Keep taking amitriptyline and go for a 6 months course in Homeopathy from a good Homeopath. Ensure not to discontinue the allopathic medicines. You will be fine.

Sorry to hear and thanks for sharing, we don’t answer personal health questions in the comments section for privacy reasons. If you’re looking to get answers from Joe, please join SelfHacked VIP at https://selfhacked.lpages.co/selfhackedvip/. Feel free to get in touch with us with any questions about how our VIP members area works at [email protected].

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Hi Dana, we don’t recommend the use of this drug or any pharmaceutical drugs. We are only trying to provide information about how the drugs are used and their side effects. We mention that the use of this drug has been fatal in some cases and the dangers and side effects of it. To be more clear that we don’t recommend this drug, I rephrased some sections of this article to emphasize its dangers. Thank you for your comment.
-Caroline

If this site is honest, they will allow my comment.

Thank you for all the information.

We are by no means promoting amitriptyline as a go-to solution for any of these problems. All of these health issues are complex, and there are a number of ways to approach them. Also what works for one person, may not necessarily work for the other.

We do have many posts on natural substances that help with many of these issues. We also have a post about progesterone and its benefits.

The information here is provided for people who cannot avoid using this drug, and for those who would like to know more about it and its effects.

https://www.ncbi.nlm.nih.gov/pubmed/26408166 Endocannabinoids and the Endocrine System in Health and Disease.

https://www.ncbi.nlm.nih.gov/pubmed/10397281 Acute effect of alcohol on estradiol, estrone, progesterone, prolactin, cortisol and luteinizing hormone in premenopausal women.

Bioidentical hormones are needed to restore hormone levels- not synthetic progesterone like medroxyprogesterone because synthetic progesterones are foreign to our bodies and do not match exactly to our hormone receptors and do not activate the dopanergic and serotonergic pathways to prevent neurodegeneration or activate the p53 tumor suppressor or inhibit mTOR to put the brakes on cancer.

https://www.ncbi.nlm.nih.gov/pubmed/17217322 A comprehensive review of the safety and efficacy of bioidentical hormones for the management of menopause and related health risks. Bioidentical hormones match the structure and function of hormones produced in our bodies. Although synthetic progesterones are known to be different with respect to molecular structure, receptor affinity, metabolism, and other physiological traits, most have been treated as if they were clinically identical to bioidentical hormones, but they are not identical with different clinical outcomes in the breast, endometrium, bone, cardiovascular system, and brain. The studies reviewed suggest bioidentical progesterone does not have a negative effect on blood lipids or vasculature as do many synthetic progestins, and may carry less risk with respect to breast cancer incidence. Studies of both bioidentical estrogens and progesterone suggest a reduced risk of blood clots compared to non-bioidentical preparations. (In other words, our health is improved with real normalized hormone levels. Synthetic hormones are bad or you! Synthetic hormones were made so pharmaceutical companies could get a patent and make more money. Recently the way pharmaceutical companies have been able to get patents on real hormones is by making estradiol in a patch and by micronizing progesterone. So that’s how they are making big money.)

Amitriptyline is an anticholinergic which its side effect is dementia. https://www.medscape.com/viewarticle/838788 ‘Strongest Evidence Yet’ Links Anticholinergic Drugs, Dementia

Amitriptyline over time disrupts Delta wave sleep.Delta sleep is important in Parkinson’s, Schizophrenia, diabetes and insulin resistance, fibromyalgia, narcolepsy, depression, anxiety, obsessive compulsive disorder, attention deficit hyperactive disorder, juvenile chronic arthritis. https://en.wikipedia.org/wiki/Delta_wave (Progesterone, GABA with HTP, tryptophan, rosemary, and Ashwagandha enhance Delta sleep.)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076958/ Antidepressant and Antipsychotic Drugs The antidepressant and antipsychotic drugs are a set of agents with a wide range of different pharmacologic effects. Many of these pharmacologic effects impact sleep-wake function. This can involve promoting sleep, promoting wakefulness, altering the amount or timing of sleep stages across the night and increasing the likelihood of restless legs syndrome and/or periodic movements of sleep which can disturb sleep.

Depression-
Low levels of progesterone decrease serotonin, which can cause poor sleep and depression. Also, diminished amounts of progesterone prevent the balancing of the stimulating effects of estrogen and can lead to anxiety. … Cortisol: Depression has been associated with both elevated and low levels of cortisol. https://socalbhrt.com/depression-and-irritability/
Also, in particular, certain 3α-reduced metabolites of progesterone such as 3α,5α-tetrahydroprogesterone (allopregnanolone) and 3α,5β-tetrahydroprogesterone (pregnanolone) are potent positive allosteric modulators of the GABA(A) receptor complex. During the last years, the downregulation of neurosteroid biosynthesis has been intensively discussed to be a possible contributor to the development of anxiety and depressive disorder. Reduced levels of allopregnanolone in the peripheral blood or cerebrospinal fluid were found to be associated with major depression, anxiety disorders, premenstrual dysphoric disorder, negative symptoms in schizophrenia, or impulsive aggression. The importance of allopregnanolone for the regulation of emotion and its therapeutical use in depression and anxiety may not only involve GABAergic mechanisms, but probably also includes enhancement of neurogenesis, myelination, neuroprotection, and regulatory effects on HPA axis function. https://www.ncbi.nlm.nih.gov/pubmed/24215796 “The role of allopregnanolone in axiety and depression.”

Migraines-
2% natural progesterone cream: The estrogen dominance that is so common during perimenopause can trigger a migraine, due to estrogen’s excitory nature. Often, 2% bioidentical progesterone cream is all you need to relieve premenstrual or menopausal migraines https://www.drnorthrup.com/migraines/
Click here for scientific research curing all patients of migraines http://www.ncbi.nlm.nih.gov/pubmed/26707041 “Is migraine a consequence of neurohormonal and metabolic integrity?”
Also- http://www.lifeextension.com/magazine/2006/12/cover_migraine/page-01

Fibromalgia –
Sleep disturbances are common in fibromyalgia, and progesterone enhances slow wave deep Delta sleep phase, the hormone restorative phase.
https://www.ncbi.nlm.nih.gov/pubmed/28545798 “Sleep disturbances in fibromyalgia: A meta-analysis of case-control studies.” https://en.wikipedia.org/wiki/Delta_wave

IBS-
Recent clinical and experimental findings support the modulatory actions of sex hormones exerted at different levels of the brain-gut-microbiota axis in irritable bowel syndrome (IBS). Sex hormones may influence peripheral and central regulatory mechanisms contributing to the alterations in visceral sensitivity, motility, permeability, and immune activation of intestinal mucosa. A new concept of “microgenderome” is emerging based on the observations that the gender bias present in numerous diseases may be reinforced by the commensal microbiota of the host. Significant sex differences in epidemiology, symptomatology, and treatment outcome in IBS indicate the necessity for sex-tailored therapeutic approach in this disorder. Furthermore, a growing body of evidence indicates a protective role of androgens in pain modulation and anti-inflammatory properties of testosterone that may inhibit the development of visceral hyperalgesia.
Sex steroid hormones such as progesterone, estradiol, and testosterone play a number of important physiological roles including reproduction, differentiation, development, cell proliferation, apoptosis, inflammation, metabolism, homeostasis, and brain function. They are mainly synthesized by gonads, the adrenal gland, and the placenta and are released into the blood stream to act both in peripheral target tissues and the central nervous system. Sex steroid hormones exert their function by binding to either specific intracellular receptors that act as ligand-dependent transcription factors (classical mechanism) or membrane receptors that stimulate several signal transduction pathways (nonclassical mechanism).
Interestingly, sex steroid hormones also participate in the communication between microorganisms and mammal hosts. This type of communication is commonly referred to as “interkingdom signaling” and can be used by microbial pathogens to activate their virulence factors and control the course and outcome of infection. Notably, human and animal males, in general, are more susceptible to protozoan, fungal, bacterial, and viral infections than females. This susceptibility could be due to the lower immune responses presented in males than in females, since innate responses, antibody-mediated, and cellular responses are typically lower in males than in females.
Numerous studies have reported the effects of sex steroid hormones on the dimorphic sex differences in the response to microbial and viral infections. In addition to affecting host immunity, sex hormones alter gene expression and behavior that influence susceptibility and resistance to infection. This paper mainly focuses on the participation of sex hormones in the interaction between pathogenic bacteria and their hosts, their involvement in the host mechanisms used to minimize and eradicate the infection, as well as in the pathways used by bacteria to evade the immune response. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949254/ “Sex hormones in the modulation of irritable bowel syndrome”

Inflammation-
Progesterone acts as an antiinflammatory agent and regulates the immune response. https://en.wikipedia.org/wiki/Progesterone
Real progesterone increases T cells synergistically with Vitamin D. Real progesterone with vitamin D promotes generation of induced regulatory T cells with increased stability. Real progesterone is responsible for immune function in cooperation with vitamin D which fail with lowered progesterone and lowered vitamin D both causing autoimmune disorders and other diseases. Vitamin D makes progesterone effective. Progesterone works synergistically with Vitamin D in the central nervous system and in immune function increasing T cells.

Parkinson’s-
Sleep disturbances, as well as dementia are common features of Parkinson’s disease, and patients with this disease show disrupted brain wave activity. The drug Rotigotine, developed for the treatment of Parkinson’s disease, has been shown to increase delta power and slow-wave sleep. Delta-wave inducing peptide injected into the substantia nigra of the rat model has been shown to increase Parkinsonian symptoms. https://en.wikipedia.org/wiki/Delta_wave
Progesterone enhances Delta wave sleep. https://books.google.com/books?id=D1fOTC6CP3kC&pg=PA49&lpg=PA49&dq=progesterone+enhances+delta+sleep&source=bl&ots=_8sBxqnnT7&sig=9gB-f4OHVd4QDL-aCnBRIn1xNGE&hl=en&sa=X&ved=0ahUKEwixvaK_zt_XAhXo44MKHQllD58Q6AEIQzAE#v=onepage&q=progesterone%20enhances%20delta%20sleep&f=false “Neurosteroids and the Nervous System”

Delta sleep stimulates the release of human growth hormone and human growth hormone which growth hormone is linked to Klotho, the anti-aging hormone, which regulates calcium and phosphate homeostasis and vitamin D metabolism. Klotho Protein Fragment Improves Brain Function, Resilience in Mice; May Eventually Benefit Parkinson’s Patients. https://parkinsonsnewstoday.com/2017/08/14/klotho-protein-improves-brain-function-resilience-mice-may-potentially-benefits-parkinsons-alzheimers/

Histamine-
Progesterone is needed to upregulate DAO. Estrogen downregulates DAO. Estrogen triggers histamine release. Progesterone can also directly inhibit the release of histamine from mast cells, even during allergic reactions that trigger their degranulation.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377947/ Role of sex hormones, estradiol and progesterone, in mast cell behavior. Frontiers in Immunology, 3(169).
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537328/ Estrogen effects in allergy and asthma. Current Opinion in Allergy and Clinical Immunology, 13(1), 92-99.

Stomach ulcers-
The gastric acid secretion was determined in rats with gastric ulcers equipped with chronic gastric fistula. Treatment with progesterone significantly accelerated ulcer healing and increased the gastric and lingual blood flow at margin of these ulcers. https://www.ncbi.nlm.nih.gov/pubmed/15608364 The role of female and male sex hormones in the healing process of preexisting lingual and gastric ulcerations.

PCOS-
Combined Follicle Stimulating Hormone and progesterone treatments restored estradiol level and reduced cystic signs in the follicles, and attenuates PCOS characteristics. https://www.ncbi.nlm.nih.gov/pubmed/29062793 Ultra-low Doses of Follicle Stimulating Hormone and Progesterone Attenuate the Severity of Polycystic Ovary Syndrome Features in a Hyperandrogenized ….

Cancer-
With The Women’s Health Initiative, the estrogen plus progestin trial was stopped in July 2002, after investigators found that the associated health risks of the combination hormone therapy outweighed the benefits. Participants were followed for an average of 5.6 years. The study found that conjugated equine estrogen and synthetic progesterone that were once popular cause cancer by 30% or more. They are foreign to our bodies. However, real or micronized progesterone (not synthetic) both inhibits mTOR and activates the p53 tumor suppressor gene which together both p53 and mTOR kill and put the brakes on cancer. Now pharmaceutical companies have estradiol patches and micronized progesterone instead; however, at below normal levels to prevent spotting.
The well-established body of literature demonstrating the harmful effects of non-bioidentical hormones might lead some women to fear taking bio-identical hormones as well. A review of the published scientific literature indicates those fears are misunderstood and unfounded. For example, thirteen studies document that non-bioidentical progestin significantly increases estrogen-stimulated breast cell replication and growth. In stark contrast; seven studies have shown that bioidentical progesterone does not induce estrogen-stimulated breast cell proliferation.

Progesterone levels equal to the third trimester- (468 nmol/l) kill ovarian cancer. Progesterone is recommended in advanced stage ovarian cancer disease.
https://www.ncbi.nlm.nih.gov/pubmed/21761364 “Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: Implications for progesterone-induced signaling events.” The high mortality rates associated with ovarian cancer are largely due to a lack of highly effective treatment options for advanced stage disease; a time when initial diagnosis most commonly occurs. Progesterone which possess anti-tumorigenic properties is recommended in advanced stage ovarian cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189458/ “Protective Effect of Progesterone during Pregnancy against Ovarian Cancer”
https://www.ncbi.nlm.nih.gov/pubmed/9149021/ “Progesterone induces apoptosis and up-regulation of p53 expression in human ovarian carcinoma cell lines.”
https://www.ncbi.nlm.nih.gov/pubmed/14534535/ “Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enhanced expression of FasL.”
.
Progesterone kills brain cancer. http://www.oncologynurseadvisor.com/headlines/progesterone-could-be-added-to-brain-cancer-therapies/article/356841/ Progesterone could become part of therapy against the most aggressive form of brain cancer.

Progesterone and estrogen double lung cancer survival. https://www.lungcancerfoundation.org/2014/03/lung-cancer-survival-rate-doubled-with-progesterone-and-oestrogen-therapy/ Progesterone and estrogen doubled lung cancer survival rate.

Click here below for scientific research curing all patients of migraines http://www.ncbi.nlm.nih.gov/pubmed/26707041 “Is migraine a consequence of neurohormonal and metabolic integrity?”

Also http://www.lifeextension.com/magazine/2006/12/cover_migraine/page-01

Click here for scientific research curing all patients of migraines http://www.ncbi.nlm.nih.gov/pubmed/26707041 “Is migraine a consequence of neurohormonal and metabolic integrity?”

Also http://www.lifeextension.com/magazine/2006/12/cover_migraine/page-01

Delta sleep is important for producing growth hormone and for also producing Klotho, the anti aging hormone that regulates calcium and phosphorous homeostasis. Delta sleep is also when your core body temperature drops which is usually 1 hour after falling asleep, so then brain cells shrink 60% and the body’s glymphatic system, the nighttime brain housekeeping system, goes to work with cerebrospinal fluid washing out the brains toxins including Beta amyloid produced during the day by a hardworking brain and made soluble by progesterone allowing the Beta amyloid to be washed out. When progesterone declines with age starting in your late 30s, then luteinizing hormone rises which raises the night time core body temperature decreasing Delta sleep not allowing the body core temperature to drop like normal for quality Delta sleep. Without Delta sleep, you are in danger of developing dementia, Alzheimer’s, Parkinsons, ALS, and other neurodegenerative diseases. A 20 year old spends 20% of the night in Delta sleep, a 40 year old spends 5% of the night in Delta sleep, and an 80 year old spends 0% of the night in Delta sleep. 30% of people over 85 have dementia. Rosemary, Ashwagandha, GABA with 5HTP, vitamin D, tryptophan, and progesterone increase Delta sleep. Valerian reduces Delta sleep and so does Amitryptyline and other anticholinergics.

Amitryptyline is an anticholinergic which anticholinergics are implicated in dementia and neurodegenerative diseases. Anticholinergics are a group that encompasses medications for colds and allergies, anxiety, depression, insomnia, high blood pressure, and incontinence…. Pretty much any medicine that makes you groggy and your mouth really dry. Taking an anticholinergic for the equivalent of 3 years or more was associated with a 54% higher dementia risk than taking the same dose for 3 months or less. “The Beer’s List published by the American Geriatrics Society has long recognized benzodiazepines, antihistamines, and tricyclic antidepressants, including Amitryptyline, as potentially inappropriate for older adults, given their side effects,” says Dr. Lauren J. Gleason, a physician in the Division of Aging at Harvard-affiliated Brigham and Women’s Hospital. Such drugs are on the list because they share troubling side effects—confusion, clouded thinking, and memory lapses—that can lead to falls, fractures, and auto accidents. https://www.health.harvard.edu/mind-and-mood/two-types-of-drugs-you-may-want-to-avoid-for-the-sake-of-your-brain

Your first source in this article about the 14 people and Delta sleep increase is from 1973. Since then, they have found that Amitriptyline initially improves sleep symptom scores and patients have a meaningful response, however, by six months the response declines. Check here. CLINICAL SLEEP DISORDERS 2012 https://books.google.com/books?id=-ZTfjy2GLBYC&pg=PA463&lpg=PA463&dq=amitriptyline+delta+sleep&source=bl&ots=C9wuvwD6Tr&sig=EEIBDW4dNQBNphdmPlbCsSh-9Kg&hl=en&sa=X&ved=0ahUKEwiZ28nJ1NjXAhUFMd8KHazwDEkQ6AEIWjAH#v=onepage&q=amitriptyline%20delta%20sleep&f=false

https://www.sleepsomatics.com/sleepsomatics-journal-blog-about-sleep/what-causes-deficient-restorative-sleep/2014/7/18 It must be stated here that you should never alter or adjust your prescription medication usage without direction from or supervision of the prescribing physician. Nor should a patient assume that because a medication is listed below that Stage N3 delta or Stage REM suppression or sleep disruption are guaranteed or confirmed effects.

The list below is only a sample of medications within those categories or medication groups, and it is the groups that are commonly associated with sleep architecture changes. Psychiatric prescription medications that can potentially reduce, delay, or worsen physiologically-restorative and hormone-balancing Stage N3 delta slow-wave sleep and/or reduce cognitively-restorative Stage REM sleep include: :

•Benzodiazepines ◦Alprazolam (Xanax)
◦Clonazepam (Klonopin)
◦Diazepam (Valium)
◦Lorazepam (Ativan)
◦Temazepam (Restoril)

•MAOI (monoamine oxidase inhibitor) ◦Isocarboxazid (Marplan)
◦Phenelzine (Nardil)
◦Selegiline (Emsam)
◦Tranylcypromine (Parnate)

•Selective SNRI (serotonin and norepinephrine reuptake inhibitor) ◦Desvenlafaxine (Pristiq)
◦Duloxetine (Cymbalta)
◦Venlafaxine (Effexor)

•SSRI (selective serotonin reuptake inhibitors) ◦Citalopram (Celexa)
◦Escitalopram (Lexapro)
◦Fluoxetine (Prozac)
◦Paroxetine (Paxil)
◦Sertraline (Zoloft)

•TCA (tricyclic antidepressants) ◦Amitriptyline (Elavil)

Be aware that all anti-histamines including Benadryl, sleeping pills and sleep aids, including Seroquel, and over the counter cold pills also reduce, delay or worsen Delta slow wave deep sleeps. Below are sites listing dementia causing drugs and medicines.

Are Your Drugs Raising Your Risk for Dementia? – The People’s …
https://www.peoplespharmacy.com/2015/01/27/are-your-drugs-raising-your-risk-for-dementia/

‘Strongest Evidence Yet’ Links Anticholinergic Drugs, Dementia https://www.medscape.com/viewarticle/838788 Jan 27, 2015

Please speak to your doctor.