Comments on: Pregnenolone Uses, Side Effects & Safety

By: Carlos

Carlos — Wed, 02 Jun 2021 09:34:45 +0000

Hello

I am a nutritionist, I am writing to you from Spain

At what age is it recommended to take prenegnolone supplements?

In which pathologies is its use not recommended, without medical supervision?

By: Kay

Kay — Fri, 16 Apr 2021 14:14:02 +0000

Surely it depends on the person, their age, current hormonal profile, genetic profile and also the dose. I am highly suspicious of high dosages. Perhaps tiny dosages would be more appropriate when warranted.

By: John Ferrari

John Ferrari — Sat, 30 May 2020 22:22:50 +0000

Thank for the good info.

What do you think of Nootropics like Pramiracetam and Coluracetam? I have tried them and they have a definite effect on my mental state. The only drawback is that they can cause headache if you take too much.

John

By: TERESA VANDERPOOL

TERESA VANDERPOOL — Sat, 14 Dec 2019 22:28:22 +0000

Well, I would like to know has the FDA approved Pregnenolone for humans, and is it safe?

By: Dr Zeljka Clark

Dr Zeljka Clark — Tue, 19 Nov 2019 20:23:22 +0000

Excellent paper. I would like to ask if there is any data on potential benefits of Pregnenolone for GSM.

By: Simone

Simone — Sat, 13 Jul 2019 16:19:30 +0000

You mention ‘reduce cortisol’ – how can you reduce cortisol?
I think pregnenolone would benefit me though my cortisol is already high? any advise?

By: Ana Aleksic, MSc (Pharmacy)

Ana Aleksic, MSc (Pharmacy) — Tue, 18 Jun 2019 20:28:06 +0000

In reply to Michelle Joy Mugavin. Hi Michelle, more research supports the use of pregnenolone in capsules.

By: Michelle Joy Mugavin

Michelle Joy Mugavin — Wed, 12 Jun 2019 07:54:33 +0000

Is it better to take pregnenolone in capsules or use cream.

By: Jeffrey Florentino

Jeffrey Florentino — Wed, 05 Jun 2019 01:33:23 +0000

In reply to Michael (NW).

Thanks for your comment. To get answers to your health questions, please join SelfHacked VIP at https://selfhacked.lpages.co/selfhackedvip/. Feel free to get in touch with us with any questions about how our VIP members area works at [email protected].

By: Michael (NW)

Michael (NW) — Tue, 04 Jun 2019 13:35:56 +0000

“Inhibiting cortisol production may also help.

This way, pregnenolone will go more to making progesterone, DHEA, and testosterone instead of estradiol and cortisol.”

How do you inhibit cortisol production?

Thank you.

By: Candace

Candace — Tue, 28 May 2019 18:32:22 +0000

Self hack has great insight and information. I tried pregnenolone according to the recommendations and feel noticeably more aware, energetic, cheerful and optimistic. Basically, at around 65 I feel more like 30. Thanks!

By: Toros Demircioglu

Toros Demircioglu — Wed, 01 May 2019 20:54:45 +0000

THanks

By: Jeffrey Florentino

Jeffrey Florentino — Tue, 30 Apr 2019 22:34:40 +0000

In reply to Lance Templet.

By: Lance Templet

Lance Templet — Sat, 27 Apr 2019 02:12:48 +0000

Is it possible that pregnenlone taken in the morning could make you feel sleepy during the day?

By: Ana Aleksic, MSc (Pharmacy)

Ana Aleksic, MSc (Pharmacy) — Tue, 02 Apr 2019 20:14:31 +0000

In reply to Laura Milagros.

Hi Laura, thanks for your comment. To get answers to your health questions, please join SelfHacked VIP at https://selfhacked.lpages.co/selfhackedvip/. Feel free to get in touch with us with any questions about how our VIP members area works at [email protected].

By: Laura Milagros

Laura Milagros — Mon, 01 Apr 2019 20:31:14 +0000

4/1/19 Im 65, in rather poor health (non age related). I must take Estradiol (1 mg) & Provera (2.5mg) every day. I have 3 auto-immune diseases & the words exhaustion, fatigue & chronic insomnia cant even begin to describe how unbearable I feel every day. I take high doses of most B vitamins, which mildly increase my energy. I also take VERY high doses of the combo Biotin/Keratin for the inevitable autoimmune alopecia. (I cant take a B complex bc Im deathly “allergic” to Niacin.) Im planning to begin a regimen of: DHEA, Pregnenolone & B5. However, I have no clue what dosages to take. The vast amount of info is confusing & somewhat contradictory. This subject is not particularly interesting to my PCP, so I am seeking some advice & guidance. My fear is by taking my HRT with Preg & DHEA, they will all end up cancelling out each other, thus leaving me TOTALLY hormone depleated. Any suggestions as to beginning dosages for these 3 supplements? Thanks.

By: NancyS

NancyS — Wed, 14 Nov 2018 13:06:38 +0000

I have an expired bottle of this. Read about it years ago, bought some and then was scared to use it. It’s 8am and I think I’ll go try it right now. Thank you for this site. . I’ll save it and let you know what I think after a day or more. NancyS .

By: Selma Da Silva

Selma Da Silva — Sun, 11 Nov 2018 01:39:02 +0000

My Dr.recomend this med. For low energy, and hair loss. Is anyone had the same problem and got help from this med.???

By: Josh O

Josh O — Sun, 29 Jul 2018 17:47:15 +0000

ROBERT SMYK, You’re message is concerning. I think it’s either you are trolling or you are suffering from adult onset schizophrenia or a delusional bi-polar disorder. I can’t see pregnenolone ever making you act different enough to get you fired from a job, and if it did, you would certainly notice the changes yourself. Were you taking full bottles at once. or regular dosages? Studies have been done on 10-20 times the average dosage everyday for weeks and there was never any symptoms you described.

The fact you equated sport celebrities dieing for no apparent reason (which I can’t think of an instance of that happening in recent history), to the use of pregnenolone and HGH is massive projection, and is seen in schizophrenic individuals. You then say that you correlate their deaths to the abrupt cessation of use, so that is what you did. Either you are stating you wanted to die, or your logic and reasoning is suffering.

To be honest, the only common hormones used that have an inherent health risk when used for performance enhancement are androgens like testosterone, dht, and their derivatives. HGH is much less likely to cause problems when used properly and pregnenolone is as close to benign as endogenous hormones get. That’s not to say that any hormone is risk-free, nor should you use any without doctor supervision.

I would suggest you see a doctor as soon as possible in regards to your symptoms, as there is a high chance they were not caused by pregnenolone. The symptoms are classic signs of mental illness or drug-induced psychosis. Whichever the case here, you need help. I apologize if this comes across as demeaning but I have family and friends who have suffered from schizophrenia, bi-polar disorder, and drug addiction. The are all forms of mental illness, which can only get better when one seeks treatment. Even if you don’t believe my reasoning, it can’t hurt to see the doctor anyways and bring up the same experience and thoughts you shared here, and see what his/her opinion is.

By: Dee

Dee — Wed, 25 Jul 2018 04:12:29 +0000

I am hypopituitary. I have to take cortisone, but am so sensitive to it, I have dropped the dosage down from 20 mgs daily ( homicidal) to 7mgs. My question is simple, can I take pregnenone? I am desperate for sleep, relief from fatigue, and in general I would like to live again. I have zero libido, even though I take bio identical hormones. Included in my cream is testosterone, which does nada. My poor husband deserves better. What say you? Yay or nay?

By: Tshego

Tshego — Tue, 24 Jul 2018 20:48:14 +0000

Can I take Progesterone and Pregnenolone together?

By: Carol Labelle

Carol Labelle — Tue, 03 Jul 2018 02:12:11 +0000

I always that that generally when the body is provided with a precursor, it will only make what it needs. Is this not the case? Tks.

By: Carol Labelle

Carol Labelle — Tue, 03 Jul 2018 02:07:48 +0000

Generally when the body is provided with a precursor, it will only make what it needs.

By: Jim

Jim — Fri, 15 Jun 2018 11:57:00 +0000

Is Pregnenolone suppressive