{"id":25789,"date":"2019-12-10T06:17:06","date_gmt":"2019-12-10T14:17:06","guid":{"rendered":"https:\/\/selfhacked.com\/?p=25789"},"modified":"2021-09-20T09:18:02","modified_gmt":"2021-09-20T16:18:02","slug":"l-casei","status":"publish","type":"post","link":"https:\/\/selfhacked.com\/blog\/l-casei\/","title":{"rendered":"10+ Health Benefits of Lactobacillus casei Probiotics"},"content":{"rendered":"<p><em>L. casei<\/em> is a beneficial gut microbe that may have probiotic benefits for gut health, stress, immunity, and more. Read on to learn more.<\/p>\n<p><!--more--><\/p>\n<h2><span id=\"What_is_Lactobacillus_casei\"><a id=\"post-25789-_gmc97trxsrao\"><\/a><strong>What is <em>Lactobacillus casei<\/em>?<\/strong><\/span><\/h2>\n<p><em>Lactobacillus casei <\/em>is a Gram-positive, nonpathogenic <a href=\"http:\/\/selfhacked.com\/blog\/the-brains-secret-backup-generator\/\">lactic acid<\/a> bacterium (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4936475\/\">R<\/a>). It is found in fermented dairy products (e.g. cheese), plant materials (e.g. wine, pickles) and in the reproductive and gastrointestinal tracts of humans and animals (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4887021\/\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4705108\/\"> R<\/a>).<\/p>\n<p>As a nutritional supplement, <em>Lactobacillus casei <\/em>has been shown to improve intestinal microbial balance, arthritis, type 2 diabetes and to have potential anti-cancer properties (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4631296\/\">R<\/a>).<\/p>\n<h3><span id=\"Antioxidant_Activity\"><a id=\"post-25789-_k5n1hse5c228\"><\/a><strong>Antioxidant Activity<\/strong><\/span><\/h3>\n<p><em>L. casei<\/em> combined with prebiotic <a href=\"https:\/\/selfhacked.com\/blog\/health-benefits-inulin\/\">inulin<\/a> improved human plasma antioxidant capacity (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4808675\/\">R<\/a>).<\/p>\n<p>Treatment with <em>L. casei<\/em> reduced<a href=\"https:\/\/selfhacked.com\/blog\/oxidative-stress-101\/\"> oxidative stress<\/a> caused by aflatoxin and induced a significant improvement in all the biochemical and histological liver parameters in rats (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21658402\">R<\/a>).<\/p>\n<h2><span id=\"Potential_Benefits_of_L_casei\"><a id=\"post-25789-_beg1c0qm40sh\"><\/a><strong>Potential Benefits of <em>L. casei<\/em><\/strong><\/span><\/h2>\n<p><em>L. casei<\/em> probiotic supplements have not been approved by the FDA for medical use and generally lack solid clinical research. Regulations set manufacturing standards for them but don&#8217;t guarantee that they&#8217;re safe or effective. Speak with your doctor before supplementing.<\/p>\n<h3><span id=\"Possibly_Effective_For\"><a id=\"post-25789-_qemxk866r0qq\"><\/a>Possibly Effective For<\/span><\/h3>\n<h4><a id=\"post-25789-_xll3nl37wlu0\"><\/a>1) Gut Health<\/h4>\n<h4><a id=\"post-25789-_s1qz2b6o0avb\"><\/a><strong>Intestinal Microbiota<\/strong><\/h4>\n<p><em>L. casei<\/em> consumption altered the composition and diversity of human intestinal<a href=\"https:\/\/selfhacked.com\/blog\/how-your-gut-microbiota-can-make-you-fat-or-thin\/\"> microbiota<\/a>. There is a positive correlation between <em>L. casei <\/em>and <em>Prevotella<\/em>, <em>Lactobacillus<\/em>, <em>Faecalibacterium<\/em>, <em>Propionibacterium<\/em>, <em>Bifidobacterium<\/em> and some Bacteroidaceae and Lachnospiraceae, and a negative correlation with the presence of <em>Clostridium<\/em>, <em>Phascolarctobacterium<\/em>, <em>Serratia<\/em>, <em>Enterococcus<\/em>, <em>Shigella, <\/em>and <em>Shewanella<\/em> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24702028\">R<\/a>).<\/p>\n<p><em>L. casei <\/em>suppressed potentially harmful <em>Pseudomonas<\/em> and <em>Acinetobacter<\/em> in volunteers (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24854958\">R<\/a>).<\/p>\n<p>Fermented milk containing <em>L. casei<\/em> preserved the diversity of the <a href=\"https:\/\/selfhacked.com\/blog\/how-your-gut-microbiota-can-make-you-fat-or-thin\/\">gut microbiota<\/a>, relieved abdominal dysfunction, and prevented an increase in cortisol levels in healthy medical students exposed to academic stress (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27208120\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_alm3yy2j26q8\"><\/a><strong>Constipation and Diarrhea<\/strong><\/h4>\n<p>Continuous consumption of fermented milk containing <em>L. casei<\/em> <strong>alleviated constipation-related symptoms<\/strong>, provided satisfactory bowel habits, and resulted in earlier recovery from hemorrhoids in women after childbirth (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25380801\">R<\/a>).<\/p>\n<p>A fermented milk beverage containing <em>L. casei<\/em> relieved irregular bowel movement in gastrectomized patients. It reduced the degree of constipation and improved diarrhea (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24621348\">R<\/a>).<\/p>\n<p><em>L. casei<\/em> intake was associated with less antibiotic-associated diarrhea in patients (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24044687\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4229551\/\"> R<\/a>), reduced the incidence, duration, and severity of diarrhea in children (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3222668\/\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3858332\/\"> R<\/a>), and prevented constipation in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25955533\">R<\/a>).<\/p>\n<aside class=\"sh-partner shp-form sponsored sh-et-7388fa\">\n  <div>\n          <div class=\"partner-heading\">Get the Regimen of A Top Biohacker<\/div>\n    \n    <div class=\"partner-content\">\n      <p><span style=\"font-weight: 400\">Joe Cohen is well-known for his work as a successful entrepreneur in the health field after he overcame his many health issues using a personalized regimen. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health.\u00a0<\/span><\/p>\n    <\/div>\n\n    <div class=\"subscribe-form-container\">\n      <form method=\"POST\" action=\"\/wp-json\/wp\/v2\/posts\/25789\" class=\"sh-subscribe-form\">\n        <input type=\"email\" name=\"subscribe_form_data[email]\"\n            pattern=\"^[a-zA-Z0-9.!#$%&\u2019*+\/=?^_`{|}~-]+@[a-zA-Z0-9-]+(?:\\.[a-zA-Z0-9-]+)*$\" required\n            placeholder=\"Enter your email\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: PartnerAd Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"SH Optin: Joes Regimen\">\n                  <input type=\"hidden\" name=\"subscribe_form_data[tags][]\" value=\"PartnerAd\">\n                <button type=\"submit\" class=\"btn btn-primary subscribe-submit\">Get The Regimen<\/button>\n      <\/form>\n    <\/div>\n  <\/div>\n          <style>aside.sponsored.sh-et-7388fa::before{content:\"Advertisement\"}<\/style>\n<\/aside>\n<h4><a id=\"post-25789-_ep8pp7fs4n2v\"><\/a><strong>Intestinal Injury and Inflammation<\/strong><\/h4>\n<p><em>L. casei <\/em>relieved aspirin-associated small bowel injury (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21556830\">R<\/a>), induced complete recovery in mice with enteropathy (such as Coeliac disease) (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21615450\">R<\/a>), and ameliorated <a href=\"https:\/\/selfhacked.com\/blog\/ibd-ulcerative-colitis-crohn-genetics-lifestyle-stress-infections\/\">colitis<\/a> in rats (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21893695\">R<\/a>) and mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27107798\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_xxd70g3ed0lh\"><\/a><strong>IBD<\/strong><\/h4>\n<p><em>L. casei <\/em>decreased the severity of intestinal inflammation in mice with inflammatory bowel disease (IBD) (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3222668\/\">R<\/a>) and can counteract the pro-inflammatory effects of <em>E. coli<\/em> on Crohn\u2019s disease inflamed mucosa by downregulating proinflammatory cytokines (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18839424\">R<\/a>).<\/p>\n<h3><span id=\"Insufficient_Evidence_For\"><a id=\"post-25789-_9kykw3licepr\"><\/a>Insufficient Evidence For<\/span><\/h3>\n<p>The following purported benefits are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of <em>L. casei<\/em> for any of the below-listed uses. Remember to speak with a doctor before taking <em>L. casei<\/em> probiotics, and never use them in place of something your doctor recommends or prescribes.<\/p>\n<h4><a id=\"post-25789-_48wcsm4n29a4\"><\/a>2) Stress<\/h4>\n<p>In a study of 47 medical students undertaking an authorized nationwide examination to test their response to stress, <em>L. casei<\/em> increased <a href=\"https:\/\/selfhacked.com\/blog\/how-to-increase-serotonin\">serotonin<\/a> levels, lowered the rate of subjects experiencing common abdominal and <a href=\"http:\/\/selfhacked.com\/blog\/12-reasons-embrace-cold\/\">cold<\/a> symptoms and decreased the total number of days students experienced these symptoms (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26689231\">R<\/a>).<\/p>\n<p><em>L. casei <\/em>lowered academic stress-induced increases in <a href=\"https:\/\/selfhacked.com\/blog\/need-know-cortisol-health-effects\/\">cortisol<\/a> and the incidence of physical symptoms in students. In rats, <em>Lactobacillus casei <\/em>suppressed blood corticosterone levels (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26896291\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_1svcin8eizo0\"><\/a>3) Immunity<\/h4>\n<p><strong><em>L. casei<\/em> enhanced the immune system<\/strong> during its transit in the digestive tract of animals (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3858332\/\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19053856\"> R<\/a>) and was shown to stimulate nitric oxide, cytokine, and <a href=\"https:\/\/selfhacked.com\/blog\/prostaglandins\/\">prostaglandin<\/a> production (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23353862\">R<\/a>).<\/p>\n<p><em>L. casei<\/em> promoted the recovery of immunosuppression caused by chemotherapeutic agents in mice, by activating natural killer (NK) cells, cytotoxic T cells and macrophages (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23672525\">R<\/a>). These are all<a href=\"https:\/\/selfhacked.com\/blog\/how-to-increase-and-decrease-white-blood-cells\/\"> white blood cells<\/a> that recognize and eliminate tumor cells and infected cells.<\/p>\n<h5><a id=\"post-25789-_m5uk5fmgh2xl\"><\/a>Respiratory and Gastrointestinal Infections<\/h5>\n<p>While some studies found no evidence that consuming <em>L. casei<\/em> protects against respiratory symptoms (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22440853\">R<\/a>), many others have found that <em>L. casei <\/em>was beneficial in both respiratory and gastrointestinal infections.<\/p>\n<p><em>L. casei<\/em> significantly <strong>lowered the incidence and duration of upper respiratory tract infections<\/strong> (URTIs) in healthy middle-aged office workers (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26419583\">R<\/a>).<\/p>\n<p>Similarly, in healthy shift workers,<em> L. casei<\/em> d<strong>ecreased the incidence of gastrointestinal and respiratory common infectious disease<\/strong> (CIDs), increased the time to the first occurrence of CID, and reduced the total number of CIDs in the subgroup of smokers. In the course of CID, the total duration of fever was lower and an increase in leukocyte, <a href=\"https:\/\/selfhacked.com\/blog\/neutrophils\/\">neutrophil<\/a>, and natural killer (NK) cell counts and activity was observed (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21504972\">R<\/a>).<\/p>\n<p><em>L. casei<\/em> also <strong>lowered the incidence of common infectious diseases<\/strong> (CIDs) in children (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2906750\/\">R<\/a>), decreased the duration of CID, and especially lessened upper-respiratory-tract infections (URTI) such as rhinopharyngitis in the elderly (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19747410\">R<\/a>).<\/p>\n<p>In athletic men and women who engaged in endurance-based physical activities in winter, <em>L. casei <\/em>lowered the proportion of subjects who experienced 1 or more weeks with upper-respiratory-tract infection (URTI) symptoms and decreased the number of URTI episodes (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21411836\">R<\/a>).<\/p>\n<p>Administration of the probiotic <em>L. casei <\/em>in conjunction with albendazole reduced the <em>Giardia<\/em> infection and enhanced recovery in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23559378\">R<\/a>).<\/p>\n<h5><a id=\"post-25789-_ge0484lu9zz0\"><\/a>Viral Infections<\/h5>\n<p>Continuous intake of <em>L. casei<\/em> contributes to the alleviation of fever caused by norovirus gastroenteritis by correcting the imbalance of the intestinal microflora in the elderly (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21521545\">R<\/a>).<\/p>\n<h5><a id=\"post-25789-_5502jmm5momw\"><\/a>Parasites<\/h5>\n<p>Frequent treatment of mice with <em>L. casei<\/em> induced total protection against infection with <em>Trichinella spiralis<\/em> parasite worms (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21541750\">R<\/a>).<\/p>\n<h5><a id=\"post-25789-_ah7yl938fpou\"><\/a>Pregnancy<\/h5>\n<p>The intake of milk fermented with <em>L. casei <\/em>during the lactation period modestly contributed to the modulation of the mother\u2019s immunological response after delivery and decreases the incidence of gastrointestinal episodes in the breastfed child (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18341756\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_rt7q9kh4k4o9\"><\/a>4) Inflammation<\/h4>\n<p><em>L. casei<\/em> improved natural killer (NK) cell activity and produced a more anti-inflammatory cytokine profile in 30 healthy, non-immunocompromised elderly subjects (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23307112\">R<\/a>).<\/p>\n<p><em>L. casei <\/em>acts as an anti-inflammatory agent (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26782605\">R<\/a>). It was shown that this bacterium has anti-inflammatory effects when it is administered as a supplement in mice fed a high-fat-<a href=\"https:\/\/selfhacked.com\/blog\/elimination-diet-safest-foods-people-sensitive-everything\/\">diet<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26059375\">R<\/a>).<\/p>\n<p><em>L<\/em>. <em>casei<\/em> increased the prevalence of Lactobacilli in mice <a href=\"http:\/\/selfhacked.com\/blog\/how-your-gut-microbiota-can-make-you-fat-or-thin\/\">microbiota<\/a> and alters the expression of cytokines in a manner consistent with an anti-inflammatory response (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4705108\/\">R<\/a>).<\/p>\n<p><em>L. casei <\/em>protects mice from anaphylaxis (acute allergic inflammation) and arthritis (autoimmune inflammation) (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21810608\">R<\/a>).<\/p>\n<p>Live <em>L. casei<\/em> counteracted the proinflammatory effects of <em>E. coli<\/em> on Crohn\u2019s disease inflamed mucosa by specific downregulation of proinflammatory cytokines (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18839424\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3858332\/\"> R<\/a>).<\/p>\n<h4><a id=\"post-25789-_6vng6mbtjx97\"><\/a>5) Arthritis<\/h4>\n<p><em>L. casei <\/em>supplementation helped alleviate symptoms and improve inflammatory cytokines in 46 women with rheumatoid arthritis (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24673738\">R<\/a>).<\/p>\n<p><em>L. casei <\/em>protected mice from autoimmune arthritis (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21810608\">R<\/a>), and its consumption prior to infection abolishes intestinal and joint inflammation triggered by <em>Salmonella in mice<\/em> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3858332\/\">R<\/a>).<\/p>\n<p><em>L. casei<\/em> positively contributed to osteoarthritis treatment in rats, by reducing <a href=\"https:\/\/selfhacked.com\/blog\/23-ways-to-combat-pain-naturally-by-increasing-your-opioids\/\">pain<\/a>, inflammatory responses, and articular cartilage degradation. <em>L. casei<\/em> together with<a href=\"https:\/\/selfhacked.com\/blog\/glucosamine\/\"> glucosamine<\/a> decreased expression of various pro-inflammatory cytokines and matrix metalloproteinases while up-regulating anti-inflammatory cytokines (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21167838\">R<\/a>).<\/p>\n<p>Similarly, <em>L. casei<\/em> effectively suppressed symptoms of rheumatoid arthritis in rats, paw swelling, <a href=\"https:\/\/selfhacked.com\/blog\/lymphocytes\/\">lymphocyte<\/a> infiltration and destruction of cartilage tissues. Anti-inflammatory cytokines were increased, while pro-inflammatory cytokines were decreased (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18804867\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18243320\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20838859\"> R<\/a>).<\/p>\n<h4><a id=\"post-25789-_6qlb49di4erl\"><\/a>6) Allergies<\/h4>\n<p>Volunteers with seasonal allergic rhinitis treated with <em>L. casei<\/em> showed a significant reduction in levels of antigen-induced cytokines, showing that probiotic supplementation modulated immune responses in allergic rhinitis and may have the potential to alleviate the severity of symptoms (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18510694\">R<\/a>).<\/p>\n<p><em>L. casei<\/em> protected mice from acute allergic inflammation (anaphylaxis) (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21810608\">R<\/a>).<\/p>\n<p>Following airway allergen administration, mice fed <em>L. casei<\/em> showed evidence of attenuation of lung inflammation, as well as reductions in proinflammatory cytokines (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19001789\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_b2sbim7xym5t\"><\/a>7) Dental Health<\/h4>\n<p>Oral administration of <em>L. casei<\/em> reduced the number of pathogenic (periodontopathic) bacteria in healthy volunteers with mild to moderate gum inflammation (periodontitis) (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26672414\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_1w7b6fk2blub\"><\/a>8) Cardiovascular Disease<\/h4>\n<p><em>L. casei <\/em>improved <a href=\"http:\/\/selfhacked.com\/blog\/top-tips-for-fixing-insulin-resistance\/\">insulin sensitivity<\/a> index in humans, an important risk factor for cardiovascular morbidity, especially stroke and coronary heart disease and mortality (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4926461\/\">R<\/a>) and was shown to reduce <a href=\"https:\/\/selfhacked.com\/blog\/cholesterol\/\">cholesterol<\/a> in laboratory experiments (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23252703\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_kwwjr9j4vkj4\"><\/a>9) Diabetes<\/h4>\n<p>A synbiotic blend including <em>L. casei<\/em> improved fasting blood sugar and insulin in 38 subjects with insulin resistance [<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4926461\/\">R<\/a>].<\/p>\n<p><em>L. casei<\/em> attenuates the hyperglycemic response to glucose and blood glycerol levels in rats (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4023578\/\">R<\/a>).<\/p>\n<p>Furthermore, long\u2010term ingestion of <em>L. casei <\/em>ameliorates insulin resistance and glucose intolerance in rats fed a high-fat diet (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4023578\/\">R<\/a>), rats with hyperinsulinemia (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23797890\">R<\/a>), and obese mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4023578\/\">R<\/a>).<\/p>\n<p><em>L. casei<\/em> significantly lowers blood levels of pro-inflammatory cytokines and <a href=\"https:\/\/selfhacked.com\/blog\/neutrophils\/\">neutrophils<\/a> in diabetic rats, lowering the risk of diabetes mellitus and its complications (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26781677\">R<\/a>).<\/p>\n<p><em>L. casei<\/em> significantly improved glucose intolerance, dyslipidemia, immune-regulatory properties, and oxidative stress in mice with type 2 diabetes (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25102821\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_rm8sfccbitmn\"><\/a>10) Complications from Smoking<\/h4>\n<p>Cigarette smoking reduces natural killer (NK) activity. <em>L. casei<\/em> intake prevented the smoke-dependent NK activity reduction in 72 Italian male smokers (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22142891\">R<\/a>).<\/p>\n<h3><span id=\"Animal_Cell_Research_Lacking_Evidence\"><a id=\"post-25789-_x4j2jhguvovd\"><\/a>Animal &amp; Cell Research (Lacking Evidence)<\/span><\/h3>\n<p>No clinical evidence supports the use of <em>L. casei<\/em> for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.<\/p>\n<h4><a id=\"post-25789-_yn53n5f0qj40\"><\/a>11) Dermatitis<\/h4>\n<p>An <em>L. casei<\/em> protein P14 reduced symptoms of atopic dermatitis in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25687448\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_3yo50h6wmrp3\"><\/a>12) Candidiasis<\/h4>\n<p>The addition of <em>L. casei <\/em>to the diet of mice improves survival and resistance against <em>C. albicans<\/em> infection. This bacterium normalizes the immune response, allowing efficient recruitment and activation of phagocytes, as well as the effective release of pro-inflammatory cytokines (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21395664\">R<\/a>).<\/p>\n<p>Even heat-killed <em>L. casei <\/em>protects immunodeficient mice against <em>C. albicans <\/em>(<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10826722\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_zfl83y8xlk2k\"><\/a>13) Obesity<\/h4>\n<p><em>L. casei<\/em> supplementation improved body<a href=\"https:\/\/selfhacked.com\/blog\/a-comprehensive-list-of-effective-ways-to-lose-weight\/\"> weight<\/a> in rats fed a <a href=\"http:\/\/selfhacked.com\/blog\/low-carb-diet-vs-high-carb-diet\/\">high-fat diet<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4689799\/\">R<\/a>) and had anti-inflammatory effects when it is administered as a supplement in mice fed a high-fat-diet (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26059375\">R<\/a>).<\/p>\n<p><em>L. casei<\/em> improved <a href=\"https:\/\/selfhacked.com\/blog\/top-tips-for-fixing-insulin-resistance\/\">insulin resistance<\/a> and <a href=\"https:\/\/selfhacked.com\/blog\/glucose\/\">glucose<\/a> intolerance in mice with diet-induced<a href=\"https:\/\/selfhacked.com\/blog\/132-biological-mechanisms-for-weight-modulation\/\"> obesity<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21281408\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_5ude5m3censw\"><\/a>14) <em>H. pylori<\/em><\/h4>\n<p><em>L. casei<\/em> was effective against <em>H. pylori in laboratory experiments<\/em> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4704617\/\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_cdppafvrht2v\"><\/a>15) Liver Function<\/h4>\n<p><em>L. casei<\/em> attenuated alcohol-induced liver cell damage in a dish (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24485689\">R<\/a>).<\/p>\n<p>In chronic alcohol-induced mice, whey fermented with <em>L. casei<\/em> significantly attenuated the increased levels of <a href=\"https:\/\/selfhacked.com\/blog\/alanine-aminotransferase\/\">alanine aminotransferase<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/aspartate-aminotransferase-ast\/\">aspartate aminotransferase<\/a>, and <a href=\"https:\/\/selfhacked.com\/blog\/triglycerides\/\">triglycerides<\/a>; increased antioxidant activity; and improved liver parameters (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24767886\">R<\/a>).<\/p>\n<p><em>L. casei <\/em>protects against the onset of non-alcoholic fatty liver disease (NAFLD) in mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22749137\">R<\/a>), and suppresses nonalcoholic steatohepatitis development, by reducing blood lipopolysaccharide concentrations, suppressing inflammation and fibrosis in the liver, and reducing colon inflammation (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24113768\">R<\/a>).<\/p>\n<p><em>L. casei <\/em>significantly improved the survival of rats with liver injury, via its anti-oxidative and anti-inflammatory capacities (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23146349\">R<\/a>).<\/p>\n<p>In rats with acute liver failure, <em>L. casei <\/em>inhibits pro-inflammatory cytokines, attenuates hepatic inflammation, prevents intestinal injury and modulates the intestinal microbiota by increasing <em>Lactobacillus<\/em> and <em>Bifidobacterium<\/em> levels (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25893720\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_mxas3lkjin3a\"><\/a>16) Toxins<\/h4>\n<p><em>Lactobacillus casei<\/em> can bind to heterocyclic aromatic amines and can decrease their concentration and their toxicity (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4961978\/\">R<\/a>).<\/p>\n<p><em>Lactobacillus casei<\/em> decreases the cytotoxic effects of pesticides on human cells (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4961978\/\">R<\/a>).<\/p>\n<p><em>Lactobacillus casei<\/em> supplementation reduces the level of aflatoxin in blood and can improve the adverse effect on body weight and blood parameters in rats (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23351087\">R<\/a>).<\/p>\n<p>A fermented milk drink containing <em>Lactobacillus casei<\/em> may reduce aflatoxin toxicity in humans (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26490018\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_b3zsr1bmdpus\"><\/a>17) Histamine Intolerance<\/h4>\n<p><em>L. casei <\/em>degrades<a href=\"https:\/\/selfhacked.com\/blog\/deal-histamine\/\"> biogenic amines<\/a> (BAs) and reduces<a href=\"https:\/\/selfhacked.com\/blog\/deal-histamine\/\"> histamine<\/a> and tyramine accumulation in cheese (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22721727\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_88l4egn5ampi\"><\/a>18) Cognitive Performance<\/h4>\n<p><em>L. casei<\/em> potentiated the effect of proanthocyanidins extracted from lotus seedpod, ameliorated memory impairment in mice, and improved total antioxidant capacity level (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4232518\/\">R<\/a>).<\/p>\n<h3><span id=\"Cancer_Research\"><a id=\"post-25789-_5ly6k9qw0y4i\"><\/a><strong>Cancer Research<\/strong><\/span><\/h3>\n<p>Consumption of soy isoflavones in combination with <em>L. casei<\/em> was inversely associated with breast cancer among Japanese women (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23992486\">R<\/a>).<\/p>\n<p><em>L. casei <\/em>administration significantly reduced the recurrence rate of bladder cancer and colorectal cancer in cancer patients (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21329565\">R<\/a>).<\/p>\n<h4><a id=\"post-25789-_o2qasugr4of\"><\/a>Animal &amp; Cell Studies<\/h4>\n<p>In animals, <em>L. casei <\/em>has demonstrated considerable antitumor activity, mainly by activating macrophages, modulating the host&#8217;s immune response and regulating tumor cell death (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4936475\/\">R<\/a>). <em>L. casei<\/em> exhibits cytotoxic activity against various tumor cells (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4936475\/\">R<\/a>).<\/p>\n<p><em>L. casei<\/em> is able to suppress the growth of adult T-cell leukemia cells, acute lymphoblastic leukemia cells and promonocytic leukemia cells (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2121856\">R<\/a>).<\/p>\n<p><em>L. casei<\/em> extract killed gastric cancer cells (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22505595\">R<\/a>) <em>and<\/em> decreased the viability of liver cancer cells by 77% (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3743185\/\">R<\/a>).<\/p>\n<p><em>L. casei<\/em> decreased cell migration and invasion of colorectal cancer cells (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25773690\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22830611\"> R<\/a>), inhibited human and mouse colon cancer cell growth, and resulted in an 80% reduction in tumor volume of treated mice (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4744000\/\">R<\/a>).<\/p>\n<p>Administration of milk fermented by <em>L. casei<\/em> delayed and suppressed tumor growth in mice with breast cancer, both when it was administered preventively and as a treatment. <em>L. casei <\/em>further reduced tumor vascularity and lung metastasis, and prolonged survival (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25962107\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24646876\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22761192\"> R<\/a>).<\/p>\n<p><em>L. casei <\/em>decreased breast tumor volume and tumor vascularity in rats (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23992486\">R<\/a>).<\/p>\n<h3><span id=\"Mechanisms\"><a id=\"post-25789-_146h89xz5hit\"><\/a><strong>Mechanisms<\/strong><\/span><\/h3>\n<p>In cell and animal studies, researchers have observed that <em>L. casei<\/em>:<\/p>\n<ul>\n<li>Decreased pro-inflammatory cytokines such as <a href=\"http:\/\/selfhacked.com\/blog\/supplements-lifestyle-factors-influence-tnf-interleukin-6-il-6\/\">TNF-\u03b1<\/a>, <a href=\"https:\/\/selfhacked.com\/blog\/interferon-gamma-how-to-increase-decrease-high-low-levels\/\">IFN-\u03b3<\/a>, interleukins <a href=\"http:\/\/selfdecode.com\/gene\/il2\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">IL-2<\/a>,<a href=\"https:\/\/selfhacked.com\/blog\/interleukin-6\/\"> IL-6<\/a>, <a href=\"http:\/\/selfhacked.com\/blog\/il-8\/\">IL-8<\/a>, <a href=\"http:\/\/selfhacked.com\/blog\/interleukin-1\/\">IL-1<\/a><a href=\"http:\/\/selfhacked.com\/blog\/th17\/\">7<\/a>, <a href=\"https:\/\/selfdecode.com\/gene\/il23r\/?utm_source=seo&amp;#38;utm_medium=selfhacked&amp;#38;utm_campaign=id00002\">IL-23<\/a>, <a href=\"http:\/\/selfhacked.com\/blog\/interleukin-1\/\">IL-1\u03b2<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4705108\/\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26059375\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26782605\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18839424\"> R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3858332\/\"> R<\/a>).<\/li>\n<li>Increased anti-inflammatory cytokines such as <a href=\"http:\/\/selfhacked.com\/blog\/il-10\/\">IL-10<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4705108\/\">R<\/a>,<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26782605\"> R<\/a>).<\/li>\n<li>Inhibited nuclear factor <a href=\"https:\/\/selfhacked.com\/blog\/nuclear-factor-kappa-b\/\">NF-\u03baB<\/a> (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26782605\">R<\/a>).<\/li>\n<li>May have prevented inflammation in patients who had already synthesized specific IgE or autoantibodies (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21810608\">R<\/a>).<\/li>\n<\/ul>\n<h2><span id=\"Safety\"><a id=\"post-25789-_tz7xiruzlyfu\"><\/a><strong>Safety<\/strong><\/span><\/h2>\n<p><em>Lactobacillus casei<\/em> is generally well tolerated. The use of <a href=\"https:\/\/selfhacked.com\/blog\/probiotics-good-bacteria\/\">probiotics<\/a> should be avoided in patients with organ failure, immunocompromised status, and dysfunctional gut barrier mechanisms. To avoid adverse effects, talk to your doctor before starting any new probiotic supplements.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><em>L. casei<\/em> is a beneficial gut microbe that may have probiotic benefits for gut health, stress, immunity, and more. Read on to learn more.<\/p>\n","protected":false},"author":26632,"featured_media":21288,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[22,283],"tags":[279,280],"yst_prominent_words":[15223,6776,30013,20856,20857,1352,554,6770,6771,6777,5713,6773,511,515,529,6169,548,30014,6779,6778],"_links":{"self":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/25789"}],"collection":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/users\/26632"}],"replies":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/comments?post=25789"}],"version-history":[{"count":9,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/25789\/revisions"}],"predecessor-version":[{"id":112343,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/posts\/25789\/revisions\/112343"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media\/21288"}],"wp:attachment":[{"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/media?parent=25789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/categories?post=25789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/tags?post=25789"},{"taxonomy":"yst_prominent_words","embeddable":true,"href":"https:\/\/selfhacked.com\/wp-json\/wp\/v2\/yst_prominent_words?post=25789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}