Baicalin and baicalein are flavones under investigation for potential benefits to the nervous system & in rheumatoid arthritis. Learn more here.<\/p>\n
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Baicalein is a flavone, a type of polyphenolic flavonoid, that is extracted from the roots of Scutellaria baicalensis<\/em> and Scutellaria lateriflora<\/em> that have a wide variety of health benefits.<\/p>\n Baicalin is a flavone glycoside, the glucuronide of baicalein, which is obtained through the binding of glucuronic acid to baicalein. It is primarily used in Asian countries as an herbal supplement.<\/p>\n Baicalin and baicalein supplements have not been approved by the FDA for medical use and generally, lack solid clinical research. Regulations set manufacturing standards for them but don’t guarantee that they’re safe or effective. Speak with your doctor before supplementing.<\/p>\n In one study of 374 patients with rheumatoid arthritis and coronary artery disease (which are frequently comorbid), 500 mg of baicalin per day significantly reduced blood lipids and markers of inflammation [R<\/a>].<\/p>\n No clinical evidence supports the use of baicalin for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed below should not be interpreted as supportive of any health benefit.<\/p>\n Baicalein and baicalin inhibited the action potential of the neurons that raise anxiety (R<\/a>).<\/p>\n In mice, baicalin produced anxiety-lowering effects without causing drowsiness or muscle relaxation (R<\/a>).<\/p>\n Baicalin improved cognitive dysfunction<\/a> in mice via its anti-neuroinflammatory activity, leading authors to suggest it as a potential candidate for the treatment of Alzheimer\u2019s Disease (AD) (R<\/a>).<\/p>\n It improved Amyloid beta-induced learning and memory deficit, hippocampus injury and neuron apoptosis (mice) (R<\/a>).<\/p>\n Baicalin improved learning and memory impairment induced by brain injury in mammals (R<\/a>).<\/p>\n Treatment with this flavonoid in animals, post-stroke, promoted neuron development in damaged sections of the brain, including the new formation of cells in the hippocampus (R<\/a>).<\/p>\n<\/a>Potential Health Benefits<\/strong><\/span><\/h2>\n
<\/a>Possibly Effective For<\/span><\/h3>\n
<\/a>1) Rheumatoid Arthritis & CAD<\/h4>\n
<\/a>Animal Research (Lacking Evidence)<\/span><\/h3>\n
<\/a>2) Anxiety<\/h4>\n
<\/a>3) Neuroprotection<\/h4>\n