Comments on: 5-HT1A: The “Single” & “Self-Transcendent” Receptor? https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/ Cutting-Edge Solutions For a Better Life Wed, 06 Jan 2021 18:44:39 +0000 hourly 1 https://wordpress.org/?v=5.8.1 By: Faiyaz https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-122888 Wed, 06 Jan 2021 18:44:39 +0000 https://selfhacked.com/?p=10508#comment-122888 Numerous studies (including one you referenced) indicate a strong correlation between downregulating 5HT-1A activity & the rectifying of sexual dysfunction stemming from SSRIs. 5HT-1A is an INHIBITORY autoreceptor. Thus blunting its activity – be it via desensitization, antagonism or down-regulation of receptor count – is hypothesized to dis-inhibit (and thus further activate) serotonergic circuitry). A number of studies even show that the mood-elevating efficacy of certain SSRIs (e.g. Escitalopram) can likely be attributed to their desensitization effect on 5HT-1AR’s. The bulk of your (rather confusing) article focuses on this autoreceptor’s activation being correlated to mood / social-behavior enhancement. I’d say the evidence likely points to the contrapositive.

]]> By: ed https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-36989 Tue, 07 Aug 2018 12:53:29 +0000 https://selfhacked.com/?p=10508#comment-36989 I read the ashwaghanda study. It says that Ash lowers presynaptic 5ht1a and increases 5ht2a. Isnt this bad?

]]> By: davefx https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-34684 Thu, 14 Jun 2018 21:21:29 +0000 https://selfhacked.com/?p=10508#comment-34684 *bursting (instead of brusting)

]]> By: davefx https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-34680 Thu, 14 Jun 2018 21:10:15 +0000 https://selfhacked.com/?p=10508#comment-34680 Just like the headline, probably one of the worst and most meaningless articles on this site (which is already dubious to begin with). Some of the reactions are telling enough. Measures and counter-measures jumbled together in one without clear recommendation, even layout, and often wishy-washy terminology.

It also ignores such fundamental matters that not only does this at the heart seem to be the most orthodox, indoctrinated view serotonine and anti-depressants (you’d never guess with this presentation…), but also that the internet is brusting with people with lasting side-effects from this bone-headed course of treatmeant, like anhedonia, PSSD, akathisia etc. etc. Of course this is wrapped up in this like everything else bad in psychiatry, of which in fact can’t be told anything good, save that cheesy, clichéd, kind of sordid apocryphal sh*t that is sold as the “science” basis of it, and that is directly at the cost of respectful treatment of people’s feelings and issues, which would solve 95% and prevent all (100%) of the 70% of atrocious, life-quality decreasing side-effects within those same 95%.

]]> By: Amyl https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-31394 Mon, 19 Mar 2018 18:09:58 +0000 https://selfhacked.com/?p=10508#comment-31394 HI – Just a note that the reference you cited for “chronic SSRI administration etc” points to a paper that is not the primary source. The paper you cite here merely states that Chronic intake of SSRIs induces less sensitivity of the auto- and post-synaptic 5-HT1A receptors, and then goes on to tests something else.

]]> By: jtg1 https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-27594 Fri, 10 Nov 2017 01:24:19 +0000 https://selfhacked.com/?p=10508#comment-27594 Where are you reading the 5-HT1A activation results in dopamine release? This needs references.

]]> By: Andy V https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-23174 Sat, 05 Aug 2017 00:41:25 +0000 https://selfhacked.com/?p=10508#comment-23174 I’m not understanding the ashwagandha study, if you could elaborate…

Decreasing 5-ht1a autoreceptor / Increasing postsynaptic receptor sensitivity = Good

The ashwagandha study states in the discussion: 4 weeks Asvagandha treatment resulted in a significant diminution in the functional sensitivity of the 5HT1A postsynaptic receptors, as indicated by the reduced expression of ‘5HT syndrome’.

So could ashwagandha supplementation be a negative as it relates to 5-ht1a agonism?

]]> By: charles mitchell https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-22625 Tue, 18 Jul 2017 18:44:40 +0000 https://selfhacked.com/?p=10508#comment-22625 How about Creatine? I feel a substantial calming effect from taking it

https://www.ncbi.nlm.nih.gov/pubmed/23352985

]]> By: Ed https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-20800 Tue, 16 May 2017 11:18:25 +0000 https://selfhacked.com/?p=10508#comment-20800 So, what could be better for premature ejactulation? According to the studies done in dapoxetine, 5-ht2c hypofunction and/or 5-ht1a hyperfunction is neurobiological cause of PE.

Some anti-depressant produces delayed ejaculation however the problem is that at the same time produces weaker erections and less pleasurable orgasm. So the idea is to only reduce the activity of post-synaptic 5-ht1a only?

]]> By: Denis Varvanets https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-18918 Wed, 07 Dec 2016 23:24:04 +0000 https://selfhacked.com/?p=10508#comment-18918 Joseph – please write about angiotensin 2type 1 receptor and how to downregulate it. also – interesting about the way to decrease the level of antibodies to AT II receptors
https://www.fightaging.org/archives/2016/12/angiotensin-receptor-autoimmunity-correlates-with-age-related-frailty-and-hypertension/

]]> By: Joseph M. Cohen https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-17332 Fri, 20 May 2016 20:39:09 +0000 https://selfhacked.com/?p=10508#comment-17332 In reply to Judd Crane.

Thanks :)

]]> By: Judd Crane https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-17326 Fri, 20 May 2016 08:12:31 +0000 https://selfhacked.com/?p=10508#comment-17326 Decreased signaling from Aswhagandha:

http://www.ncbi.nlm.nih.gov/pubmed/22556838

]]> By: Lynn D https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-14634 Sun, 09 Aug 2015 13:21:07 +0000 https://selfhacked.com/?p=10508#comment-14634 Well, tried to scan thru yesterday and again today. Time to go out and chase butterflies or something fun. Listed as GG , GG, TT. Think have higher serotonin and lower dopamine . In the past tried St Johns and felt really flat , Walking, gardening, bike riding… help best, being out and noticing all the amazing life. Will consider some of the other supplements but really rather just eat food! (anything help up appetite? or thirst?).
Thank you for all this information

]]> By: Maija Haavisto https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-14595 Fri, 07 Aug 2015 06:16:24 +0000 https://selfhacked.com/?p=10508#comment-14595 In reply to forgotmypreviousnick.

San Pellegrino mineral water supposedly has a lot of lithium.

Re: the article, Albizzia julibrissin may also be a 5-HT1A agonist. https://www.ncbi.nlm.nih.gov/pubmed/17477962

]]> By: lordilol https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-14491 Fri, 31 Jul 2015 17:22:56 +0000 https://selfhacked.com/?p=10508#comment-14491 i have a question and i have no clue where to put it.

i go to bed in 12 and get up at 6
its too hot in the summer to sleep more but i noticed a strange pattern in myself, usually i feel
not wanting to do anything but once darkness(sometimes) sets in i feel alive and i want to do things
and i become more DARING, and focused? i feel less stress too
what the heck is going on? why do i feel like this? i
have no idea but i cant really replicate this shit to other time zones, and or other circumstances.
i only noticed 3 days like this in the past month. i am super curious. its reminds of what i read about cereblysin .

]]> By: Joseph M. Cohen https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-14389 Sat, 25 Jul 2015 14:26:01 +0000 https://selfhacked.com/?p=10508#comment-14389 In reply to Dana.

Interesting….Lol :)

]]> By: Dana https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-14388 Sat, 25 Jul 2015 14:04:55 +0000 https://selfhacked.com/?p=10508#comment-14388 Interesting stuff! I remember using Butyrate to help with methylation at one point..it was one of the very few things I’ve tried over time that caused an immediate reaction–red, hot ears (looked very strange), and a rash on my arm. Went away in about 20 minutes, and overall there was a positive effect-a little more clarity, more energy. I didn’t know its relationship to this gene…

…and sounds like a lucky girl :)

]]> By: Deltrus https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-14376 Sat, 25 Jul 2015 00:48:49 +0000 https://selfhacked.com/?p=10508#comment-14376 CC here, for once I lucked out. Not planning on being in a relationship for a long time though. Too many health issues.

]]> By: Joseph M. Cohen https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-14373 Fri, 24 Jul 2015 20:40:07 +0000 https://selfhacked.com/?p=10508#comment-14373 In reply to Guin.

hehe

]]> By: Guin https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-14371 Fri, 24 Jul 2015 19:27:24 +0000 https://selfhacked.com/?p=10508#comment-14371 I’m GG and I respond positively to melatonin, NDT, fish oil, magnesium, and zinc–looking forward to trying butyrate, SJW, and lithium.

My husband should apply for Sainthood. Good luck.

]]> By: forgotmypreviousnick https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-14369 Fri, 24 Jul 2015 10:47:58 +0000 https://selfhacked.com/?p=10508#comment-14369 There is no decent source of lithium available in my beloved country of miracles. I know, some plants have higher lithium accumulation than others. Could it be good enough?

]]> By: Ole https://selfhacked.com/blog/rs6295-the-single-and-self-transcendent-gene-5-ht1a-receptor/#comment-14368 Fri, 24 Jul 2015 08:26:27 +0000 https://selfhacked.com/?p=10508#comment-14368 Top notch info as usual!

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