Comments on: NAD+: The Molecule of Youth? + Factors That Increase It

By: Elaine

Elaine — Tue, 28 Sep 2021 17:45:58 +0000

Why can’t someone just tell us specifically in low language what supplements to take and even the specific kinds since so much is out in the market. For example, I have MS. I am obese, high blood pressure, high cholesterol, and I suffer migraines without ora. What kinds and levels of supplements should I take?

By: Jeannaé Quadri

Jeannaé Quadri — Sat, 07 Dec 2019 17:21:43 +0000

I really appreciate this article. I was trying to figure out whether it could be taken with a t3/t4 rx of thyroid. Couldn’t determine from what I read so a bit afraid of buying nad. Great site. Very informative.

By: Richard Webb

Richard Webb — Mon, 20 May 2019 18:38:53 +0000

5 stars.
I am about to begin use of nasal NAD, this article was extremely beneficial to understanding what I might experience

By: Philip Miller

Philip Miller — Thu, 16 May 2019 15:54:54 +0000

A very complete but overly complex view of Mitochondrial metabolism and function.
But … the ETC requires NADH not NAD+ NADH donates electrons. NAD+ is the result not the driver of critical ETC reactions. It is the opposite in the Krebb’s Cycle where NAD+ is the driver.

By: D Smith

D Smith — Tue, 14 May 2019 19:47:22 +0000

Paul,
The only relationship between the two the I know of is they both help the heart and increase exercise stamina. NAD increases the blood vessels in the muscles, helps with exercise recovery, and some studies have shown potential to help with heart issues along with repairing DNA and RNA in your cells. CoQ10 helps with exercise stamina and recovery, and is recommend for its potential to help heart patients. Most cardiologist recommend CoQ10 to their patients at many different doses( 400-1200). Those in a congestive heart failure study were given 1200mg CoQ10 with really good results.

By: D Smith

D Smith — Tue, 14 May 2019 19:32:38 +0000

I agree with Bea, When you increase NAD via NMN or NR it only stays in your blood for approx. 15 minutes. After that time it is no longer detectable in the blood. No need for constant IV’s. There is a ceiling and it will not increase the NAD past the ceiling limit no matter how much you take. I am not discounting what happened to your husband. I know when you are desperate for help you will try just about anything. I would suggest that taking a precursor in the dose the scientist doing the studies recommend,on a daily basis, may be a better course of action instead of spending 10 thousand for a week of IV precursors. The NAD increase will not stay in your system more then a week and you are back to where you started. I am glad he is doing better and wish you all the best.

Deb

By: D Smith

D Smith — Tue, 14 May 2019 19:17:37 +0000

When you use NMN or NR to increase your NAD it will increase both NADH and NAD+. Increasing NAD helps with many other things including inflammation in the body so I would say NAD is the most important.

By: D Smith

D Smith — Tue, 14 May 2019 19:13:25 +0000

NMN is available. Studies suggest that the proper dose is 8mg/kg/day or 552mg per day . NR studies suggest the proper dose is 1000mg per day.

By: MWW

MWW — Tue, 24 Jul 2018 02:47:53 +0000

I don’t understand. If “NADH is the most significant carrier of these electrons and it becomes NAD+ when it gives away those electrons.” Then should we boost the level of NADH instead of boosting NAD+ ?

My second question is: anti-oxidation and boosting NAD+/NADH … which one is more important to prevent age-related diseases?

By: Aileen R Sirey

Aileen R Sirey — Tue, 03 Jul 2018 16:08:50 +0000

interested

By: Laura

Laura — Thu, 24 May 2018 23:22:32 +0000

This is SUCH interesting stuff to learn about!!!

By: TLJohns

TLJohns — Sat, 14 Apr 2018 18:47:25 +0000

Harris, why are you so angry? Honest to God…my husband was on his last leg, had lost 50 lbs, was physically and mentally destroyed after 3 years of using IV drugs. He is a smart, wonderful man, highly educated, but suffers from bipolar disorder and was living mostly on the streets. He had been to countless treatmentd over the 3 years (which was a relapse that began after 9 years sober when he was prescribed meds for his MH issues that made him hypomanic — and then, the same psychiatrist prescribed ambient for severe insomnia that accompanied the hypomania.) it was 3 years that was a nightmare of inescapable suffering for him, his children and whole family. We stumbled upon IV NAD+ treatment and just knew we had to help him get it as a last resort. He wouldn’t be alive today if he hadn’t had it. I promise you, on my life, the recovery he experienced mentally and physically was a complete miracle. Im not able to provide any good scientific or medical explanation … but it worked for him. He’s been sober and his bipolar disorder and severe anxiety have been completely manageable and he’s healthy, happy, functional…and sober.
So, please don’t shoot something so amazing down that you really may not have enough first hand nor definitive information on.
It 100% worked incredibly well for my husband. He’s living, breathing proof. My boys didn’t lose their dad to cruel mental health illness and addiction.

By: Bea

Bea — Tue, 13 Mar 2018 18:51:05 +0000

Hi Harris, So many products out there to claim revolutionary results, clinical trials (won’t list product names here) of NAD+ . These pills often contain Nicotinamide Riboside and Pterostilbene. Can anyone go to the doctor and request these two type of bloodworks you mentioned above? Where can you get such NAD therapies and Nutriceutical supplements, and which works vs scam? thanks for your time.

By: Paul

Paul — Thu, 08 Mar 2018 20:05:40 +0000

Is there a relationship between coq10 and NAD?

By: Jack

Jack — Thu, 08 Mar 2018 03:41:19 +0000

Peter, you are very well informed and clear thinking. I now believe that mitochondrial health is everything. If one focuses on that, everything downstream will be aces. Focusing on NAD+/NADH is a fool’s game. Only your body knows the right amount of these and every other substance needed for life and health. Our job is to provide substrate… to eat a wide variety of nutrient-rich “live” food (“live” meaning it is not denatured), consume enough “good” fat to stimulate ketone production, avoid all carbohydrate-rich food, avoid all toxins, get outside in the sun every day, exercise sufficiently to prevent an over-abundance of free electrons from “rusting” our mitochondria, getting enough sleep to allow minor repairs to be made and the garbage to be taken out and – last but not least – to be at peace with ourself and live in the moment. Thanks for sharing, Peter.

By: Oskar Grande

Oskar Grande — Mon, 25 Dec 2017 14:14:12 +0000

Hi Tara, please let me also know of any vital information, my daughter in law suffers from fatigue syndrome, sitting in wheelchair.
I myself started suddenly to age fast, no Alkohol non smoking,
Kind regards from Vienna
Oskar

By: Dom

Dom — Wed, 06 Dec 2017 16:24:15 +0000

Any thoughts or experience about taking NADH vs. NR and/or NAM?

By: Etteluap

Etteluap — Tue, 28 Nov 2017 13:23:03 +0000

Hi Tara I would be interested in the articles you mentioned. Could you provide info or a link? Thank you.

By: Etteluap

Etteluap — Tue, 28 Nov 2017 13:20:53 +0000

Yes, I’d also read that NAD does not cross cell membrane. The article I read suggested NMN would / could be a more effective supplement but I don’t think it’s available. Seems hope is dashed.

By: ROBIN K BENNETT

ROBIN K BENNETT — Thu, 09 Nov 2017 02:38:11 +0000

Very interesting correlation!

By: Juan

Juan — Sun, 29 Oct 2017 14:56:13 +0000

Yo utilizo HMB y NR y tengo otra vez la fuerza de los 30 años. Tengo 58 años. Hago 20 dominadas en la primera serie, luego hago 9 series de diez elevaciones. Creo que el efecto es sinergico. Mejor sueño. Tomo astragalo. Leucina. Lapachona. Mejor humor, lucidez, sueños, libido. Todo aumenta la sinergia.
Aparento 40 años. Mas o menos.

By: Alex Mark

Alex Mark — Mon, 11 Sep 2017 03:14:56 +0000

You made the statement that resveratrol was useless and I tend to disagree. I had used an extract of Japanese knot weed for years without any ill effects. I had minimal regrowth in areas on my head due to typical male pattern baldness. I read an article about piperin raising both the levels of resveratrol in the blood (2x) and casing it to remain in the blood for approx 3 to 4 hours rather than the typical 30 minutes. What was interesting was that I had substantial hair regrowth in the area above my ears and that hair came in dark instead of the salt and pepper grey that I was experiencing. So although this is anecdotal I would suggest that resveratrol does something. I would like to suggest if it had that effect on me perhaps it affects other parts of the body as well.

By: Angela

Angela — Mon, 21 Aug 2017 10:39:49 +0000

Hi, where was this conference?

By: Angela

Angela — Mon, 21 Aug 2017 10:38:11 +0000

If there was a supplement that caused redox signaling in the mitochondria, would that be helpful?