Comments on: Tips on Rebalancing an Elevated Th2 Immune System

By: Eric

Eric — Sat, 22 May 2021 12:06:48 +0000

Contrary to this article, NAC increases Th2 levels and decreases Th2 levels according to research below. Can someone clarfiy this?

The effects of N-acetylcysteine on the Th1/Th2
ratio in elderly patients with chronic
obstructive pulmonary disease: http://www.ijcem.com/files/ijcem0084328.pdf

https://www.researchgate.net/publication/49757691_Alteration_of_immune_functions_and_Th1Th2_cytokine_balance_in_nicotine-induced_murine_macrophages_Immunomodulatory_role_of_eugenol_and_N-acetylcysteine

By: Macoman

Macoman — Tue, 31 Mar 2020 20:17:51 +0000

You said zinc deficiency lowers TH2 dominance, but here is a quote: “Experiments in humans revealed that Zn deprivation decreases the production of Th1 cytokines but has less effect on the production of Th2 cytokines (IL-4, IL-6, and IL-10), so the Th1/Th2 balance is disturbed and shifted toward Th2”

Yes, it may actually lower TH2 a little, but it lowers TH1 more, hence leading to TH2 dominance from zinc deficiency.

By: Borelioza

Borelioza — Mon, 09 Mar 2020 16:38:04 +0000

Th1 cells dominate the immune response in the synovial fluid of patients with Lyme as well as those with rheumatoid or other types of chronic inflammatory arthritis.

By: Pamela Hennes

Pamela Hennes — Fri, 18 Oct 2019 18:37:42 +0000

Prior to my Hashi’s diagnosis I recognized I was very sick. Weight walked up 100 lbs and GERD was debilitating. I began to use my body as a human guinea pig…the 1st supplement I took was a lectin shield or lectin blocker…a positive result was immediate. I cook with Ashibita, Wild Ramp (cholesterol dropped 30 pts in 90 days) , Three fold Blend Savory, Three Fold Blend Sweet (smoothies) and the low oxalate greens. I take 2 lectin blockers if I prepare any cruciferous vegetables. Fact is these powders are grown without the chemicals that I have developed sensitivities to. Looking forward to following your approach to wellness.

By: Sean

Sean — Fri, 13 Sep 2019 17:03:12 +0000

I’m confused: Astragalus and licorice root are listed in the top 13 supplements to take for Th2 dominance but also on the list of supplements to avoid if you’re Th2 dominant. Can someone please clarify??

By: Ana Aleksic, MSc (Pharmacy)

Ana Aleksic, MSc (Pharmacy) — Thu, 29 Aug 2019 12:15:16 +0000

In reply to Erika.

Hi Erika, which article are you referring to? In one study, quercetin reduced the Th2 response (https://www.ncbi.nlm.nih.gov/pubmed/19061976). Other studies support its immune-balancing effects.
However, more research is needed and it’s not as straightforward.
For example, another study showed that it can increase the Th2 immune response when given together with an irritant, such as ovalbumin (https://www.ncbi.nlm.nih.gov/pubmed/28380410). Quercetin didn’t have this effect when it wasn’t given at the same time as the irritant. This is beneficial! It means quercetin might work as a natural adjuvant to vaccines by boosting the immune response to foreign invaders (that is, their antigens).

By: Johnmack

Johnmack — Sat, 24 Aug 2019 15:08:18 +0000

Oxymatrine (often used for CFS) increases TH1 and lowers TH2
https://www.ncbi.nlm.nih.gov/pubmed/15640867

By: Yana

Yana — Mon, 19 Aug 2019 15:22:52 +0000

What about Astragalus? In this article you mention it as TH2 decreasing and increasing supplement.

By: Joe Cohen, BS

Joe Cohen, BS — Tue, 09 Jul 2019 23:24:25 +0000

In reply to Thea. It's overall a Th1 stimulant

By: Thea

Thea — Fri, 28 Jun 2019 22:31:46 +0000

I am confused about Astragalus. It seems to be on both recommended and bad for T2 type.

By: Erika

Erika — Sat, 01 Jun 2019 17:20:54 +0000

A different article I read on this subject mentioned Quercetin as a Th2 stimulant. This article says it can decrease Th2 dominance. Do you have any insight on the difference in this information? Thanks.

By: Jason

Jason — Fri, 09 Nov 2018 01:46:24 +0000

In reply to Jean. Hi Jean, I have been looking into Beta glucan,but been hesitant to try in case it increased my TH2 cells,so do you have an update on the Beta Glucan and Th2?

By: Stephen Beville

Stephen Beville — Sun, 17 Jun 2018 01:34:25 +0000

There are a number of contradictory statements on this page due to conflicting scientific paper findings. This is a great resource, but will be further improved by having one of the research team PhD’s go through this with a fine tooth comb and identify this inconsistencies and provide more nuance to the recommendations.

By: Olav

Olav — Fri, 01 Jun 2018 17:43:00 +0000

For those who have seasonal allergies (hay fever), Fish Oil (EPA) may also help. While Arachonic acid (Omega 6 fatty acid) is correlated with more hay fever.
https://www.nature.com/articles/1602213

By: DougP

DougP — Sun, 08 Apr 2018 00:05:48 +0000

Wouldn’t someone with elevated Th2 want to avoid Lion’s Mane, since elevated Th2 correlates with histamine intolerance, and LM boosts NGF which increases histamine?

By: LEE

LEE — Wed, 14 Feb 2018 06:57:06 +0000

What dose did you start at? If you have an autoimmune issue you have to start really low and work up the the final dosage. I took ldn 6 yrs ago for pain, and started at 4.5 mg with no problems. Went off after a couple years. Then my pituitary crashed after a miscarriage, due to autoimmune Hypophysitis. I went back on ldn because i was having much worse pain. I started at 4.5 mg and became very ill, that i stopped after 4 days because of severe nausea. I thought i had the flu! But turns out it was like rocket fuel for my pituitary. I had thyroid storm it tripled my TSH in 4 days. Made me hot, pouring sweat, sick. Felt just like when i had my cortisol stimulation test but worse, because it caused my adrenals to kick out so much homone all at once. So a year later when i figured out why i got so sick i started again but at 0.5 mg and gradually worked my way up to 4.5mg over 4-6 wks.

By: Mick

Mick — Mon, 05 Feb 2018 13:24:45 +0000

FOS/Inulin (R)(bananas, onions, chicory root, garlic, asparagus, and leeks) – avoid.

However…i notice that in the study, the rats had 13g of sugars/kg. So at 70kg I would need to take 1kg of sugar for it to be a problem. That’s a lot. I guess total quantity matters – I wonder what the result would be if they had only 6.5g/kg. But i guess the total load on the body matters – so if you have a little of this and a little of that – then the total load on the body would be too high. Food for thought – i will continue with a food rotation diet – ensuring not too much of anything and have the odd 24 hours fast

By: Michael NW

Michael NW — Sun, 21 Jan 2018 05:12:36 +0000

Hi, I keep trying Quercetin but it seems to make me flush. Isn’t Quercetin supposed to do the opposite?

By: jay

jay — Fri, 29 Dec 2017 14:35:34 +0000

Curious why astragalus is listed in the 13 things to take, but then lower in the article it’s also listed as things to avoid.

By: George

George — Fri, 08 Dec 2017 22:14:36 +0000

Maybe you have mercury toxicity?

By: James

James — Wed, 22 Nov 2017 09:27:02 +0000

Karen. I had same experience. Sjogrens much worse after ldn. My sjogrens seems to be worse as my rheumatoid arthritis gets worse

By: Karen

Karen — Wed, 25 Oct 2017 13:18:08 +0000

THIS. I really need to get a handle on this. I started LDN, and within days, my Sjogren’s symptoms escalated. Consequently, I have an almost full bottle of it that I’m afraid to use. I’m really, really hoping Joe can shed some light on this.

By: whisperingsage

whisperingsage — Wed, 18 Oct 2017 16:15:47 +0000

I had insomnia , and worked nights, couldn’t sleep in the daytime w/o 100 mg of Benadryl, found it was one of the causes of my arthritis. Look up Joel Wallach’s Dead Doctors Don’t Lie video and much if his other videos, and also a print form of Wallach encyclopedia, the kingmaker folks have transcribed excerpts of his various talks and put them under headings alphabetically. There I found calcium deficiency was a big problem with my insomnia. I was on every other supplement but not calcium as I figured I got plenty of dietary calcium. I was wrong. Plenty of other online docs I respected warn against deitary calcium, say we get too much. But Joel Wallach says no, we only get a fraction of our intake. I began to take 2000 mg a day and my arthritis reduced more, my leg cramps went away ( I had been treating w magnesium and vitamin D, but they weren’t enough). But also I began to be more receptive to melatonin. It had been ineffective for me for years. And the possible explanation I found was that the pineal gland was froze up and calcium was needed to make it active again. However I still need to take it, look up research from Russel Reiter on melatonin, he found it safe up to 100 mg but didn’t research any further. Know that alcohol damages the pineal and dry alcoholics can never recover it’s function. Fluoride also damages it, and I think that’s what happened to me.
More on sleep aides, lavender, and moringa and valerian. Valerian stinks like feet. Yes I still have to take a lot of things but I am healing from a lot of things.

By: Nattha Wannissorn, PhD

Nattha Wannissorn, PhD — Mon, 07 Aug 2017 22:59:50 +0000

In reply to Mickey. It's under "may increase Th2", so in principle avoid.