Comments on: Nicotinamide Riboside Health Benefits + Side Effects

By: August

August — Wed, 06 Nov 2019 20:48:39 +0000

This was all good until a new study just found that NR could be a disaster for mitochondrial health. What do we do now?
https://doi.org/10.3390/nu11102439

By: Ray E. Cobb

Ray E. Cobb — Sat, 24 Aug 2019 18:24:30 +0000

Thanks, great article, answered all of my questions.

By: Jim Macke

Jim Macke — Thu, 30 May 2019 19:54:42 +0000

I heard an audio blog that NAD+ help with recovery from drug abuse, but this was an intravenous dosage.

By: Michael Gewirz

Michael Gewirz — Wed, 22 May 2019 01:43:55 +0000

If Nicotinamide Riboside ‘worsens physical performance’ what is the reason for taking it ?

By: LA, MD-JD

LA, MD-JD — Thu, 30 Aug 2018 20:11:23 +0000

The cited safety reference is done on rats and thus it really can’t elucidate side effects except that there was a measurable decrease in feed intake at certain levels, and an increase in organ size and elevation in certain liver function tests (ALT), especially in females. 10.1177/0960327115626254

My own experience on rather low dose (250 mg on empty stomach in morning for about 18 months now) is of intermittent abdominal pain, definite decrease in appetite and weight loss, and also an isolated elevation in that particular LFT. Noticeably changed appetite—I’ve become almost averse to meat and alcohol.
Granted, I can’t prove these are related to Niagen; but while I’m undergoing ulcer evaluation/treatment I think it’s time for a break. I wish Joe had shared his reasoning, and his schedule for taking breaks from this therapy. I can’t find anything specific in the literature, but anecdotally it seems a lot of people are experiencing abdominal pain. I have had my B3 levels checked (Spectracell) and they are 97th%-ile. I am female, human.

By: Nathan K Wright

Nathan K Wright — Thu, 26 Jul 2018 20:15:17 +0000

Chris Masterjohn just released a podcast episode where he details how NR depletes methyl groups and can have harmful side effects for some people. All the other sources of info about NR have led me to believe it’s perfectly safe and without many serious side effects. Thoughts?

By: HT

HT — Fri, 15 Jun 2018 19:50:37 +0000

besides NR, there is mitoQ. Should both be taken? What is the role of each in supporting mitochondria?

By: Patrick

Patrick — Sun, 10 Jun 2018 11:48:56 +0000

I have been taking NR now for a few weeks. I take in the morning on an empty stomach, often with a coffee. Getting a feeling of unease and heart rate bumping up by 20 BPM for a couple of hours. I also straining my calf muscle on a run (never happened in 15 years of running) I have lowered the dosage but still getting that feeling of unease. Unfortunately I feel its not for me

By: Angela

Angela — Thu, 10 May 2018 09:54:03 +0000

How would effect a mthfr c677t one copy under methylator? Not all supplements/additions to our symptoms/issues, benefit all as we all have such different needs. Anything?

By: Geoffrey Parker

Geoffrey Parker — Sat, 28 Apr 2018 17:05:36 +0000

Interaction/reaction with cannabis?

By: Paula

Paula — Mon, 23 Apr 2018 11:41:34 +0000

You lost me a 35% worse exercise performance. Why would anyone want that ?

By: CSue

CSue — Mon, 23 Apr 2018 02:27:54 +0000

What’s the best way to take this? Morning? Empty stomach? I heard good to take with resveratrol or blueberry extract. But I remember reading some other things NOT to take at the same time… Any thoughts?

By: Just Wondering

Just Wondering — Sat, 24 Feb 2018 02:08:37 +0000

“Nicotinamide riboside is a precursor to nicotinamide adenine dinucleotide (NAD), which means it is needed to make NAD+.”

Maybe a foolish question, but since NAD+ is essential and therefore must be made, and NR is, reportedly, barely existent (if not, what foods is it in in any relevant amount?)… how is it “needed” to make NAD+

By: Sebastian

Sebastian — Wed, 20 Sep 2017 07:43:14 +0000

I’m supplementing with NR & resveratrol by Lifeextension (OPTIMIZED NAD+ CELL REGENERATOR). Now I heard about Controversial roles of NAD+ in promoting versus suppressing cancer. What’s your take on that? Is it like with folic acid that’s protecting DND in healthy cells but also keeping cancer cells alive?

By: Judd Crane

Judd Crane — Fri, 01 Sep 2017 18:26:50 +0000

How long do you use Niagen before cycling off?

By: Nattha Wannissorn, PhD

Nattha Wannissorn, PhD — Fri, 18 Aug 2017 16:29:58 +0000

In reply to Sam.

https://selfhacked.com/blog/nad-important-increase/ – Fasting and saunas?

By: Sam

Sam — Thu, 17 Aug 2017 23:38:35 +0000

Is there a way to increase NAD+ naturally through food or other means, w/o pills?

By: Ev

Ev — Sat, 11 Feb 2017 15:05:34 +0000

In reply to Radek Pilich. Same thoughts, I was thinking about the d-ribose angle of increase nadh or nad plus. Is it effective or safe?

By: Robert Miller

Robert Miller — Fri, 16 Dec 2016 06:04:03 +0000

Joe when you say performance decrease are they not talking about a phenomena we see with those on NAD+ boosters and protective diets where the anaerobic threshold kicks in at a far higher HR because the ETC stalls far later due to better oxygenation and later signalling of pseudo hypoxia? Initially we too thought that performance was being impeded until we realised that we were basing that on when anaerobic functionality kicked in and that was actually happening far later meaning we were actually performing better, not worse.

By: asdf

asdf — Sun, 23 Oct 2016 22:19:34 +0000

“In mice, NR supplementation worsens exercise performance”
But the dose was huge.

By: Jane

Jane — Tue, 04 Oct 2016 18:03:52 +0000

In reply to Eduardo. Nicotinamide riboside (NR) is a precursor to NAD+, then NADH...the even more reduced form. I personally take NADH successfully, 50 mg daily. But for NR, I've seen recommended doses based on limited studies at 300mg a day. A study showed that whether 300 mg or 1000 mg, they both raised our NAD+ levels by 50%.

By: Eduardo

Eduardo — Sat, 24 Sep 2016 22:42:56 +0000

You said you take six pills to feel it, but how much is in a pill?

By: Joseph M. Cohen

Joseph M. Cohen — Sat, 24 Sep 2016 00:17:11 +0000

In reply to Radek Pilich. Dk

By: Radek Pilich

Radek Pilich — Fri, 23 Sep 2016 19:30:21 +0000

I’ve heard Dr. Mercola on Ben Greenfield’s Podcast talking about cheap DIY approach to get nicotinamide riboside effects by combining niacin with d-ribose. What do you think about that Joe?