Comments on: What Do We Know About Picamilon? Purported Uses, Side-Effects + More

By: Mary

Mary — Mon, 27 Sep 2021 02:35:54 +0000

When I saw the date of this article (Sept. 20, 2021), I assumed that it contained some new information, yet I see nothing new at all. What’s the point?

By: Jeffrey Florentino

Jeffrey Florentino — Tue, 09 Jul 2019 00:06:40 +0000

In reply to Diana Rangelova.

Sorry to hear and thanks for sharing, we don’t answer personal health questions in the comments section for privacy reasons. If you’re looking to get answers from Joe, please join SelfHacked VIP at https://selfhacked.lpages.co/selfhackedvip/. Feel free to get in touch with us with any questions about how our VIP members area works at [email protected].

By: Diana Rangelova

Diana Rangelova — Sat, 06 Jul 2019 07:26:52 +0000

That was very informative thank you very much. I have purchased the Picamilon and cant wait to try it. I am fighting huge moodswings and depression and social anxiety. I have a question. I am taking L-glutamine for gut health and curbing sugar cravings. Is glutamine related to the produced glutamate in the brain? Seems like elevated levels of that cause the problems i am fighting with. Or i could be wrong… Please let me know if you have any information since if this is the case i better stop taking it

By: Charlie

Charlie — Sat, 30 Dec 2017 06:25:03 +0000

I tried Picamilon in earnest several years ago at dosages up to 500 mg but it had no perceptible effect. (I really wanted it to work so I kept raising my doses.) However, on a educated guess, I suggested to my wife to try it for her severe Restless Legs Syndrome, and she reports that it’s effective roughly 75% of the time. I dissolve 250 mg Picamilon in 1 ml of distilled water in a small syringe and she holds it SL for about 30 seconds before swallowing.
Note that I’ve also tried Phenibut, another GABA supplement with some similarities to Picamilon, but it also had no perceptible effect, at doses up to 4 grams.
I subscribed to Self-Decode today so maybe I’ll discover some clues to my odd GABA chemistry lurking in the SNPs.

By: Will Hunter

Will Hunter — Fri, 22 Dec 2017 17:48:39 +0000

In reply to Clément.

Hi Clément,

It does not appear to cause tolerance with short-term use (under 30 days). While there isn’t any research on long-term tolerance, there is a risk of tolerance due to constant activation of the GABA receptors. This study in rats showed that picamilon did not cause downregulation of GABA receptors: http://europepmc.org/abstract/med/20821973 . The niacin in picamilon wouldn’t cause tolerance as it is a water-soluble B vitamin and your body will excrete what it does not use.

By: Jimmy Surface

Jimmy Surface — Wed, 20 Dec 2017 15:36:03 +0000

IAS, international anti ageing systems, is a reputable company. I have purchased many products from them since the late 1990’s with not one complaint! They are located in England but ship to the US.

By: Clément

Clément — Tue, 19 Dec 2017 16:34:01 +0000

Is there any risk of developing tolerance to it?
Would it cause downregulation of GABA production and/or receptors and cause withdrawal?

Thanks

By: Will Hunter

Will Hunter — Tue, 19 Dec 2017 00:46:42 +0000

In reply to Lisa Kay. Hi Lisa, Thank you for pointing out this error. I have corrected it to say glutamate.

By: LEE TURNER

LEE TURNER — Sun, 17 Dec 2017 21:36:20 +0000

As much as I want to try picamilon, where can I buy it? Can’t find it anywhere on-line. And if you do find a seller, how do you know that its not talcum powder? I use phenibut, and its a lifesaver for someone suffering from insomnia. I would like to cycle with picamilon… so where can I buy picamilon?
Thanks!

By: Lisa Kay

Lisa Kay — Sun, 17 Dec 2017 17:30:58 +0000

Is this correct? “Too much GABA can contribute to feelings of anxiety, muscular tension, and even increased the risk of seizures” – I thought it was the opposite. did you mean to say too much Glutamate…?