Please speak with your doctor or pharmacist about any potential drug interactions. For other health-related questions, join SelfHacked VIP to get answers from Joe at https://selfhacked.lpages.co/selfhackedvip/.

Hi, thanks for pointing that out! I’ve fixed the numbering. :)

To add to your longevity booster list. Check out a total of 212 anti aging agents in this research paper, including 62 clinical medicines with anti- aging activity including rapamyacin, metformin, aspirin, berberine, huperzine A, minocycline, phenformin, vitamin E, buformin, melatonin, ivabradine, acarbose, metoprolol, nebibolol, cortisone, myriocin, caffeine, and more. Interestingly, the anti-aging mechanism of most drugs here are different from their clinical applications.
These are just a few of the many anti-aging natural plant sources listed, plus one bug, one yeast, two bacteria and bee by products: Yellow mealworm extract, cinnamon, Mexican Willow primrose, jujube, cranberry, Rosa damasceana flower extract, blueberry, Siberian ginseng, Oriental arborvitae leaf extract, Reishi mushroom, Mon Tsai Tai (Asian greens with purple stems used in stir fry), KPE-7 (Rosemary, thyme, curcumin, licorice, grapeseed, Siberian ginseng, silk protein, marigold), Er Chen Wa (ginger, poria, tangerine rind), Huan Shao Dan (Cistanche, Morinda root, licorice, Rehmannia, dogwood fruit, Eucomiae, Poria, Discoraea, schizandra, polygala, jujube), Liu Wei Huang Wan (Rehmannia, dogwood fruit, maten, Discorea, Poria, Alismetis), Sheng mai Wan (ginseng, Ophiopogon, Schizandra, Codonopsis), Shi Quan Dobu Wan (Astragalus, cinnamon, Rehmannia, peony, Ligustrum, Angelica, ginseng, Poria, licorice, Astactodes), mulberry leaf, Urn orchid, currant, curcumin, Rhodiola, Indian Gooseberry, a leaf tea from a bamboo called Sassa senanensis, green vegetables, hydrolyzed maize protein, ferula, Stereospermum suavalens, vitamin E, Premna integrifolia, common hop, broccoli, ginkgo biloba, extra virgin olive oil, royal jelly, propolis, walnut, Pinus densiflorus (Scots pine), Pinus sylvestris (Red Pine), Abies grandes (fir), garlic, Plumbago zeylanica, burdock, legumes, alfalfa, a bacteria called Bacillus subrillisvar and the penicillin bacteria, milk thistle, strawberry, raspberry, Tree of Heaven, nuts, black tea, green tea, onions, grapes, Eucalyptus leaf, a yeast called Saccharomyces cerevisiae, Thunder God vine, olive leaf, Eklonia cava, soybeans, Ophiopogon japonicas tuber, Chinese Lacquer tree, Korean mistletoe extract, Neem leaf extract, apple, cocoa, gastrodin from an orchid, stinging nettle, black cumin seed, Chinese Tea Tree Mushroom, Cordyceps mushroom, Cynomerium songaricum, resveratrol from Polygonum cuspidatum, Chinese Skullcap, tomatoes, carrots, wheat, coffee, algae, berberry, Horny Goat Weed, grape seed, olive, grape juice, sesame seed, pomegranate, sage, rosemary, thyme, oregano, peppermint, spearmint, basal, red algae, Adzuki bean, Sargassum seaweed, Euonymous seeds, and saffron. These anti-aging agents are amino acids: creatine, lysine, arginine, alanine, leucine, glutamine, asparagine, theanine, cysteine, histidine, proline, serine, ornithine, homocysteine, isoleucine, methionine, carnosine, spermidine, taurine, threonine, valine, tyrosine, tryptophan. These anti-aging agents are nucleotides: guanosine, nicotinomide riboside, nicotinamide mononucleotide. These anti-aging agents are hormones: pregnenolone, estradiol, cholesterol, vitamin D3. Here are more anti-aging agents: lithochollic acid, butein, citrus, hydrogen sulfide, withanolide, trehalose, quercetin, kaempferol, fisetin, lutein, chlorophyll, genistein, guanosine, TA-65, alpha lipoic acid, astxanthin, catechin, fucoxanthin, rosmarinic acid, gallic acid, glycerol, lactate, vitexin, urolithin A., Baicelain, catalpol, chlorogenic acid, caffeoyl, carotenoids, coQ10, inositol, glucosamine, acetic acid, natural polyamines, vinegars, ketoglutarate, and more. They list the chemical structure, clinical application, source, and the anti-aging activity and proposed anti-aging mechanism, plus the percentage increase in life extension. Check out more. This is just a partial list of 212 anti-aging agents.

In the last 20 years, pharmaceutical companies have been enthusing their drug development strategy of high throughput screening and combinatorial synthesis of enormous synthetic libraries of small molecules. The achievement of new lead discovery and new drug approval has been very disappointing. They neglected natural products. Compared to synthetic compounds, natural products are secondary metabolites, evolutionarily optimized with biologically relevant chemical space and preferred ligand binding motif, and are not only biologically active but have a high degree of bioavailability, suitable for functional and phenotypic assays. Natural products are an invaluable source and provide great promise for developing anti-aging medicine.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4941334/ Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes

[biofoundations] Delaying the Chronological Aging of the Yeast Saccharomyces cerevisiae by Six Plant Extracts

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239441/#R3 Six plant extracts delay yeast chronological aging through different signaling pathways

also….

The bottom line is that glucosamine supplementation lowers human mortality

Glucosamine and Chondroitin Sulfate have already been shown in a large epidemiological study to lower overall mortality and reduce cancer risks – a 5-year study of 77,719 elderly residents of Washington State. We found several publications based on different analyses of data based on this population.

Conclusions:

For most of the supplements we examined, there was no association with total mortality. Use of glucosamine and use of chondroitin were each associated with decreased mortality.”

Both of these papers were done on the same group of 77,719 people. We note that this is as great an effect as combining vegan diet and fish consumption! We find this quite surprising. Glucosamine appears to have a comparable or greater effect on mortality reduction and lifespan extension than Metformin, Rapamycin, 2DG, Veganism, and Resveratrol in nematodes and rodents.

RESULTS: Persons reporting use of glucosamine + chondroitin on 4+ days/week for 3+ years had a non-statistically significant 45 % lower Colorectal Cancer risk than non-users

Epidemiological evidence exists that glucosamine and chondroitin supplementation reduces inflammatory biomarkers.

Glucosamine supplementation may be protective against lung cancer.

* A 2010 publication suggests that taking high doses of glucosamine or prolonged use it glucosamine reduces levels of SIRT1, leads to apoptosis of pancreatic cells and could increase the risk of developing diabetes.

* keep dosage under 750 mg?

Thanks.