Comments on: Glucuronidation: Detox, Balance Hormones, & Genes

By: Sebastian

Sebastian — Wed, 29 Sep 2021 03:53:43 +0000

I would like to know if “glucuronidation”-way like supplements help to stop initial or later stages of covid-19 infections… Thanks for the attention… and many thanks for the page and for the site…

By: Maryann

Maryann — Sat, 20 Mar 2021 14:30:07 +0000

Hi Dr Biljana. Thank you for your very interesting article. My 17 year old son has Gilbert’s syndrome. He has no symptoms except for the yellowing of his eyes. Otherwise he is a healthy teenage boy. I heard of calcium d glucarate and Dinndolyinemethane to help bilirubin levels. I got him this supplement which had helped him tremendously especially with the yellowing of his eyes. What is your opinion on this. I do know my son probably has high estrogen levels in his body because he also had gynaecomastica. Whilst taking this supplements it went away. Drs told me not to take anything and that the Gilbert’s is nothing serious, but as a mother I do worry although he is fine. I give him the supplements on my own accord and not the Doctors. Although Gilbert’s is harmless they say. The high bilirubin levels do worry me. I haven’t had them checked since he went on supplements as it took the yellowing away. All his other blood works were fine.

Regards. Maryann

By: Michelle

Michelle — Thu, 29 Oct 2020 12:08:50 +0000

Anke Koelman told me phase2liver detox/glucaronic acid enzyme missing. Do U know how I can treat it please?IM DESPERATE. Both my sisters have died & I’m scared I’m dying. Please help me ASAP.

By: Tammy Jutsum

Tammy Jutsum — Thu, 25 Jun 2020 23:42:56 +0000

Biljana
I was trying to understand this article. I had a GI test that said I had no glucuronidase it was 0
Can you explain article for that…low beta-glucuronidase
Does that mean I cannot detox well? I truly have that problem no matter what I eat. If so…any suggestions to help?

By: Tanya Zivin

Tanya Zivin — Mon, 06 Apr 2020 19:31:02 +0000

So, I’m confused. Does Milk Thistle inhibit or promote Glucuronidation?

By: Lisa

Lisa — Mon, 09 Dec 2019 09:10:43 +0000

Thank you so much for this article. It is another piece in the jigsaw puzzle to resolving my SIBO and endrometriosis condition. The two are definitely linked and I didn’t know how exactly but this article explains a lot. The endometriosis got a lot worse as SIBO symptoms developed. I’ll take some of these dietary recommendations on board and see if I can clear some estrogen. Fingers crossed.
I have always wondered if it was chicken or egg first. Would this mean SIBO caused excess estrogen or increased estrogen caused SIBO?

By: Ana Aleksic, MSc (Pharmacy)

Ana Aleksic, MSc (Pharmacy) — Thu, 29 Aug 2019 11:02:51 +0000

In reply to Rhonda.

Hi Rhonda, milk thistle supports detoxification in humans. It does block glucuronidation in cells, but overall increases antioxidants and detox enzymes in humans, which overrides the effect observed in cells. Milk thistle also helps the liver regenerate. This goes to say that we can’t always assume how a herb will act in humans based on a single cell study–the human body is much more complex. For more info about milk thistle, please read through this article: https://selfhacked.com/blog/milk-thistle/

By: Rhonda

Rhonda — Tue, 13 Aug 2019 22:48:56 +0000

There are a few too many confounding references here. Milk thistle is good or bad for detox support? Anyone, please commend if they have data. Thanks

By: Steve

Steve — Tue, 29 May 2018 14:17:55 +0000

The risk of cancer I have seen with GS is due to incomplete detoxification and elimination of estrogens. This can increase risk of breast cancer

By: Heather L. Hubbard

Heather L. Hubbard — Fri, 30 Mar 2018 21:51:03 +0000

Well Im officially terrified now. So happy to be part of the 10% that has the gene for pancreatic cancer. Ive already had pancreatitis and have extremely low enzymes. :(

By: ibh

ibh — Mon, 31 Jul 2017 13:10:52 +0000

A lot of great info. Just wanted to add a comment regarding Gilbert’s Syndrome, as it made me a bit nervous to see it in bold in your article as a risk factor for cancer (I might have misunderstood). I do have Gilbert’s Syndrome and I thought I have read over the years that it is protective from CVD and cancer, due to slightly elevated billirubin’s significant antioxidant protection. A lot of reading is easily found on this subject and PubMed has a study ”Iatrogenic Gilbert syndrome — a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin”. Anyway, just thought this might be useful info for those with Gilbert’s Syndrome :)

By: Jules

Jules — Thu, 13 Jul 2017 14:54:18 +0000

Thank you for a very concise summary