{"id":25929,"date":"2016-09-16T11:36:42","date_gmt":"2016-09-16T18:36:42","guid":{"rendered":"https:\/\/selfhacked.com\/?p=25929"},"modified":"2020-03-31T01:37:06","modified_gmt":"2020-03-31T08:37:06","slug":"constitutive-androstane-receptor","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/constitutive-androstane-receptor\/","title":{"rendered":"Constitutive Androstane Receptor (CAR) Benefits & Reactions"},"content":{"rendered":"
Image credit: http:\/\/dmd.aspetjournals.org\/content\/38\/12\/2091\/F1.expansion.html<\/em><\/h6>\n

Constitutive Androstane Receptor (CAR) is important for the metabolism of the body. It helps break down foreign and toxic substances as well as decreases insulin resistance. Read more below to learn about CAR and what to do about it.<\/p>\n

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What is the Constitutive Androstane Receptor?<\/span><\/h2>\n

Constitutive Androstane Receptor (CAR) is a protein encoded by the NR1I3<\/a> gene and is part of the Nuclear Receptor family.<\/p>\n

Nuclear Receptor proteins, in general, are responsible for the homeostasis and metabolism of the body. They work by sensing the presence of steroids, hormones, and other molecules, and in response, regulate the expression of certain genes.<\/p>\n

The CAR protein is involved in regulating the breakdown of both substances from outside as well as inside the body, such as bilirubin (a substance in the intestines) and drugs\/medications. Damaged CAR proteins or genes can result in diseases such as biliary tract disease and hyperparathyroidism (R<\/a>).<\/p>\n

CAR was originally characterized as a \u201cxenobiotic sensor\u201d that is activated in response to xenobiotic stress (ingesting anything that is not natural to the body) (R<\/a>).<\/p>\n

The drug-metabolizing enzyme cytochrome P450 3A4 (CYP3A4<\/a>) is thought to be involved in the metabolism of nearly 50% of all the drugs currently prescribed. Alteration in the activity or expression of this enzyme seems to be a key predictor of drug responsiveness and toxicity. The constitutive androstane receptor increases CYP3A4 production (R<\/a>).<\/p>\n

Additionally, CAR is also activated in response to metabolic or nutritional stress (R<\/a>).<\/p>\n

CAR also influences fatty acids oxidation and glucose homeostasis (R<\/a>).<\/p>\n

CAR is produced primarily in the liver and intestines (R<\/a>).<\/p>\n

Do You React to All Supplements Because of Low CAR?<\/span><\/h2>\n

Many clients can\u2019t seem to tolerate ANY drugs and low CAR might be the reason (in addition to low PXR and RXR).<\/p>\n

Inflammation reduces both CAR and PXR, which can harm all 3 stages of drug metabolism (R<\/a>).<\/p>\n

CAR controls phase I (CYP2B and CYP3A), phase II (GSTA, UGT1A1), and transporter (MDR1<\/a>, SLC21A6, MRP2) genes involved in drugs metabolism, bile acids and bilirubin clearance in response to xenobiotics (R<\/a>).<\/p>\n

Other nuclear factors that are also involved in the detoxification of drugs\/supplements:<\/p>\n