Lolinda
- All
my numerous food intolerances pointed to the gut. In final desperation of
my ME (20 hours of sleep in total over 10 days, almost unable to eat
anything or to think
), I still could read and
grab straws . I read about starving out bad
bugs in the gut by the specific carbohydrate diet. I immediately knew by
experience, I would not tolerate the simple sugars still permitted on that
diet, so I went full low-carb paleo. Within 2 weeks ME was resolved and I
was able to carry a backpack. And eat more foods. And sleep a bit. And
run, but not sprint and no pushups or any more demanding calisthenics.
Digging soil in my moms
garden was ok at the price of some sleeping probs. - I
noticed that within my low carb diet, it is not that it was ketogenic but
I needed very low carb. I needed to avoid other stuff than carbs, too,
that feeds gut bugs such as foods with high choline or carnitine contents.
E.g. for eating beef, I got punished with regression into more exercise
intolerance for some time.
- Transdermal
vitamins. My crappy gut does not tolerate any oral vitamins and I had all
sort of deficiencies according to my labs and my cronometer
nutrition reports, too. So in desperation, I smeared vitamins on skin. It
was a looong try-and-error and retest retest retest at labs
(rotating doctors who signed prescriptions so
I don't exhaust anyone's goodwill ) until I replenished all
according to the labs. By-and-large, I need very very
roughly something in the ballpark of 50x of the RDA on skin to replenish.
It works for me with B2 (200mg), B3 (200mg), B5 (500mg), B6 (100mg), and
biotin (20mg). Choline as citicoline I need only 500mg. If you try, be
warned that absorption and hence dosage will strongly vary by skin type.
My dosages bring me from deficient labs into the normal range and improve
symptoms. In other words, only tiniest fractions absorb. Still, beware:
never ever start using these doses. These doses are my final doses after
working up myself starting with milligrams over months!! B3 can be utterly
dangerous suddenly in bigger doses, even leading to arrythmias. I had
some, and cramps too. The other vitamins aren't fun either if a deficient
body is overwhelmed.
Result: Choline was my first successful transdermal vitamin, which improved motility and I felt more calm, but I still needed further motility aids (artemisia, leccino). I tried before choline: B2, B3 and B6 but failed. (Just for completeness, I also took transdermal Mg-Cl and orally cod liver/oil with good results). After choline, B2 succeeded, first in tiny doses only. Bigger ones caused gut trouble. B2 stopped my neuropathy attacks. Then, B6 brought down my homocysteine as expected. B5 made me able to eat more calories. Biotin made me able to sleep on my left side without my heart and gut rambling, and calmed my itching scalp. B3 (as niacin) I could start only after reaching some levels with those before. It was only then a big winner. At the price of a red skin initially, It cured my carpal tunnel (the niacin burning is sooooo pleasant if you have a carpal tunnel syndrome and it has a lasting curative effect too). Smearing it on face, it gave me back the young glow of my skin (after the red blush is gone of coure, but now I always have good
looking red cheeks, even without niacin . I guess make-up is an imitation
of being healthy) and B3 made my thinking quick and clear (aka the rest of
brain fog resolved. The first round came due to Konynenburg
methylation, the second due to low carb paleo). And back to the topic of
this thread, all these improved together my running speed. Oh I forgot to
mention B1, which I succeeded to replenish by food which not only
replenished my lab values but brought down my excessive noradrenalin,
which in turn I credit to enable me to sprint (that "sprint" at
that time others would have called just normal running... ). And currently I am
experimenting with adding creatine to my transdermal mix, if you have
experiences, oral or transdermal, please comment here. - And
now my last and main winner: carnitine. See details on
dosage on this thread for people who had deficient carnitine labs. In brief, it brought me back to
full normal sports and hard physical work, without regrets!! Pushups?
Pull-ups? Bum and leg exercises? Run up stairs
carrying my groceries to the top floor? Carry home an oversized clay pot
from the garden center? No problem. I love to feel my body and every bit
of it as I put in effort. And to see my shape slowly rounding where it
should be round, thanks to sports and thanks to eating well. How come: I
found out that I have had a carnitine deficiency (see here for my labs). This carnitine deficiency did
not come about because of my keto diet (maybe it was reinforced) but was
already there before. How do I know? I can't fully prove it but carnitine
resolved symptoms that were there already long before. My gut motility was
always crappy already as a child, and I had Aspergers.
Both can be caused by low carnitine and in me, on carnitine
supplementation, my gut motility is the best I ever had in my life. And
while after B3 I was satisfied with my thinking, I was still good at the
oh so academic "skill" of finding complicated solutions for
simple problems. This last bit of an aspie I am
happy to have killed now, very happy because it simply saves time which I
need so much to resolve my rest of issues: neuropathy and POTS. And then
live my hard-won life again and have a happy family, most of all . If you didn't get a carnitine
test yet
she either used a liquid
oral form of the vitamin and rubbed it on her skin, or she used the contents of
a capsule mixed with water or some other diluent and rubbed that on
her skin. An inventive and innovative approach that may not work for everybody,
but to all appearances did work for her.
Also, take heed of Lolinda's
warning: she had to get various vitamin's lab readings up into or at least closer
to normal range before she could proceed with some of the others
- percyval577 Carb avoidance at least helps greatly, though I too
likely never achieved keto. Most important avoidance in my case is
manganese. In addition meat might be an issue, I am not sure, but if so I
would blame the nuclei. Two restrictions I discovered only recently, wheras manganese is now a slow 5 years thing, but
since a nice success I am still sensitive to it. I think avoidances might
actually be prerequisite.
- Bīs
have been of quite some help, especially 5, 7, 2, 1, occasionally 3 and
12, but avoiding 6 and 9. To me it seems that they code for geometrical
actions in the brain, though itīs of course only my impression. I found
that small amounts (in water) and taken separately is good. B7 brings some
concentration about, B5 brings some enlightment
about, B1 might support confidence or so, B2 (for me the most important
one) might support poise or so. (All this not for psychological reasons, I
think it happens in the basal ganglia and thalamus).
- MgCl - This was my second intervention one year after
having discovered low Mn. It worked only together with hydrogencarbonate:
I put a small amount in a vitamin effervescent tablets, drank it
completely, and it made "woosh" in my brain, and I was able for
three days to clean my flat! But then the effect stopped. Only now, four
years later, I rediscovered it. And now I do only sips, probabaly matching you
transdermal experience. For one time I also had good effects from a mineralwater. I now ordered potassium (supp contains
citrate), good effect too! Magnesium has in combination with these two a
better effect as well. I seperate K (normal
amounts) and Cl (only a drop of a MgCl-dissolving
in water, again, with normal amounts of Mg, B12 and vitC
from effervescent tablets).
- I
want to add mentioning acetate, especially in a sequence with the
electrolytes, only a drop of vinegar, I tested it only in a separate water
- very helpfull! I think acetate, B12 and vitC make up one category, readjusting epigenetics,
protein actions and stem cells.
- Also
citrate, which I had tested along with acetate, B12 and vitC. Its a chelator of
quite some metals, and their distribution might need to get readjusted as
well. Chocolate contains these metals, and I now find the potassium in
cocoa helpful. I also tested some metals separetely,
and my impression is that the effects are comparable to the Bīs, with zinc
being most important (bringing a focus about), nickel like B5, chromium
like B7, aluminium (amounts leaching from dishes
are too high) makes me feeling "growing outwards" or so.
After I just a few days ago
rediscovered MgCl and discovered the other two
electrolytes, I find that the Bīs and transition metals are not anymore working
like they had before; to take them like I used to do with quite some success
seems even to be detrimental.
I already started quite some theoretical
threads, for later sharing my experiences, but now I think electrolytes - (Mg)
Cl !!! - might be next to and upon one or more avoidances most important, but
are probably not already sufficient. And crucial may be to take up the stuff in
a slow but perhaps nevertheless pronounced manner
Learner1 As you have done, testing, developing a comprehensive
protocol, retesting, and tweaking the protocol is what will help, ideally
understanding a lot if biochemistry in the way. You didn't mention how you beat
back EBV, which takes a strong antiviral for many of us, and I guess you were
lucky not to have other infections, immunodeficiency and/or autoimmunity that
many of us also have, requiring further treatment.
Like you, I've been on a low-carb Paleo diet,
high dose B1, B2, NAD+//NMN, B5, B6, 5-MTHF, and B12, with phospholipids and
carnitine, but though they helped, they did not make me well.
Attention to oxidative and nitrosative
stress by a comprehensive antioxidant protocol, addressing NO and peroxynitrites, taking BH4, chelating heavy metals, taking
care of mold, addressing hormones and amino acid deficiencies were all key
steps. Along with beating back 6 other infections, getting IVIG for
immunodeficiency and autoimmunity, and dealing with 3 autoimmune problems
helped, too. And understanding my genetics, which made me prone to done of gear
challenges, and applying nutrigenomics help paid off as well.
And @percyval577 manganese is extremely important for many of us, as
it is needed to make MnSOD, which defangs superoxide
radicals thrown off by mitochondria in the process of making ATP. Glad you
don't need any, but a lot of us need it.
Again, I'm not suggesting that anyone fo exactly as I have, but I did all the things that helped
you, and they didn't fix me. It took a lot more. The best thing is for each
patient to get testing that uncovers these problems and then follow a
comprehensive plan to address what is found
percyval577 its
a guess on resident stem cells (in the brain), following two findings on pluripotent
embryoninc stem cells ("Vitamin C and L-Prolline Antagonistic Effects Capture Alternative States in
the Plurypotency Continuum" DīAniello
et al 2017 and "Vitamin C induces a pluripotent state in mouse embryoninc stem cells by modulating microRNA expression"
And [USER=29858]@percyval577 manganese is
extremely important for many of us, as it is needed to make MnSOD,
which defangs superoxide radicals thrown off by mitochondria in the process of
making ATP. Glad you don't need any, but a lot of us need it.
To my knowledge it
converts superoxide to hydrogen peroxide [O2ī(-) to H2O2], the latter coming
out of the mitochondria, and being further converted to to
other molecules including radicals. There is research on tasks of such
"signaling metabolites
Pearshaped
regarding transdermal
vitamins:
I used to use a cream called Oxi-cell.
(from the US)
did you use that @Lolinda?
It contains Gluthathione,SOD,B2,B3,ALA and
many other things.
I crashed everytime
I used it but I can imagine that it can work for others
sb4
I was linked to this study a while ago
on another forum. It is paywalled but the abstract is interesting.
Acetyl-L-carnitine activates the
peroxisome proliferator-activated receptor-γ
coactivators PGC-1α/PGC-1β-dependent signaling cascade of mitochondrial biogenesis
and decreases the oxidized peroxiredoxins content in old rat liver.
Abstract
The behavior of the peroxisome proliferator-activated receptor-γ coactivators PGC-1α/PGC-β-dependent mitochondrial biogenesis signaling pathway, as well
as the level of some antioxidant enzymes and proteins involved in mitochondrial
dynamics in the liver of old rats before and after 2 months of
acetyl-L-carnitine (ALCAR) supplementation, was tested. The results reveal that
ALCAR treatment is able to reverse the age-associated decline of PGC-1α, PGC-1β, nuclear respiratory
factor 1 (NRF-1), mitochondrial transcription factor A (TFAM), nicotinamide
adenine dinucleotide (NADH) dehydrogenase subunit 1 (ND1), and cytochrome c
oxidase subunit IV (COX IV) protein levels, of mitochondrial DNA (mtDNA) content, and of citrate synthase activity. Moreover,
it partially reverses the mitochondrial superoxide dismutase 2 (SOD2) decline
and reduces the cellular content of oxidized peroxiredoxins. These data
demonstrate that ALCAR treatment is able to promote in the old rat liver a new
mitochondrial population that can contribute to the cellular oxidative stress
reduction. Furthermore, a remarkable decline of Drp1 and of Mfn2 proteins is
reported here for the first time, suggesting a reduced mitochondrial dynamics
in aging liver with no effect of ALCAR treatment.