Comments on: CYP2D6: Can It Predict Personality Traits? Genetics Explained

By: robt116cpr@aol.com robt116cpr@aol.com

robt116cpr@aol.com robt116cpr@aol.com — Sat, 14 Aug 2021 23:42:50 +0000

Hi- great to see this is being shared on here.
Once you realize you have a reduced CYP2D6 enzyme, what, if any, drugs do you need to compensate for this deficit; and/or, what natural or form of supplements, and allowed foods, do you need to consume to increase the enzyme activity and effectively metabolize appropriately- without causing a toxic build-up and further depletion to your skeletal structure?
Thank you for your response,
Robin

Note: I see how this can tie into other autoimmune disorders. Have you studied Folate vs Folic Acid- great example for need vs form of compensation dependent on how you metabolize …

By: Harriet Gilman

Harriet Gilman — Mon, 28 Jun 2021 04:57:25 +0000

If this information is portrayed accurately, I think
It should be taught to every high school student as part of the health education curriculum. We all need to know our bodies’ unique characteristics, strengths and susceptibilities!

By: Michelle

Michelle — Tue, 16 Mar 2021 07:03:13 +0000

Very interesting article, thank you! Just found out I am an ultra rapid metaboliser – explains why a codeine bill cant keep my up all night and most anti-depressent and psychiatric medication did not work for me.. wish I had known about this stuff years ago!

By: Roy Tolles

Roy Tolles — Fri, 22 Nov 2019 00:49:13 +0000

I am having trouble getting off of Tramadol. I took it for 3 months for surgery 3.5 years ago and then I haven taken it for 2+ months now, starting in Sept. 2019.

Since my first surgery, I have continued to feel more depressed that I ever was before surgery. Now, even 1/4 of a 25 mg pill make me feel better but after 2-3 days the aching comes back!

This article was very interesting but I’m not sure where to go from here. Could Tramadol have LONG-TERM impacts on mood and cognitive functioning? Thanks

By: Tami Copeland

Tami Copeland — Mon, 11 Nov 2019 16:55:57 +0000

I have read alot about CYP2D6 UM since my daughter was diagnosed, this is the first I have read about this enzyme being in the brain and not just the liver. Makes me think that in addition to affecting how anti-depressants are processed that it could be a contributor to her depression. Can you share additional studies/data on this? My daughter is a 17 year old Caucasian, this seems to be a rare condition for north american Caucasians, so there is not enough data out there. I am looking to anything to help her live her best life. Your response is appreciated.

By: Kim

Kim — Wed, 21 Aug 2019 01:23:40 +0000

In reply to renee trusky.

Sorry to hear and thanks for sharing, we don’t answer personal health questions in the comments section for privacy reasons. If you’re looking to get answers from Joe, please join SelfHacked VIP at https://selfhacked.lpages.co/selfhackedvip/. Feel free to get in touch with us with any questions about how our VIP members area works at [email protected].

By: renee trusky

renee trusky — Mon, 19 Aug 2019 19:24:38 +0000

I do not know where to begin. My 8 year old had a surgery at about 2.5 years old. Before surgery he was healthy and all milestones normal walking and talking. During the surgery they had problems keeping him under, the surgery was done and he was not the same since. In the next two weeks his speech slowed until it stopped completely and he became very wobbly. Falling all the time. Doctors kept telling me he was in shock and to just love on him. Weeks went by doctor visit after doctor visit. They tried to tell me my son was deaf, autistic, Asperger’s, some forms of down or anything to make us go away. In an ENT appointment I broke down sobbing when I told them this happened in a matter of days of a surgery and how my son gets sick after Tylenol , hives with antibiotics , Benadryl put him to sleep for a day. The doctors eyes lit up and she ordered a pharmacogenetic test immediately. She also advised to stop any medication and supplements. They also tested for other things. The results came back the geneticist called me, advised to not give him any medications and come in asap. The only thing that came back was that his CYP2D6 gene wasn’t right. She said in that gene 1 is paralyzed, 1 works negatively, and an extra that works fine…

So here we are 6 years later, my son has had lots of therapy and his talking is so much better. I just have no answers about what else to watch out for and if he should have a certain diet. Nothing, the geneticist said to me she wished she never tested him because she has no answers for me. I don’t know what to do. Can you help me Please?

By: Ren

Ren — Sat, 20 Jul 2019 16:42:25 +0000

What does it mean to increase or decrease CYP2D6?

By: Jeannaé quadri

Jeannaé quadri — Sat, 18 May 2019 01:27:06 +0000

Thanks

By: Ana Aleksic, MSc (Pharmacy)

Ana Aleksic, MSc (Pharmacy) — Mon, 08 Apr 2019 14:33:06 +0000

In reply to Tony.

Hi Tony,

Thanks for your comment. I’m not sure if you’re looking to get the opinion of other readers or advice from the SelfHacked team. You might want to take a look at SelfDecode (https://selfdecode.com/) if you haven’t already. It’s our tool for making sense of genetic information and you’ll also find DNA reports, gene packs, and natural recommendations specific to your genes inside. If you have any questions about SelfDecode, get in touch with us at [email protected].

By: Tony

Tony — Mon, 08 Apr 2019 05:42:27 +0000

Can anyone help me? I have three ultrarapid genes and suffer from some unique issues, any insight is hugely appreciated. Might someone be able to help me?
My profile is:
CYP2C19 *1/*17 (Ultrarapid)
CYP2D6 *1/*2A+*2B (Ultrarapid)
CYP1A2 *1/*1F (Ultrarapid)
VKORC1 G/A (intermediate)
COMT *1/*2 (intermediate)
CYP2C9 *1/*1 (normal)
CYP3A4 *1/*1 (normal)

By: Sole

Sole — Wed, 05 Sep 2018 21:19:35 +0000

Hello my gene cyp2D6 is danger-strong increased what means? Thank you

By: Debra stein

Debra stein — Mon, 04 Jun 2018 04:42:09 +0000

I have cyp2d6 Gene. Can CBD oil help with venlafaxine tapering

By: Kathy

Kathy — Wed, 27 Dec 2017 19:23:18 +0000

I have 2d6++ 2 genes and comt++. Trying to find ways to detox, help anxiety and inflammation. Any suggestions?

By: Marina

Marina — Tue, 01 Aug 2017 15:58:05 +0000

This article is utterly fascinating. Years ago, I took Paxil (Paroxetene) for 2 days, then stopped. I then began to have muscle twitching that made it nearly impossible to sleep for up to one year, and that came intermittently for 6 years following.

Years later, I had genetic testing done, and found that, indeed, I have two defective alleles of CYP2D6.

I have no doubt that my poor CYP2D6 metabolism was the cause of my adverse reaction to Paxil, which no doctor at the time could understand.

What I am likewise amazed by, however, reading your article, is the further correlation to personality traits.

I totally identify with these:

– increased anxiety (was the reason why I was prescribed Paxil in the first place)
– higher impulsivity
– performing well in tasks that demand sustained attention – have always been able to focus for long hours
– “high conscientiousness/responsibility, orderliness, and the pursuit of achievement through perseverance.”

Also, you mention a correlation to autoimmune disease. Indeed, I was diagnosed with Hashimoto’s hypothyroidism at the age of 12.

Thank you so much for your research, and for making it so easily accessible.

Blessings.

By: Sam

Sam — Sun, 04 Jun 2017 18:01:05 +0000

“…the activity of mitochondrial CYP2D6 can be high, and there have been correlations between these variants and the incidence of Parkinson’s disease.”

“If we add MPTP to dopamine-sensitive neurons and also add a CYP2D6 inhibitor, we see marked protection of the neuronal function,” Avadhani said. “We believe this is a paradigm shift in how we think about the mechanism of Parkinson’s.”

[neurosciencenews]

By: Sam

Sam — Sun, 04 Jun 2017 06:50:34 +0000

and here is a whole textbook of “all” plants, tea, gfj, Schisandra, resveratrol,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477257/

By: Sam

Sam — Sun, 04 Jun 2017 06:43:05 +0000

Andrographolide, curcumin, and lycopene produced no significant induction effects on CYP1A2, CYP2D6, and CYP3A4.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237480/

By: Sam

Sam — Sun, 04 Jun 2017 06:22:27 +0000

Nice to know, But what’s your point? It seems you want to increase CYP2D6 activity to avoid developmental /psychological diseases and flush toxins. So don’t take onions, apples, no kale, and no spices? and broccoli?
it seems every Hindu/Indian lives on all of these spices, yet there is no mental disease and the consensus you do want to take these spices all the time to induce detox.