Comments on: Is MAOA the “Warrior Gene”? High/Low Levels & Testing

By: howard engel

howard engel — Wed, 15 Sep 2021 00:37:34 +0000

i am +/+ for MAO. does that mean I have too much, or 2 little? Confusing stuff, this SNP testing..

By: Michelle Smith

Michelle Smith — Tue, 25 May 2021 03:40:52 +0000

Hi, my grown up children have done genetic reports here in Australia. They have 2 red MAOA snps
MAOA rs 909525 intron variant AA -/-
and
MAOA rs632 R297R TT -/-
apparently the first is fast and the second is slow. i thought that -/- meant fast and +/+ meant slow in these genes but the report says different. what should we do about this? do they balance each other out or is one stronger than the other. I also don’t understand the repeats?(they also have a fast COMT)

any help would be great. Thank you. Michelle

By: melissa

melissa — Fri, 20 Nov 2020 17:28:32 +0000

I wish there were more trials about women with low MAOA. I am about to send off for a DNA test specific to that gene but I would like to participate in future trials if my results prove my genetics.
Also, I’ve noticed I have to eat different foods and stay away from certain medications because it will cause my mood to change. If you are aware of any future trials or can recommend a dna test specific to low MAOA in women, please let me know.
Thanks!

By: Jeffrey Florentino

Jeffrey Florentino — Thu, 02 May 2019 04:34:42 +0000

In reply to Zoltan Nemeth.

Thanks for your comment. To get answers to your health questions, please join SelfHacked VIP at https://selfhacked.lpages.co/selfhackedvip/. Feel free to get in touch with us with any questions about how our VIP members area works at [email protected].

By: Zoltan Nemeth

Zoltan Nemeth — Wed, 01 May 2019 13:34:46 +0000

Dear Joe,

I saw that if someone wants to raise his MAO A levels has to do SIRT1 activating stuff. And Cold exposure, fasting, all of the good stuff activates the SIRT1 levels.
But what to do if someone has HIGH MAO A levels? Is it means he has to avoid any SIRT1 activating activity? Fasting, cold, sun, sauna, exercise, fructose.. just to mention a few of them. These are influencing directly the activation of SIRT1 but there are a lot of supplements which are increasing directly NAD+ levels what influences the SIRTI1 levels indirectly.

“Anything that increases NAD+, will increase SIRT1 activity.”

You wrote this artcile and i made the consequences I wrote above:
https://selfhacked.com/blog/nad-and-sirt1-their-role-in-chronic-health-issues/

Please help me, I am a bit confused.. How I know I have high levels of MAO A. Am I right?
I have rs6323 GG,
rs909525 CC

Thank you a lot for your time and consideration!

By: Lahdeedah

Lahdeedah — Sun, 04 Nov 2018 02:16:08 +0000

I’m a female and have the TT MAO-A mutation, and I can say from experience, I’ve always had general anxiety and social anxiety, and have a tendency towards fight or flight response. I do display outward anger, and will pursue the person, even physically. I otherwise appear very calm, but underneath that cool exterior, I am alert. I’ve been working on my response to conflict, and trying to figure out the best way to cope with stimulants. I have been taking SAMe 400mg/day and Ashwagandha 600mg/day to increase seretonin and regulate cortisol production, respectively. I recently suffered two miscarriages and am trying to see if there is any correlation between the Warrior Gene in women and PCOS (polycistic ovarian syndrome, which is basically shorthand for elevated testosterone, and imbalanced estrogen/progesterone) – I suspect that the Warrior Gene could contribute to higher production of androgens (Testosterone) and would therefore cause symptoms of PCOS, and thus lead to infertility and miscarriages. I saw someone above mention that she also has the TT and elevated testosterone. Which is interesting because it points towards my hypothesis being correct, or at least having a possibility of being correct.

By: Jaclyn

Jaclyn — Thu, 01 Nov 2018 20:35:16 +0000

In reply to Kay. I also have TT and I have PCOS. hmm interesting correlation!

By: Reese

Reese — Wed, 27 Jun 2018 16:58:41 +0000

I recently found out I am homozygous, MAO A R297R rs6323 TT +/+.
I am incredibly not aggressive or super impulsive. I overthink and analyze everything to death. I have a bachelors degree and was a member of Mensa, so my IQ is in the 98th percentile. So everything I have read about having this gene doesn’t seem to pertain to me at all. Am I missing something? I am new to studying genetics to this degree and am trying to understand these mutations as much as possible, thank you.

By: Matt E.

Matt E. — Mon, 09 Apr 2018 23:03:36 +0000

Hi everyone, showing my cards!

rs6323 – GG
rs1137070 – TT
rs2064070- AA
rs909525- CC

High or low Mao a?? Thank you, Matt

By: Elmas Ålsnäs

Elmas Ålsnäs — Thu, 15 Feb 2018 20:48:49 +0000

Hi, I made DNA test recently and had my result last week. I have warrior gene also both X chromosome. Mine is rs909525(G;G)

Geno Mag Summary
(A;A) 1.2 Probably MAOA 4 or 5 repeats: not Warrior Gene.
(A;G) 2 Probably one Warrior Gene and one non-Warrior Gene.
(G;G) 2 Perhaps MAOA 3 repeats: Warrior Gene

By: Helen

Helen — Tue, 02 Jan 2018 21:39:01 +0000

In reply to Katie. Hi Katie, in that study, ammonia increased MAO-A activity in rat brains. Unfortunately, since that study is in Russian, we don't know the exact results.

By: Katie

Katie — Tue, 02 Jan 2018 20:45:47 +0000

Hi Helen,
Thanks for the info!
Is the above link suggesting that ammonia increases MAO-A? It was my understanding that ammonia inhibits it.

By: Helen

Helen — Tue, 02 Jan 2018 17:47:53 +0000

In reply to Katie.

Hi Katie, there is not a lot of scientific evidence available regarding ammonia and its effects on MAO-A: https://www.ncbi.nlm.nih.gov/pubmed/14735783

By: Katie

Katie — Mon, 01 Jan 2018 03:41:20 +0000

Hi, I just discovered the CBS-MAO connection. I also have high CBS. I also found out that ammonia lowers MAO-A as well. Is there more to this story? Do you have any links? And how exactly does molybdenum come into the equation?

By: Travis

Travis — Sat, 16 Dec 2017 17:39:21 +0000

Hello sir; I believe we share the same variant, and oddly enough I discovered the perfect complement. Anyway, I started on progesterone topical cream, male formulation, and I can honestly say it was a good move. And the changes to my mood and physical appearance we’re pretty immediate (basically, stress fat areas began to minimize slightly). Worth looking into.

By: kristina

kristina — Fri, 10 Nov 2017 19:34:13 +0000

I believe low MAO is what makes you NOT lazy.

By: Katie

Katie — Thu, 02 Nov 2017 00:27:40 +0000

I am thinking of trying PQQ for SIRT1 activation in order to increase MAO-A. It seems that there may be a more direct correlation between PQQ and MAO-A, however… But any studies or other info that I find that link the two is very brief. The clearest info that I can find simply states something about MAO-A being dependent on PQQ (although I do not know if this is what it is actually trying to say).

By: Bill Scar

Bill Scar — Tue, 26 Sep 2017 02:15:01 +0000

James W… What an ignorant string of assumptions. The whole point of high MAO is that it lowers certain neurotransmitters in the brain, which may contribute to low motivation.

And you said there is no such thing as low Dopamine — you are a fool; try to stay off this discussion board until your mania passes.

By: Nattha Wannissorn, PhD

Nattha Wannissorn, PhD — Thu, 21 Sep 2017 22:41:46 +0000

In reply to James Wagner. MAOA isn't the only enzyme or factor that controls motivation. For example, Joe finds that if he eats tomatoes, he will have no motivation for a few days.

By: James Wagner

James Wagner — Thu, 21 Sep 2017 22:18:40 +0000

I have genetic variants for “low MAO-A” whereas my friend has genetic variants for “high MAO-A” he can’t get his lazy ass off the couch to join me for even a quarter of my morning run, he can make it once or twice a month.

So how is it that I’m oh so much more motivated, and have zest for life when I’ve got the shortcomings? Doesn’t make much sense does it.

He’s just lazy, and anyone looking for shortcuts or genes for help being motivated is wasting their time. Just get out and do stuff.

By: James Wagner

James Wagner — Thu, 21 Sep 2017 22:12:24 +0000

No, none of these common genetic variants will cause a reduction in neurotransmitters. Your environment, diet and attitude will.

Just stop being lazy, get out and do stuff. Motivation isn’t given, it’s earned. You must be motivated to increase motivation.

There’s no such thing as “insufficient dopamine”, we already know serotonin is involved in mood, not dopamine.

Just quit being lazy. “Low or high MAO-A” cannot be predicted, especially not through genes. And even if it could, person a with Low MAO-A vs person B with high MAO-A will not have any easier of a time getting motivated or have any increase in mood.

By: Kay

Kay — Fri, 01 Sep 2017 21:00:15 +0000

Hi Ann! Same here with TT and also have high testosterone for a lady Is yours PCOS related?

By: Katie

Katie — Tue, 22 Aug 2017 15:20:36 +0000

I’d just like to point out hat estrogen actually inhibits MAO-A. Progesterone does help though (increases it).

By: Ann

Ann — Sat, 29 Jul 2017 15:32:11 +0000

The only thing I notice is anxiety. I can get this easily, and sometimes out of nowhere which is annoying and makes me think I have something with my heart or something lol even tho my blood tests are excellent. But reading through the comments this may have something to do with it.