As my name says I have both ASD and arthritis, everything that lowers IL17, TLR4 benefits me. I decided to gave PQQ a try and wow what a difference, I wouldnt call it life changing but it comes close to it. Dramatic increase in sleep quality and one of the studies on PQQ said that participants had an increase in tendency to contentness with life, I definetely notice this, these effects are very real.
Anyhow I also have immune dysfunction (auto immunity I suspect), immuno supressors tend to alleviate my mental and some of my physical problems.
Fast foward while 10-12 days on it (20mg biopqq per day), I start to get more headaches which i definetely link to pqq and also I seem to get skin problems and a like, for instance Im getting fordyce on my lip which Ive never ever had in my life.
I looked it up and turns out that PQQ is a potent immusupressant, help dont know what to do, I like PQQ, in fact I like it A LOT but help discover how to mitigate the side/effects negatives.
FYI:
Pyrroloquinoline Quinone Decelerates Rheumatoid Arthritis Progression by Inhibiting Inflammatory Responses and Joint Destruction via Modulating NF-κB and MAPK Pathways.
https://www.ncbi.nlm.nih.gov/pubmed/26319019
Pyrroloquinoline quinone (PQQ) is a naturally occurring redox cofactor that acts as an essential nutrient and antioxidant and has been reported to exert potent immunosuppressive effects.
Mice treated with PQQ demonstrated marked attenuation of arthritic symptoms based on histopathology and clinical arthritis scores. These results collectively suggested that PQQ might be a promising therapeutic agent for alleviating the progress of RA.
thanks, love your website
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