Comments on: All About mTOR + Natural mTOR Inhibitors & Activators https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/ Cutting-Edge Solutions For a Better Life Mon, 15 Nov 2021 14:20:57 +0000 hourly 1 https://wordpress.org/?v=5.8.1 By: Mathias https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-154657 Mon, 15 Nov 2021 14:20:57 +0000 https://selfhacked.com/?p=6775#comment-154657 It is an interesting little tidbit that mTOR is practically inhibited by all natural (plant) substances (aside from those non-plant substances conventionally used for sport), which at the same time is the main reason for all their many side-effects… (Also for medication side-effects like dyskinesia, akathisia, and the sexual side-effects that are driving many crazy. Of course mostly starting with PI3K/Akt signalling etc.)
What’s also worth mentioning is that all this popular playing around with dopamine and serotonin neurotransmitters is beside the point and has no effect if mTOR is deactivated. And playing around with cAMP in contrast is very popular again (never any real reason, explanation deemed necessary or convincing if attempted), but it’s sort of one of the neuronal counter-players to mTOR, which is certainly no less important. (It appears there is some Dopamine 1 and 2 distribution, for example, aside from cAMP overactivity with lack of mTOR being part of many side-effects.)
One shouldn’t be led amiss by most studies’ focus on “oncogenic” effects and inhibition, and therefore shallowly conclude, without specific investigation, that one can just get rid of something and that would be “good”. Chances are that’s where a lot of problems lie…

]]> By: Mattkd https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-147848 Tue, 05 Oct 2021 02:47:42 +0000 https://selfhacked.com/?p=6775#comment-147848 This is foolish, making it basically all about it being “bad” (with it being good not mentioned but downplayed as some basic functions with some crude “back in the savannah” kind of philosophizing that pop scientists reserve for TV).
One can find a list of all the “bad” things for anything else, including mTOR inhibition. Downright silly to be so simplistic. It is extremely important in the brain for normal function.

]]> By: Ralph Pike https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-138520 Mon, 21 Jun 2021 09:26:01 +0000 https://selfhacked.com/?p=6775#comment-138520 Fascinating article and dovetails nicely with my current knowledge. I am looking to replace sirolimus, mycophenalate and prednisolone required due to a liver allograft.
Three years in I have had to cease CNI’s due to the side-effects but I am also concerned about drug supply into the future. I also require insulin as genetic LADA type 1, have genetic haemochromatosis and require testosterone due to primary hypogonadism. Aromatisation is a problem. Which doesn’t help!
Not asking for a regime but would appreciate any comments you might have on a “top 3” for mTOR inhibition.

]]> By: t.Gardoen https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-137296 Tue, 08 Jun 2021 09:19:13 +0000 https://selfhacked.com/?p=6775#comment-137296 Thanks Joe,

This article “All About mTOR + Natural mTOR Inhibitors & Activators”, is an important must read for all laymen.
Thanks for highlighting it.
I am doing cancer research – from the angle of the newer metabolic approaches to healing and or/slowing it in its tracks. So your article is a big step in that direction and opening laymen minds that complementary strategies exist in the battle against cancer.

For too long the conservative chemo/radio treatment group of oncologists have rebuffed the public that other treatments than their own can only treat cancer.
Not any more – people like you are needed to spread the word.
I am not the either/or type of researcher as I find that some good still exists in conventional therapies,
and also much good exists in alternative therapies.
Its the die-hards on both sides which may at times obscure our search for the truth.

Every wish for your continued health, success and serendipity in life.

sincerely t.gardoen

]]> By: Jacqueline Turner https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-137235 Mon, 07 Jun 2021 11:25:01 +0000 https://selfhacked.com/?p=6775#comment-137235 This is very interesting and I was wondering if the MTor could also have a contributing factor to vitiligo autoimmune issue?

]]> By: Ken https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-53413 Fri, 09 Aug 2019 00:30:11 +0000 https://selfhacked.com/?p=6775#comment-53413 How do you test for mTOR? Do you order a specific blood test?

]]> By: Ana Aleksic, MSc (Pharmacy) https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-45497 Tue, 30 Apr 2019 14:48:54 +0000 https://selfhacked.com/?p=6775#comment-45497 In reply to PointO.

Hello, studies suggest it would lead to mTOR activation (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819476/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189635/).

]]> By: PointO https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-45372 Sun, 28 Apr 2019 17:06:31 +0000 https://selfhacked.com/?p=6775#comment-45372 Any thoughts on testosterone replacement therapy and if it would lead to over expression of mTOR?

]]> By: David Lyness https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-43884 Sat, 06 Apr 2019 18:05:37 +0000 https://selfhacked.com/?p=6775#comment-43884 Meant to say the latter is more profound ….oatmeal causes a more profound insulin release, and therefore has a longer TOR expression.

]]> By: David Lyness https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-43883 Sat, 06 Apr 2019 18:03:45 +0000 https://selfhacked.com/?p=6775#comment-43883 Rapamycin is a natural substance. It’s available by prescription, but it’s “natural” nonetheless.

Also, this article would be more informative if you describe what’s known about the magnitude of TOR expression as a result of leucine or insulin. The former leads to a shorter term stimulation, and the latter causes a longer time frame for TOR expression. Eating a steak and eating a bowl of oatmeal both stimulate TOR, but the former is more profound due to its greater insulin provocation

]]> By: Caroline Lam https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-39481 Mon, 08 Oct 2018 05:05:17 +0000 https://selfhacked.com/?p=6775#comment-39481 In reply to LO.

Hi Lo,

Thanks for your comment! I believe we left out rapamycin because it’s a pharmaceutical drug and the article is about natural ways to inhibit mTOR.

Best,
Caroline

]]> By: John https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-38783 Wed, 26 Sep 2018 21:23:01 +0000 https://selfhacked.com/?p=6775#comment-38783 I think you should point out that NAC could increase mTOR as well. Under a starvation condition, using NAC as an ROS scavenger, causes AMPK activation to be reduced, and mTOR signaling to be increased. Here is a link:

https://www.ncbi.nlm.nih.gov/pubmed/23000343

]]> By: LO https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-38473 Tue, 18 Sep 2018 13:28:57 +0000 https://selfhacked.com/?p=6775#comment-38473 How is it possible to write an article about mTOR without mentioning Rapamycin? MTOR stands for “mechanistic target of rapamycin”. This is the cleanest way to down regulate mTOR IMHO.

]]> By: Olympus https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-36125 Wed, 18 Jul 2018 11:52:21 +0000 https://selfhacked.com/?p=6775#comment-36125 When does leucine activate mTor and when does it activate AMPK as leucine does something with longevity?

]]> By: James https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-32362 Fri, 13 Apr 2018 04:53:17 +0000 https://selfhacked.com/?p=6775#comment-32362 Try good oils ( hemp/olive/flax seed/coconut) lots of leafy greens and eating the protein in spread out smaller amounts rather than in one big meal,
Go to youtube and search “Muscle Growth Science, mTOR & Leucine w/ Gabrielle Lyon, DO” it talks about the advantages of stimulating MTOR, I cant help thinking that the answer is somewhere downstream of MTOR

]]> By: Corinne https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-31759 Sat, 31 Mar 2018 04:50:10 +0000 https://selfhacked.com/?p=6775#comment-31759 Question: I have hypothyroidism and no matter what pills they put me on I am always fatigue and have some brain fog. I have lots to do and it’s getting stressful. Odd part is I am exhausted all day long then BOOM, insomina. I recently started taking meds for my insomnia but all I want is to feel normal again. I know I am having inflammation in my body, as that is part of the hypothyroidism. After reading this I’m unsure how to use this info to help my condition and diet

]]> By: Bente Øvereng https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-30101 Sun, 04 Feb 2018 20:50:03 +0000 https://selfhacked.com/?p=6775#comment-30101 Great article.

]]> By: Bente https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-30100 Sun, 04 Feb 2018 20:25:54 +0000 https://selfhacked.com/?p=6775#comment-30100 Great info. Tank you.

]]> By: CSue https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-29271 Sat, 06 Jan 2018 19:12:31 +0000 https://selfhacked.com/?p=6775#comment-29271 Agree with other posters, please post something on length of cycles. Should we be high mTor for a day to build muscle, then low for 2 days? Or high for a month then low for 2 months? Etc. There are many of us who want to balance muscle with longevity

]]> By: kelly trosper https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-29202 Thu, 04 Jan 2018 14:02:37 +0000 https://selfhacked.com/?p=6775#comment-29202 You’re right to look at protein. Rosedale has been on the case of mTOR for quite some time.
his recommendation is to limit protein intake to .6g/kg lean mass to avoid overstimulating the mTOR pathway.

]]> By: Thomas https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-28555 Wed, 13 Dec 2017 11:17:15 +0000 https://selfhacked.com/?p=6775#comment-28555 As noted correctly in the article about HMB:
HMB increases “(2) The stimulation of protein synthesis and muscle hypertrophy by increasing the rapamycin (mTOR) signaling pathway (R, R1, R2).”

]]> By: Michael https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-28461 Sat, 09 Dec 2017 00:58:12 +0000 https://selfhacked.com/?p=6775#comment-28461 How is mTOR measured? How can we assess mTOR and what optimal levels should we look for to know if we are increasing or decreasing mTOR?

]]> By: Gonzalo https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-28202 Wed, 29 Nov 2017 20:19:10 +0000 https://selfhacked.com/?p=6775#comment-28202 How do you know luteolin es the most powerfull inhibitor of mtor?

]]> By: Sam https://selfhacked.com/blog/mtor-natural-mtor-inhibitors/#comment-27116 Sun, 29 Oct 2017 22:19:45 +0000 https://selfhacked.com/?p=6775#comment-27116 Do you know which compounds (and dosages) simulate/approximate actions of metformin/neomycin,I would rather eat food than pop a pill.

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