Comments on: AMPK: Metabolism & Insulin + Ways to Activate

By: Peter Violand RN

Peter Violand RN — Sat, 10 Jul 2021 13:17:36 +0000

I am absolutely fascinated by this article. Particularly, I am interested in the role Metformin plays in the production of AMPK. I am an RN, not a scientist, so this article required me to re-read and cross reference. But just a question: if one is using Metformin along with Insulin (Levemir), would this negate the beneficial effects Metformin re increased AMPK production?

By: Deborah Fuess

Deborah Fuess — Wed, 23 Dec 2020 16:46:10 +0000

Best article I’ve ever read about differences between hypothalmic and fatty and liver production of AMPK. Thank you for answering so many questions I’ve had regarding my weight ups and downs.

By: Jeffrey Florentino

Jeffrey Florentino — Tue, 09 Jul 2019 00:08:10 +0000

In reply to Baldie.

Thanks for your comment, we don’t answer personal health questions in the comments section for privacy reasons. If you’re looking to get answers from Joe, please join SelfHacked VIP at https://selfhacked.lpages.co/selfhackedvip/. Feel free to get in touch with us with any questions about how our VIP members area works at [email protected].

By: Baldie

Baldie — Wed, 03 Jul 2019 09:19:50 +0000

So would taking aspirin, along with ALA and maybe St Johns Wort (for Quercetin) be an effective way to increase ampk in the liver and muscles and reduce it in the brain?

By: Michael Rosenberg

Michael Rosenberg — Sat, 27 Apr 2019 20:39:17 +0000

Hi Linda,

Did you ever get answer on whether you can take Metformin and ampk activator together without deleterious side effects?

Thanks,
MIke

By: martin

martin — Thu, 01 Nov 2018 17:38:39 +0000

thank you

By: sumario

sumario — Fri, 01 Jun 2018 20:26:40 +0000

“Given the above, it is suggested that AMPK activation is beneficial for cancer prevention but not for cancer treatment”

Metformin is used for cancer treatment, please correct this !

By: James Bowes

James Bowes — Tue, 13 Mar 2018 09:33:03 +0000

Hi Linda, I am in the same boat as you, can I take Metformin with AMPK. I take 850m Metformin and my type 2 is under control. I am now overweight not obese with more muscle than fat. Like to hear from you.

By: Ed

Ed — Wed, 31 Jan 2018 17:40:41 +0000

Has anyone here tried LA3 by Live Cell Research for AMPK activation? It contains Berberine Gynostemma and Quercetin. Its a formulation by Doc Rand McClaine

By: Dave

Dave — Thu, 31 Aug 2017 13:34:49 +0000

I have been taking Active-PK for over a month now in an effort to reduce the visceral fat they speak of. I am down almost 20 pounds. However my employee medical monitoring uncovered a disturbing trend in my fasting blood glucose that is 3x high than should be. trying to determine cause. i am either becoming diabetic, or its the supplement, which states on this page to increase sugars (or release more). I tend to believe the supplement is providing an effect similar to that of diabetes, so i am suspending the supplement for 3 months to see if my levels drop down.

As for the supplement, or just coincidentally, i have lost weight, had reduced cravings, especially for my coffee and sweetener, tend to get full on smaller portioned meals, and feel slightly more energy. My wife has even bought into the supplement but she has had no results.

Guess we’ll wait and see. I hope its the supplement, but if its pumping more sugar into bloodstream, that’s not necessarily a good thing,

If you haven’t yet started the supplement, get a baseline glucose test. I’d be curious to see any change there if i were you…

By: Mat Davis

Mat Davis — Sat, 24 Jun 2017 20:23:11 +0000

Has anyone tried active pk by HCR Health?

By: Cookie

Cookie — Mon, 06 Mar 2017 04:03:30 +0000

In reply to ngvst. No. Fasting is empty stomach. Eat only according to the specific meal plan you are on for that week. That is the only way to help you know what foods make you bloat and what foods are working for you. Don't mess with that.

By: Joanne Walker

Joanne Walker — Sun, 05 Feb 2017 07:29:03 +0000

In reply to Thobekile Twala. Drawing a conclusion is some what difficult as to whether getting a therapeutic level and what that level should be is left unanswered (why?)

By: Oskar

Oskar — Sat, 26 Nov 2016 15:01:05 +0000

Mulberry and green coffee extracts also have been proved to activate AMPK

By: Dr. H

Dr. H — Tue, 18 Oct 2016 00:27:13 +0000

Awesome Article Dude. Excellent way to connect the dots.

By: Thobekile Twala

Thobekile Twala — Tue, 19 Jul 2016 06:58:57 +0000

I am taking AMPK activator for weight loss. Do I have to excercise? does this mean if I dont excercise I cant loose fat?

By: Remy

Remy — Thu, 02 Jun 2016 00:40:20 +0000

How does NAC fit into this picture? From what I’m reading, it seems to reduce AMPK and increase mTOR…which would seem to be the opposite of what one would want if looking to lose weight and increase energy? http://www.ncbi.nlm.nih.gov/pubmed/23000343

By: bob

bob — Tue, 03 May 2016 11:53:08 +0000

I take a lot of supplements. I count 16 different one’s (some are foods) that increase AMPK and 4 that decrease it in the hypothalamus.

I’d guess I don’t need LEF’s AMPK activator…..

By: Ty

Ty — Thu, 14 Apr 2016 02:33:20 +0000

Hi, Kathy.
AMPk is not something you take, but rather an enzyme that you can activate via supplementation, exercise etc (as cited in the article). There are a few supplements that combine the various nutrients that can activate AMPk.

By: Kathy

Kathy — Sun, 21 Feb 2016 17:07:00 +0000

In reply to Tamera. Can you take Ampk if you have a fatty liver?

By: Jim Keller

Jim Keller — Sat, 13 Jun 2015 15:06:08 +0000

Interesting regarding AMPK activation and increased risk of Alzeimers.

Yet, a 2015 study may suggest otherwise

“AMPK activation ameliorates Alzheimer’s disease-like pathology and spatial memory impairment in a streptozotocin-induced Alzheimer’s disease model in rats.”

Yet again…confused.

By: Gabriel

Gabriel — Mon, 08 Jun 2015 13:47:16 +0000

Very interesting post. Thanks.
What would be an adequate dose of aspirin for AMPK activation?
Will you take it daily or before or after exercise?

By: Linda Reynolds

Linda Reynolds — Tue, 14 Apr 2015 20:44:26 +0000

Two things–is alpha lipoic acid the same as R-lipoic? And can I take ampk activator with metformin? I am supposed to take two 500 mg (for weight loss and pre diabetes) and when I was consistent did notice some loss but the literature says AMPK is more efficient than metfomin. Can I take both? Also does the AMPK activator Life Extentsion sells, have the same risk of lactic acidosis and do you need to take extra b 12 as you do with Metformin?

By: Tamera

Tamera — Tue, 07 Apr 2015 12:28:58 +0000

Can you take this is you are on a thyroid perception?