Comments on: 5HT2A Receptors: Link to Anxiety, Fatigue & Sleep Problems?

By: macetheace@gmx.de macetheace@gmx.de

macetheace@gmx.de macetheace@gmx.de — Sat, 26 Dec 2020 04:55:14 +0000

Th 5-HT2A receptor is definitely an anti-stress (not stress) receptor, blocking it causes stress, upregulating it increases ability to handle stress or lifts “depression”. That animal test might not so easily relate to “stress” how one understands it, if it translates to humans at all. Inferring from BDNF that there is no stress is not really conclusive. As with many “treatment” ideas, that immediately become dogmas, it may be that 5HT2A-antagonism shuts the brain down so far that its issues become completely different than before. BDNF release may be associated with some forms of stress, and less with others. Indeed 5HT2A antagonism in my experiences increases confusion, discomfort, and the brain may react wirh BDNF to a different kind of stress that seems more physical, related to basic function, than only psychological. Meanwhile the animal may be more confused and in discomfort than just anxious, frustrated. I am directly translating how I would react to 5HT2A here, but it’s just a proposal (and they translate even more crudely and loosely, I maintain).

By: sam

sam — Sat, 17 Oct 2020 15:05:14 +0000

what are the positive effects of stress?

By: Jacqueline P.

Jacqueline P. — Sat, 31 Aug 2019 03:15:10 +0000

I took a gene therapy type test at one point to help my dr. figure out the best antidepressant for me. It did not really end up in resulting in a change of my depression, however I did learn that some genes may affect medication results. I am currently trying microdosing with psilocybin (due to my unresolved depression issues with western medication approach) but unfortunately I have had really zero change in mood, or anything. I feel zero difference. I am wonderful after reading the above if this might have something to do with the gene mutations? I am a bit confused though. I am going to paste the different mutations below. If anyone has any comments on this, I would love some feedback. (Also might mention I suffer from chronic migraines, brain fog, obesity, anxiety, insomnia, and restless leg syndrome…it seems some of these also may have something to do with this?)
Serotonin Transporter(SLC6A4)S/S[Higher risk of non-response]
Serotonin Receptor 2C(5HT2C)C/C[Weight gain risk]
Dopamine 2 Receptor(DRD2)C/DEL[Intermediate risk for poor response]
Methylenetetrahydro-folate Reductase(MTHFR)C677T:C/T A1298C:A/A [Intermediate activity]
CYP2C19IM*1/*2[Intermediate activity]
CYP2D6IM*4/*41[Intermediate activity]
CYP3A4*1/*1 CYP3A5*1/*3Fast Metabolizer[High activity]
Thank you.
*i understand any comments are not meant to be medical advice and will not treat any comments as such. I am just looking for general explanation.

By: Adamo Quaranta

Adamo Quaranta — Fri, 19 Jul 2019 18:44:13 +0000

In the list of blockers you can add ganoderma lucidum (reishi) as this functions as an antagonist and I found a great relief for stress, I’m low MAO A producer.

By: James Dean Truax

James Dean Truax — Fri, 24 May 2019 10:46:14 +0000

Really is this why MDMA and LSD are being used around the world to treat depression anxiety and PTSD come on let start telling the truth

By: Pauline

Pauline — Sun, 21 Oct 2018 07:20:07 +0000

Found this after reading an interesting article looking for solutions to what I now define as drug induced psychosis through LSD in 2014. All of this stuff is very informative and interesting but I am looking to help my brain since this “difficult” trip years ago…have never been on any medications just taking different vitamins…this thread and article are all in relation to the difficult trip I experienced years ago. (Which, side note, I have tripped since then and had a couple of more difficult experiences where I️ experienced Catatonia once and then I always tripped again and had a beautiful eye opening experience that most of us have while tripping) just looking for more info on supplements for my brain. Thanks for all your input and this article. Any suggestions are welcomed and I’d be happy to in to more detail about any experience to figure out what supplements to begin. All I️ can say is that I’ve felt different since those difficult experiences. Thanks!

By: FxH

FxH — Tue, 22 May 2018 14:06:51 +0000

@Stenseven
“MDMA causes depression that takes months, sometimes years, to recover from. It wrings out the serotonin from your system like squeezing a wet sponge until it’s completely dry. I suspect that many of the chronic depression diagnosis today are the result of MDMA usage.”

Count on it, anything this site says will be completely wayward and fanatically counter-productive in one way or another, with a typical dark online poser’s air self-importance and devious destructiveness.

By: FxH

FxH — Tue, 22 May 2018 14:01:24 +0000

I remember… You’re that a**hole site that comes across as little else than a site where nazi psychiatrists would be “Trump” and you would be Trumpsters, with about the same toxicity, creepy underhandedness and unhinged zeal.

By: Stenseven

Stenseven — Mon, 26 Feb 2018 21:21:26 +0000

MDMA causes depression that takes months, sometimes years, to recover from. It wrings out the serotonin from your system like squeezing a wet sponge until it’s completely dry. I suspect that many of the chronic depression diagnosis today are the result of MDMA usage.

By: Stenseven

Stenseven — Mon, 26 Feb 2018 21:17:03 +0000

I am 60 years old and have microdosed LSD most of my life. For some reason it does the opposite of what is outlined in this article. Cannabis and alcohol, however, cause a lot of problems for me and I avoid them.

Dilution of blotter LSD can be done using 80% distilled water and 20% 100 proof vodka. It takes a couple days for the dispersion, shaking every 8 hours or so. Be sure to do the math to get the dosage correct.

By: Caitlyn Daniels

Caitlyn Daniels — Sat, 17 Feb 2018 01:20:14 +0000

I couldn’t agree more. Quetiapine falls into this category, and it is VERY well known for causing/contributing to joint problems. What I don’t know yet is if this can be reversed by going off of it… it’s also incredibly difficult to get off of, which is yet another reason why it’s simply irresponsible to casually include it in a list of drugs that people might want to try. It is literally going to take me a year to get off it from a dose of 16 mg!!!

By: Caitlyn Daniels

Caitlyn Daniels — Sat, 17 Feb 2018 01:15:11 +0000

Please do not promote the use of quetiapine. Drug companies are already doing a very efficient job of that. And it is simply not true to flatly state that it ‘decreases depression.” The antidepressant effect has never been shown to work for more than 25% of all subjects in studies and only for a limited amount of time. This is a drug with profound and negative side effects. it’s probably appropriate for people who have been diagnosed with schizophrenia, but it is also widely prescribed off label for insomnia, which is what happened to me. Weight gain, dissociation, INCREASED depression, INCREASED anxiety, lowered cognitive functioning, much lower creativity, lack of motivation, fuzzy and out of it feeling all morning long, etc etc etc… I do not like to see this drug casually recommended, and I have first hand experience with it. So please do not do it again. I’m sure that this blog provides a lot of valuable information for a lot of people, but it is just plain irresponsible to put quetiapine in a list of drugs that people should take without a lot of information on the horrible side effects.

By: Skal

Skal — Sun, 07 Jan 2018 07:21:54 +0000

Psilocybin (mushrooms) has also been shown to reduce the 5HT2A receptors in the brain.

By: Conrad

Conrad — Wed, 20 Dec 2017 17:52:58 +0000

SO, after all that’s said, which of these supplements does actually DOWNREGULATE 5ht2a, not only “disconnect it temporarily”?

I guess there’s a lot, lot more to investigate in these areas, and it would be awesome to actually get the results that ones actually looking for bout this.

By: Haim Benchimol

Haim Benchimol — Sat, 11 Nov 2017 23:01:00 +0000

I’m not sure about inositol, I felt some benefits and some disadvantages, but for sure, agmatine isn’t for people with some PSTD symptoms like me. I tried it once to try to lower my blood pressure and it was like a kick in my head, terrible anxiety more than ever and a profound sense of hopeless.

By: An-Marie

An-Marie — Wed, 13 Sep 2017 18:36:00 +0000

So calcium supplements can be an issue ?

By: Rob

Rob — Tue, 05 Sep 2017 22:35:15 +0000

You are right. These informations are completely wrong. 5H2A Receptors activation may cure several psychological issues. Terrific results have been showed on chronic ptsd patients, also, read this article : https://www.sciencedaily.com/releases/2017/09/170904093724.htm . Sure, it s about therapeutic setting, otherwise that window of super neuronal plasticity could backfire.

By: jackvern

jackvern — Wed, 24 May 2017 17:12:22 +0000

By reading the information above, i have read that activation of the 5ht2a receptors like taking psychedelics causes bad effects of “anxiety and obesity”….i would very much disagree with this misinformation stated at this site by the author but not to offend…As these information to the public are quite crucial for the facts…I have experienced much psychedelics and i do not find or see anyhow by activating 5ht2a receptors can cause a person anxiety at all, in fact the other way around that it relieves anxiety a lot because it fills and completes all your curiousities answers…It gives you an inner feeling of peace…and for the obesity part as well, most people that takes psychedelics the first time could almost turn into a vegan permanently due to the high feeling of empathy towards animal killing and commercial farming…so in a way for the author of stating the wrong bad effects could assume that the author has never had a psychedelic experience qualified to provide the accurate information above..no pun intended..just concerned with misinformation to public

By: mitchell

mitchell — Wed, 17 May 2017 17:52:50 +0000

Lots of info here, with seemingly little understanding. Such a different take on all this as contrasted with: [raypeat]

By: Andrew Donald Wilders

Andrew Donald Wilders — Sun, 19 Mar 2017 16:38:11 +0000

In reply to Joseph M. Cohen.

Lithium increases 5ht2a activation, worsens chronic fatigue, worsens ocd, worsens depression, worsens hallucinations, worsens suicidal ideation, etc., etc. Make lithium recommended for increasing 5ht2a activity.

While inositol supposedly counteracts 5ht2a activation, it seems to do the opposite in higher dosages and feels exactly like taking tryptophan. Does it work against 5ht2a activation induced ocd? People claim so but I doubt it. People claim it lowers serotonin (the neurotransmitter in the blood) but I really seriously doubt it, I think it does the opposite.

Anyway, I really love this webpage, great info and great help, couldn’t do the research myself. :D

By: Mikey

Mikey — Tue, 24 Jan 2017 22:18:00 +0000

Inositol seems to resensitize serotonin receptors across the brain- personally it felt as if it did the opposite of what I’m looking for when I tried using it. The studies on this one are all over the board and mostly confounded with precious illness and gender so it’s hard to say what’s what.

On that note, Cyclobenzaprine (even in low doses) has been a godsend for sleep- it lowered my prolactin and manipulated some other things that all fall in line with quieting 5HT2A activity. Also, as a 5HT2A antagonist it downregulates the receptor as well and has shown some clinical promise in attenuating some symptoms of fibromyalgia.

By: Hypolaristic

Hypolaristic — Wed, 28 Dec 2016 11:16:53 +0000

In reply to Hi C. So you're saying: LSD causes glutamate excitotoxicity in the long term and I should counteract that with memantine?

By: Hypolaristic

Hypolaristic — Wed, 28 Dec 2016 11:11:35 +0000

In reply to luke. Same here. Effect lasted for about 1 week afterwards.

By: Nolan

Nolan — Sat, 04 Jun 2016 03:23:56 +0000

There is this interesting study that associates antagonistic cross-talk between the 5-HT1A and 5-HT2A receptors (studied in midbrain pyrimidal neurons – although likely localize in the same fashion elsewhere in body).

It was observed that 5-HT1A agonists decreased the head shake response and antagonized the excitatory effect of 5-HT2A agonists (AMPAR and *mGluR type II)

*side note: mGluR II stimulation has a suppressive effect on HPA activity. Just look up eGlumegad.

I would posit that loss of function variants in the 5-HT1A receptor would exacerbate gain of function variants in the 5-HT2A receptors.

This relationship may explain the therapeutic benefit of mixed serotonin agonists like LSD (which is actually a slightly stronger as a 5-HT1A agonist – see wiki page).

I would like to add more to be more thorough, but I can’t at the moment. The whole piece is really valuable and just wanted to put this in your court.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC446220/#!po=57.4675