Comments on: 8 Important Roles of Glutamate + Is It Bad in Excess?

By: Brenda

Brenda — Sun, 20 Dec 2020 03:46:54 +0000

Hi, I am really concerned about blood I recently had 11/20/2020. My amino acid are all screwed up and no one is helping.

Glutamate 283.6 these are beyond above normal. No one has done anything.

I have an appointment with the metabolic doctor i was seeing before the tests. I have been seeing so many doctors and no one is listening to me or cares to find a solution.

I told my GP there is something wrong with my body odor and urine smell, my hands are extremely swollen with rashes on my palms. Both arms I have tingling sensation, numbness from shoulder to hands. My hands burn, itch and I can fold them, they are three times their normal size. My vision is blurry and I see lights streaking in both eyes. Memory fog, slurred speech, hard to concentrate. Eleven disk herniations, torn labrum left shoulder, torn meniscus left knee. I have trouble walking, its so hard to get up in the morning. I am in pain everyday, my situation is started with a horrible rash in 2012, Under arms, back of neck, under breast, inside elbows, and groan.

I am so upset and terrified.
Please help me, please.

Brenda

By: Nmx

Nmx — Fri, 31 Jul 2020 17:37:28 +0000

Glutamate is very dangerous… the body makes enough and doesn’t need to be supplemented… Protein Drinks are dangerous because in the processing much glutamate is created by the heat… Some people develop ALS after just one encounter with MSG or glutamate… Avoid anything with these substances in them.. also called Glutamic Acid… Glutamine is different…apparently safe.

By: Tami

Tami — Tue, 28 Aug 2018 12:50:10 +0000

I think Magnesium intake is helpful with being and antagonist when it comes to glutamate receptors.
Mag T is a version that is great for the brain.

By: James

James — Tue, 07 Aug 2018 02:05:56 +0000

I’m confused about the link between GABA & GLUTAMATE. I do know too much MSG / glutamate can & will over time flood my brain & create a GRAND MAL seizure. Is a GABA supplement required to use to limit or control the Glutamate in the brain, or is glutamate required to make more GABA ? << That can be dangerous for me if glutamate is required, as I know some drugs with MSG's in them could cause seizures also.

By: Crosswind

Crosswind — Sun, 29 Apr 2018 17:59:33 +0000

Good article. Thank you. I’m trying to figure out what a list of “”Low glutamate”” diet would look like. Any good links you can share, please?

By: The Lofts @ Hollywood & Vine

The Lofts @ Hollywood & Vine — Fri, 06 Apr 2018 12:58:35 +0000

My father had ALS and by the time I had graduated high school, he had gone from using a cane (9th grade) to being bed ridden and only able to communicate by blinking 1 time for yes and 2 times for no. He was only 33 when he died. I’m much older now than he was, idk how well any of this diet supplement will work for you , but I hope it does help. People have beaten their own ailments with diet and excercise diabetes being just one: take care and be kind to others but mostly take it easy on yourself. Stress over something outside of your direct control will not help.
Be well:

By: Nancy ohrman

Nancy ohrman — Wed, 04 Apr 2018 20:56:34 +0000

I also would like to know if there is a way to know if glutamate levels are dangerously high. My mother died from ALS

By: Lori Tucker

Lori Tucker — Mon, 26 Mar 2018 15:26:21 +0000

I had to stop eating bone broth after because it had negative effects on my health: dizziness, weakness, insomnia, etc., etc. unfortunately, it took a long time for me to find info such as yours. Thank you, LT

By: DG

DG — Tue, 13 Feb 2018 08:26:04 +0000

Oops sorry – it was L-Glutamine that made me swell up.

By: DG

DG — Tue, 13 Feb 2018 08:23:22 +0000

I took glutamate and started to swell up. I have seen it mentioned on one or two sites but not here. It took awhile to de-swell. Any ideas why?

By: Caravaggio

Caravaggio — Thu, 28 Dec 2017 19:04:52 +0000

I don’t know if it applies to the CNS but it surely does to the PNS.

I just know some people get diarrhea from MSG. I have constipation and it is always relieved when I eat soy isolate protein (the highest source of glutamic acid).

So high Glutamate (or a lack of GLU receptors/hypersensitivity in the intestines) causes diarrhea and low Glutamate (or high amount of GLU receptors/hyposensitivity in the intestines) causes constipation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698427/

By: Wendy

Wendy — Thu, 09 Nov 2017 00:18:11 +0000

Look at the Reid program-Whole food based diet to block glutamate. Lots of herbs, herbal teas, dark green leafy vegetables, anti inflammatory

By: Maree Chambers

Maree Chambers — Sun, 05 Nov 2017 18:44:04 +0000

At 75 years of age I have been diagnosed with Motor Neuron Disease. (ALS). So glutamate is my problem. I would however love to find something other than Rilsuzole which blocks glutamate so I am told. Side affects liver which is bad for ALS patients. We need a good working liver. So far still up and able. Taking high antioxidants..

By: SallyS

SallyS — Tue, 24 Oct 2017 17:47:05 +0000

Are there any reliable labs to determne if one is low or high in glutamate?

By: Dean Monaghan

Dean Monaghan — Mon, 16 Oct 2017 19:27:32 +0000

What can I do or use to upregulate glutamate receptor sites/ promote healing? Herbs, supplement, anything.

Thanks

By: Nattha Wannissorn, PhD

Nattha Wannissorn, PhD — Sun, 23 Jul 2017 15:01:44 +0000

In reply to Diane.

We have 3 posts specific to blood brain barrier https://selfhacked.com/blog/fix-leaky-blood-brain-barrier/. Leaky gut post in the near future. We actually found very little scientific support for the GABA challenge but we discussed it anyway on the post https://selfhacked.com/blog/blood-brain-barrier-causes-tests-leaky-brain/.

By: Diane

Diane — Sun, 23 Jul 2017 01:31:19 +0000

Annoying…that was supposed to be a reply to Nattha’s comment below, but somehow it ended up here at the top of the page with no context.

By: Diane

Diane — Sun, 23 Jul 2017 01:29:41 +0000

Where are these “perfectly healthy people”? I don’t know any! :)

Seriously, I’ve come to the conclusion that there are VERY few who don’t have a leaky brain & leaky gut, even if they have no idea about it. For example, consider the “GABA challenge” test, and the comments here:

By: Nattha Wannissorn, PhD

Nattha Wannissorn, PhD — Tue, 20 Jun 2017 16:46:37 +0000

In reply to Maria.

Yes we do mention these in our book Biohacking Insomnia: https://selfhacked.com/sleepbook.

By: Maria

Maria — Tue, 20 Jun 2017 12:53:45 +0000

Since Self Hacked talks a lot about insomnia, I want to make sure people are aware of the excess glutamate and glutamine supplements in the diet and how it can actually harm us. Since collagen and bone broth are “all the rage” it can be impacting sleep in a big way! Plus, hardly anybody is “perfectly healthy” with all the food intolerances, toxins, pollution, EMF’s, and all the toxins that are impossible to avoid. Yes, we can decide what we eat and sometimes perfectly healthy foods cause inflammation that we are totally unaware of. Like, salmon or tomatoes or cauliflower or black pepper, etc…

By: Nattha Wannissorn, PhD

Nattha Wannissorn, PhD — Mon, 19 Jun 2017 04:43:50 +0000

In reply to Maria. If you have a leaky blood brain barrier and some issues with glutamate to GABA conversion, this can happen. It doesn't happen to perfectly healthy people.

By: Maria

Maria — Sun, 18 Jun 2017 23:55:11 +0000

Be careful about glutamate in Foods! I know everyone is on the collagen and bone broth bandwagon and eating tons of bone broth but those two foods are high in glutamate and if you have trouble with glutamate, these Foods will wreck your sleep! Happened to me, I found myself suffering from insomnia after about a year of eating bone north or collagen a few times a week (not in excess). Once i took those Foods out, I was sleeping again. Too much glutamate will shut down GABA in the brain which is needed for sleep! And you will lie wide awake at night and have trouble shutting your brain off. Don’t take glutamine supplements if you suffer from being wide awake and trouble falling asleep.

By: Turner

Turner — Sun, 11 Jun 2017 22:00:28 +0000

After unwittingly raising my glutamate levels with fried & slow cooked meats I appear to have relieved my situation temporarily by balancing glutamine & GABA as per [holistichelp]. I think this article would benefit with a short description of the distinction between glutamine & glutamate. I am very appreciative of your posts on orexin & oxitocin for my deficiency & will ‘see’ you soon with my 23 & me results.