One last thing: Your phrasing is incredibly eloquent. “A study of adolescent substance use (cigarette smoking, alcohol, and cannabis) FOUND A COMPLEX ASSOCIATION between COMT methylation and substance abuse” … I feel the depth in your knowledge from that single phrase (although it’s evident throughout the site) and love the way you share it!

Thanks again,
Annie @biomedbitch

Best way to make sure one is maintaining with appropriate lifestyle interventions and not takin g one step forward and two steps back?

Are there any other herbs or vitamins suggest to help increase dopamine production?

This article used to contain a variety of supplements, vitamins, and drugs that will assist someone with with either low dopamine levels/High COMT and those who have high dopamine levels/Low COMT. Would you please list those substances again in in a future update of this article explaining the differences in the COMT gene among a person’s DNA?

After conducting some basic research on the “Warrior Gene,” I’ve become somewhat confused on what appears to be an issue between two different perspectives or concepts. For example, I’ve seen articles on the “Warrior Gene” that refer to the rs4680 G/G and the increased COMT breakdown of dopamine, epinephrine, and norepinephrine, which in return allows for lower levels of these hormones in those who possess the rs4680 to help better manage stress levels. However, a second “Warrior Gene” concept pertains to the MAOA-L, in which a person who possesses this trait has higher levels of serotonin, norepinephrine, and dopamine, which then correlates with less ability of handling stress levels.

Here’s one article of several that goes into this issue on the MAOA-L.

https://www.psychologytoday.com/us/blog/psychology-writers/201104/triggering-the-warrior-gene-in-villain-or-hero

So, my question is: What am I missing between these two “Warrior Gene” concepts regarding the breakdown of hormones. Additionally, as the rs4680 mentions epinephrine, the MAOA-L mentions serotonin. With that, am I seeing some inconsistencies between these “Warrior Gene” concepts? That is, and as a reiteration, one appears allow for better stress management (rs4680 G/G) while the other for less stress management (MAOA-L).

Sincerely, Bryant Daniels

By getting tested with SelfDecode.com

I’ve found coffee made me drowsey, but usualy when it’s warm. Coffee itself can be a relaxant and stress/tension releaser.

RESULTS:
Six-month old male but not female ArKO mice develop compulsive behaviors such as excessive barbering, grooming and wheel-running. Excessive activities were reversed by 3 weeks of 17beta-estradiol replacement. Interestingly, the presentation of compulsive behaviors is accompanied by concomitant decreases (p < .05) in hypothalamic COMT protein levels in male ArKO mice. These values returned to normal upon 17beta-estradiol treatment. In contrast, hepatic and frontal cortex COMT levels were not affected by the estrogen status, indicating region- and tissue-specific regulation of COMT levels by estrogen. No differences in COMT levels were detectable between female animals of both genotypes.

CONCLUSIONS:
This study describes the novel observation of a possible link between estrogen, COMT and development of compulsive behaviors in male animals which may have therapeutic implications in obsessive compulsive disorder (OCD) patients.