/a>), and liver carcinoma cells (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25798529\">R<\/a>).<\/p>\n<p><em>L. helveticus<\/em> inhibited the development of fibrosarcoma in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16831211\">R<\/a>).<\/p>\n<p><em>L. helveticus<\/em> delayed the development of breast tumors in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16831211\">R<\/a>).<\/p>\n<p>The relevance of these studies to human cancer is unknown.<\/p>\n<h3><span id=\"Mechanism_of_Effect\"><a id=\"post-26180-_umpgb6ayph1j\"><\/a>Mechanism of Effect<\/span><\/h3>\n<p>In cell and animal studies, researchers have observed that <em>L. helveticus<\/em>:<\/p>\n<ul>\n<li>Decreased <a href=\"http:\/\/selfhacked.com\/blog\/interleukin-6\/\">IL-6<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16831211\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1175061\/\"> R<\/a>), <a href=\"http:\/\/selfhacked.com\/blog\/interleukin-1\/\">IL-1\u03b2<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24881786\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22735758\"> R<\/a>) and <a href=\"http:\/\/selfhacked.com\/blog\/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6\/\">TNF-\u03b1<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22735758\">R<\/a>).<\/li>\n<li>Inhibited inflammatory enzymes <a href=\"http:\/\/selfhacked.com\/blog\/cox2-natural-cox2-inhibitors\/\">COX-2<\/a> and <a href=\"https:\/\/selfdecode.com\/gene\/nos2\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">iNOS<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22735758\">R<\/a>).<\/li>\n<li>Reduced the activation of <a href=\"https:\/\/selfhacked.com\/blog\/nuclear-factor-kappa-b\/\">NF-\u03baB<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3568609\/\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22735758\"> R<\/a>).<\/li>\n<li>Increased <a href=\"http:\/\/selfhacked.com\/blog\/interleukin-1\/\">IL-1<\/a><a href=\"https:\/\/selfhacked.com\/blog\/il-10\/\">0<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22735758\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1175061\/\"> R<\/a>) and <a href=\"https:\/\/selfdecode.com\/gene\/il4\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">IL-4<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1175061\/\">R<\/a>).<\/li>\n<\/ul>\n<h2><span id=\"Safety\"><a id=\"post-26180-_2914sm3jusl3\"><\/a><strong>Safety<\/strong><\/span><\/h2>\n<p><em>L. helveticus <\/em>is considered generally safe. However, probiotics should be avoided in immunocompromised individuals, people with organ failure, and dysfunctional gut barrier, where they may cause infection.<\/p>\n<p>To avoid adverse effects and unexpected interactions, talk to your doctor before starting <em>L. helveticus<\/em> probiotics.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><em>L. helveticus<\/em> makes cheese taste great. It also confers a multitude of health benefits. The most promising results have come from studies on blood pressure, while other clinical trials have observed benefits to mental health, sleep, immunity, and more.<\/p>\n","protected":false},"author":14185,"featured_media":63002,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[22,283],"tags":[279,280],"yst_prominent_words":[6932,6928,14903,501,2892,1553,6923,6929,6924,6922,6925,6930,30523,6926,1352,554,511,548,20843,6927],"_links":{"self":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/26180"}],"collection":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/users\/14185"}],"replies":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/comments?post=26180"}],"version-history":[{"count":5,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/26180\/revisions"}],"predecessor-version":[{"id":112574,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/26180\/revisions\/112574"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media\/63002"}],"wp:attachment":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media?parent=26180"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/categories?post=26180"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/tags?post=26180"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/yst_prominent_words?post=26180"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}