There is a company I am watching called Exicure, they have developed what is called SNA (spherical neucleic acid) on a nanoparticle. It absorbs exceptionally well apparently through the skin. Their first target is TNF-a (for psoriasis) and is in phase 2 clinicals I think. it is anti-sense technology, so it knocks out the function of TNF-a mRNA preventing transcription. It is probably also deliverable in other formats other than transdermally, they are working on something undisclosed for the gut also. In the pipeline is another formula for IL-1b. So the trigeminal nerve is very close to the surface over the forehead and jaw and by the ears. Also behind mucous membranes in the nose and perhaps gums. topical it might work. no idea half-life. might be injectable at some point or another delivery.

Aspirin also works to interfere with prostaglandins in a way that other NSAIDs don’t. We have luck aborting migraine sometimes with 2 ecotrin aspirin, 2 Magtein (magnesium threonate) and a cup of coffee.

Lisa, in addition to low carb, you may want to try adding some coconut oil as MCT oils are always metabolized to ketones, and ketones soothe the brain. Buckwheat is a natural source of inositol, which is a secondary insulin signaler. It helps your body use insulin more effectively, so it may play with your blood glucose and insulin level…might contribute to the issue if you have low blood sugar naturally.

thanks for sharing about Molybdenum.

Lisa, you need some carbs to feed the friendly flora in the colon prebiotic starches. Those are key to getting migraines healed. In the absence of those good carbs the histamine-producing gut flora predominate.

You can find out more about how I healed my migraines on my website.

There is also something tied up with electrolyte balance. Neurons have sodium-potassium “pumps” on them which facilitate the charge necessary for the neuron to “fire” for lack of a better term. If the intracellular/extracellular balance is off the pumps get stuck. We get a lot of potassium from our food, and many have restricted salt. Salt your food. Especially those high in potassium for balance.

Have you tried an epsom salt bath? Magnesium is important and somehow so is sulfate, and epsom is magnesium sulfate. There is some new research on melatonin also in reducing migraine, and what is interesting is that while we sleep our brains transport melatonin into the ventricles and the spinal fluid that resides in there, but it must be bound to sulfate for that transport to happen apparently. sometimes in an ER they will use IV mag sulfate to abort a migraine. It can take a long time for mag levels to build in tissues. So keep taking oral mag too. any head injuries, even if they were months or even a year or two before onset?