​specialized neurons in the arcuate nucleus of the hypothalamus (ARC) are responsible for monitoring energy balance Brainstem nuclei perform a similar function to the hypothalamus, sensing and responding to interoceptive cues by triggering autonomic reflexes, which maintain set points for blood pressure, breathing rate and other organ functions The subfornical organ (SFO) and median preoptic nucleus (MnPO) regulate fluid homeostasis The preoptic area (POA) is a key player in the neural control of thermoregulation Neurons in the arcuate nucleus (ARC) control feeding behavior Nucleus of the solitary tract (NTS) neurons are implicated in the baroreceptor reflex The Bötzinger (Bo) and pre-Bötzinger complexes (PrBo) and rostral division of the ventral respiratory group (RVRG) are involved in respiration Endogenous opiates and behavior https://doi.org/10.1016/j.peptides.2019.170223 Intracerebroventricular administration of an adenosine A1 receptor (A1AR) antagonist prevents torpor entry in AGS and induces emergence from hibernation The activation of A1AR+ neurons in the brainstem nucleus of the solitary tract (NTS) is sufficient to induce this torpor-like state adenosinergic signaling in hypothermic states hibernation is promoted by the action of endogenous opioids, known as endorphins administration of opioid receptor antagonists, including naloxone 

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