Comments on: TMAO: Why It Increases & Factors That May Reduce TMAO levels

By: markhagerty@ymail.com markhagerty@ymail.com

markhagerty@ymail.com markhagerty@ymail.com — Sat, 16 Jan 2021 21:37:12 +0000

Concerned my tmao level was sky high despite all other blood lipids and hs CRP being quite good.

By: Laura

Laura — Wed, 09 Sep 2020 14:54:18 +0000

Great information as many people take Carnitine for heart problems which seems it might not be the best idea if it increases TMAO levels. Do you know if taking carnosine would have the same effect as carnitine on TMAO levels?

By: George Goldsmith

George Goldsmith — Mon, 30 Dec 2019 21:53:22 +0000

Excellent article, Carlos. Wish you had gone farther. TMAO is implicated pretty conclusively in CKD and CVD, which are two of the most destructive diseases afflicting humankind. Recently Taurisolo, a grape pomace extract, was shown to dramatically reduce TMAO levels in all test subjects. When pectin was added, that had no increased effect. Taurisolo may have worked better than other grape seed products because of the way it is made — specifically to bypass the stomach acids and is thus much more bioavailable. I don’t find many, if any, similarly well thought through products available in America and Taurisolo is not available here as far as I can see, so if you know where it can be purchased by Americans, please let the readers (and me) know asap.
Many thanks.

By: Suzi Hawkins

Suzi Hawkins — Wed, 13 Nov 2019 12:15:26 +0000

Hi, Anastasia. Thanks for your article. I have been reading a lot around Phosphatidylcholine and the productions of TMAO in PubMed and other medical trials. I am wondering if you could answer a question on this subject.
Most of the trials were tracked by men and women eating high PhosCholin diets of Red meat.
My question concerns those that do not eat red meat or drink alcohol and eat mostly a fish/vegetarian diet but often take PhosCholin supplementation, as it’s a major part of what our cells are made up off. My question is: Have any tests been completed with people who do not eat red meat, TMAO inducing food but instead who take Phosphatidylcholine as a supplement? I would be interested to know what results are found when PhosCholine is taken in people as a supplement, who do not consume red meat?
Red meat is a whole food containing both the Phosphatidylcholine and saturated fats plus others. These interactions of chemicals within the red meat may also have an interaction alongside the Phosphatidylcholine that precipitates its action and results into TMAO. It would be interesting to know what happens to those who take just the PhosCholine without consuming red meat. I hope this is a reasonable question to ask? Many thanks, Suzi

By: Veronica Hardy

Veronica Hardy — Mon, 04 Nov 2019 19:30:39 +0000

What are supplements I can take to lower my TMAO levels?

By: Tom Ng

Tom Ng — Fri, 11 Oct 2019 22:55:36 +0000

Very useful information on how to lower TMAO and ultimately CVD risk. Thanks a lot. Will share

By: Loro

Loro — Thu, 03 Oct 2019 20:04:35 +0000

TMAO also increases prostate cancer risk.

By: Leanne

Leanne — Tue, 01 Oct 2019 21:44:35 +0000

I am 52, have had 2 heart attacks (age 44 and 51) but otherwise healthy. I have 5 stents because of plaque in arteries. My functional medicine doc prescribed phosphotidycholine (sp?) as part of my supplement protocol because i have the apoe4/4 gene which is a risk for cardiovascular issues and Alzheimer’s. Am I reading this article correctly that I should NOT be taking added choline? Thanks!

By: Sam

Sam — Tue, 10 Apr 2018 07:06:46 +0000

Rob White, good point,but that are the levels of dha/epa in a bird. One case is to grow your own:”To minimize cost, while achieving adequate breast meat n-3 enrichment, carcass weight, and meat yield, feeding 10% flaxseed for 24.1 d before processing is recommended as an optimal breast meat n-3 enrichment strategy. The optimal thigh meat n-3 enrichment strategy was to feed 10% flaxseed for 4.54 d before processing.”
https://academic.oup.com/ps/article/88/5/1108/2962787

By: Evguenia Alechine

Evguenia Alechine — Fri, 01 Dec 2017 02:53:59 +0000

In reply to Elizabeth Swope.

Hi Elizabeth,
When you get a new comment, at the bottom of the window there is a link that says “unsubscribe from all follow-up comments.” Hope this helps! If not, please send us an email to support(at)selfhacked(dot)com

By: Biljana N

Biljana N — Sun, 26 Nov 2017 14:55:26 +0000

In reply to Mary Do. Exactly, this is a review of what we know at this point about TMAO (through scientific research). But there is a lot of ground left to cover here. There are those who stress the importance of TMAO as THE answer to why we have heart disease, and those who say this is all rubbish. The truth is most likely somewhere in-between. Hopefully, more meaningful studies will soon follow.

By: Nattha Wannissorn, PhD

Nattha Wannissorn, PhD — Sat, 25 Nov 2017 16:03:09 +0000

In reply to Colin. Click on the lock on the left hand side of the URL in your browser and then under Notifications, click Block.

By: Elizabeth Swope

Elizabeth Swope — Fri, 24 Nov 2017 16:19:15 +0000

Hello Joe, I refer to your site all the time because of the excellent information, but I would like to unsubscribe to the automatic comments. I don’t see a place to unsubscribe. How would one do that.
Thank you

By: Colin

Colin — Fri, 24 Nov 2017 04:57:38 +0000

Stop sending messages in this manner. Its intrusive and i dont like the way you just barge in unenvited with no unsubscribe contact. Your messages come in with no email… nothing… please go away.

By: Mary Do

Mary Do — Fri, 24 Nov 2017 03:08:27 +0000

It seemed that the results of these studies somewhat contradicts one another…It is not a clear simple answer that we should not eat those foods/ supplements those were claimed to increase TMA, because to me, once again, science is looking at a single compound without looking at the big picture where there are complec interractiond between various compounds including this TMA, plus many other factors those are also influencing the body conditions. In my personal opinion, this is another piece of the puzzle, but we need the whole picture!

By: Eli

Eli — Tue, 21 Nov 2017 19:50:18 +0000

So a tablespoon of sunflower lecithin a day in my smoothies to help with heart and cholesterol, brain health, liver health, blood pressure isn’t advised?

By: MARK ALMAN

MARK ALMAN — Mon, 20 Nov 2017 03:02:02 +0000

…SMH

By: Rob White

Rob White — Sun, 19 Nov 2017 17:20:25 +0000

I supplement with a tablespoon of non defatted dessicated beef liver powder most mornings. Is this likely to raise TMAO?

By: Rob White

Rob White — Sun, 19 Nov 2017 17:11:53 +0000

V interesting how fish is a big contributor to high TMAO.

One way to get the benefits of DHA /EPA without consuming fish could be to replace it with high omega 3 poultry that is now available in many supermarkets.

By: Mats

Mats — Tue, 14 Nov 2017 19:04:46 +0000

Hello! Thank you for this favourite site! Im in every day. :)
May i ask, do you advice me to stop taking choline, lecithin, and L-carnitine as supplements? Im eating them as suplements.