Last year I started waking with terrible anxious feelings which quickly also became depression, I stopped eating. After 2 weeks of not eating I had bloods taken my serum B12 was within the reference range of 252ng, low folates at 2.2. Low vitamin D at 28. I had another 4 weeks of not being able to eat due to the nausea from this anxiety finally I got an anti nausea tablet and within 3 days I started eating again.

During the course of this I sought out a practitioner of the Walsh method for treating mental health issues. I had tests done with them at this point Id been eating again for 2 weeks. My B12 was 156ng, folates less than 0.8 and I had a Homocysteine of 81. Not good

I am now on a regimen of originally daily Methylcobalomin 2500mcg sublingual, 1.6mg Methylfolate and 250mg B6 and 50 P5P past couple of weeks I dropped the Methylcobalomin as convinced GP to give me Hydroxy injections as I had pins and needles, balance issues, tachycardia, extreme fatigue and memory problems. I will probably be able to go back on the B12 injections as Neurologist thinks symptoms could be B12 related.

I am wondering if I have the MTHFR gene but in the UK nobody seems to know much about it and getting tested may not help me at all really as my GP barely understands the falls in a serum B12 especially for people like me who were in the sort of “grey zone” eg between 200-350/400ng

I think the only way to get tested is 23 and me but not sure if it would really beenfit me to know as not a lot of people seem to be sure what the implications are from what ive found online

Also, if you have MTHFR, if might raise your risk of many cancers. But once you have cancer, it is my understanding, that you should not take any of the B vitamins or try to encourage methylation as it can feed the cancer and encourage it to grow.

Hi, you can ask Joe inside of VIP: https://selfhacked.lpages.co/selfhackedvip/ or over a consult at selfhacked.com/consult.

My son is recently diagnosed with Schizoaffective disorder. He is Hetrozygous MTHFR A1298C. His gene test states that he processes Folic Acid normally. Could this be a slower processing? Could there still be links that do not deal with Folic acid that I need to look into? The medications have all been adjusted according to genesight report, but I am concerned that we could possibly do more? Any advice would be appreciated.

Book a consult with Joe at Selfhacked.com/contact and try SelfDecode to learn about the best supplements for your scenario.

gs193 indicates double mutations in both snps, and people with this are believed to be critically impacted, however several promethease users have self reported this genotype with no apparent consequences.

i am guessing this is really bad and not that common. i have many health issues. i found this blog trying to figure out what MTHFR is and what i should do! Sny advice would be great as i have no idea where to start! thanks in advance for any info!

Thank you. I am aware that these are potentials. Let’s just thank whoever, that my teachers were always complaining that I don’t live up to my potential.

I have sent Joe an email.

Hi Vicki,
First of all, the SNPs can tell if you have a genetic tendency to something, but it doesn’t mean you will absolutely have the problems. Gotta look at the whole person and the environment as well. You can’t cure your SNPs but you can manage your environment and nutrition. If you want some help answering individual questions or genetic consulting, you can book an appointment with Joe here: https://selfhacked.com/contact/. ~Natcha @ Team SelfHacked

P.S. They say I have 5 personalities, are these them? LoL

From a psychiatric standpoint do I need to increase or decrease dopamine? Is there a homeopathic solution to these genotype problems? Am I a movie title or curable?

I would really appreciate some input, as when I put the articles together, they don’t work. There doesn’t seem to be a low Comt and Low Dopamine option. Anywhere. I feel low dopamine but the met is AA, that means high right?

Anyways, I know this is messy but if you could try to help me out?

Thanks,
Vicki

From a psychiatric standpoint do I need to increase or decrease dopamine? Is there a homeopathic solution to these genotype problems? Am I a movie title or curable?

I would really appreciate some input, as when I put the articles together, they don’t work. There doesn’t seem to be a low Comt and Low Dopamine option. Anywhere. I feel low dopamine but the met is AA, that means high right?

Anyways, I know this is messy but if you could try to help me out?

Thanks,
Vicki

I recently found out I have an MTHFR C677T mutation as well as COMT mutations. Both are homozygous. I am about 6 weeks pregnant and have been taking methylfolate and methyl b12, but have been experiencing side effects (mostly extreme anxiety). In the past, I have had high blood levels of folate. Do you have any experience with this type of issue? I know I need methylfolate for a healthy pregnancy, but I also know the COMT mutation makes it very difficult for my body to handle methyl groups. Just curious if you have any thoughts on this!

Thanks so much

T=A
C=G

A and G are the positive strand.

one of the main reasons for the Rael, is that people may be “methyl trapping”. There has to be enough B12 on board FIRST before adding the methyl folate. One probably needs some lithum on board too in order to drive the B12 into the cells. A good practitioner would know and recognize this and adjust accordingly.