Comments on: Tempol: Potential Health Benefits + Risks https://selfhacked.com/blog/tempol/ Cutting-Edge Solutions For a Better Life Wed, 03 Nov 2021 09:12:02 +0000 hourly 1 https://wordpress.org/?v=5.8.1 By: Roxanna Guinan https://selfhacked.com/blog/tempol/#comment-146284 Mon, 13 Sep 2021 17:41:59 +0000 https://selfhacked.com/?p=23867#comment-146284 Interesting article. I wish there was more effort to develop drugs that can fight/minimize the effects of Covid rather than expecting people to continuously get vaccines.

]]> By: Svetlana Shvetsova https://selfhacked.com/blog/tempol/#comment-61189 Sun, 20 Oct 2019 20:26:35 +0000 https://selfhacked.com/?p=23867#comment-61189 How do I administer tempol? Dosage? Thanks

]]> By: John DiMaccio https://selfhacked.com/blog/tempol/#comment-41104 Fri, 26 Oct 2018 01:26:24 +0000 https://selfhacked.com/?p=23867#comment-41104 Anyone know what this means? I don’t understand if this means that it increases dopamine
or decreases it? Thank you

“Tempol also decreased D1 receptor phosphorylation and restored receptor
G-protein coupling. Dopamine inhibited Na+-K+-ATPase activity, and SKF-38393
elicited a natriuretic response in tempol-treated obese rats. Thus in obese
Zucker rats, tempol ameliorates oxidative stress and improves insulin
sensitivity. Consequently, hyperphosphorylation of D1 receptor is reduced,
leading to restoration of receptor–G-protein coupling and the natriuretic
response to SKF-38393”

]]> By: William Dayton https://selfhacked.com/blog/tempol/#comment-41061 Thu, 25 Oct 2018 14:08:36 +0000 https://selfhacked.com/?p=23867#comment-41061 Could you give us information on dosing for different conditions.

]]> By: John DiMaccio https://selfhacked.com/blog/tempol/#comment-40392 Fri, 19 Oct 2018 19:03:43 +0000 https://selfhacked.com/?p=23867#comment-40392 Any updates on Tempol? Daily dosing, time of use, affects/effects,etc..? Thanks

]]> By: Mike https://selfhacked.com/blog/tempol/#comment-35176 Thu, 28 Jun 2018 06:10:13 +0000 https://selfhacked.com/?p=23867#comment-35176 What would be dosage for kidney & heart benefit?

]]> By: Maddy https://selfhacked.com/blog/tempol/#comment-33545 Thu, 17 May 2018 16:03:30 +0000 https://selfhacked.com/?p=23867#comment-33545 What does #3 with dopamine above have to do with Tempol?
SOD3 mutations have a lot to do with neuropathic pain. when the NMDA receptors are stimulated somehow superoxide is involved in the pathogenesis of hyperalgesia and central sensitization. Removal of superoxide stops this cascade. So this stuff is very interesting. Implications in fibromyalgia, migraine, MS, other… PEA also upregulates MgSOD for those with an SOD3 mutation.

]]> By: Nattha Wannissorn, PhD https://selfhacked.com/blog/tempol/#comment-24200 Sat, 02 Sep 2017 15:54:00 +0000 https://selfhacked.com/?p=23867#comment-24200 In reply to Jay.

millimolar – but this is a concentration not a dose. Sorry we’ll put this in a queue to fix.

]]> By: Jay https://selfhacked.com/blog/tempol/#comment-24199 Sat, 02 Sep 2017 15:28:05 +0000 https://selfhacked.com/?p=23867#comment-24199 What does 1 mM mean? Millimeter? Can’t find any info on that dosage.

]]> By: Jack Basi https://selfhacked.com/blog/tempol/#comment-17991 Tue, 16 Aug 2016 13:08:52 +0000 https://selfhacked.com/?p=23867#comment-17991 Tempol Potential Risks – Tested on Rats? – What about FDA Approval?
But, what would be a safe dosage for Humans? or is this a one-time treatment?

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