Comments on: What is TGF Beta? + Factors that May Inhibit/Increase It

By: Randy Beran

Randy Beran — Sat, 06 Feb 2021 12:44:11 +0000

Dear Doctor Yazdi,

Would you please tell me if boron increases TNF beta? I am thinking about buying a boron supplement but do not want to increase TNF beta. I have erectile dysfunction and do not want to increase the chances for penile fibrosis and reactive oxygen speciies. Thank you.

Randy

By: Cheryl Diamond

Cheryl Diamond — Fri, 21 Aug 2020 01:21:12 +0000

Dr. Yazdi, will butryate increase my tgf beta 1? I have dupyuters contracters, and would like to know if butyrate will make my condition worse? Is it safe to continue taking it?

By: Shana Redmon

Shana Redmon — Tue, 05 Nov 2019 10:42:31 +0000

I have a tgf beta 1 of 6366 is this high?

By: August Rich

August Rich — Tue, 16 Jul 2019 01:56:42 +0000

https://sciencebeta.com/fibroblasts-fat-cells/
I would like to know how to specifically prevent tgf-b from causing dermal fat loss with aging. Now that we know it’s the cause – and that dermal fat loss is the number one cause of wrinkles and saggy arms, then on to fragile skin – why isn’t there a lot more discussion about it?

By: Jeffrey Florentino

Jeffrey Florentino — Thu, 02 May 2019 04:35:39 +0000

In reply to August.

Thanks for your comment. To get answers to your health questions, please join SelfHacked VIP at https://selfhacked.lpages.co/selfhackedvip/. Feel free to get in touch with us with any questions about how our VIP members area works at [email protected].

By: August

August — Wed, 01 May 2019 02:38:03 +0000

Great article as always. I would like to understand why recent studies show that higher tgf-b levels with aging cause subcutaneous fat loss under skin ( wrinkles, sagging) while another study shows lack of tgf-b is the cause of uterine cancer.
Will piog save skin fat ( a p gamma activator and lipodystrophy treatment ) while at same time thickening uterus – a very bad thing?

By: Jeffrey Florentino

Jeffrey Florentino — Tue, 30 Apr 2019 22:46:39 +0000

In reply to Peter Leuenberger.

By: Peter Leuenberger

Peter Leuenberger — Tue, 23 Apr 2019 08:47:57 +0000

So I have to high th9 and th17, a bit low cd19 normal most others. Long time Lynne disease and digestive issues. Does that indicate something in addition of what you wrote here and on the th17 page? Thanks!

By: Elad

Elad — Sat, 11 Aug 2018 07:53:29 +0000

Ginger;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329177/

By: sheri

sheri — Tue, 17 Jul 2018 01:45:11 +0000

I had TGF beta tested for mold concerns–should I have had TGf Beta1 tested instead, or is that the same?

By: Pam

Pam — Fri, 27 Oct 2017 00:06:33 +0000

Greetings Joseph,
Thank you for this succinct information. I have breast cancer and my TGF beta 1 dropped from 18,000 to roughly 4,000 over the last month. Do you know any research of hyperbaric treatments with lowering the TGF beta 1?
Thanks

By: Dar

Dar — Tue, 10 Oct 2017 00:40:38 +0000

I have a situation; I was on Losartan for blood pressure and pharmacy changed the company which they bought from. I was highly allergic to the new company’s pill and was very sick all year. We didn’t catch this new company or allergy. I had so many things wrong and food intolerances came from blood work. However, after eliminating all this my symptoms were not resolved so Dr. went the mold route. 14 vials of blood for all the mold markers. ANY way. I show markers for mold sickness but my TGF Beta 1 scores were raised with the Losartan! I got off med after a year and the TGF Beta scores went below 2308. My symptoms went away. So HOw s it my scores were up on Losartan? The only symptoms I have now is fatigue and the vegas nerve going haywire.

By: Tam

Tam — Thu, 10 Aug 2017 12:00:39 +0000

Hello,
Do you know if TGF-beta Inhibitors would be effective in reducing the damage of Marfan’s Syndrome?

By: Barbie

Barbie — Mon, 17 Apr 2017 17:47:05 +0000

pregnenolone both increases and decreases?

By: Amanda

Amanda — Wed, 02 Nov 2016 15:12:28 +0000

This is so interesting! I’m doing a lot of research into Loeys-Dietz Syndrome (Type 4 to be exact with a mutation on the transforming growth factor beta-2 ligand “TGFΒ2”). I assume the increase of TGF in the beta-2 acts the same as an increase of beta-1 and that perhaps the same things used to decrease it cross both.

By: MollyMolly

MollyMolly — Mon, 24 Oct 2016 19:27:33 +0000

Shoemaker’s range (<2380) is a lot lower than LabCorp. According to LabCorp I'm normal at 4031 (ref 622-4625). Any thoughts?

By: Joseph M. Cohen

Joseph M. Cohen — Tue, 13 Sep 2016 06:50:37 +0000

In reply to Oliver Chalfant. Same...

By: Oliver Chalfant

Oliver Chalfant — Tue, 13 Sep 2016 00:22:29 +0000

Are there any solid resources for high levels correlating with mold exposure? I’ve not found anything published other than the word of Shoemaker

By: Joe

Joe — Mon, 07 Mar 2016 06:34:48 +0000

Wow, this is great. I admire your research skills, this is the only list of TGF beta inhibitors I was able to find. So this has saved me time crawling through pubmed(which I had already been doing for hours. Are you aware of any other TGF-Beta inhibitors, that you may not have included, such as pharmaceuticals like Perfenidone?

Thank you.

(Awesome website BTW)

By: alexgierczyk

alexgierczyk — Wed, 17 Feb 2016 06:21:04 +0000

In reply to Joseph M. Cohen. Nice.

By: Joseph M. Cohen

Joseph M. Cohen — Tue, 16 Feb 2016 04:09:14 +0000

In reply to alexgierczyk. I just interviewd Shoemaker today :)

By: Joseph M. Cohen

Joseph M. Cohen — Tue, 16 Feb 2016 04:08:53 +0000

In reply to alexgierczyk. Nice!

By: alexgierczyk

alexgierczyk — Tue, 16 Feb 2016 03:48:23 +0000

Another hypothesis is that TGFb is endogenously activated to counter chronic inflammatory conditions: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905006/

This makes sense as Ritchie Shoemaker’s protocol works and addresses TGFb last.
https://web.archive.org/web/20150306213104/http://www.woodlandhillspharmacy.com/biotoxin_illness.html

Unfortunately the etiology of chronic TGFb activation is not well understood:
https://en.wikipedia.org/wiki/Transforming_growth_factor_beta#Activation
Wikipedia lists ROS, injury, MMP as activators.
https://en.wikipedia.org/wiki/Transforming_growth_factor_beta#Integrin-independent_activation

If you know someone with CIRS they might want to check for MARCoNs: http://biotoxinjourney.com/marcons/
That article explains how to do it correctly.

By: alexgierczyk

alexgierczyk — Tue, 16 Feb 2016 02:35:57 +0000

Looks like EMF can upregulate TGFb http://onlinelibrary.wiley.com/doi/10.1016/S0736-0266(01)00084-5/pdf