Comments on: 13 Vitamin B6 (Pyridoxine) Benefits + Sources, Side Effects

By: greg

greg — Thu, 09 May 2019 09:53:47 +0000

For further sound information on B6 and the other B vitamins please research Orthomolecular Medicine. Research and form your own opinions, always keep an open mind…

By: Ann

Ann — Fri, 02 Nov 2018 02:21:33 +0000

I also have Morton toe and many of the symptoms

By: TM

TM — Wed, 10 Oct 2018 05:46:59 +0000

Hi, is there a ratio to follow when giving both B6 and P5P? My son is on high dose (grams) of P5P before taking B6 lately. How do I know which works better?

By: Angela Berry-Koch

Angela Berry-Koch — Fri, 28 Sep 2018 15:29:54 +0000

My son has schizophrenia type symptoms and a positive dx for lyme (by culture). He was slightly high on pyrrole test many years back. But he was ART tested and did not tolerate P5P but was fine with regular B6. Still only a few times a week. Not regularly. I am trying to figure out why someone could not metabolize P5P which according to Klinghardt is 10 percent of the population? ? Thinking it may give me some hints on cause of the psychosis. I have wondered about porphyria because I have heard that these people cannot tolerate B6 very easily? Any wisdom on this appreciated, Angela

By: Joseph Arsanis

Joseph Arsanis — Sat, 16 Jun 2018 18:21:03 +0000

If I am taking B6 300 mg plus B-Complex100 = 400 mg of b6 Daily for tardive dyskinesia and I changed over to P5P B6 how much would be the same? P5P is activated and b6 isn’t , so perhaps the same ?

By: Debra

Debra — Thu, 10 May 2018 14:57:27 +0000

Can you take p5 p while tapering venlafaxine?

By: Sean Braughton

Sean Braughton — Sun, 31 Dec 2017 23:44:12 +0000

Looks like I was doing this off the top of my head and replaced 12 with 6, but there are interesting studies to show that we should be limiting doses of most B vitamins as many of them tend to super dose us.

By: Eva v T

Eva v T — Thu, 03 Aug 2017 20:09:11 +0000

My daughter have pyrrole and is also very high in histamine, she need B6 but I don’t dare give it to her due to that it increases histidine decarboxylase. What to do?

By: irais lec

irais lec — Sat, 22 Apr 2017 22:09:42 +0000

What about the max dosage for a 4 year old child with Autism of P5P?

By: Daniel Crawford

Daniel Crawford — Mon, 27 Mar 2017 01:36:58 +0000

In reply to Nancy M. Sounds like you might have Pyrrole Disorder A common feature of many behavior and emotional disorders is pyroluria, an inborn error of pyrrole chemistry which results in a dramatic deficiency of zinc and Vitamin B-6. Common symptoms include explosive temper, emotional mood swings, poor short-term memory, and frequent infections. These patients are easily identified by their inability to tan, poor dream recall, abnormal fat distribution, and sensitivity to light and sound. The decisive laboratory test is analysis for pyrrole levels in urine. Treatment centers on normalizing blood levels of B-6 and zinc.

By: Daniel Crawford

Daniel Crawford — Mon, 27 Mar 2017 01:36:00 +0000

Great write up. Though you are missing probably the most common related b6 issue.

Pyrrole Disorder

A common feature of many behavior and emotional disorders is pyroluria, an inborn error of pyrrole chemistry which results in a dramatic deficiency of zinc and Vitamin B-6. Common symptoms include explosive temper, emotional mood swings, poor short-term memory, and frequent infections. These patients are easily identified by their inability to tan, poor dream recall, abnormal fat distribution, and sensitivity to light and sound. The decisive laboratory test is analysis for pyrrole levels in urine. Treatment centers on normalizing blood levels of B-6 and zinc.

By: Bethany

Bethany — Tue, 07 Mar 2017 16:53:04 +0000

In reply to Terry.

Do you by chance have Morton’s toe?
I’m not a doctor, but I have Morton’s toe and I understand that genetically, we can have the problems you described.

By: Terry

Terry — Sun, 01 Jan 2017 02:33:23 +0000

Hi, Joesehph Cohen – Do you have any suggestions for people with naturally elevated B-6 levels? I don’t supplement it but my labs are at 223.4 with a reference range of 20.0 – 125.0 nmol/L (Pyridoxal 5-Phosphate). I’ve seen several forums with confused people like me who never take B-6 but are always high in serum labs. I wish I could say I feel great, but despite a good CRP level I still have some inflammation. In fact, I feel like I should be low in B-6. Thanks for any feedback, and for your excellent site.

By: Jing Xu

Jing Xu — Wed, 28 Dec 2016 06:43:49 +0000

It caught my attention that PL is an aldehyde, which is toxic. Can you explain more to us how PL is used and metabolized since I don’t see the benefit of it lingering inside body for long.

Thanks!

By: Joseph M. Cohen

Joseph M. Cohen — Sun, 14 Aug 2016 17:09:16 +0000

In reply to Nancy M. You should just use a b complex

By: Nancy M

Nancy M — Sat, 13 Aug 2016 13:24:58 +0000

Thank you for this interesting article. I am puzzled/frustrated by the fact that all of the supplements listed and those that I have found on the internet, far exceed the recommended dose mentioned. There are many references to P-5-P toxicity experiences found on the internet and yet you cannot but this in a dose below 25 mg. Jarrow B complex has it in 10 mg (closer to the 1 mg I am seeking for my child) but it has other vitamins that an individual may not be tolerant of.

By: Eduardo

Eduardo — Wed, 01 Jun 2016 23:11:42 +0000

I love everything you share. Can I make a suggestion? It would be great if you could let us know what the half lives of vitamins and other substances (like antioxidants) are, so we know whether we need to take them more than once a day. For instance, alpha lipoic acid has a really short half life. I tried to find this information about water soluble vitamins, but could not.
Thanks!

By: Joseph M. Cohen

Joseph M. Cohen — Wed, 01 Jun 2016 23:07:04 +0000

In reply to Brett.

Interesting…
This one?

By: Joseph M. Cohen

Joseph M. Cohen — Wed, 01 Jun 2016 23:06:02 +0000

In reply to daz. I haven't seen any studies on it...

By: Brett

Brett — Wed, 01 Jun 2016 14:56:23 +0000

I have some kind of weird B6 issue where my levels test rock-bottom (0) on a Organic Acids Test, despite making an effort to eat foods containing B6. I developed an insufficiency where the symptoms were this relentless “wired but tired” insomnia. I took the Source Naturals Coenzymated B6 (P5P) Sublingual lozenges – these were extremely potent, faster acting that swallowed tablets. I could feel a major serotonin rush within minutes of putting it under my tounge and I would fall right aslseep. After I built my levels up from regular use, they seemed to take on a more stimulating effect.

By: daz

daz — Wed, 01 Jun 2016 00:13:55 +0000

thx for the post Joe,

on the subject of b6 supps,
I see that Country Life do another Active B6 supp,
which is half p5p & half PAK (Pyridoxine alpha-ketoglutarate).

could you comment on the PAK ingredient if possible