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<\/p>\nKlotho is a protein that plays a role in intelligence and longevity. Read on to learn about genetic and environmental factors that may increase it.
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Klotho is a protein that circulates in the blood and brain throughout life. It declines with age, in conjunction with cognitive deficits [R<\/a>, R<\/a>, R<\/a>, R<\/a>].<\/p>\n According to some research, it plays a role in longevity [R<\/a>, R<\/a>].<\/p>\n It also helps regenerate muscle<\/b> (by inhibiting TGF<\/a>) [R<\/a>].<\/p>\n People with genetic variants with higher levels of Klotho had lower rates of heart disease in one study [R<\/a>].<\/p>\n Klotho suppresses<\/b> insulin<\/b><\/a> and<\/b> IGF-1<\/b><\/a> pathways in mice. It suppresses the production of biologically active <\/b>vitamin D<\/b><\/a> (decreases 1alpha-hydroxylase) [R<\/a>, R<\/a>].<\/p>\n Klotho may also enhance antioxidant balance<\/b> [R<\/a>].<\/p>\n The below findings should guide further investigational efforts, but they should not be interpreted as supportive of any health effect of Klotho protein in humans.<\/i><\/p>\n According to the observations of some researchers, some mice bred for higher levels of Klotho<\/b>:<\/p>\n According to other observations, some mice bred to have lower levels of Klotho experience<\/b>:<\/p>\n The role of Klotho protein in human health and disease is not fully clear. Improving your Klotho levels won\u2019t necessarily cause health improvement of any kind.<\/i><\/p>\n The following is a list of factors and complementary approaches that may increase Klotho levels. Additional large-scale studies are needed before making any conclusions. Remember to talk to your doctor before making any major changes to your day-to-day routine.<\/i><\/p>\n The following decrease klotho:<\/p>\n If you have your genetic data sequenced, you can find out whether you have a high or low producing variation of the Klotho<\/i> gene<\/a>.<\/p>\n The most significant Klotho SNP is:<\/p>\nMouse Studies on Klotho<\/b><\/span><\/h2>\n
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Factors That Increase Klotho Levels<\/b><\/span><\/h2>\n
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Factors that Decrease Klotho<\/b><\/span><\/h2>\n
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Klotho Genes and SNPs<\/b><\/span><\/h2>\n